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The IntFOLD Server Results

Please cite the following papers:

McGuffin, L.J., Atkins, J., Salehe, B.R., Shuid, A.N. & Roche, D.B. (2015) IntFOLD: an integrated server for modelling protein structures and functions from amino acid sequences. Nucleic Acids Research, 43, W169-73. PubMed

Roche, D. B., Buenavista, M. T., Tetchner, S. J. & McGuffin, L. J. (2011) The IntFOLD server: an integrated web resource for protein fold recognition, 3D model quality assessment, intrinsic disorder prediction, domain prediction and ligand binding site prediction. Nucleic Acids Res., 39, W171-6. PubMed

Links to graphical output:
Download machine readable results in CASP format:
Results will be available for 21 days after job completion (subject to server capacity)

Top 5 3D models for T0515 | Help
Model name
(PDBsum links for templates used)
Confidence
and P-value
Global model quality score Local model quality plot
(click images to download plots)
Model coloured by local quality
(click images to view models, local errors and target coverage interactively)
nFOLD4_multi
_HHsearch_TS1

2p3eA
2qghA
CERT:
1.037E-4
0.6503
nFOLD4_2qghA
_HHsearch_TS2
CERT:
1.05E-4
0.6488
nFOLD4_2qghA
_COMA_TS6
CERT:
1.08E-4
0.6455
nFOLD4_1twiA
_COMA_TS3
CERT:
1.112E-4
0.6421
nFOLD4_1twiA
_HHsearch_TS5
CERT:
1.124E-4
0.6409
Disorder prediction is carried out using DISOclust:
McGuffin, L. J. (2008) Intrinsic disorder prediction from the analysis of multiple protein fold recognition models. Bioinformatics, 24, 1789-1804. PubMed
Disorder prediction for T0515 | Help
Click image to download plot in PostScript format.
Domain boundary prediction for T0515 | Help
Click image to download model or view prediction using Jmol. The model above is coloured according to the predicted domains.
Ligand binding site prediction is carried out using FunFOLD:
Roche, D. B., Tetchner, S. J. & McGuffin, L. J. (2011) FunFOLD: an improved automated method for the prediction of ligand binding residues using 3D models of proteins. BMC Bioinformatics, 12, 160. PubMed
Ligand binding residues prediction for T0515 | Help
Click image to download model or view prediction using Jmol. Predicted ligand binding residues are shown as blue sticks in the image above.
Model quality assessment is carried out using ModFOLDclust2:
McGuffin, L. J. & Roche, D. B. (2010) Rapid model quality assessment for protein structure predictions using the comparison of multiple models without structural alignments. Bioinformatics, 26, 182-188. PubMed
Full model quality assessment results for T0515 | Help
Model name
(PDBsum links for templates used)
Confidence
and P-value
Global model quality score Local model quality plot
(click images to download plots)
Model coloured by local quality
(click images to view models, local errors and target coverage interactively)
nFOLD4_multi
_HHsearch_TS1

2p3eA
2qghA
CERT:
1.037E-4
0.6503
nFOLD4_2qghA
_HHsearch_TS2
CERT:
1.05E-4
0.6488
nFOLD4_2qghA
_COMA_TS6
CERT:
1.08E-4
0.6455
nFOLD4_1twiA
_COMA_TS3
CERT:
1.112E-4
0.6421
nFOLD4_1twiA
_HHsearch_TS5
CERT:
1.124E-4
0.6409
nFOLD4_2p3eA
_HHsearch_TS1
CERT:
1.172E-4
0.6360
nFOLD4_2p3eA
_COMA_TS2
CERT:
1.22E-4
0.6314
nFOLD4_2j66A
_HHsearch_TS3
CERT:
1.397E-4
0.6160
nFOLD4_7odcA
_HHsearch_TS10
CERT:
1.398E-4
0.6159
nFOLD4_1tufa
_sp3_TS2
CERT:
1.411E-4
0.6149
nFOLD4_2o0tA
_HHsearch_TS4
CERT:
1.458E-4
0.6112
nFOLD4_2oo0A
_HHsearch_TS8
CERT:
1.486E-4
0.6091
nFOLD4_2j66A
_COMA_TS5
CERT:
1.502E-4
0.6078
nFOLD4_1knwA
_HHsearch_TS6
CERT:
1.518E-4
0.6066
nFOLD4_1knwA
_COMA_TS9
CERT:
1.52E-4
0.6065
nFOLD4_2yxxA
_COMA_TS1
CERT:
1.523E-4
0.6063
nFOLD4_7odcA
_COMA_TS10
CERT:
1.527E-4
0.6061
nFOLD4_2pljA
_HHsearch_TS9
CERT:
1.557E-4
0.6039
nFOLD4_1f3tA
_HHsearch_TS7
CERT:
1.558E-4
0.6038
nFOLD4_2yxxa
_sp3_TS5
CERT:
1.665E-4
0.5964
nFOLD4_2todA
_COMA_TS4
CERT:
1.68E-4
0.5955
nFOLD4_1hkva
_sp3_TS3
CERT:
1.68E-4
0.5955
nFOLD4_1hkva
_spk2_TS3
CERT:
1.716E-4
0.5932
nFOLD4_2nvaA
_COMA_TS8
CERT:
1.813E-4
0.5872
nFOLD4_7odca
_spk2_TS4
CERT:
1.85E-4
0.5850
nFOLD4_7odca
_sp3_TS4
CERT:
1.871E-4
0.5838
nFOLD4_2plja
_spk2_TS7
CERT:
1.892E-4
0.5826
nFOLD4_1tufa
_spk2_TS2
CERT:
1.924E-4
0.5808
nFOLD4_2j66a
_sp3_TS6
CERT:
1.933E-4
0.5803
nFOLD4_2plja
_sp3_TS7
CERT:
1.934E-4
0.5803
nFOLD4_2j66a
_spk2_TS6
CERT:
2.006E-4
0.5763
nFOLD4_1knwa
_sp3_TS1
CERT:
2.325E-4
0.5608
nFOLD4_1knwa
_spk2_TS1
CERT:
2.352E-4
0.5595
nFOLD4_2yxxa
_spk2_TS5
CERT:
2.998E-4
0.5347
nFOLD4_3btnA
_COMA_TS7
CERT:
3.262E-4
0.5264
nFOLD4_7odca
2_sp3_TS9
HIGH:
1.696E-3
0.3820
nFOLD4_7odca
2_spk2_TS9
HIGH:
2.004E-3
0.3693
nFOLD4_3gwqa
_sp3_TS8
HIGH:
2.216E-3
0.3618
nFOLD4_3gwqa
_spk2_TS8
HIGH:
2.58E-3
0.3507
nFOLD4_7odca
1_sp3_TS10
LOW:
9.248E-2
0.1494
nFOLD4_7odca
1_spk2_TS10
POOR:
1.387E-1
0.1320

Contact

Tel: 0118 378 6332

Email: l.j.mcguffin
@reading.ac.uk

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