Anisha Wijeyesekera

Email:
a.wijeyesekera@reading.ac.uk
Phone:
+44 (0) 118 378 6648
Job title:
Associate Professor

Responsibilities:

Co-Director of Postgraduate Research Studies
Module Convenor for Fundamental Biochemistry in Food and Nutrition (FB1BFN)
Member of the SCFP Diversity and Inclusion Committee.

Office

2-51

Building location

Harry Nursten

Areas of interest

¹H-NMR and LC-MS based metabolic phenotyping of human and animal biological samples.
Assessment of age and diet-associated markers of health and disease.
Functional assessment of the microbiome, and capture of gut-host interactions.

Research centres and groups

Food Microbial Sciences Unit (FMSU).

Academic qualifications

PhD in Chemistry – Imperial College London, 2009
MSc in Bioinformatics – University of Exeter, 2004
BSc (Hons) in Biomedical Sciences – University of Durham, 2003.

Publications

Jackson, P. , Wijeyesekera, A. ORCID: 0000-0001-6151-5065 , Theis, S. , Van Harsselaar, J. , Rastall, R. ORCID: 0000-0003-1775-5226 (2023) Effects of food matrix on the prebiotic efficacy of inulin-type fructans: a randomised trial. Beneficial Microbes pp 18. ISSN: 1876-2891 | doi: https://dx.doi.org/10.1163/18762891-20220120
Jackson, P. , Wijeyesekera, A. ORCID: 0000-0001-6151-5065 , Williams, C. ORCID: 0000-0003-4452-671X , Theis, S. , van Harsselaar, J. , Rastall, R. (2023) Inulin-type fructans and 2'fucosyllactose alter both microbial composition and appear to alleviate stress-induced mood state in a working population compared to placebo (maltodextrin): the EFFICAD Trial, a randomized, controlled trial. The American Journal of Clinical Nutrition pp 0. ISSN: 1938-3207 | doi: https://dx.doi.org/10.1016/j.ajcnut.2023.08.016
Jackson, P. ORCID: 0000-0003-0098-4719 , Wijeyesekera, A. ORCID: 0000-0001-6151-5065 , Rastall, R. (2023) Oligofructose alone and in combination with 2'fucosyllactose induces physiologically relevant changes in γ-aminobutyric acid and organic acid production compared to sole 2'fucosyllactose supplementation: an in vitro study. FEMS microbiology ecology , 99 (9). pp 0. ISSN: 0168-6496 | doi: https://dx.doi.org/10.1093/femsec/fiad100
Jackson, P. , Wijeyesekera, A. ORCID: 0000-0001-6151-5065 , van Harsselaar, J. , Theis, S. , Rastall, R. (2023) Oligofructose, 2'fucosyllactose and β-glucan in combination induce specific changes in microbial composition and short-chain fatty acid production compared to sole supplementation. Journal of Applied Microbiology , 134 (2). pp 0. ISSN: 1364-5072 | doi: https://dx.doi.org/10.1093/jambio/lxac069
Monteagudo-Mera, A. , Shalunkhe, A. , Duhduh, A. , Walton, G. ORCID: 0000-0001-5426-5635 , Gibson, G. , Pereira, D. , Wijeyesekera, A. ORCID: 0000-0001-6151-5065 , Andrews, S. ORCID: 0000-0003-4295-2686 (2023) Impact of inorganic iron and haem on the human gut microbiota; an in vitro batch-culture approach. Frontiers in Microbiology , 14 ISSN: 1664-302X | doi: https://dx.doi.org/10.3389/fmicb.2023.1074637
Monteagudo-Mera, A. , Fanti, V. , Rodriguez-Sobstel, C. , Gibson, G. , Wijeyesekera, A. ORCID: 0000-0001-6151-5065 , Karatzas, K. , Chakrabarti, B. ORCID: 0000-0002-6649-7895 (2023) Gamma aminobutyric acid production by commercially available probiotic strains. Journal of Applied Microbiology , 134 (2). ISSN: 1364-5072 | doi: https://dx.doi.org/10.1093/jambio/lxac066
Jackson, P. ORCID: 0000-0003-0098-4719 , Wijeyesekera, A. ORCID: 0000-0001-6151-5065 , Rastall, R. (2023) Inulin‐type fructans and short‐chain fructooligosaccharides—their role within the food industry as fat and sugar replacers and texture modifiers—what needs to be considered!. Food Science & Nutrition , 11 (1). pp. 17-38. ISSN: 2048-7177 | doi: https://dx.doi.org/10.1002/fsn3.3040

