Sue Todd
-
+44 (0) 118 378 8917
-
Professor
- Department Director of Impact
- Research Division Impact Lead: Mathematics and Statistics
- Department Management Group
Office
Room 300Building location
MathematicsAreas of interest
- Adaptive designs
- Group sequential clinical trials
- Epidemiology
My research areas of interest are adaptive designs and group sequential clinical trials. Recent work has considered methodology for novel study design and analysis in these areas, in particular phase II/III clinical trials involving treatment selection and multiple endpoints of interest.
Publications
-
Emmerson, J.
,
Todd, S.
ORCID: 0000-0002-9981-923X
,
Brown, J.
(2021)
Recommendations for designing and analysing multi-arm non-inferiority trials: a review of methodology and current practice.
Trials
, 22
(1).
ISSN:
1745-6215
|
doi:
https://dx.doi.org/10.1186/s13063-021-05364-9
-
Markey, O.
,
Vasilopoulou, D.
,
Kliem, K.
,
Fagan, C.
,
Grandison, A.
,
Sutton, R.
,
Humphries, D.
,
Todd, S.
ORCID: 0000-0002-9981-923X
,
Jackson, K.
ORCID: 0000-0002-0070-3203
,
Givens, D.
,
Lovegrove, J.
(2021)
Postprandial fatty acid profile, but not cardiometabolic risk markers, is modulated by dairy fat manipulation in adults with moderate cardiovascular disease risk: the randomized controlled REplacement of SaturatEd fat in dairy on Total cholesterol (RESET) study.
Journal of Nutrition
, 151
(7).
pp.
1755-1768.
ISSN:
1541-6100
|
doi:
https://dx.doi.org/10.1093/jn/nxab050
-
Howard, D.
,
Hockaday, A.
,
Brown, J.
,
Gregory, W.
,
Todd, S.
ORCID: 0000-0002-9981-923X
,
Munir, T.
,
Oughton, J.
,
Dimbleby, C.
,
Hillmen, P.
(2021)
A platform trial in practice: adding a new experimental research arm to the ongoing confirmatory FLAIR trial in chronic lymphocytic leukaemia.
Trials
, 22
(1).
ISSN:
1745-6215
|
doi:
https://dx.doi.org/10.1186/s13063-020-04971-2
-
Dimier, N.
and
Todd, S.
ORCID: 0000-0002-9981-923X
(2021)
Assessment of the information theory approach to
evaluating time-to-event surrogate and true endpoints in a
meta-analytic setting.
Pharmaceutical Statistics
, 20
(2).
pp.
335-347.
ISSN:
1539-1612
|
doi:
https://dx.doi.org/10.1002/pst.2080
- Dimairo, M. , Pallmann, P. , Wason, J. , Todd, S. , Jaki, T. , Julious, S. , Mander, A. , Weir, C. , Koenig, F. , Walton, M. , Nicholl, J. , Coates, E. , Biggs, K. , Hamasaki, T. , Proschan, M. , Scott, J. , Ando, Y. , Hind, D. , Altman, D. (2020) The adaptive designs CONSORT Extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design. British Medical Journal , 369 ISSN: 1468-5833 | doi: https://dx.doi.org/10.1136/bmj.m115
- Kimani, P. , Todd, S. , Renfro, L. , Glimm, E. , Khan, J. , Kairalla, J. , Stallard, N. (2020) Point and interval estimation in two-stage adaptive designs with time to event data and biomarker-driven subpopulation selection. Statistics in Medicine , 39 (19). pp. 2568-2586. ISSN: 0277-6715 | doi: https://dx.doi.org/10.1002/sim.8557
- Flight, L. , Julious, S. , Brennan, A. , Todd, S. , Hind, D. (2020) How can health economics be used in the design and analysis of adaptive clinical trials? A qualitative analysis. Trials , 21 ISSN: 1745-6215 | doi: https://dx.doi.org/10.1186/s13063-020-4137-2
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Vasilopoulou, D.
,
Markey, O.
,
Kliem, K.
