Jeremy Spencer

Email:
j.p.e.spencer@reading.ac.uk
Phone:
+44 (0) 118 378 8724
Job title:
Professor

Responsibilities:

Programme Director for MSc Nutrition and Food Science
Leader the Food Chain and Health sub-theme "Plant Bioactives and Health"
Member of the Neuroscience at Reading Steering Committee
Member of the Quality Assurance in Research team
Seminar coordinator for the Nutrition Research Group.

Office

2-62

Building location

Harry Nursten

Areas of interest

Professor Spencer's research group (currently 4 PDRA's, 1 research nurse, 2 research technicians and 14 PhD students) is recognised as one of the leading groups in the world dedicated to working mechanistically at the interface of dietary phytochemicals and brain function. His initial work focused on the cellular and molecular mechanisms underlying neuronal death in Parkinson's and Alzheimer's disease. Recent interests concern how flavonoids and other (poly)phenols influence brain health through their interactions with specific cellular signalling pathways pivotal in protection against neurotoxins, in preventing neuroinflammation and in controlling memory, learning and neuro-cognitive performance.

A major output from the group has been to help define the paradigm-changing concept of how flavonoids and other polyphenols act via non-antioxidant mechanisms of action in vivo to mediate physiologically/clinically significant benefits on human brain and vascular function. His group have defined how a number of flavonoids/polyphenols and their metabolites exert specific interactions within ERK and PI3 kinase/Akt signalling pathways, leading to increases in the expression of neuroprotective and neuromodulatory proteins and an increase in the number of, and strength of, connections between neurons. Furthermore, they have detailed effects on the vascular system, which may lead to enhancements in cognitive performance through increased brain blood flow and an ability to initiate neurogenesis in the hippocampus.

The group operates at three main levels:

implementation of human clinical trials to investigate the physiological/clinical benefits of foods, most notably flavonoid-rich foods on the vascular system and the brain
cell and molecular studies designed to investigate the underpinning mechanisms of action of polyphenols with respect to neurodegeneration, cognition, vascular disease and cancer
analytical analysis to: a) characterise flavonoids/polyphenols and other non-nutrient components in foods/beverages; and b) to investigate absorption and metabolism of polyphenols in human pharmacokinetic studies.

Research centres and groups

Nutrition Research Group.

Academic qualifications

Postgraduate Certificate in Academic Practice (Merit), 2007
PhD Medical Biochemistry/Pharmacology – King’s College London, 1997
BSc (Hons) Biochemistry, First Class – University of Warwick, 1993.

Awards and honours

Senior Research Award at the ICPH Conference in Harrogate, November 2009
Nutrition Society Silver Medal at the Nutrition Society meeting, July 2009
Outstanding Research Award at the ICPH Conference in Kyoto, December 2007.

External activities

Scientific Advisory Committee for the 4th Wine and Health meeting; Sept 2013, Sydney, Australia
Scientific Advisory Committee for the 6th International Conference on Polyphenols and Health; Sept 2013, Buenos Aires, Argentina
Editorial Board of Free Radical Research, Archives of Biochemistry and Biophysics, Nutritional Neuroscience
2009-present: External Examiner for the MSc and BSc Nutrition and Dietetics degree courses at University of Surrey
2009-present: Member of the Nutrition Society Council and the Nutrition Society Programmes Committee
2010-present: Nutrition and Mental Health Task Force; ILSI Europe
2010-present: Member of the International Scientific Forum on Alcohol Research (ISFAR).

Publications

ALbuloshi, T. ORCID: 0000-0002-4609-3623 , Kamel, A. ORCID: 0000-0002-3791-5998 , Spencer, J. (2022) Factors associated with low vitamin D status among older adults in Kuwait. Nutrients , 14 (16). pp 1. ISSN: 2072-6643 | doi: https://dx.doi.org/10.3390/nu14163342
Albuloshi, T. , Dimala, C. , Kuhnle, G. ORCID: 0000-0002-8081-8931 , Bouhaimed, M. , Dodd, G. , Spencer, J. (2022) The effectiveness of vitamin D supplementation in reducing depressive symptoms: a systematic review and meta-analysis of Randomized Controlled Trials (RCTs). Nutrition and Healthy Aging , 6 (4). pp. 301-318. ISSN: 2451-9502 | doi: https://dx.doi.org/10.3233/nha-200094

Huarte, E. ORCID: 0000-0002-8492-1805 , Serra, G. , Monteagudo-Mera, A. , Spencer, J. , Cid, C. ORCID: 0000-0001-6464-5412 , de Peña, M. ORCID: 0000-0002-9994-4268 (2021) Raw and sous-vide-cooked red cardoon stalks (cynara cardunculus L. var. altilis DC): (poly)phenol bioaccessibility, anti-inflammatory activity in the gastrointestinal tract, and prebiotic activity. Journal of Agricultural and Food Chemistry , 69 (32). pp. 9270-9286. ISSN: 1520-5118 | doi: https://dx.doi.org/10.1021/acs.jafc.1c03014
Vauzour, D. , Rendeiro, C. , D'Amato, A. , Waffo-Teguo, P. , Richard, T. , Merillon, J. , Pontifex, M. , Connell, E. , Muller, M. , Butler, L. , Williams, C. ORCID: 0000-0003-4452-671X , Spencer, J. (2021) Anthocyanins promote learning through modulation of synaptic plasticity related proteins in an animal model of ageing. Antioxidants , 10 (8). ISSN: 2076-3921 | doi: https://dx.doi.org/10.3390/antiox10081235
Turner, A. , Michaelson, L. , Shewry, P. , Lovegrove, A. , Spencer, J. (2021) Increased bioavailability of phenolic acids and enhanced vascular function following intake of feruloyl esterase-processed high fibre bread: a randomized, controlled, single blind, crossover human intervention trial. Clinical Nutrition , 40 (3). pp. 788-795. ISSN: 0261-5614 | doi: https://dx.doi.org/10.1016/j.clnu.2020.07.026

Flanagan, E. , Lamport, D. , Brennan, L. , Burnet, P. , Calabrese, V. , Cunnane, S. , de Wilde, M. , Dye, L. , Farrimond, J. , Emerson Lombardo, N. , Hartmann, T. , Hartung, T. , Kalliomäki, M. , Kuhnle, G. , La Fata, G. , Sala-Vila, A. , Samieri, C. , Smith, A. , Spencer, J. , Thuret, S. , Tuohy, K. , Turroni, S. , Vanden Berghe, W. , Verkuijl, M. , Verzijden, K. , Yannakoulia, M. , Geurts, L. , Vauzour, D. (2020) Nutrition and the ageing brain: moving towards clinical applications. Ageing Research Reviews , 62 pp 0. ISSN: 1568-1637 | doi: https://dx.doi.org/10.1016/j.arr.2020.101079
Bell, L. , Whyte, A. , Lamport, D. ORCID: 0000-0002-4592-0439 , Spencer, J. , Butler, L. , Williams, C. ORCID: 0000-0003-4452-671X (2020) Grape seed polyphenol extract and cognitive function in healthy young adults: A randomised, placebo-controlled, parallel-groups acute-on-chronic trial. Nutritional Neuroscience , 25 (1). pp. 54-63. ISSN: 1028-415X | doi: https://dx.doi.org/10.1080/1028415X.2019.1708033
Alañón, M. , Castle, S. , Serra, G. , Lévèques, A. , Poquet, L. , Actis-Goretta, L. , Spencer, J. (2020) Acute study of dose-dependent effects of (-)-epicatechin on vascular function in healthy male volunteers: a randomized controlled trial. Clinical Nutrition , 39 (3). pp. 746-754. ISSN: 0261-5614 | doi: https://dx.doi.org/10.1016/j.clnu.2019.03.041

