Marcus Tindall
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+44 (0) 118 378 8989
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Professor
- Research Division Lead
- Lead Mathematical Biology group
- Lead Reading Systems Biology Network
- Lead UK Quantitative Systems Pharmacology Network
- Director of outreach
Office
Room 208Building location
MathematicsAreas of interest
I am a mathematical biologist whose primary interest is in the mathematical modelling of biological and biomedical systems. I work with international leading life scientists in academic institutions and industry to formulate and solve mathematical models which are used to understand the system of interest, test hypotheses and direct future experimental/practical work.
Biological application areas - Genetic regulation of cholesterol biosynthesis, lipid metabolism, protein-protein interaction networks in cardiovascular cell biology (myocytes and platelets), quantitative systems pharmacology, bacterial chemotaxis, tumour growth and crop growth.
Mathematical expertise - Ordinary and partial differential equations, multi-scale modelling, numerical methods for ordinary and partial differential equations, agent based modelling, cellular automata, model parameterisation, dynamical systems theory, asymptotic perturbation theory.
My work is funded by the BBSRC, ESPRC, British Heart Foundation, collaborative institutions and industry.
Impact, enterprise and outreach overview
- Lead UK Quantitative Systems Pharmacology Network
- Number of projects with industry
- STEM Ambassador
- Hold regular outreach days on mathematical modelling for A-level students
Teaching
I teach and lead a range of modules in both Biological Sciences and Mathematics and Statistics:
- Mathematical Biology for third and fourth year undergraduate students, and MSc students (MA3MB, MA4MB)
- Biological Sciences - Introduction to Bioinformatics and Computational Biology (BI2BT5).
Current teaching (2023/24):
Research centres and groups
Websites/blogs
Publications
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Norton, V.
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Lovegrove, J.
ORCID: 0000-0001-7633-9455
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Tindall, M.
,
Rodriguez Garcia, J.
ORCID: 0000-0002-4986-3144
,
Lignou, S.
ORCID: 0000-0001-6971-2258
(2024)
Fibre4life: investigating older adults dietary fibre preferences and the role of targeted educational materials on modulating future dietary fibre intake.
Appetite
, 192
ISSN:
1095-8304
|
doi:
https://dx.doi.org/10.1016/j.appet.2023.107109
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Tindall, M.
ORCID: 0000-0001-6069-5260
,
Cucurull-Sanchez, L.
,
Mistry, H.
,
Yates, J.
(2023)
Quantitative systems pharmacology and machine learning: a match made in heaven or hell?.
The Journal of Pharmacology and Experimental Therapeutics
, 387
(1).
pp.
92-99.
ISSN:
1521-0103
|
doi:
https://dx.doi.org/10.1124/jpet.122.001551
- Dodd, J. , Sweby, P. , Mayes, S. , Murchie, E. , Karunaratne, A. , Massawe, F. , Tindall, M. (2023) A multiscale mathematical model describing the growth and development of bambara groundnut. Journal of Theoretical Biology , 560 ISSN: 0022-5193 | doi: https://dx.doi.org/10.1016/j.jtbi.2022.111373
- Tindall, M. , Chappell, M. , Yates, J. (2022) The ingredients for an antimicrobial mathematical modelling broth. International Journal of Antimicrobial Agents , 60 (4). pp 0. ISSN: 0924-8579 | doi: https://dx.doi.org/10.1016/j.ijantimicag.2022.106641
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Vavouraki, N.
ORCID: 0000-0003-2581-4935
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Tomkins, J.
ORCID: 0000-0003-3010-6634
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Kara, E.
ORCID: 0000-0001-5428-6743
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Houlden, H.
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Hardy, J.
,
Tindall, M.
,
Lewis, P.
ORCID: 0000-0003-4537-0489
,
Manzoni, C.
(2021)
Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias.
iScience
, 24
(5).
