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Joanne Dunster

Email:
j.l.dunster@reading.ac.uk
Phone:
+44 (0) 118 378 5012
Job title:
Postdoctoral Research Associate

Responsibilities:

Areas of interest

My research focuses on formulating and analysing mathematical models that describe problems in the life sciences and medicine.

Research centres and groups

Mathematical Biology

Websites/blogs

Dr Dunster's personal website

Publications

Mitchell, J. , Dunster, J. , Kriek, N. , Unsworth, A. , Sage, T. , Mohammed, Y. , De Simone, I. , Taylor, K. , Bye, A. ORCID: 0000-0002-2061-2253 , Ólafsson, G. , Brunton, M. , Mark, S. , Dymott, L. , Whyte, A. , Ruparelia, N. , Mckenna, C. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Jones, C. ORCID: 0000-0001-7537-1509 (2023) The rate of platelet activation determines thrombus size and structure at arterial shear. Journal of Thrombosis and Haemostasis ISSN: 1538-7836 | doi: https://dx.doi.org/10.1016/j.jtha.2023.03.044
Nelson, M. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Dunster, J. (2023) Platelet-driven routes to chaos in a model of hepatitis. Chaos, Solitons & Fractals ISSN: 1873-2887
Tantiwong, C. , Dunster, J. , Cavill, R. , Tomlinson, M. , Wierling, C. , Heemskerk, J. , Gibbins, J. ORCID: 0000-0002-0372-5352 (2023) An agent-based approach for modelling and simulation of glycoprotein VI receptor diffusion, localisation and dimerisation in platelet lipid rafts. Scientific Reports , 13 ISSN: 2045-2322

Dunster, J. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Nelson, M. (2022) Exploring the constituent mechanisms of hepatitis: a dynamical systems approach. Mathematical Medicine and Biology: A Journal of the IMA ISSN: 1477-8599 | doi: https://dx.doi.org/10.1093/imammb/dqac013
Downes, K. , Zhao, X. , Gleadall, N. , Antanavicius, N. , McKinney, H. , Kempster, C. , Batista, J. , Thomas, P. , Cooper, M. , Michael, J. , Kreuzhuber, R. , Wedderburn, K. , Waller, K. , Varney, B. , Kriek, N. , Ashford, S. , Stirrups, K. , Dunster, J. , McKenzie, S. , Ouwehand, W. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Yang, J. , Astle, W. , Ma, P. (2022) G protein-coupled receptor kinase 5 regulates thrombin signaling in platelets via PAR-1. Blood Advances , 6 (7). pp. 2319-2330. ISSN: 2473-9529 | doi: https://dx.doi.org/10.1182/bloodadvances.2021005453

Fernández, D. ORCID: 0000-0002-5055-9019 , Provenzale, I. , Cheung, H. , van Groningen, J. , Tullemans, B. , Veninga, A. , Dunster, J. ORCID: 0000-0001-8986-4902 , Honarnejad, S. ORCID: 0000-0002-4558-501X , van den Hurk, H. , Kuijpers, M. , Heemskerk, J. (2021) Ultra-high throughput Ca2+ assay in platelets to distinguish ITAM-linked and G-protein coupled receptor activation. iScience , 25 (1). ISSN: 2589-0042 | doi: https://dx.doi.org/10.1016/j.isci.2021.103718
Dunster, J. , Mitchell, J. , Mohammed, Y. , Taylor, K. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Jones, C. (2021) Kinetx: a combined flow cytometry assay and analysis software framework to quantitatively measure and categorize platelet activation in real-time. Journal of Visualized Experiments , 176 ISSN: 1940-087X | doi: https://dx.doi.org/10.3791/62947
Dunster, J. , Bye, A. , Kriek, N. , Sage, T. , Mitchell, J. , Kempster, C. , Batista, J. , KcKinney, H. , Thomas, P. , Jones, C. ORCID: 0000-0001-7537-1509 , Downes, K. , Unsworth, A. , Gibbins, J. ORCID: 0000-0002-0372-5352 (2021) Multi-parameter phenotyping of platelet reactivity for stratification of human cohorts. Blood Advances , 5 (20). pp. 4017-4030. ISSN: 2473-9529 | doi: https://dx.doi.org/10.1182/bloodadvances.2020003261

Martyanov, A. , Balabin, F. , Dunster, J. , Panteleev, M. , Gibbins, J. , Sveshnikov, A. (2020) Control of platelet CLEC-2-mediated activation by receptor clustering and tyrosine kinase signalling. Biophysical Journal , 118 (11). ISSN: 0006-3495 | doi: https://dx.doi.org/10.1016/j.bpj.2020.04.023
Bayani, A. , Dunster, J. , Crofts, J. , Nelson, M. (2020) Mechanisms and points of control in the spread of inflammation: a mathematical investigation. Bulletin of Mathematical Biology , 82 (4). ISSN: 1522-9602 | doi: https://dx.doi.org/10.1007/s11538-020-00709-y
Dunster, J. , Unsworth, A. , Bye, A. , Haining, E. , Sowa, M. , Di, Y. , Sage, T. , Pallini, C. , Pike, J. , Hardy, A. , Nieswandt, B. , García, Á. , Watson, S. , Poulter, N. , Gibbins, J. , Pollitt, A. (2020) Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation. Journal of Thrombosis and Haemostasis , 18 (2). pp. 485-496. ISSN: 1538-7836 | doi: https://dx.doi.org/10.1111/jth.14673

Dunster, J. , Panteleev, M. , Gibbins, J. , Sveshnikova, A. (2018) Mathematical techniques for understanding platelet regulation and the development of new pharmacological approaches. In: Gibbins, J. and Mahaut-Smith, M. , (eds.) Platelets and Megakaryocytes: Volume 4, Advanced Protocols and Perspectives. Methods in Molecular Biology , 1812. Methods in molecular biology (Clifton, N.J.) , 1812 pp. 255-279. ISSN: 1940-6029 ISBN: 9781493985845 | doi: https://dx.doi.org/10.1007/978-1-4939-8585-2_15
Belyaev, A. , Dunster, J. , Gibbins, J. , Panteleev, M. , Volpert, V. (2018) Modelling thrombosis in silico: frontiers, challenges, unresolved problems and milestones. Physics of Life Reviews , 26-27 pp. 57-95. ISSN: 1571-0645 | doi: https://dx.doi.org/10.1016/j.plrev.2018.02.005

Mazet, F. , Dunster, J. , Jones, C. , Vaiyapuri, S. , Tindall, M. , Fry, M. , Gibbins, J. (2015) A high-density immunoblotting methodology for quantification of total protein levels and phosphorylation modifications. Scientific Reports , 5 ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/srep16995
Dunster, J. , Mazet, F. , Fry, M. , Gibbins, J. , Tindall, M. (2015) Regulation of early steps of GPVI signal transduction by phosphatases: a systems biology approach. PLoS Computational Biology , 11 (11). ISSN: 1553-734X | doi: https://dx.doi.org/10.1371/journal.pcbi.1004589