Soycan, G. , Schar, M. , Kristek, A. , Boberska, J. , Alsharif, S. , Corona, G. , Shewry, P. , Spencer, J. (2019) Composition and content of phenolic acids and avenanthramides in commercial oat products: are oats an important polyphenol source for consumers?. Food Chemistry: X , 3 ISSN: 2590-1575 | doi: https://dx.doi.org/10.1016/j.fochx.2019.100047
Dodd, G. , Williams, C. , Butler, L. , Spencer, J. (2019) Acute effects of flavonoid-rich blueberry on cognitive and vascular function in healthy older adults. Nutrition and Healthy Aging , 5 (2). pp. 119-132. ISSN: 2451-9502 | doi: https://dx.doi.org/10.3233/nha-180056
Mascal, M. , Hafezi, N. , Wang, D. , Hu, Y. , Serra, G. , Dallas, M. ORCID: 0000-0002-5190-0522 , Spencer, J. (2019) Synthetic, non-intoxicating 8,9-dihydrocannabidiol for the mitigation of seizures. Scientific Reports , 9 (1). ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-019-44056-y
Kristek, A. , Wiese, M. , Heuer, P. , Kosik, O. , Schar, M. , Soycan, G. , Alsharif, S. , Kuhnle, G. , Walton, G. , Spencer, J. (2019) Oat bran, but not its isolated bioactive β-glucans or polyphenols, have a bifidogenic effect in an in vitro fermentation model of the gut microbiota. British Journal of Nutrition , 121 (5). pp. 549-559. ISSN: 0007-1145 | doi: https://dx.doi.org/10.1017/S0007114518003501

Rees, A. , Dodd, G. , Spencer, J. (2018) The effects of flavonoids on cardiovascular health: a review of human intervention trials and implications for cerebrovascular function. Nutrients , 10 (12). ISSN: 2072-6643 | doi: https://dx.doi.org/10.3390/nu10121852
Vauzour, D. , Corsini, S. , Müller, M. , Spencer, J. (2018) Inhibition of PP2A by hesperetin may contribute to Akt and ERK1/2 activation status in cortical neurons. Archives of Biochemistry and Biophysics , 650 pp. 14-21. ISSN: 0003-9861 | doi: https://dx.doi.org/10.1016/j.abb.2018.04.020
Kristek, A. , Schar, M. , Soycan, G. , Alsharif, S. , Kuhnle, G. , Walton, G. , Spencer, J. (2018) The gut microbiota and cardiovascular health benefits: a focus on wholegrain oats. Nutrition Bulletin , 43 (4). pp. 358-373. ISSN: 1471-9827 | doi: https://dx.doi.org/10.1111/nbu.12354
Baldrick, F. , McFadden, K. , Ibars, M. , Sung, C. , Moffatt, T. , Megarry, K. , Thomas, K. , Mitchell, P. , Wallace, J. , Pourshahidi, L. , Ternan, N. , Corona, G. , Spencer, J. , Yaqoob, P. , Hotchkiss, S. , Campbell, R. , Moreno-Rojas, J. , Cuevas, F. , Pereira-Caro, G. , Rowland, I. , Gill, C. (2018) Impact of a (poly)phenol-rich extract from the brown algae Ascophyllum nodosum on DNA damage and antioxidant activity in an overweight or obese population: a randomized controlled trial. American Journal of Clinical Nutrition , 108 (4). pp. 688-700. ISSN: 0002-9165 | doi: https://dx.doi.org/10.1093/ajcn/nqy147
Marques, C. , Fernandes, I. , Meireles, M. , Faria, A. , Spencer, J. , Mateus, N. , Calhau, C. (2018) Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins. Scientific Reports , 8 (1). pp 0. ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-018-29744-5
Ottaviani, J. , Heiss, C. , Spencer, J. , Kelm, M. , Schroeter, H. (2018) Recommending flavanols and procyanidins for cardiovascular health: revisited. Molecular Aspects of Medicine ISSN: 0098-2997 | doi: https://dx.doi.org/10.1016/j.mam.2018.02.001
Amini, A. , Spencer, J. , Yaqoob, P. (2018) Effects of pelargonidin-3-O-glucoside and its metabolites on lipopolysaccharide-stimulated cytokine production by THP-1 monocytes and macrophages. Cytokine , 103 pp. 29-33. ISSN: 1096-0023 | doi: https://dx.doi.org/10.1016/j.cyto.2017.12.031
Miquel, S. , Champ, C. , Day, J. , Aarts, E. , Bahr, B. , Bakker, M. , Bánáti, D. , Calabrese, V. , Cederholm, T. , Cryan, J. , Dye, L. , Farrimond, J. , Korosi, A. , Layé, S. , Maudsley, S. , Milenkovic, D. , Mohajeri, M. , Sijben, J. , Solomon, A. , Spencer, J. , Thuret, S. , Vanden Berghe, W. , Vauzour, D. , Vellas, B. , Wesnes, K. , Willatts, P. , Wittenberg, R. , Geurts, L. (2018) Poor cognitive ageing: vulnerabilities, mechanisms and the impact of nutritional interventions. Ageing research reviews , 42 pp. 40-55. ISSN: 1568-1637 | doi: https://dx.doi.org/10.1016/j.arr.2017.12.004
Schar, M. , Corona, G. , Soycan, G. , Dine, C. , Kristek, A. , Alsharif, S. , Behrends, V. , Lovegrove, A. , Shewry, P. , Spencer, J. (2018) Excretion of avenanthramides, phenolic acids and their major metabolites following intake of oat bran. Molecular Nutrition and Food Research , 62 (2). ISSN: 1613-4133 | doi: https://dx.doi.org/10.1002/mnfr.201700499

Serra, G. , Deiana, M. , Spencer, J. , Corona, G. (2017) Olive oil phenolics prevent oxysterol-induced proinflammatory cytokine secretion and reactive oxygen species production in human peripheral blood mononuclear cells, through modulation of p38 and JNK pathways. Molecular Nutrition & Food Research , 61 (12). ISSN: 1613-4125 | doi: https://dx.doi.org/10.1002/mnfr.201700283
Amini, A. , Muzs, K. , Spencer, J. , Yaqoob, P. (2017) Pelargonidin-3-O-glucoside and its metabolites have modest anti-inflammatory effects in human whole blood cultures. Nutrition Research , 46 pp. 88-95. ISSN: 1879-0739 | doi: https://dx.doi.org/10.1016/j.nutres.2017.09.006
Corona, G. , Coman, M. , Guo, Y. , Hotchkiss, S. , Gill, C. , Yaqoob, P. , Spencer, J. , Rowland, I. (2017) Effect of simulated gastrointestinal digestion and fermentation on polyphenolic content and bioactivity of brown seaweed phlorotannin-rich extracts. Molecular Nutrition and Food Research , 61 (11). ISSN: 1613-4133 | doi: https://dx.doi.org/10.1002/mnfr.201700223
Saibandith, B. , Spencer, J. , Rowland, I. , Commane, D. (2017) Olive polyphenols and the metabolic syndrome. Molecules , 22 (7). ISSN: 1420-3049 | doi: https://dx.doi.org/10.3390/molecules22071082
Esteban-Fernández, A. , Rendeiro, C. , Spencer, J. , Del Coso, D. , de Llano, M. , Bartolomé, B. , Moreno-Arribas, M. (2017) Neuroprotective effects of selected microbial-derived phenolic metabolites and aroma compounds from wine in human SH-SY5Y neuroblastoma cells and their putative mechanisms of action. Frontiers in Nutrition , 4 ISSN: 2296-861X | doi: https://dx.doi.org/10.3389/fnut.2017.00003
Sansone, R. , Ottaviani, J. , Rodriguez-Mateos, A. , Heinen, Y. , Noske, D. , Spencer, J. , Crozier, A. , Merx, M. , Kelm, M. , Schroeter, H. , Heiss, C. (2017) Methylxanthines enhance the effects of cocoa flavanols on cardiovascular function: randomized, double-masked controlled studies. American Journal of Clinical Nutrition , 105 (2). pp. 352-360. ISSN: 0002-9165 | doi: https://dx.doi.org/10.3945/ajcn.116.140046
Mills, C. , Flury, A. , Marmet, C. , Poquet, L. , Rimaldi, S. , Sartori, C. , Rexhag, E. , Brenner, R. , Allman, Y. , Zimmerman, D. , Gibson, G. , Mottram, D. , Oruna-Concha, M. , Actis-Goretta, L. , Spencer, J. (2017) Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: two randomized, controlled, crossover intervention trials. Clinical Nutrition , 36 (6). pp. 1520-1529. ISSN: 0261-5614 | doi: https://dx.doi.org/10.1016/j.clnu.2016.11.013
Vauzour, D. , Camprubi-Robles, M. , Miquel-Kergoat, S. , Andres-Lacueva, C. , Bánáti, D. , Barberger-Gateau, P. , Bowman, G. , Caberlotto, L. , Clarke, R. , Hogervorst, E. , Kiliaan, A. , Lucca, U. , Manach, C. , Minihane, A. , Mitchell, E. , Perneczky, R. , Perry, H. , Roussel, A. , Schuermans, J. , Sijben, J. , Spencer, J. , Thuret, S. , van de Rest, O. , Vandewoude, M. , Wesnes, K. , Williams, R. , Williams, R. , Ramirez, M. (2017) Nutrition for the ageing brain: towards evidence for an optimal diet. Ageing research reviews , 35 pp. 222-240. ISSN: 1568-1637 | doi: https://dx.doi.org/10.1016/j.arr.2016.09.010
Lockyer, S. , Rowland, I. , Spencer, J. , Yaqoob, P. , Stonehouse, W. (2017) Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: a randomised controlled trial. European Journal of Nutrition , 5 (4). pp. 1421-1432. ISSN: 1436-6215 | doi: https://dx.doi.org/10.1007/s00394-016-1188-y