,
Fagan, C.
,
Grandison, A.
,
Humphries, D.
,
Todd, S.
ORCID: 0000-0002-9981-923X
,
Jackson, K.
ORCID: 0000-0002-0070-3203
,
Givens, D.
,
Lovegrove, J.
(2020)
Reformulation initiative for partial replacement of saturated with unsaturated fats in dairy foods attenuates the increase in LDL cholesterol and improves flow-mediated dilatation compared with conventional dairy: the randomized, controlled REplacement of SaturatEd fat in dairy on Total cholesterol (RESET) study.
The American Journal of Clinical Nutrition
, 111
(4).
pp.
739-748.
ISSN:
1938-3207
|
doi:
https://dx.doi.org/10.1093/ajcn/nqz344
- Stallard, N. , Todd, S. , Ryan, E. , Gates, S. (2020) Comparison of Bayesian and frequentist group-sequential clinical trial designs. BMC Medical Research Methodology , 20 (1). ISSN: 1471-2288 | doi: https://dx.doi.org/10.1186/s12874-019-0892-8
- Stallard, N. , Todd, S. , Parashar, D. , Kimani, P. , Renfro, L. (2019) On the need to adjust for multiplicity in confirmatory clinical trials with master protocols. Annals of Oncology , 30 (4). pp. 506-509. ISSN: 1569-8041 | doi: https://dx.doi.org/10.1093/annonc/mdz038
- Flight, L. , Arshad, F. , Barnsley, R. , Patel, K. , Julious, S. , Brennan, A. , Todd, S. (2019) A review of clinical trials with an adaptive design and health economic analysis. Value in Health , 22 (4). pp. 391-398. ISSN: 1098-3015 | doi: https://dx.doi.org/10.1016/j.jval.2018.11.008
- Kliem, K. , Humphries, D. , Markey, O. , Vasilopoulou, D. , Fagan, C. , Grandison, A. , Jackson, K. , Todd, S. , Givens, I. , Lovegrove, J. (2019) Food chain approach to lowering the saturated fat of milk and dairy products. International Journal of Dairy Technology , 72 (1). pp. 100-109. ISSN: 1364-727X | doi: https://dx.doi.org/10.1111/1471-0307.12564
- Abery, J. and Todd, S. (2019) Comparing the MAMS framework with the combination method in multi-arm adaptive trials with binary outcomes. Statistical Methods in Medical Research , 28 (6). pp. 1716-1730. ISSN: 0962-2802 | doi: https://dx.doi.org/10.1177/0962280218773546
- Dimairo, M. , Coates, E. , Pallmann, P. , Todd, S. , Julious, S. , Jaki, T. , Wason, J. , Mander, A. , Weir, C. , Koenig, F. , Walton, M. , Biggs, K. , Nicholl, J. , Hamasaki, T. , Proschan, M. , Scott, J. , Ando, Y. , Hind, D. , Altman, D. (2018) Development process of a consensus-driven CONSORT extension for randomised trials using an adaptive design. BMC Medicine , 16 (210). ISSN: 1741-7015 | doi: https://dx.doi.org/10.1186/s12916-018-1196-2
- Kimani, P. , Todd, S. , Renfro, L. , Stallard, N. (2018) Point estimation following two-stage adaptive threshold enrichment clinical trials. Statistics in Medicine , 37 (22). pp. 3179-3196. ISSN: 0277-6715 | doi: https://dx.doi.org/10.1002/sim.7831
- Przemska-Kosicka, A. , Childs, C. , Maidens, C. , Dong, H. , Todd, S. , Gosney, M. , Tuohy, K. , Yaqoob, P. (2018) Age-related changes in the natural killer cell response to seasonal influenza vaccination are not influenced by a synbiotic; a randomised controlled trial. Frontiers in Immunology , 9 ISSN: 1664-3224 | doi: https://dx.doi.org/10.3389/fimmu.2018.00591