ISSN:
2589-0042
|
doi:
https://dx.doi.org/10.1016/j.isci.2021.102484
- Derrick, D. , Wolton, K. , Currie, R. , Tindall, M. (2021) A mathematical model of the role of aggregation in sonic hedgehog signalling. PLoS computational biology , 17 (2). ISSN: 1553-7358 | doi: https://dx.doi.org/10.1371/journal.pcbi.1008562
- Mazet, F. , Tindall, M. , Gibbins, J. , Fry, M. (2020) A model of the PI cycle reveals the regulating roles of lipid-binding proteins and pitfalls of using mosaic biological data. Scientific Reports , 10 (1). pp 0. ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-020-70215-7
- Stainer, A. , Sasikumar, P. , Bye, A. , Unsworth, A. , Holbrook, L. , Tindall, M. , Lovegrove, J. , Gibbins, J. (2019) The metabolites of the dietary flavonoid quercetin possess potent antithrombotic activity, and interact with aspirin to enhance antiplatelet effects. TH Open , 3 (3). pp. e244-e258. ISSN: 2512-9465 | doi: https://dx.doi.org/10.1055/s-0039-1694028
- Stainer, A. , Sasikumar, P. , Bye, A. , Unsworth, A. , Holbrook, L. , Tindall, M. , Lovegrove, J. , Gibbins, J. (2019) Quercetin and its methylated metabolites possess anti-thrombotic properties that interact with aspirin to enhance its anti-platelet effects. TH Open , 3 (3). pp. e244-e258. ISSN: 2512-9465 | doi: https://dx.doi.org/10.1055/s-0039-1694028
- Ward, J. , Franks, S. , Tindall, M. , King, J. , Curtis, A. , Evans, G. (2019) Mathematical modelling of contact dermatitis from nickel and chromium. Journal of Mathematical Biology , 79 (2). pp. 595-630. ISSN: 0303-6812 | doi: https://dx.doi.org/10.1007/s00285-019-01371-2
- Cucurull-Sanchez, L. , Chappell, M. , Chelliah, V. , Amy Cheung, S. , Derks, G. , Penney, M. , Phipps, A. , Malik-Sheriff, R. , Timmis, J. , Tindall, M. , van der Graaf, P. , Vicini, P. , Yates, J. (2019) Best practices to maximize the use and reuse of quantitative and systems pharmacology models: recommendations from the United Kingdom quantitative and systems pharmacology network. CPT: Pharmacometrics & Systems Pharmacology , 8 (5). pp. 259-272. ISSN: 2163-8306 | doi: https://dx.doi.org/10.1002/psp4.12381
- Maldonado, E. , Fisher, C. , Mazzatti, D. , Barber, A. , Tindall, M. , Plant, N. , Kierzek, A. , Moore, J. (2018) Multi-scale, whole-system models of liver metabolic adaptation to fat and sugar in non-alcoholic fatty liver disease. NPJ Systems Biology and Applications , 4 ISSN: 2056-7189 | doi: https://dx.doi.org/10.1038/s41540-018-0070-3
- Tindall, M. (2018) System insights into hemostasis: open questions and the role of mathematical modelling: comment on “Modeling thrombosis in silico: Frontiers, challenges, unresolved problems and milestones” by A.V. Belyaev et al.. Physics of Life Reviews , 26-27 pp. 106-107. ISSN: 1571-0645 | doi: https://dx.doi.org/10.1016/j.plrev.2018.06.011
- Pool, F. , Sweby, P. , Tindall, M. (2018) An integrated mathematical model of cellular cholesterol biosynthesis and lipoprotein metabolism. Processes , 6 (8). ISSN: 2227-9717 | doi: https://dx.doi.org/10.3390/pr6080134
- Snowden, T. , van der Graaf, P. , Tindall, M. (2018) Model reduction in mathematical pharmacology: integration, reduction and linking of PBPK and systems biology models. Journal of Pharmacokinetics and Pharmacodynamics , 45 (4). pp. 537-555. ISSN: 1573-8744 | doi: https://dx.doi.org/10.1007/s10928-018-9584-y
- Edgington, M. and Tindall, M. (2018) Mathematical analysis of the Escherichia coli chemotaxis signalling pathway. Bulletin of Mathematical Biology , 80 (4). pp. 758-787. ISSN: 1522-9602 | doi: https://dx.doi.org/10.1007/s11538-018-0400-z