Esteban-Fernández, A. , Corona, G. , Vauzour, D. , Spencer, J. (2016) Neuroprotective effects associated with wine and its phenolic constituents. In: Moreno-Arribas, M. and Bartolomé Suáldea, B. , (eds.) Wine Safety, Consumer Preference, and Human Health. Springer pp. 279-292. ISBN: 9783319245126 | doi: https://dx.doi.org/10.1007/978-3-319-24514-0_14
Alanon, M. , Castle, S. , Siswanto, P. , Cifuentes-Gomez, T. , Spencer, J. (2016) Assessment of flavanol stereoisomers and caffeine and theobromine content in commercial chocolates. Food Chemistry , 208 pp. 177-184. ISSN: 0308-8146 | doi: https://dx.doi.org/10.1016/j.foodchem.2016.03.116
Neshatdoust, S. , Saunders, C. , Castle, S. , Vauzour, D. , Williams, C. , Butler, L. , Lovegrove, J. , Spencer, J. (2016) High-flavonoid intake induces cognitive improvement linked to changes in serum brain-derived neurotrophic factor: two randomised,controlled trials. Nutrition and Healthy Ageing , 4 (1). pp. 81-93. ISSN: 2451-9502 | doi: https://dx.doi.org/10.3233/NHA-1615
Esteban-Fernández, A. , Gigorro del Coso, D. , González de Llano, D. , Spencer, J. , Bartolomé, B. , Moreno-Arribas, M. , eds. (2016) Understanding the protective effects of wine components and their metabolites in the brain function. In: Aurand, J. , (eds.) BIO Web of Conferences , 7 pp. 4008. ISSN: 2117-4458 | doi: https://dx.doi.org/10.1051/bioconf/20160704008
Rendeiro, C. , Dong, H. , Saunders, C. , Harkness, L. , Blaze, M. , Hou, Y. , Belanger, R. , Corona, G. , Lovegrove, J. , Spencer, J. (2016) Flavanone-rich citrus beverages counteract the transient decline in postprandial endothelial function in humans: a randomised, controlled, double-masked, cross-over intervention study. British Journal of Nutrition , 116 (12). pp. 1999-2010. ISSN: 0007-1145 | doi: https://dx.doi.org/10.1017/S0007114516004219
Lamport, D. , Pal, D. , Macready, A. , Barbosa Boucas, S. , Fletcher, J. , Williams, C. , Spencer, J. , Butler, L. (2016) The effects of flavanone-rich citrus juice on cognitive function and cerebral blood flow: an acute, randomised, placebo controlled crossover trial in healthy young adults. British Journal of Nutrition , 116 (12). pp. 2160-2168. ISSN: 1475-2662 | doi: https://dx.doi.org/10.1017/S000711451600430X
Alqurashi, R. , Galante, L. , Rowland, I. , Spencer, J. , Commane, D. (2016) Consumption of a flavonoid-rich acai meal is associated with acute improvements in vascular function and a reduction in total oxidative status in healthy overweight men. American Journal of Clinical Nutrition , 104 (5). pp. 1227-1235. ISSN: 0002-9165 | doi: https://dx.doi.org/10.3945/ajcn.115.128728
Dong, H. , Sargent, L. , Chatzidiakou, Y. , Saunders, C. , Harkness, L. , Bordenave, N. , Rowland, I. , Spencer, J. , Lovegrove, J. (2016) Orange pomace fibre increases a composite scoring of subjective ratings of hunger and fullness in healthy adults. Appetite , 107 pp. 478-405. ISSN: 0195-6663 | doi: https://dx.doi.org/10.1016/j.appet.2016.08.118
Corona, G. , Ji, Y. , Anegboonlap, P. , Hotchkiss, S. , Gill, C. , Yaqoob, P. , Spencer, J. , Rowland, I. (2016) Gastrointestinal modifications and bioavailability of brown seaweed phlorotannins and effects on inflammatory markers. British Journal of Nutrition , 115 (7). pp. 1240-1253. ISSN: 1475-2662 | doi: https://dx.doi.org/10.1017/S0007114516000210
Ravishankar, D. , Corona, G. , Hogan, S. , Spencer, J. , Greco, F. , Osborn, H. (2016) Thioflavones as novel neuroprotective agents. Bioorganic & Medicinal Chemistry , 24 (21). pp. 5513-5520. ISSN: 0968-0896 | doi: https://dx.doi.org/10.1016/j.bmc.2016.09.006
Ottaviani, J. , Borges, G. , Momma, T. , Spencer, J. , Keen, C. , Crozier, A. , Schroeter, H. (2016) The metabolome of [2-(14)C](-)-epicatechin in humans: implications for the assessment of efficacy, safety, and mechanisms of action of polyphenolic bioactives. Scientific reports , 6 ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/srep29034
Dong, H. , Rendeiro, C. , Kristek, A. , Sargent, L. , Saunders, C. , Harkness, L. , Rowland, I. , Jackson, K. , Spencer, J. , Lovegrove, J. (2016) Addition of orange pomace to orange juice attenuates the increases in peak glucose and insulin concentrations after sequential meal ingestion in men with elevated cardiometabolic risk. Journal of Nutrition , 146 (6). pp. 1197-1203. ISSN: 1541-6100 | doi: https://dx.doi.org/10.3945/jn.115.226001
Alharbi, M. , Lamport, D. , Dodd, G. , Saunders, C. , Harkness, L. , Butler, L. , Spencer, J. (2016) Flavonoid-rich orange juice is associated with acute improvements in cognitive function in healthy middle-aged males. European Journal of Nutrition , 55 (6). pp. 2021-2029. ISSN: 1436-6215 | doi: https://dx.doi.org/10.1007/s00394-015-1016-9