- Weech, M. , Altowaijri, H. , Mayneris-Perxachs, J. , Vafeiadou, K. , Madden, J. , Todd, S. , Jackson, K. , Lovegrove, J. , Yaqoob, P. (2018) Replacement of dietary saturated fat with unsaturated fats increases numbers of circulating endothelial progenitor cells and decreases number of microparticles: findings from the randomized, controlled DIVAS study. American Journal of Clinical Nutrition , 107 (6). pp. 876-882. ISSN: 0002-9165 | doi: https://dx.doi.org/10.1093/ajcn/nqy018
- Enani, S. , Przemska-Kosicka, A. , Childs, C. , Maidens, C. , Dong, H. , Conterno, L. , Tuohy, K. , Todd, S. , Gosney, M. , Yaqoob, P. (2018) Impact of ageing and a synbiotic on the immune response to seasonal influenza vaccination; a randomised controlled trial. Clinical Nutrition , 37 (2). pp. 443-451. ISSN: 0261-5614 | doi: https://dx.doi.org/10.1016/j.clnu.2017.01.011
- Howard, D. , Brown, J. , Todd, S. , Gregory, W. (2018) Recommendations on multiple testing adjustment in multi-arm trials with a shared control group. Statistical Methods in Medical Research , 27 (5). pp. 1513-1530. ISSN: 0962-2802 | doi: https://dx.doi.org/10.1177/0962280216664759
- Markey, O. , Vasilopoulou, D. , Kliem, K. , Koulman, A. , Fagan, C. , Summerhill, K. , Wang, L. , Grandison, A. , Humphries, D. , Todd, S. , Jackson, K. , Givens, D. , Lovegrove, J. (2017) Plasma phospholipid fatty acid profile confirms compliance to a novel saturated fat-reduced, monounsaturated fat-enriched dairy product intervention in adults at moderate cardiovascular risk: a randomized controlled trial. Nutrition journal , 16 (1). ISSN: 1475-2891 | doi: https://dx.doi.org/10.1186/s12937-017-0249-2
- Dimier, N. and Todd, S. (2017) An investigation into the two-stage meta-analytic copula modelling approach for evaluating time-to-event surrogate endpoints which comprise of one or more events of interest. Pharmaceutical Statistics , 16 (5). pp. 322-333. ISSN: 1539-1612 | doi: https://dx.doi.org/10.1002/pst.1812
- Kunz, C. , Stallard, N. , Parsons, N. , Todd, S. , Friede, T. (2017) Blinded versus unblinded estimation of a correlation coefficient to inform interim design adaptations. Biometrical Journal , 59 (2). pp. 344-357. ISSN: 0323-3847 | doi: https://dx.doi.org/10.1002/bimj.201500233
- Przemska-Kosicka, A. , Childs, C. , Enani, S. , Maidens, C. , Dong, H. , Dayel, I. , Tuohy, K. , Todd, S. , Gosney, M. , Yaqoob, P. (2016) Effect of a symbiotic on the response to seasonal influenza vaccination is strongly influenced by degree of immunosenescence. Immunity & Aging , 13 (1). ISSN: 1742-4933 | doi: https://dx.doi.org/10.1186/s12979-016-0061-4
- Dimairo, M. , Julious, S. , Todd, S. , Nicholl, J. , Boote, J. (2015) Cross-sector surveys assessing perceptions of key stakeholders towards barriers, concerns and facilitators to the appropriate use of adaptive designs in confirmatory trials. Trials , 16 (1). ISSN: 1745-6215 | doi: https://dx.doi.org/10.1186/s13063-015-1119-x
- Stevely, A. , Dimairo, M. , Todd, S. , Julious, S. , Nicholl, J. , Hind, D. , Cooper, C. (2015) An investigation of the shortcomings of the CONSORT 2010 statement for the reporting of group sequential randomised controlled trials: a methodological systematic review. PLoS ONE , 10 (11). ISSN: 1932-6203 | doi: https://dx.doi.org/10.1371/journal.pone.0141104
- Dimairo, M. , Boote, J. , Julious, S. , Nicholl, J. , Todd, S. (2015) Missing steps in a staircase: a qualitative study of the perspectives of key stakeholders on the use of adaptive designs in confirmatory trials. Trials , 16 (1). ISSN: 1745-6215 | doi: https://dx.doi.org/10.1186/s13063-015-0958-9