- Pool, F. , Currie, R. , Sweby, P. , Salazar, J. , Tindall, M. (2018) A mathematical model of the mevalonate cholesterol biosynthesis pathway. Journal of Theoretical Biology , 443 pp. 157-176. ISSN: 0022-5193 | doi: https://dx.doi.org/10.1016/j.jtbi.2017.12.023
- Dede, E. , Tindall, M. , Cherrie, J. , Hankin, S. , Collins, C. (2018) Physiologically-based pharmacokinetic and toxicokinetic models for estimating human exposure to five toxic elements through oral ingestion. Environmental toxicology and pharmacology , 57 pp. 104-114. ISSN: 1872-7077 | doi: https://dx.doi.org/10.1016/j.etap.2017.12.003
- Snowden, T. , van der Graaf, P. , Tindall, M. (2017) Methods of model reduction for large-scale biological systems: a survey of current methods and trends. Bulletin of Mathematical Biology , 79 (7). pp. 1449-1486. ISSN: 1522-9602 | doi: https://dx.doi.org/10.1007/s11538-017-0277-2
- Snowden, T. , van der Graaf, P. , Tindall, M. (2017) A combined model reduction algorithm for controlled biochemical systems. BMC Systems Biology , 11 (1). ISSN: 1752-0509 | doi: https://dx.doi.org/10.1186/s12918-017-0397-1
- Mazet, F. , Dunster, J. , Jones, C. , Vaiyapuri, S. , Tindall, M. , Fry, M. , Gibbins, J. (2015) A high-density immunoblotting methodology for quantification of total protein levels and phosphorylation modifications. Scientific Reports , 5 ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/srep16995
- Dunster, J. , Mazet, F. , Fry, M. , Gibbins, J. , Tindall, M. (2015) Regulation of early steps of GPVI signal transduction by phosphatases: a systems biology approach. PLoS Computational Biology , 11 (11). ISSN: 1553-734X | doi: https://dx.doi.org/10.1371/journal.pcbi.1004589
- Edgington, M. and Tindall, M. (2015) Understanding the link between single cell and population scale responses of Escherichia coli in differing ligand gradients. Computational and Structural Biotechnology Journal , 13 pp. 528-538. ISSN: 2001-0370 | doi: https://dx.doi.org/10.1016/j.csbj.2015.09.003
- Edgington, M. and Tindall, M. (2014) Fold-change detection in a whole-pathway model of Escherichia coli chemotaxis. Bulletin of Mathematical Biology , 76 (6). pp. 1376-1395. ISSN: 0092-8240 | doi: https://dx.doi.org/10.1007/s11538-014-9965-3
- Tindall, M. and Clerk, A. (2014) Modelling negative feedback networks for activating transcription factor 3 predicts a dominant role for miRNAs in immediate early gene regulation. PLoS Computational Biology , 10 (5). ISSN: 1553-734X | doi: https://dx.doi.org/10.1371/journal.pcbi.1003597
- Bhattacharya, B. , Sweby, P. , Minihane, A. , Jackson, K. , Tindall, M. (2014) A mathematical model of the sterol regulatory element binding protein 2 cholesterol biosynthesis pathway. Journal of Theoretical Biology , 349 pp. 150-162. ISSN: 0022-5193 | doi: https://dx.doi.org/10.1016/j.jtbi.2014.01.013
- Lee, T. , Baines, M. , Langdon, S. , Tindall, M. (2013) A moving mesh approach for modelling avascular tumour growth. Applied Numerical Mathematics , 72 pp. 99-114. ISSN: 1689274 | doi: https://dx.doi.org/10.1016/j.apnum.2013.06.001
- Wright, B. , Tindall, M. , Lovegrove, J. , Gibbins, J. (2013) Investigating flavonoids as molecular templates for the design of small-molecule inhibitors of cell signaling. Journal of Food Science , 78 (12). pp. N1921-N1928. ISSN: 1750-3841 | doi: https://dx.doi.org/10.1111/1750-3841.12293
- Kojadinovic, M. , Armitage, J. , Tindall, M. , Wadhams, G. (2013) Response kinetics in the complex chemotaxis signalling pathway of Rhodobacter sphaeroides. Journal of the Royal Society Interface , 10 (81). ISSN: 1742-5662 | doi: https://dx.doi.org/10.1098/rsif.2012.1001
- Tindall, M. (2012) Mathematics as a tool in the Life Sciences.