Cifuentes-Gomez, T. , Rodriguez-Mateos, A. , Gonzalez-Salvador, I. , Alañon, M. , Spencer, J. (2015) Factors affecting the absorption, metabolism, and excretion of cocoa flavanols in humans. Journal of Agricultural and Food Chemistry , 63 (35). pp. 7615-7623. ISSN: 1520-5118 | doi: https://dx.doi.org/10.1021/acs.jafc.5b00443
Toro-Funes, N. , Morales-Gutiérrez, F. , Veciana-Nogués, M. , Vidal-Carou, M. , Spencer, J. , Rodriguez-Mateos, A. (2015) The intracellular metabolism of isoflavones in endothelial cells. Food & Function , 6 (1). pp. 97-107. ISSN: 2042-650X | doi: https://dx.doi.org/10.1039/c4fo00772g
Lockyer, S. , Corona, G. , Yaqoob, P. , Spencer, J. , Rowland, I. (2015) Secoiridoids delivered as olive leaf extract induce acute improvements in human vascular function and reduction of an inflammatory cytokine: a randomised, double-blind, placebo-controlled, cross-over trial. British Journal of Nutrition , 114 (1). pp. 75-83. ISSN: 0007-1145 | doi: https://dx.doi.org/10.1017/S0007114515001269
Lovegrove, J. , Commane, D. , Jackson, K. , Karani, V. , Kennedy, O. , Kuhnle, G. , Spencer, J. , Wagstaff, C. , Yaqoob, P. (2015) The Hugh Sinclair Unit of Human Nutrition – 20 years of research 1995–2015. Nutrition Bulletin , 40 (4). pp. 303-314. ISSN: 1467-3010 | doi: https://dx.doi.org/10.1111/nbu.12176
Rodriguez-Mateos, A. , Hezel, M. , Aydin, H. , Kelm, M. , Lundberg, J. , Weitzberg, E. , Spencer, J. , Heiss, C. (2015) Interactions between cocoa flavanols and inorganic nitrate: additive effects on endothelial function at achievable dietary amounts. Free Radical Biology and Medicine , 80 pp. 121-128. ISSN: 0891-5849 | doi: https://dx.doi.org/10.1016/j.freeradbiomed.2014.12.009
Sansone, R. , Rodriguez-Mateos, A. , Heuel, J. , Falk, D. , Schuler, D. , Wagstaff, R. , Kuhnle, G. , Spencer, J. , Schroeter, H. , Merx, M. , Kelm, M. , Heiss, C. (2015) Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study. British Journal of Nutrition , 114 (8). pp. 1246-1255. ISSN: 0007-1145 | doi: https://dx.doi.org/10.1017/S0007114515002822
Eid, N. , Osmanova, H. , Natchez, C. , Walton, G. , Costabile, A. , Gibson, G. , Rowland, I. , Spencer, J. (2015) Impact of palm date consumption on microbiota growth and large intestinal health: a randomised, controlled, cross-over, human intervention study. British Journal of Nutrition , 114 (8). pp. 1226-1236. ISSN: 1475-2662 | doi: https://dx.doi.org/10.1017/S0007114515002780
Lamport, D. , Pal, D. , Moutsiana, C. , Field, D. , Williams, C. , Spencer, J. , Butler, L. (2015) The effect of flavanol-rich cocoa on cerebral perfusion in healthy older adults during conscious resting state: a placebo controlled, crossover, acute trial. Psychopharmacology , 232 (17). pp. 3327-3234. ISSN: 0033-3158 | doi: https://dx.doi.org/10.1007/s00213-015-3972-4
Heiss, C. , Sansone, R. , Karimi, H. , Krabbe, M. , Schuler, D. , Rodriguez Mateos, A. , Krämer, T. , Cortese-Krott, M. , Kuhnle, G. , Spencer, J. , Schroeter, H. , Merx, M. , Kelm, M. (2015) Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial. AGE , 37 (3). ISSN: 0161-9152 | doi: https://dx.doi.org/10.1007/s11357-015-9794-9
Vogiatzoglou, A. , Mulligan, A. , Bhaniani, A. , Lentjes, M. , McTaggart, A. , Luben, R. , Heiss, C. , Kelm, M. , Merx, M. , Spencer, J. , Schroeter, H. , Khaw, K. , Kuhnle, G. (2015) Associations between flavan-3-ol intake and CVD risk in the Norfolk cohort of the European Prospective Investigation into Cancer (EPIC-Norfolk). Free Radical Biology and Medicine , 84 pp. 1-10. ISSN: 0891-5849 | doi: https://dx.doi.org/10.1016/j.freeradbiomed.2015.03.005
Kean, R. , Lamport, D. , Dodd, G. , Freeman, J. , Williams, C. , Ellis, J. , Butler, L. , Spencer, J. (2015) Chronic consumption of flavanone-rich orange juice is associated with cognitive benefits: an 8-wk randomised, double-blind, placebo-controlled trial in healthy older adults. American Journal of Clinical Nutrition , 101 (3). pp. 506-514. ISSN: 0002-9165 | doi: https://dx.doi.org/10.3945/ajcn.114.088518
Mills, C. , Touzonis, X. , Oruna-Concha, M. , Mottram, D. , Gibson, G. , Spencer, J. (2015) In vitro colonic metabolism of coffee and chlorogenic acid results in selective changes in human faecal microbiota growth. British Journal of Nutrition , 113 (8). pp. 1220-1227. ISSN: 0007-1145 | doi: https://dx.doi.org/10.1017/S0007114514003948

Vauzour, D. , Pinto, J. , Cooper, A. , Spencer, J. (2014) The neurotoxicity of 5-S-cysteinyldopamine is mediated by the early activation of ERK1/2 followed by the subsequent activation of ASK1/JNK1/2 pro-apoptotic signalling. Biochemical Journal , 463 (1). pp. 41-52. ISSN: 0264-6021 | doi: https://dx.doi.org/10.1042/BJ20131519
Eid, N. , Enani, S. , Walton, G. , Corona, G. , Costabile, A. , Gibson, G. , Rowland, I. , Spencer, J. (2014) The impact of date palm fruits and their component polyphenols, on gut microbial ecology, bacterial metabolites and colon cancer cell proliferation. Journal of nutritional science , 3 ISSN: 2048-6790 | doi: https://dx.doi.org/10.1017/jns.2014.16
Lamport, D. , Saunders, C. , Butler, L. , Spencer, J. (2014) Fruits, vegetables, 100% juice, and cognitive function. Nutrition Reviews , 72 (12). pp. 774-789. ISSN: 1753-4887 | doi: https://dx.doi.org/10.1111/nure.12149
Eid, N. , Walton, G. , Costabile, A. , Kuhnle, G. , Spencer, J. (2014) Polyphenols, glucosinolates, dietary fibre and colon cancer: Understanding the potential of specific types of fruit and vegetables to reduce bowel cancer progression. Nutrition and Aging , 2 (1). pp. 45-67. ISSN: 1879-7725 | doi: https://dx.doi.org/10.3233/NUA-130029
Rendeiro, C. , Foley, A. , Lau, V. , Ring, R. , Rodriguez-Mateos, A. , Vauzour, D. , Williams, C. ORCID: 0000-0003-4452-671X , Regan, C. , Spencer, J. (2014) A role for hippocampal PSA-NCAM and NMDA-NR2B receptor function in flavonoid-induced spatial memory improvements in young rats. Neuropharmacology , 79 pp. 335-344. ISSN: 0028-3908 | doi: https://dx.doi.org/10.1016/j.neuropharm.2013.12.003
de Jager, C. , Dye, L. , de Bruin, E. , Butler, L. , Fletcher, J. , Lamport, D. , Latulippe, M. , Spencer, J. , Wesnes, K. (2014) Criteria for validation and selection of cognitive tests for investigating the effects of foods and nutrients.. Nutrition reviews , 72 (3). pp. 162-179. ISSN: 1753-4887 | doi: https://dx.doi.org/10.1111/nure.12094
Macready, A. ORCID: 0000-0003-0368-9336 , George, T. , Chong, M. , Alimbetov, D. , Jin, Y. , Vidal, A. , Spencer, J. , Kennedy, O. , Tuohy, K. , Minihane, A. , Gordon, M. , Lovegrove, J. (2014) Flavonoid-rich fruits and vegetables improve microvascular reactivity and inflammatory status in men at risk of cardiovascular disease – FLAVURS: a randomized controlled trial. American Journal of Clinical Nutrition , 99 (3). pp. 479-489. ISSN: 1938-3207 | doi: https://dx.doi.org/10.3945/ajcn.113.074237