- Stallard, N. , Kunz, C. , Todd, S. , Parsons, N. , Friede, T. (2015) Flexible selection of a single treatment incorporating short-term endpoint information in a phase II/III clinical trial. Statistics in Medicine , 34 (23). pp. 3104-3115. ISSN: 0277-6715 | doi: https://dx.doi.org/10.1002/sim.6567
- Cohen, D. , Todd, S. , Gregory, W. , Brown, J. (2015) Adding a treatment arm to an ongoing clinical trial: a review of methodology and practice. Trials , 16 ISSN: 1745-6215 | doi: https://dx.doi.org/10.1186/s13063-015-0697-y
- Siqueira, A. , Todd, S. , Whitehead, A. (2015) Sample size considerations in active-control non-inferiority trials with binary data based on the odds ratio. Statistical Methods in Medical Research , 24 (4). pp. 453-461. ISSN: 0962-2802 | doi: https://dx.doi.org/10.1177/0962280214520729
- Kimani, P. , Todd, S. , Stallard, N. (2015) Estimation after subpopulation selection in adaptive seamless trials. Statistics in Medicine , 34 (18). pp. 2581-2601. ISSN: 0277-6715 | doi: https://dx.doi.org/10.1002/sim.6506
-
Vafeiadou, K.
,
Weech, M.
,
Altowaijri, H.
,
Todd, S.
,
Yaqoob, P.
,
Jackson, K.
ORCID: 0000-0002-0070-3203
,
Lovegrove, J.
(2015)
Replacement of saturated with unsaturated fats had no impact on vascular function but beneficial effects on lipid biomarkers, E-selectin and blood pressure: results from the randomized, controlled Dietary Intervention and VAScular function (DIVAS) study.
American Journal of Clinical Nutrition
, 102
(1).
pp.
40-48.
ISSN:
0002-9165
|
doi:
https://dx.doi.org/10.3945/ajcn.114.097089
- Kunz, C. , Friede, T. , Parsons, N. , Todd, S. , Stallard, N. (2015) A comparison of methods for treatment selection in seamless phase II/III clinical trials incorporating information on short-term endpoints. Journal of Biopharmaceutical Statistics , 25 (1). pp. 170-189. ISSN: 1054-3406 | doi: https://dx.doi.org/10.1080/10543406.2013.840646
- Wu, S. , Mayneris-Perxachs, J. , Lovegrove, J. , Todd, S. , Yaqoob, P. (2014) Fish oil supplementation alters numbers of circulating endothelial progenitor cells and micro particles independent of eNOS genotype. American Journal of Clinical Nutrition , 100 (5). pp. 1232-1243. ISSN: 1938-3207 | doi: https://dx.doi.org/10.3945/ajcn.114.088880
- Kunz, C. , Friede, T. , Parsons, N. , Todd, S. , Stallard, N. (2014) Data-driven treatment selection for seamless phase II/III trials incorporating early-outcome data. Pharmaceutical Statistics , 13 (4). pp. 238-246. ISSN: 1539-1612 | doi: https://dx.doi.org/10.1002/pst.1619
- Weech, M. , Vafeiadou, K. , Hasaj, M. , Todd, S. , Yaqoob, P. , Jackson, K. , Lovegrove, J. (2014) Development of a food-exchange model to replace saturated fat with MUFAS and n-6 PUFAS in adults at moderate cardiovascular risk. Journal of Nutrition , 144 (6). pp. 846-855. ISSN: 1541-6100 | doi: https://dx.doi.org/10.3945/jn.114.190645
- Kimani, P. , Todd, S. , Stallard, N. (2014) A comparison of methods for constructing confidence intervals after phase II/III clinical trials. Biometrical Journal , 56 (1). pp. 107-128. ISSN: 0323-3847 | doi: https://dx.doi.org/10.1002/bimj.201300036