Jackson, P. , Wijeyesekera, A. ORCID: 0000-0001-6151-5065 , Rastall, R. (2022) Determining the metabolic fate of human milk oligosaccharides: it may just be more complex than you think?. Gut Microbiome , 3 ISSN: 2632-2897 | doi: https://dx.doi.org/10.1017/gmb.2022.8
Sanz Morales, P. , Wijeyesekera, A. ORCID: 0000-0001-6151-5065 , Robertson, M. , Jackson, P. , Gibson, G. (2022) The potential role of human milk oligosaccharides in irritable bowel syndrome. Microorganisms , 10 (12). ISSN: 2076-2607 | doi: https://dx.doi.org/10.3390/microorganisms10122338
Kean, I. , Wagner, J. , Wijeyesekera, A. ORCID: 0000-0001-6151-5065 , De Goffau, M. , Thurston, S. , Clark, J. , White, D. , Ridout, J. , Agrawal, S. , Kayani, R. , O’Donnell, R. , Ramnarayan, P. , Peters, M. , Klein, N. , Holmes, E. , Parkhill, J. , Baker, S. , Pathan, N. (2022) Profiling gut microbiota and bile acid metabolism in critically ill children. Scientific Reports , 12 (1). pp 0. ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-022-13640-0
Jackson, P. , Wijeyesekera, A. ORCID: 0000-0001-6151-5065 , Theis, S. , van Harsselaar, J. , Rastall, R. (2022) Food for thought! Inulin-type fructans: does the food matrix matter?. Journal of Functional Foods , 90 ISSN: 1756-4646 | doi: https://dx.doi.org/10.1016/j.jff.2022.104987

Newland, G. , Gibson, G. , Jackson, F. , Wijeyesekera, A. ORCID: 0000-0001-6151-5065 (2021) Assessment of stool collection and storage conditions for in vitro human gut model studies. Journal of Microbiological Methods , 185 ISSN: 0167-7012 | doi: https://dx.doi.org/10.1016/j.mimet.2021.106230
Curi-Quinto, K. , Sanchez, A. , Lago-Berrocal, N. , Penny, M. , Murray, C. , Nunes, R. ORCID: 0000-0003-0829-4130 , Favara, M. , Wijeyesekera, A. ORCID: 0000-0001-6151-5065 , Lovegrove, J. , Soto-Caceres, V. , Vimaleswaran, K. (2021) Role of government financial support and vulnerability char-acteristics associated with food insecurity during the COVID-19 pandemic among young Peruvians. Nutrients , 13 (10). ISSN: 2072-6643 | doi: https://dx.doi.org/10.3390/nu13103546
Sayers, B. ORCID: 0000-0003-2711-238X , Wijeyesekera, A. ORCID: 0000-0001-6151-5065 , Gibson, G. (2021) Exploring the potential of prebiotic and polyphenol-based dietary interventions for the alleviation of cognitive and gastrointestinal perturbations associated with military specific stressors. Journal of Functional Foods , 87 ISSN: 1756-4646 | doi: https://dx.doi.org/10.1016/j.jff.2021.104753

Lawson, M. , O'Neill, I. , Kujawska, M. , Gowrinadh Javvadi, S. , Wijeyesekera, A. ORCID: 0000-0001-6151-5065 , Flegg, Z. , Chalklen, L. , Hall, L. (2020) Breast milk-derived human milk oligosaccharides promote Bifidobacterium interactions within a single ecosystem. ISME Journal , 14 pp. 635-648. ISSN: 1751-7370 | doi: https://dx.doi.org/10.1038/s41396-019-0553-2
Scott, K. , Grimaldi, R. , Cunningham, M. , Sarbini, S. , Wijeyesekera, A. , Tang, M. , Lee, J. , Yau, Y. , Ansell, J. , Theis, S. , Yang, K. , Menon, R. , Arfsten, J. , Manurung, S. , Gourineni, V. , Gibson, G. (2020) Developments in understanding and applying prebiotics in research and practice - an ISAPP conference paper. Journal of Applied Microbiology , 128 (4). pp. 934-948. ISSN: 1364-5072 | doi: https://dx.doi.org/10.1111/jam.14424