Savignac, H. , Corona, G. , Mills, H. , Chen, L. , Spencer, J. , Tzortzis, G. , Burnet, P. (2013) Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-D-aspartate receptor subunits and D-serine. Neurochemistry International , 63 (8). pp. 756-764. ISSN: 0197-0186 | doi: https://dx.doi.org/10.1016/j.neuint.2013.10.006
Vogiatzoglou, A. , Mulligan, A. , Luben, R. , Lentjes, M. , Heiss, C. , Kelm, M. , Merx, M. , Spencer, J. , Schroeter, H. , Kuhnle, G. (2013) Assessment of the dietary intake of total flavan-3-ols, monomeric flavan-3-ols, proanthocyanidins and theaflavins in the European Union. British Journal of Nutrition , 111 (8). pp. 1463-1473. ISSN: 0007-1145 | doi: https://dx.doi.org/10.1017/S0007114513003930
Wright, B. , Spencer, J. , Lovegrove, J. , Gibbins, J. (2013) Flavonoid inhibitory pharmacodynamics on platelet function in physiological environments. Food & Function , 4 (12). pp. 1803-1810. ISSN: 2042-650X | doi: https://dx.doi.org/10.1039/C3FO60272A
Corona, G. , Vauzour, D. , Hercelin, J. , Williams, C. , Spencer, J. (2013) Phenolic acid intake, delivered via moderate champagne wine consumption, improves spatial working memory via the modulation of hippocampal and cortical protein expression/activation.. Antioxidants & Redox Signaling , 19 (4). pp. 1676-1689. ISSN: 1523-0864 | doi: https://dx.doi.org/10.1089/ars.2012.5142
Rendeiro, C. , Vauzour, D. , Rattray, M. , Waffo-Téguo, P. , Mérillon, J. , Butler, L. , Williams, C. , Spencer, J. (2013) Dietary levels of pure flavonoids improve spatial memory performance and increase hippocampal brain-derived neurotrophic factor.. PLoS ONE , 8 (5). ISSN: 1932-6203 | doi: https://dx.doi.org/10.1371/journal.pone.0063535
Mills, C. , Oruna-Concha, M. , Mottram, D. , Gibson, G. , Spencer, J. (2013) The effect of processing on chlorogenic acid content of commercially available coffee. Food Chemistry , 141 (4). pp. 3335-3340. ISSN: 0308-8146 | doi: https://dx.doi.org/10.1016/j.foodchem.2013.06.014
Eid, N. , Al-Awadi, B. , Vauzour, D. , Oruna-Concha, M. , Spencer, J. (2013) Effect of cultivar type and ripening on the polyphenol content of date palm fruit. Journal of Agricultural and Food Chemistry , 61 (10). pp. 2453-2460. ISSN: 0021-8561 | doi: https://dx.doi.org/10.1021/jf303951e
Wright, B. , Spencer, J. , Lovegrove, J. , Gibbins, J. (2013) Insights into dietary flavonoids as molecular templates for the design of anti-platelet drugs. Cardiovascular Research , 97 (1). pp. 13-22. ISSN: 0008-6363 | doi: https://dx.doi.org/10.1093/cvr/cvs304
Chong, M. , George, T. , Alimbetov, D. , Jin, Y. , Weech, M. , Macready, A. , Spencer, J. , Kennedy, O. , Minihane, A. , Gordon, M. , Lovegrove, J. (2013) Impact of the quantity and flavonoid content of fruits and vegetables on markers of intake in adults with an increased risk of cardiovascular disease: the FLAVURS Trial. European Journal of Nutrition , 52 (1). pp. 361-378. ISSN: 1436-6215 | doi: https://dx.doi.org/10.1007/s00394-012-0343-3

Rodriguez Mateos, A. , Oruna-Concha, M. , Kwik-Uribe, C. , Vidal, A. , Spencer, J. (2012) Influence of sugar type on the bioavailability of cocoa flavanols.. British journal of nutrition , 108 (12). pp. 2243-2250. ISSN: 1475-2662 | doi: https://dx.doi.org/10.1017/S0007114512000475
Lockyer, S. , Yaqoob, P. , Spencer, J. , Rowland, I. (2012) Olive leaf phenolics and cardiovascular risk reduction: Physiological effects and mechanisms of action . Nutrition and Aging , 1 (2). pp. 125-140. ISSN: 1879-7725 | doi: https://dx.doi.org/10.3233/NUA-2012-0011
Fox, B. , Schantz, J. , Haigh, R. , Wood, M. , Moore, P. , Viner, N. , Spencer, J. , Winyard, P. , Whiteman, M. (2012) Inducible hydrogen sulfide synthesis in chondrocytes and mesenchymal progenitor cells: is H2S a novel cytoprotective mediator in the inflamed joint?. Journal of Cellular and Molecular Medicine , 16 (4). pp. 896-910. ISSN: 1582-4934 | doi: https://dx.doi.org/10.1111/j.1582-4934.2011.01357.x
Rendeiro, C. , Vauzour, D. , Kean, R. , Butler, L. , Rattray, M. , Spencer, J. , Williams, C. (2012) Blueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal BDNF mRNA expression in young rats. Psychopharmacology , 223 (3). pp. 319-330. ISSN: 0033-3158 | doi: https://dx.doi.org/10.1007/s00213-012-2719-8
Rendeiro, C. , Guerreiro, J. , Williams, C. , Spencer, J. (2012) Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects. Proceedings of the Nutrition Society , 71 (2). pp. 246-262. ISSN: 1475-2719 | doi: https://dx.doi.org/10.1017/S0029665112000146
Hidalgo, M. , Oruna-Concha, M. , Kolida, S. , Walton, G. , Kallithraka, S. , Spencer, J. , Gibson, G. , de Pascual-Teresa, S. (2012) Metabolism of anthocyanins by human gut microflora and their influence on gut bacterial growth. Journal of Agricultural and Food Chemistry , 60 (15). pp. 3882-3890. ISSN: 0021-8561 | doi: https://dx.doi.org/10.1021/jf3002153
Spilsbury, A. , Vauzour, D. , Spencer, J. , Rattray, M. (2012) Regulation of NF-κB activity in astrocytes: effects of flavonoids at dietary-relevant concentrations. Biochemical and Biophysical Research Communications , 418 pp. 578-583. ISSN: 0006-291X | doi: https://dx.doi.org/10.1016/j.bbrc.2012.01.081
Vauzour, D. , Spilsbury, A. , Vafeiadou, K. , Rattray, M. , Spencer, J. (2012) Modulation of neuroinflammation by dietary flavonoids . In: Gemma, C. , (eds.) Neuroinflammation: Pathogenesis, Mechanisms and Management. Nova pp. 213-236. ISBN: 9781619424623