- Kimani, P. , Todd, S. , Stallard, N. (2013) Conditionally unbiased estimation in phase II/III clinical trials with early stopping for futility. Statistics in Medicine , 32 (17). pp. 2893-2910. ISSN: 0277-6715 | doi: https://dx.doi.org/10.1002/sim.5757
- Chapman, C. , Gibson, G. , Todd, S. , Rowland, I. (2013) Comparative in vitro inhibition of urinary tract pathogens by single- and multi-strain probiotics. European Journal of Nutrition , 52 (6). pp. 1669-1677. ISSN: 1436-6215 | doi: https://dx.doi.org/10.1007/s00394-013-0501-2
- Todd, S. , Valdes-Marquez, E. , West, J. (2012) A practical comparison of blinded methods for sample size reviews in survival data clinical trials.. Pharmaceutical Statistics , 11 (2). pp. 141-148. ISSN: 1539-1612 | doi: https://dx.doi.org/10.1002/pst.516
- Parsons, N. , Friede, T. , Todd, S. , Marquez, E. , Chataway, J. , Nicholas, R. , Stallard, N. (2012) An R package for implementing simulations for seamless phase II/III clinical trials using early outcomes for treatment selection. Computational Statistics & Data Analysis , 56 (5). pp. 1150-1160. ISSN: 0167-9473 | doi: https://dx.doi.org/10.1016/j.csda.2010.10.027
- Vafeiadou, K. , Weech, M. , Sharma, V. , Yaqoob, P. , Todd, S. , Williams, C. , Jackson, K. , Lovegrove, J. (2012) A review of the evidence for the effects of total dietary fat, SFA, MUFA and n-6 PUFA on vascular function, endothelial progenitor cells and microparticles. British Journal of Nutrition , 107 (3). pp. 303-324. ISSN: 1475-2662 | doi: https://dx.doi.org/10.1017/S0007114511004764
- Todd, S. , Baksh, M. , Whitehead, J. (2012) Sequential methods for pharmacogenetic studies. Computational Statistics & Data Analysis , 56 (5). pp. 1221-1231. ISSN: 0167-9473 | doi: https://dx.doi.org/10.1016/j.csda.2011.02.019
- Stallard, N. and Todd, S. (2011) Seamless phase II/III designs. Statistical Methods in Medical Research , 20 (6). pp. 623-634. ISSN: 0962-2802 | doi: https://dx.doi.org/10.1177/0962280210379035
- Friede, T. , Parsons, N. , Stallard, N. , Todd, S. , Valdes Marquez, E. , Chataway, J. , Nicholas, R. (2011) Designing a seamless phase II/III clinical trial using early outcomes for treatment selection: an application in multiple sclerosis. Statistics in Medicine , 30 (13). pp. 1528-1540. ISSN: 1097-0258 | doi: https://dx.doi.org/10.1002/sim.4202
- Pyke, S. , Julious, S. , Day, S. , O'Kelly, M. , Todd, S. , Matcham, J. , Seldrup, J. (2011) The potential for bias in reporting of industry-sponsored clinical trials. Pharmaceutical Statistics , 10 (1). pp. 74-79. ISSN: 1539-1612 | doi: https://dx.doi.org/10.1002/pst.429
- Matcham, J. , Julious, S. , Pyke, S. , O'Kelly, M. , Todd, S. , Seldrup, J. , Day, S. (2011) Proposed best practice for statisticians in the reporting and publication of pharmaceutical industry-sponsored clinical trials. Pharmaceutical Statistics , 10 (1). pp. 70-73. ISSN: 1539-1612 | doi: https://dx.doi.org/10.1002/pst.417
- O'Kelly, M. , Julious, S. , Pyke, S. , Day, S. , Todd, S. , Seldrup, J. , Matcham, J. (2011) Making available information from studies sponsored by the pharmaceutical industry: some current practices. Pharmaceutical Statistics , 10 (1). pp. 60-69. ISSN: 1539-1612 | doi: https://dx.doi.org/10.1002/pst.430