Wijeyesekera, A. , Wagner, J. , De Goffau, M. , Thurston, S. , Rodrigues Sabino, A. , Zaher, S. , White, D. , Ridout, J. , Peters, M. , Ramnarayan, P. , Branco, R. , Torok, M. , Valla, F. , Meyer, R. , Klein, N. , Frost, G. , Parkhill, J. , Holmes, E. , Pathan, N. (2019) Multi-compartment profiling of cacterial and host metabolites identifies intestinal dysbiosis and its functional consequences in the critically ill child. Critical care medicine , 47 (9). pp. e727-e734. ISSN: 1530-0293 | doi: https://dx.doi.org/10.1097/CCM.0000000000003841

Athersuch, T. and Wijeyesekera, A. (2018) NMR in environmental and nutritional research. In: Keun, H. , (eds.) NMR-based Metabolomics. Royal Society of Chemistry pp. 168-182. ISSN: 2044-2548 ISBN: 9781849736435 | doi: https://dx.doi.org/10.1039/9781782627937-00168

Chekmeneva, E. , dos Santos Correia, G. , Chan, Q. , Wijeyesekera, A. , Tin, A. , Young, J. , Elliott, P. , Nicholson, J. , Holmes, E. (2017) Optimization and application of direct infusion nanoelectrospray HRMS method for large-scale urinary metabolic phenotyping in molecular epidemiology. Journal of Proteome Research , 16 (4). pp. 1646-1658. ISSN: 1535-3907 | doi: https://dx.doi.org/10.1021/acs.jproteome.6b01003
Parkinson, J. , Wijeyesekera, A. , Hyde, M. , Singhal, A. , Lucas, A. , Holmes, E. , Modi, N. (2017) Early preterm nutrition and the urinary metabolome in young adult life: follow-up of a randomised controlled trial. BMJ Paediatrics Open , 1 (1). ISSN: 2399-9772 | doi: https://dx.doi.org/10.1136/bmjpo-2017-000192
Basson, A. and Wijeyesekera, A. (2017) Metabolic phenotyping for understanding the gut microbiome and host metabolic interplay. Emerging Topics in Life Sciences , 1 (4). pp. 325-332. ISSN: 2397-8562 | doi: https://dx.doi.org/10.1042/ETLS20170079

Baker, L. , Lanz, B. , Andreola, F. , Ampuero, J. , Wijeyesekera, A. , Holmes, E. , Deutz, N. (2016) New technologies – new insights into the pathogenesis of hepatic encephalopathy. Metabolic Brain Disease , 31 (6). pp. 1259-1267. ISSN: 1573-7365 | doi: https://dx.doi.org/10.1007/s11011-016-9906-y
Jackson, F. , Georgakopoulou, N. , Kaluarachchi, M. , Kyriakides, M. , Andreas, N. , Przysiezna, N. , Hyde, M. , Modi, N. , Nicholson, J. , Wijeyesekera, A. , Holmes, E. (2016) Development of a pipeline for exploratory metabolic profiling of infant urine. Journal of Proteome Research , 15 (9). pp. 3432-3440. ISSN: 1535-3907 | doi: https://dx.doi.org/10.1021/acs.jproteome.6b00234