Pinto, J. , Paiva-Martins, F. , Corona, G. , Debnam, E. , Oruna-Concha, M. , Vauzour, D. , Gordon, M. , Spencer, J. (2011) Absorption and metabolism of olive oil secoiridoids in the small intestine. British Journal of Nutrition , 105 (11). pp. 1607-1618. ISSN: 1475-2662 | doi: https://dx.doi.org/10.1017/S000711451000526X
Vauzour, D. , Corona, G. , Hercelin, J. , Garnotel, R. , Gillery, P. , Lovegrove, J. , Williams, C. , Spencer, J. (2011) Potential health effects of Champagne wine consumption. Journal of Wine Research , 22 (2). pp. 175-180. ISSN: 1469-9672 | doi: https://dx.doi.org/10.1080/09571264.2011.603251
Tzounis, X. , Rodriguez Mateos, A. , Vulevic, J. , Gibson, G. , Kwik-Uribe, C. , Spencer, J. (2011) Prebiotic evaluation of cocoa-derived flavanols in healthy humans by using a randomized, controlled, double-blind, crossover intervention study. American Journal of Clinical Nutrition , 93 (1). pp. 62-72. ISSN: 1938-3207 | doi: https://dx.doi.org/10.3945/ajcn.110.000075

Vauzour, D. , Corona, G. , Spencer, J. (2010) Caffeic acid, tyrosol and p-coumaric acid are potent inhibitors of 5-S-cysteinyl-dopamine induced neurotoxicity. Archives of Biochemistry and Biophysics , 501 (1). pp. 106-111. ISSN: 0003-9861 | doi: https://dx.doi.org/10.1016/j.abb.2010.03.016
Vauzour, D. , Buonfiglio, M. , Corona, G. , Chirafisi, J. , Vafeiadou, K. , Angeloni, C. , Hrelia, S. , Hrelia, P. , Spencer, J. (2010) Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity through the activation of ERK1/2, Nrf-2 and the upregulation of detoxification enzymes. Molecular Nutrition & Food Research , 54 (4). pp. 532-542. ISSN: 1613-4125 | doi: https://dx.doi.org/10.1002/mnfr.200900197
Spencer, J. (2010) Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain. Proceedings of the Nutrition Society , 69 (2). pp. 244-260. ISSN: 0029-6651 | doi: https://dx.doi.org/10.1017/S0029665110000054
Spencer, J. (2010) The impact of fruit flavonoids on memory and cognition. British Journal of Nutrition , 104 (Supple). pp. S40-S47. ISSN: 0007-1145 | doi: https://dx.doi.org/10.1017/S0007114510003934
Schroeter, H. , Heiss, C. , Spencer, J. , Keen, C. , Lupton, J. , Schmitz, H. (2010) Recommending flavanols and procyanidins for cardiovascular health: current knowledge and future needs. Molecular Aspects of Medicine , 31 (6). pp. 546-557. ISSN: 0098-2997 | doi: https://dx.doi.org/10.1016/j.mam.2010.09.008
Incani, A. , Deiana, M. , Corona, G. , Vafeiadou, K. , Vauzour, D. , Dessi, M. , Spencer, J. (2010) Involvement of ERK, Akt and JNK signalling in H2O2-induced cell injury and protection by hydroxytyrosol and its metabolite homovanillic alcohol. Molecular Nutrition & Food Research , 54 (6). pp. 788-796. ISSN: 1613-4125 | doi: https://dx.doi.org/10.1002/mnfr.200900098
Macready, A. , Butler, L. , Kennedy, O. , Ellis, J. , Williams, C. , Spencer, J. (2010) Cognitive tests used in chronic adult human randomised controlled trial micronutrient and phytochemical intervention studies. Nutrition Research Reviews , 23 (2). pp. 200-229. ISSN: 0954-4224 | doi: https://dx.doi.org/10.1017/S0954422410000119
Vauzour, D. , Houseman, E. , George, T. , Corona, G. , Garnotel, R. , Jackson, K. , Sellier, C. , Gillery, P. , Kennedy, O. , Lovegrove, J. , Spencer, J. (2010) Moderate Champagne consumption promotes an acute improvement in acute endothelial-independent vascular function in healthy human volunteers. British Journal of Nutrition , 103 (8). pp. 1168-1178. ISSN: 0007-1145 | doi: https://dx.doi.org/10.1017/S0007114509992959
Wright, B. , Gibson, T. , Spencer, J. , Lovegrove, J. , Gibbins, J. (2010) Platelet-mediated metabolism of the common dietary flavonoid, quercetin.. PLoS ONE , 5 (3). ISSN: 1932-6203 | doi: DOI:10.1371/journal.pone.0009673

Corona, . , Deiana, . , Incani, . , Vauzour, . , Dessi, . , Spencer, . (2009) Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1/2 and cyclin D1. Molecular Nutrition & Food Research , 53 (7). pp. 897-903. ISSN: 1613-4125 | doi: https://dx.doi.org/10.1002/mnfr.200800269
Corona, . , Spencer, . , Dessi, . (2009) Extra virgin olive oil phenolics: absorption, metabolism, and biological activities in the GI tract. Toxicology and Industrial Health , 25 (4-5). pp. 285-293. ISSN: 0748-2337 | doi: https://dx.doi.org/10.1177/0748233709102951
Frank, . , George, . , Lodge, . , Rodriguez-Mateos, . , Spencer, . , Minihane, . , Rimbach, . (2009) Daily consumption of an aqueous green tea extract supplement does not impair liver function or alter cardiovascular disease risk biomarkers in healthy men. Journal of Nutrition , 139 (1). pp. 58-62. ISSN: 0022-3166 | doi: https://dx.doi.org/10.3945/jn.108.096412
Macready, A. , Kennedy, O. , Ellis, J. , Williams, C. , Spencer, J. , Butler, L. (2009) Flavonoids and cognitive function: a review of human randomized controlled trial studies and recommendations for future studies. Genes and Nutrition , 4 (4). pp. 227-242. ISSN: 1555-8932 | doi: https://dx.doi.org/10.1007/s12263-009-0135-4
Rendeiro, . , Spencer, . , Vauzour, . , Butler, . , Ellis, . , Williams, . (2009) The impact of flavonoids on spatial memory in rodents: from behaviour to underlying hippocampal mechanisms. Genes and Nutrition , 4 (4). pp. 251-270. ISSN: 1555-8932 | doi: https://dx.doi.org/10.1007/s12263-009-0137-2
Spencer, . (2009) The impact of flavonoids on memory: physiological and molecular considerations. Chemical Society Reviews , 38 (4). pp. 1152-1161. ISSN: 0306-0012 | doi: https://dx.doi.org/10.1039/b800422f
Spencer, . (2009) Flavonoids and brain health: multiple effects underpinned by common mechanisms. Genes and Nutrition , 4 (4). pp. 243-250. ISSN: 1555-8932 | doi: https://dx.doi.org/10.1007/s12263-009-0136-3
Spencer, . (2009) Nutrients and brain health: an overview. Genes and Nutrition , 4 (4). pp. 225-226. ISSN: 1555-8932 | doi: https://dx.doi.org/10.1007/s12263-009-0140-7
Spencer, . , Vauzour, . , Rendeiro, . (2009) Flavonoids and cognition: The molecular mechanisms underlying their behavioural effects. Archives of Biochemistry and Biophysics , 492 (1-2). pp. 1-9. ISSN: 0003-9861 | doi: https://dx.doi.org/10.1016/j.abb.2009.10.003
Vafeiadou, . , Vauzour, . , Lee, . , Rodriguez-Mateos, . , Williams, . , Spencer, . (2009) The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury. Archives of Biochemistry and Biophysics , 484 (1). pp. 100-109. ISSN: 0003-9861 | doi: https://dx.doi.org/10.1016/j.abb.2009.01.016