- Chataway, J. , Nicholas, R. , Todd, S. , Miller, D. , Parsons, N. , Valdes-Marquez, E. , Stallard, N. , Friede, T. (2011) A novel adaptive design strategy increases the efficiency of clinical trials in secondary progressive multiple sclerosis. Multiple Sclerosis Journal , 17 (1). pp. 81-88. ISSN: 1477-0970 | doi: https://dx.doi.org/10.1177/1352458510382129
- Friede, T. , Nicholas, R. , Stallard, N. , Todd, S. , Parsons, N. , Valdes-Marquez, E. , Chataway, J. (2010) Refinement of the Clinical Scenario Evaluation Framework for Assessment of Competing Development Strategies with an Application to Multiple Sclerosis . Drug Information Journal , 44 (6). pp. 713-718. ISSN: 0092-8615
- Whitehead, J. , Branson, M. , Todd, S. (2010) A combined score test for binary and ordinal endpoints from clinical trials. Statistics in Medicine , 29 (5). pp. 521-532. ISSN: 0277-6715 | doi: https://dx.doi.org/10.1002/sim.3822
- Whitehead, . , Whitehead, . , Todd, S. , Zhou, Y. , Smith, . (2008) Fitting models for the joint action of two drugs using SAS(R) . Pharmaceutical Statistics , 7 (4). pp. 272-284. ISSN: 1539-1612 | doi: https://dx.doi.org/10.1002/pst.312
- Stallard, . , Todd, S. , Whitehead, . (2008) Estimation following selection of the largest of two normal means. Journal of Statistical Planning and Inference , 138 (6). pp. 1629-1638. ISSN: 0378-3758 | doi: https://dx.doi.org/10.1016/j.jspi.2007.05.045
- Siqueira, . , Whitehead, . , Todd, S. (2008) Active-control trials with binary data: a comparison of methods for testing superiority or non-inferiority using the odds ratio. Statistics in Medicine , 27 (3). pp. 353-370. ISSN: 0277-6715 | doi: https://dx.doi.org/10.1002/sim.2975
- Todd, S. (2007) A 25-year review of sequential methodology in clinical studies. Stat Med , 26 (2). pp. 237-52. ISSN: 0277-6715 | doi: https://dx.doi.org/10.1002/sim.2763
- Baksh, . , Haars, . , Todd, . , Van Noord, . , Whitehead, . (2006) Comparing correlations of continuous observations from two independent populations using a sequential approach. Statistics in Medicine , 25 (24). pp. 4293-4310. ISSN: 0277-6715 | doi: https://dx.doi.org/10.1002/sim.2676
- Baksh, M. , Todd, S. , Whitehead, J. , Lucini, M. (2005) Design considerations in the sequential analysis of matched case–control data. Statistics in Medicine , 24 (6). pp. 853-867. ISSN: 0277-6715 | doi: https://dx.doi.org/10.1002/sim.1968
- Rogers, . , Chang, . , Todd, S. (2005) Using group-sequential analysis to achieve the optimal sample size. Bjog-an International Journal of Obstetrics and Gynaecology , 112 (5). pp. 529-533. ISSN: 1470-0328 | doi: https://dx.doi.org/10.1111/j.1471-0528.2005.00479.x
- Kelly, . , Sooriyarachchi, . , Stallard, . , Todd, . (2005) A practical comparison of group-sequential and adaptive designs. Journal of Biopharmaceutical Statistics , 15 (4). pp. 719-738. ISSN: 1054-3406 | doi: https://dx.doi.org/10.1081/BIP-200062859
- Kelly, . , Stallard, . , Todd, . (2005) An adaptive group sequential design for phase II/III clinical trials that select a single treatment from several. Journal of Biopharmaceutical Statistics , 15 (4). pp. 641-658. ISSN: 1054-3406 | doi: https://dx.doi.org/10.1081/BIP-200062857
