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The IntFOLD Server Results

Please cite the following papers:

McGuffin, L.J., Atkins, J., Salehe, B.R., Shuid, A.N. & Roche, D.B. (2015) IntFOLD: an integrated server for modelling protein structures and functions from amino acid sequences. Nucleic Acids Research, 43, W169-73. PubMed

Roche, D. B., Buenavista, M. T., Tetchner, S. J. & McGuffin, L. J. (2011) The IntFOLD server: an integrated web resource for protein fold recognition, 3D model quality assessment, intrinsic disorder prediction, domain prediction and ligand binding site prediction. Nucleic Acids Res., 39, W171-6. PubMed

Links to graphical output:
Download machine readable results in CASP format:
Results will be available for 21 days after job completion (subject to server capacity)

Top 5 3D models for T0635 | Help
Model name
(PDBsum links for templates used)
Confidence
and P-value
Global model quality score Local model quality plot
(click images to download plots)
Model coloured by local quality
(click images to view models, local errors and target coverage interactively)
nFOLD4_multi
_HHsearch_TS1

3mn1A
3mmzA
CERT:
1.333E-4
0.6212
nFOLD4_3mn1A
_HHsearch_TS1
CERT:
1.363E-4
0.6187
nFOLD4_3mn1A
_COMA_TS1
CERT:
1.381E-4
0.6172
nFOLD4_3ij5A
_HHsearch_TS3
CERT:
1.448E-4
0.6119
nFOLD4_2r8eA
_HHsearch_TS6
CERT:
1.504E-4
0.6077
Disorder prediction is carried out using DISOclust:
McGuffin, L. J. (2008) Intrinsic disorder prediction from the analysis of multiple protein fold recognition models. Bioinformatics, 24, 1789-1804. PubMed
Disorder prediction for T0635 | Help
Click image to download plot in PostScript format.
Domain boundary prediction for T0635 | Help
Click image to download model or view prediction using Jmol. The model above is coloured according to the predicted domains.
Ligand binding site prediction is carried out using FunFOLD:
Roche, D. B., Tetchner, S. J. & McGuffin, L. J. (2011) FunFOLD: an improved automated method for the prediction of ligand binding residues using 3D models of proteins. BMC Bioinformatics, 12, 160. PubMed
Ligand binding residues prediction for T0635 | Help
Click image to download model or view prediction using Jmol. Predicted ligand binding residues are shown as blue sticks in the image above.
Model quality assessment is carried out using ModFOLDclust2:
McGuffin, L. J. & Roche, D. B. (2010) Rapid model quality assessment for protein structure predictions using the comparison of multiple models without structural alignments. Bioinformatics, 26, 182-188. PubMed
Full model quality assessment results for T0635 | Help
Model name
(PDBsum links for templates used)
Confidence
and P-value
Global model quality score Local model quality plot
(click images to download plots)
Model coloured by local quality
(click images to view models, local errors and target coverage interactively)
nFOLD4_multi
_HHsearch_TS1

3mn1A
3mmzA
CERT:
1.333E-4
0.6212
nFOLD4_3mn1A
_HHsearch_TS1
CERT:
1.363E-4
0.6187
nFOLD4_3mn1A
_COMA_TS1
CERT:
1.381E-4
0.6172
nFOLD4_3ij5A
_HHsearch_TS3
CERT:
1.448E-4
0.6119
nFOLD4_2r8eA
_HHsearch_TS6
CERT:
1.504E-4
0.6077
nFOLD4_2r8eA
_COMA_TS4
CERT:
1.505E-4
0.6077
nFOLD4_1k1ea
_spk2_TS2
CERT:
1.612E-4
0.6000
nFOLD4_1k1ea
_sp3_TS1
CERT:
1.612E-4
0.6000
nFOLD4_1k1eA
_HHsearch_TS5
CERT:
1.634E-4
0.5985
nFOLD4_1k1eA
_COMA_TS5
CERT:
1.667E-4
0.5964
nFOLD4_3mmzA
_HHsearch_TS2
CERT:
1.72E-4
0.5929
nFOLD4_3mmzA
_COMA_TS2
CERT:
1.72E-4
0.5929
nFOLD4_2p9jA
_HHsearch_TS7
CERT:
1.736E-4
0.5919
nFOLD4_3e81a
_spk2_TS1
CERT:
1.779E-4
0.5892
nFOLD4_3e81a
_sp3_TS2
CERT:
1.814E-4
0.5871
nFOLD4_3e8mA
_HHsearch_TS8
CERT:
1.836E-4
0.5859
nFOLD4_3e8mA
_COMA_TS7
CERT:
1.851E-4
0.5849
nFOLD4_3mmza
_sp3_TS4
CERT:
1.881E-4
0.5832
nFOLD4_2p9ja
_spk2_TS3
CERT:
1.911E-4
0.5815
nFOLD4_2p9ja
_sp3_TS3
CERT:
1.911E-4
0.5815
nFOLD4_3ewiA
_HHsearch_TS4
CERT:
1.956E-4
0.5790
nFOLD4_3ewiA
_COMA_TS3
CERT:
1.956E-4
0.5790
nFOLD4_3mmza
_spk2_TS4
CERT:
2.019E-4
0.5756
nFOLD4_2p9jA
_COMA_TS6
CERT:
2.16E-4
0.5685
nFOLD4_3ewia
_sp3_TS5
CERT:
2.379E-4
0.5583
nFOLD4_3ewia
_spk2_TS5
CERT:
2.639E-4
0.5477
nFOLD4_3fzqA
_HHsearch_TS10
CERT:
4.961E-4
0.4862
nFOLD4_3dnpA
_COMA_TS10
CERT:
5.052E-4
0.4844
nFOLD4_1l6rA
_HHsearch_TS9
CERT:
6.137E-4
0.4667
nFOLD4_1wr8A
_COMA_TS8
CERT:
7.135E-4
0.4533
nFOLD4_1l6rA
_COMA_TS9
CERT:
9.112E-4
0.4322
nFOLD4_2b30a
_spk2_TS7
HIGH:
1.442E-3
0.3947
nFOLD4_2b30a
_sp3_TS7
HIGH:
1.442E-3
0.3947
nFOLD4_1wr8a
_spk2_TS6
HIGH:
1.616E-3
0.3857
nFOLD4_1wr8a
_sp3_TS6
HIGH:
1.662E-3
0.3835
nFOLD4_1rlma
_spk2_TS9
HIGH:
1.755E-3
0.3794
nFOLD4_1rkqa
_sp3_TS8
HIGH:
1.945E-3
0.3716
nFOLD4_1rkqa
_spk2_TS8
HIGH:
1.969E-3
0.3706
nFOLD4_1rlma
_sp3_TS10
HIGH:
2.829E-3
0.3440
nFOLD4_3fzqa
_spk2_TS10
HIGH:
2.869E-3
0.3431
nFOLD4_1nf2a
_sp3_TS9
HIGH:
4.022E-3
0.3196

Contact

Tel: 0118 378 6332

Email: l.j.mcguffin
@reading.ac.uk

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