Williams, C. , El Mohsen, M. , Vauzour, D. , Rendeiro, C. , Butler, L. , Ellis, J. , Whiteman, M. , Spencer, J. (2008) Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels. Free Radical Biology and Medicine , 45 (3). pp. 295-305. ISSN: 1873-4596 | doi: https://dx.doi.org/10.1016/j.freeradbiomed.2008.04.008
Rainey-Smith, . , Schroetke, . , Bahia, . , Fahmi, . , Skilton, . , Spencer, . , Rice-Evans, . , Rattray, . , Williams, . (2008) Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation. Neuroscience Letters , 438 (1). pp. 29-33. ISSN: 0304-3940 | doi: https://dx.doi.org/10.1016/j.neulet.2008.04.056
Cooper, . , Pinto, . , Krasnikov, . , Niatsetskaya, . , Han, . , Li, . , Vauzour, . , Spencer, . (2008) Substrate specificity of human glutamine transaminase K as an aminotransferase and as a cysteine S-conjugate beta-lyase. Archives of Biochemistry and Biophysics , 474 (1). pp. 72-81. ISSN: 0003-9861 | doi: https://dx.doi.org/10.1016/j.abb.2008.02.038
Spencer, . (2008) Food for thought: the role of dietary flavonoids in enhancing human memory, learning and neuro-cognitive performance. Proceedings of the Nutrition Society , 67 (2). pp. 238-252. ISSN: 0029-6651 | doi: https://dx.doi.org/10.1017/s0029665108007088
Spencer, . , Mohsen, . , Minihane, . , Mathers, . (2008) Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research. British Journal of Nutrition , 99 (1). pp. 12-22. ISSN: 0007-1145 | doi: https://dx.doi.org/10.1017/s0007114507798938
Tzounis, . , Vulevic, . , Kuhnle, . , George, . , Leonczak, . , Gibson, . , Kwik-Uribe, . , Spencer, . (2008) Flavanol monomer-induced changes to the human faecal microflora. British Journal of Nutrition , 99 (4). pp. 782-792. ISSN: 0007-1145 | doi: https://dx.doi.org/10.1017/s0007114507853384
Vafeiadou, K. , Vauzour, D. , Rodriguez-Mateos, A. , Whiteman, M. , Williams, R. , Spencer, J. (2008) Glial metabolism of quercetin reduces its neurotoxic potential. Archives of Biochemistry and Biophysics , 478 (2). pp. 195-200. ISSN: 0003-9861 | doi: https://dx.doi.org/10.1016/j.abb.2008.07.014
Vauzour, D. , Ravaioli, G. , Vafeiadou, K. , Rodriguez-Mateos, A. , Angeloni, C. , Spencer, J. (2008) Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: implications for Parkinson's disease and protection by polyphenols. Archives of Biochemistry and Biophysics , 476 (2). pp. 145-151. ISSN: 0003-9861 | doi: https://dx.doi.org/10.1016/j.abb.2008.03.011
Vauzour, . , Vafeiadou, . , Rodriguez-Mateos, . , Rendeiro, . , Spencer, . (2008) The neuroprotective potential of flavonoids: a multiplicity of effects. Genes and Nutrition , 3 (3-4). pp. 115-126. ISSN: 1555-8932 | doi: https://dx.doi.org/10.1007/s12263-008-0091-4
Whiteman, . and Spencer, . (2008) Loss of 3-chlorotyrosine by inflammatory oxidants: Implications for the use of 3-chlorotyrosine as a bio-marker in vivo. Biochemical and Biophysical Research Communications , 371 (1). pp. 50-53. ISSN: 0006-291X | doi: https://dx.doi.org/10.1016/j.bbrc.2008.03.153
Whiteman, M. , Spencer, J. , Szeto, H. , Armstrong, J. (2008) Do mitochondriotropic antioxidants prevent chlorinative stress-induced mitochondrial and cellular injury?. Antioxidants & Redox Signaling , 10 (3). pp. 641-650. ISSN: 1523-0864 | doi: https://dx.doi.org/10.1089/ars.2007.1879

Angeloni, . , Spencer, . , Leoncini, . , Biagi, . , Hrelia, . (2007) Role of quercetin and its in vivo metabolites in protecting H9c2 cells against oxidative stress. Biochimie , 89 (1). pp. 73-82. ISSN: 0300-9084 | doi: https://dx.doi.org/10.1016/j.biochi.2006.09.006
Corona, . , Deiana, . , Incani, . , Vauzour, . , Dessi, . , Spencer, . (2007) Inhibition of p38/CREB phosphorylation and COX-2 expression by olive oil polyphenols underlies their anti-proliferative effects. Biochemical and Biophysical Research Communications , 362 (3). pp. 606-611. ISSN: 0006-291X | doi: https://dx.doi.org/10.1016/j.bbrc.2007.08.049
Schroeter, . , Bahia, . , Spencer, . , Sheppard, . , Rattray, . , Cadenas, . , Rice-Evans, . , Williams, . (2007) (-)Epicatechin stimulates ERK-dependent cyclic AMP response element activity and up-regulates GluR2 in cortical neurons. Journal of Neurochemistry , 101 (6). pp. 1596-1606. ISSN: 0022-3042 | doi: https://dx.doi.org/10.1111/j.1471-4159.2006.04434.x
Spencer, . (2007) The interactions of flavonoids within neuronal signalling pathways. Genes and Nutrition , 2 (3). pp. 257-273. ISSN: 1555-8932 | doi: https://dx.doi.org/10.1007/s12263-007-0056-z
Vafeiadou, K. , Vauzour, D. , Spencer, J. (2007) Neuroinflammation and its modulation by flavonoids. Endocrine, Metabolic & Immune Disorders - Drug Targets , 7 (3). pp. 211-224. ISSN: 2212-3873
Vauzour, D. , Vafeiadou, K. , Corona, G. , Pollard, S. , Tzounis, X. , Spencer, J. (2007) Champagne wine polyphenols protect primary cortical neurons against peroxynitrite-induced injury. Journal of Agricultural and Food Chemistry , 55 (8). pp. 2854-2860. ISSN: 0021-8561 | doi: https://dx.doi.org/10.1021/jf063304z
Vauzour, . , Vafeiadou, . , Rice-Evans, . , Cadenas, . , Spencer, . (2007) Inhibition of cellular proliferation by the genistein metabolite 5,7,3',4'-tetrahydroxyisoflavone is mediated by DNA damage and activation of the ATR signalling pathway. Archives of Biochemistry and Biophysics , 468 (2). pp. 159-166. ISSN: 0003-9861 | doi: https://dx.doi.org/10.1016/j.abb.2007.09.021
Vauzour, . , Vafeiadou, . , Rice-Evans, . , Williams, . , Spencer, . (2007) Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons. Journal of Neurochemistry , 103 (4). pp. 1355-1367. ISSN: 0022-3042 | doi: https://dx.doi.org/10.1111/j.1471-4159.2007.04841.x
Vauzour, . , Vafeiadou, . , Spencer, . (2007) Inhibition of the formation of the neurotoxin 5-S-cysteinyl-dopamine by polyphenols. Biochemical and Biophysical Research Communications , 362 (2). pp. 340-346. ISSN: 0006-291X | doi: https://dx.doi.org/10.1016/j.bbrc.2007.07.153
Whiteman, M. , Chu, S. , Siau, J. , Rose, P. , Sabapathy, K. , Schantz, J. , Cheung, N. , Spencer, J. , Armstrong, J. (2007) The pro-inflammatory oxidant hypochlorous acid induces Bax-dependent mitochondrial permeabilisation and cell death through AIF-/EndoG-dependent pathways. Cellular Signalling , 19 (4). pp. 705-714. ISSN: 0898-6568 | doi: https://dx.doi.org/10.1016/j.cellsig.2006.08.019