- Perkins, . , Barrett, . , Bullock, . , Gabbott, . , Todd, . , Bion, . (2005) The Acute Care Undergraduate TEaching (ACUTE) initiative: consensus development of core competencies in acute care for undergraduates in the United Kingdom. Intensive Care Medicine , 31 (12). pp. 1627-1633. ISSN: 0342-4642 | doi: https://dx.doi.org/10.1007/s00134-005-2837-4
- Siqueira, . , Whitehead, . , Todd, . , Lucini, . (2005) Comparison of sample size formulae for 2x2 cross-over designs applied to bioequivalence studies. Pharmaceutical Statistics , 4 (4). pp. 233-243. ISSN: 1539-1612 | doi: https://dx.doi.org/10.1002/pst.183
- Stallard, . and Todd, . (2005) Point estimates and confidence regions for sequential trials involving selection. Journal of Statistical Planning and Inference , 135 (1). pp. 402-419. ISSN: 0378-3758 | doi: https://dx.doi.org/10.1016/j.jspi.2004.05.006
- Todd, . and Stallard, . (2005) A new clinical trial design combining phases II and III: sequential designs with treatment selection and a change of endpoint. Drug Information Journal , 39 pp. 109-118. ISSN: 0092-8615
- Whitehead, . and Todd, . (2004) The double triangular test in practice. Pharmaceutical Statistics , 3 (1). pp. 39-49. ISSN: 1539-1612 | doi: https://dx.doi.org/10.1002/pst.91
- Branson, . , Todd, . , Whitehead, . (2004) Estimating the covariances between efficient score test statistics in comparative studies. The University of Reading (04/2).
- Siqueira, . , Whitehead, . , Todd, . , Lucini, . (2004) On sample size calculations for 2x2 cross-over designs applied to bioequivalence studies. The University of Reading (04/4).
- Elliot, . , Virankabutra, . , Jones, . , Tanudsintum, . , Lipkin, . , Todd, . , Bion, . (2003) Erythropoietin mimics the acute phase response in critical illness. Clinical Care , 7 pp. R35-R40. ISSN: 1364-8535 | doi: https://dx.doi.org/10.1186/cc2185
- Stallard, . and Todd, . (2003) Sequential designs for phase III clinical trials incorporating treatment selection. Statistics in Medicine , 22 (5). pp. 689-703. ISSN: 0277-6715 | doi: https://dx.doi.org/10.1002/sim.1362
- Todd, . (2003) An adaptive approach to implementing bivariate group sequential clinical trial designs. Journal of Biopharmaceutical Statistics , 13 (4). pp. 605-619. ISSN: 1054-3406 | doi: https://dx.doi.org/10.1081/BIP-120024197
- Kelly, . , Stallard, . , Todd, . (2003) An adaptive group sequential design for clinical trials that involve treatment selection. The University of Reading (03/1).
- Vincent, E. , Todd, S. , Whitehead, J. (2002) A sequential procedure for comparing two experimental treatments with a control. Journal of Biopharmaceutical Statistics , 12 (2). pp. 249-265. ISSN: 1054-3406 | doi: https://dx.doi.org/10.1081/BIP-120015747
- Whitehead, J. , Whitehead, A. , Todd, S. , Bolland, K. , Sooriyarachchi, M. (2001) Mid-trial design reviews for sequential clinical trials. Statistics in Medicine , 20 (2). pp. 165-176. ISSN: 0277-6715 | doi: https://dx.doi.org/10.1002/1097-0258(20010130)20:2<165::AID-SIM649>3.0.CO;2-A
- Johnson, C. , Puntis, M. , Davidson, N. , Todd, S. , Bryce, R. (2001) Randomized, dose-finding phase III study of lithium gamolenate in patients with advanced pancreatic adenocarcinoma. British Journal of Surgery , 88 (5). pp. 662-668. ISSN: 0007-1323 | doi: https://dx.doi.org/10.1046/j.0007-1323.2001.01770.x