- Tindall, M. , Gaffney, E. , Maini, P. , Armitage, J. (2012) Theoretical insights into bacterial chemotaxis. Wiley interdisciplinary reviews. Systems biology and medicine , 4 (3). pp. 247-259. ISSN: 1939-005X | doi: https://dx.doi.org/10.1002/wsbm.1168
- Giraldo, A. , Barrett, O. , Tindall, M. , Fuller, S. , Amirak, E. , Bhattacharya, B. , Sugden, P. , Clerk, A. (2012) Feedback regulation by Atf3 in the endothelin-1-responsive transcriptome of cardiomyocytes: Egr1 is a principal Atf3 target. Biochemical Journal , 444 (2). pp. 343-355. ISSN: 0264-6021 | doi: https://dx.doi.org/10.1042/BJ20120125
- Murray, P. , Edwards, C. , Tindall, M. , Maini, P. (2012) Classifying general nonlinear force laws in cell-based models via the continuum limit. Physical Review E , 85 (2). ISSN: 1550-2376 | doi: https://dx.doi.org/10.1103/PhysRevE.85.021921
- Tindall, M. , Dyson, L. , Smallbone, K. , Maini, P. (2012) Modelling acidosis and the cell cycle in multicellular tumour spheroids. Journal of Theoretical Biology , 298 pp. 107-115. ISSN: 0022-5193 | doi: https://dx.doi.org/10.1016/j.jtbi.2011.11.009
- Artzrouni, M. , Begg, C. , Chabiniok, R. , Clairambault, J. , Foss, A. , Hargrove, J. , Lee, E. , Siggers, J. , Tindall, M. (2011) The first international workshop on the role and impact of mathematics in medicine: a collective account. American Journal of Translational Research , 3 (5). pp. 492-497. ISSN: 1943-8141
- Murray, P. , Walter, A. , Fletcher, A. , Edwards, C. , Tindall, M. , Maini , P. (2011) Comparing a discrete and continuum model of the intestinal crypt. Physical Biology , 8 (2). ISSN: 1478-3975 | doi: https://dx.doi.org/10.1088/1478-3975/8/2/026011
- Tindall, M. , Porter, S. , Maini, P. , Armitage, J. (2010) Modeling chemotaxis reveals the role of reversed phosphotransfer and a bi-functional kinase-phosphatase. PLoS Computational Biology , 6 (8). ISSN: 1553-734X | doi: https://dx.doi.org/10.1371/journal.pcbi.1000896
- Tindall, M. , Wattis, . , O'Malley, . , Pickersgill, . , Jackson, K. (2009) A continuum receptor model of hepatic lipoprotein metabolism. Journal of Theoretical Biology , 257 (3). pp. 371-384. ISSN: 0022-5193 | doi: https://dx.doi.org/10.1016/j.jtbi.2008.11.016
- Tindall, . , Porter, . , Wadhams, . , Maini, . , Armitage, . (2009) Spatiotemporal modelling of CheY complexes in Escherichia coli chemotaxis. Progress in Biophysics & Molecular Biology , 100 (1-3). pp. 40-46. ISSN: 0079-6107 | doi: https://dx.doi.org/10.1016/j.pbiomolbio.2009.06.005
- Murray, . , Edwards, . , Tindall, . , Maini, . (2009) From a discrete to a continuum model of cell dynamics in one dimension. Physical Review E , 80 (3). pp. 10. ISSN: 1539-3755 | doi: https://dx.doi.org/10.1103/PhysRevE.80.031912
- Tindall, . , Please, . , Peddie, . (2008) Modelling the formation of necrotic regions in avascular tumours. Mathematical Biosciences , 211 (1). pp. 34-55. ISSN: 0025-5564 | doi: https://dx.doi.org/10.1016/j.mbs.2007.09.002
- Tindall, . , Maini, . , Porter, . , Armitage, . (2008) Overview of mathematical approaches used to model bacterial chemotaxis II: bacterial populations. Bulletin of Mathmatical Biology , 70 (6). pp. 1570-607. ISSN: 1522-9602 | doi: https://dx.doi.org/10.1007/s11538-008-9322-5
- Tindall, . , Porter, . , Maini, . , Gaglia, . , Armitage, . (2008) Overview of mathematical approaches used to model bacterial chemotaxis I: the single cell. Bullitin of Mathmatical Biology , 70 (6). pp. 1525-69. ISSN: 1522-9602 | doi: https://dx.doi.org/10.1007/s11538-008-9321-6
- Tindall, . , Maini, . , Armitage, . , Singleton, . , Mason, . (2008) Intracellular signalling during bacterial chemotaxis. SEB Experimental Biology Series , 61 (8). pp. 161-74. ISSN: 0081-1386
- Tindall, . , Peletier, . , Severens, . , Veldman, . , de Mol, . (2008) Understanding post-operative temperature drop in cardiac surgery: a mathematical model. Mathematical Medicine and Biology , 25 (4). pp. 323-35. ISSN: 1477-8602 | doi: https://dx.doi.org/10.1093/imammb/dqn022
- Franks, . , Ward, . , Tindall, . , King, . , Curtis, . , Evans, . (2008) A mathematical model of the in vitro keratinocyte response to chromium and nickel exposure. Toxicol In Vitro , 22 (4). pp. 1088-93. ISSN: 0887-2333 | doi: https://dx.doi.org/10.1016/j.tiv.2008.01.018