Corona, . , Tzounis, . , Dessi, . , Deiana, . , Debnam, . , Visioli, . , Spencer, . (2006) The fate of olive oil polyphenols in the gastrointestinal tract: implications of gastric and colonic microflora-dependent biotransformation. Free Radical Research , 40 (6). pp. 647-658. ISSN: 1071-5762 | doi: https://dx.doi.org/10.1080/10715760500373000
El Mohsen, . , Bayele, . , Kuhnle, . , Gibson, . , Debnam, . , Srai, . , Rice-Evans, . , Spencer, . (2006) Distribution of [H-3]trans-resveratrol in rat tissues following oral administration. British Journal of Nutrition , 96 (1). pp. 62-70. ISSN: 0007-1145 | doi: https://dx.doi.org/10.1079/bjn20061810
El Mohsen, M. , Marks, J. , Kuhnle, G. , Moore, K. , Debnam, E. , Srai, S. , Rice-Evans, C. , Spencer, J. (2006) Absorption, tissue distribution and excretion of pelargonidin and its metabolites following oral administration to rats. British Journal of Nutrition , 95 (1). pp. 51-58. ISSN: 1475-2662 | doi: https://dx.doi.org/10.1079/BJN20051596
Hernandez-Montes, . , Pollard, . , Vauzour, . , Jofre-Montseny, . , Rota, . , Rimbach, . , Weinberg, . , Spencer, . (2006) Activation of glutathione peroxidase via Nrf1 mediates genistein's protection against oxidative endothelial cell injury. Biochemical and Biophysical Research Communications , 346 (3). pp. 851-859. ISSN: 0006-291X | doi: https://dx.doi.org/10.1016/j.bbrc.2006.05.197
Lee, . , Munerol, . , Pollard, . , Youdim, . , Pannala, . , Kuhnle, . , Debnam, . , Rice-Evans, . , Spencer, . (2006) The reaction of flavanols with nitrous acid protects against N-nitrosamine formation and leads to the formation of nitroso derivatives which inhibit cancer cell growth. Free Radical Biology and Medicine , 40 (2). pp. 323-334. ISSN: 0891-5849 | doi: https://dx.doi.org/10.1016/j.freeradbiomed.2005.08.031
Nguyen, . , Hemandez-Montes, . , Vauzour, . , Schonthal, . , Rice-Evans, . , Cadenas, . , Spencer, . (2006) The intracellular genistein metabolite 5,7,3 ',4 '-tetrahydroxyisoflavone mediates G2-M cell cycle arrest in cancer cells via modulation of the p38 signaling pathway. Free Radical Biology and Medicine , 41 (8). pp. 1225-1239. ISSN: 0891-5849 | doi: https://dx.doi.org/10.1016/j.freeradbiomed.2006.06.026
Pollard, . , Kuhnle, . , Vauzour, . , Vafeiadou, . , Tzounis, . , Whiteman, . , Rice-Evans, . , Spencer, . (2006) The reaction of flavonoid metabolites with peroxynitrite. Biochemical and Biophysical Research Communications , 350 (4). pp. 960-968. ISSN: 0006-291X | doi: https://dx.doi.org/10.1016/j.bbrc.2006.09.131
Pollard, S. , Whiteman, M. , Spencer, J. (2006) Modulation of peroxynitrite-induced fibroblast injury by hesperetin: a role for intracellular scavenging and modulation of ERK signalling. Biochemical and Biophysical Research Communications , 347 (4). pp. 916-923. ISSN: 0006-291X | doi: https://dx.doi.org/10.1016/j.bbrc.2006.06.153
Spencer, . , Abd El Mohsen, . , Minihane, . (2006) Metabolism of dietary phytochemicals: a review of the metabolic forms identified in humans. Current Topics in Nutraceutical Research , 4 (3-4). pp. 187-203. ISSN: 1540-7535
Whiteman, . , Spencer, . , Zhu, . , Armstrong, . , Schantz, . (2006) Peroxynitrite-modified collagen-II induces p38/ERK and NF-kappa B-dependent synthesis of prostaglandin E-2 and nitric oxide in chondrogenically differentiated mesenchyrnal progenitor cells. Osteoarthritis and Cartilage , 14 (5). pp. 460-470. ISSN: 1063-4584 | doi: https://dx.doi.org/10.1016/j.joca.2005.11.002

El Mohsen, . , Iravani, . , Spencer, . , Rose, . , Fahim, . , Motawi, . , Ismail, . , Jenner, . (2005) Age-associated changes in protein oxidation and proteasome activities in rat brain: modulation by antioxidants. Biochemical and Biophysical Research Communications , 336 (2). pp. 386-391. ISSN: 0006-291X | doi: https://dx.doi.org/10.1016/j.bbrc.2005.07.201
Spencer, J. , Kuhnle, G. , Hajirezaei, M. , Mock, H. , Sonnewald, U. , Rice-Evans, C. (2005) The genotypic variation of the antioxidant potential of different tomato varieties. Free Radical Research , 39 (9). pp. 1005-1016. ISSN: 1071-5762 | doi: https://dx.doi.org/10.1080/10715760400022293

Spencer, J. , El Mohsen, M. , Rice-Evans, C. (2004) Cellular uptake and metabolism of flavonoids and their metabolites: implications for their bioactivity. Archives of Biochemistry and Biophysics , 423 (1). pp. 148-161. ISSN: 0003-9861 | doi: https://dx.doi.org/10.1016/j.abb.2003.11.010
Tortarolo, . , Crossthwaite, . , Conforti, . , Spencer, . , Williams, . , Bendotti, . , Rattray, . (2004) Expression of SOD1 G93A or wild-type SOD1 in primary cultures of astrocytes down-regulates the glutamate transporter GLT-1: lack of involvement of oxidative stress. Journal of Neurochemistry , 88 (2). pp. 481-493. ISSN: 0022-3042 | doi: https://dx.doi.org/10.1046/j.1471-4159.2003.02208.x
Williams, . , Spencer, . , Goni, . , Rice-Evans, . (2004) Zinc-histidine complex protects cultured cortical neurons against oxidative stress-induced damage. Neuroscience Letters , 371 (2-3). pp. 106-110. ISSN: 0304-3940 | doi: https://dx.doi.org/10.1016/j.neulet.2004.08.054
Williams, . , Spencer, . , Rice-Evans, . (2004) Flavonoids: antioxidants or signalling molecules?. Free Radical Biology and Medicine , 36 (7). pp. 838-849. ISSN: 0891-5849 | doi: https://dx.doi.org/10.1016/j.freeradbiomed.2004.01.001

Spencer, J. , Kuhnle, G. , Williams, R. , Rice-Evans, C. (2003) Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites. Biochemical Journal , 372 (1). pp. 173-181. ISSN: 0264-6021 | doi: https://dx.doi.org/10.1042/BJ20021972
Spencer, J. (2003) Metabolism of tea flavonoids in the gastrointestinal tract. Journal of Nutrition , 133 (10). pp. 3255S-3261S. ISSN: 1541-6100
Schroeter, H. , Boyd, C. , Ahmed, R. , Spencer, J. , Duncan, R. , Rice-Evans, C. , Cadenas, E. (2003) c-Jun N-terminal kinase (JNK)-mediated modulation of brain mitochondria function: new target proteins for JNK signalling in mitochondrion-dependent apoptosis. Biochemical Journal , 372 (2). pp. 359-369. ISSN: 0264-6021 | doi: https://dx.doi.org/10.1042/BJ20030201
Basu-Modak, S. , Gordon, M. , Dobson, L. , Spencer, J. , Rice-Evans, C. , Tyrrell, R. (2003) Epicatechin and its methylated metabolite attenuate UVA-induced oxidative damage to human skin fibroblasts. Free Radical Biology and Medicine , 35 (8). pp. 910-921. ISSN: 0891-5849 | doi: https://dx.doi.org/10.1016/S0891-5849(03)00436-2
Spencer, J. , Rice-Evans, C. , Williams, R. (2003) Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability. The Journal of Biological Chemistry , 278 (37). pp. 34783-34793. ISSN: 1083-351X | doi: https://dx.doi.org/10.1074/jbc.M305063200

Jeremy Spencer

Office

Building location

Areas of interest

Research centres and groups

Academic qualifications

Awards and honours

External activities

Publications

2022

2021

2020

2019

2018

2017

2016

2015

2014

2013

2012

2011

2010

2009

2008

2007

2006

2005

2004

2003