- Stallard, N. , Whitehead, J. , Todd, S. , Whitehead, A. (2001) Stopping rules for phase II studies. British Journal of Clinical Pharmacology , 51 (6). pp. 523-529. ISSN: 0306-5251 | doi: https://dx.doi.org/10.1046/j.0306-5251.2001.01381.x
- Todd, S. , Whitehead, A. , Stallard, N. , Whitehead, J. (2001) Interim analyses and sequential designs in phase III studies. British Journal of Clinical Pharmacology , 51 (5). pp. 394-399. ISSN: 0306-5251 | doi: https://dx.doi.org/10.1046/j.1365-2125.2001.01382.x
- Whitehead, J. , Zhou, Y. , Stallard, N. , Todd, S. , Whitehead, A. (2001) Learning from previous responses in phase I dose-escalation studies. British Journal of Clinical Pharmacology , 52 (1). pp. 1-7. ISSN: 3065251 | doi: https://dx.doi.org/10.1046/j.0306-5251.2001.01383.x
- Todd, S. and Sahdra, M. (2001) A case study of the effect of covariate adjustment in a sequential survival clinical trial. Journal of Biopharmaceutical Statistics , 11 (4). pp. 297-311. ISSN: 1054-3406 | doi: https://dx.doi.org/10.1081/BIP-120008850
- Whitehead, J. , Todd, S. , Hall, W. (2000) Confidence intervals for secondary parameters following a sequential test. Journal of the Royal Statistical Society: Series B (Statistical Methodology) , 62 (4). pp. 731-745. ISSN: 1369-7412 | doi: https://dx.doi.org/10.1111/1467-9868.00260
- Stallard, N. and Todd, S. (2000) Exact sequential tests for single samples of discrete responses using spending functions. Statistics in Medicine , 19 (22). pp. 3051-3064. ISSN: 0277-6715 | doi: https://dx.doi.org/10.1002/1097-0258(20001130)19:22<3051::AID-SIM604>3.0.CO;2-E
- Todd, S. (1999) Sequential designs for monitoring Two Endpoints in a clinical trial. Therapeutic Innovation & Regulatory Science , 33 (2). pp. 417-426. ISSN: 2168-4790 | doi: https://dx.doi.org/10.1177/009286159903300213
- Todd, S. , Woodward, M. , Tunstall-Pedoe, H. , Bolton-Smith, C. (1999) Dietary Antioxidant vitamins and Fiber in the Etiology of Cardiovascular Disease and All-Causes Mortality: Results from the Scottish Heart Health Study. American Journal of Epidemiology , 150 (10). pp. 1073-1080. ISSN: 0002-9262 | doi: https://dx.doi.org/10.1093/oxfordjournals.aje.a009931
- Todd, S. and Whitehead, J. (1997) Confidence interval calculation for a sequential clinical trial of binary responses. Biometrika ISSN: 0006-3444
- Todd, S. (1997) Incorporation of sequential trials into a fixed effects meta-analysis. Statistics in Medicine , 16 (24). pp. 2915-2925. ISSN: 0277-6715 | doi: https://dx.doi.org/10.1002/(SICI)1097-0258(19971230)16:24<2915::AID-SIM688>3.0.CO;2-0
- Todd, S. , Whitehead, J. , Facey, K. (1996) Point and interval estimation following a sequential clinical trial. Biometrika ISSN: 0006-3444
- Todd, S. , Woodward, M. , Bolton-Smith, C. , Tunstall-Pedoe, H. (1995) An investigation of the relationship between antioxidant vitamin intake and coronary heart disease in men and women using discriminant analysis. Journal of Clinical Epidemiology , 48 (2). pp. 297-305. ISSN: 8954356 | doi: https://dx.doi.org/10.1016/0895-4356(94)00177-R
- Todd, S. , Woodward, M. , Bolton-Smith, C. (1995) An investigation of the relationship between antioxidant vitamin intake and coronary heart disease in men and women using logistic regression analysis. Journal of Clinical Epidemiology , 48 (2). pp. 307-316. ISSN: 8954356 | doi: https://dx.doi.org/10.1016/0895-4356(94)00178-S