Holmes, E. , Wijeyesekera, A. , Taylor-Robinson, S. , Nicholson, J. (2015) The promise of metabolic phenotyping in gastroenterology and hepatology. Nature Reviews in Gastroenterology and Hepatology , 12 (8). pp. 458-471. ISSN: 1759-5045 | doi: https://dx.doi.org/10.1038/nrgastro.2015.114
Amiot, A. , Dona, A. , Wijeyesekera, A. , Tournigand, C. , Baumgaertner, I. , Lebaleur, Y. , Sobhani, I. , Holmes, E. (2015) 1H NMR spectroscopy of fecal extracts enables detection of advanced colorectal neoplasia. Journal of Proteome Research , 14 (9). pp. 3871-3881. ISSN: 1535-3907 | doi: https://dx.doi.org/10.1021/acs.jproteome.5b00277
Correia, G. , Ng, K. , Wijeyesekera, A. , Gala-Peralta, S. , Williams, R. , MacCarthy-Morrogh, S. , Jiménez, B. , Inwald, D. , Macrae, D. , Frost, G. , Holmes, E. , Pathan, N. (2015) Metabolic profiling of children undergoing surgery for congenital heart disease. Critical Care Medicine , 43 (7). pp. 1467-1476. ISSN: 1530-0293 | doi: https://dx.doi.org/10.1097/CCM.0000000000000982
Andreas, N. , Hyde, M. , Gomez‐Romero, M. , Lopez-Gonzalvez, M. , Villaseñor, A. , Wijeyesekera, A. , Barbas, C. , Modi, N. , Holmes, E. , Garcia-Perez, I. (2015) Multiplatform characterization of dynamic changes in breast milk during lactation. Electrophoresis , 36 (18). pp. 2269-2285. ISSN: 0173-0835 | doi: https://dx.doi.org/10.1002/elps.201500011
Elliott, P. , Posma, J. , Chan, Q. , Garcia-Perez, I. , Wijeyesekera, A. ORCID: 0000-0001-6151-5065 , Bictash, M. , Ebbels, T. , Ueshima, H. , Zhao, L. , van Horn, L. , Daviglus, M. , Stamler, J. , Holmes, E. , Nicholson, J. (2015) Urinary metabolic signatures of human adiposity. Science Translational Medicine , 7 (285). ISSN: 1946-6242 | doi: https://dx.doi.org/10.1126/scitranslmed.aaa5680
Chekmeneva, E. , Correia, G. , Denes, J. , Gomez-Romero, M. , Wijeyesekera, A. , Perenyi, D. , Koot, Y. , Boomsma, C. , Want, E. , Dixon, P. , Macklon, N. , Chan, Q. , Takats, Z. , Nicholson, J. , Holmes, E. (2015) Development of nanoelectrospray high resolution isotope dilution mass spectrometry for targeted quantitative analysis of urinary metabolites: application to population profiling and clinical studies. Analytical Methods , 7 (12). pp. 5122-5133. ISSN: 1759-9679 | doi: https://dx.doi.org/10.1039/c5ay00850f

Ladep, N. , Dona, A. , Lewis, M. , Crossey, M. , Lemoine, M. , Okeke, E. , Shimakawa, Y. , Duguru, M. , Njai, H. , Fye, H. , Taal, M. , Chetwood, J. , Kasstan, B. , Khan, S. , Garside, D. , Wijeyesekera, A. ORCID: 0000-0001-6151-5065 , Thillainayagam, A. , Banwat, E. , Thursz, M. , Nicholson, J. , Njie, R. , Holmes, E. , Taylor-Robinson, S. (2014) Discovery and validation of urinary metabotypes for the diagnosis of hepatocellular carcinoma in West Africans. Hepatology , 60 (4). pp. 1291-1301. ISSN: 1527-3350 | doi: https://dx.doi.org/10.1002/hep.27264
Klootwijk, E. , Reichold, M. , Helip-Wooley, A. , Tolaymat, A. , Broeker, C. , Robinette, S. , Reinders, J. , Peindl, D. , Renner, K. , Eberhart, K. , Assmann, N. , Oefner, P. , Dettmer, K. , Sterner, C. , Schroeder, J. , Zorger, N. , Witzgall, R. , Reinhold, S. , Stanescu, H. , Bockenhauer, D. , Jaureguiberry, G. , Courtneidge, H. , Hall, A. , Wijeyesekera, A. ORCID: 0000-0001-6151-5065 , Holmes, E. , Nicholson, J. , O'Brien, K. , Bernardini, I. , Krasnewich, D. , Arcos-Burgos, M. , Izumi, Y. , Nonoguchi, H. , Jia, Y. , Reddy, J. , Ilyas, M. , Unwin, R. , Gahl, W. , Warth, R. , Kleta, R. (2014) Mistargeting of peroxisomal EHHADH and inherited renal Fanconi's syndrome. The New England Journal of Medicine , 370 (2). pp. 129-138. ISSN: 1533-4406 | doi: https://dx.doi.org/10.1056/NEJMoa1307581

Anisha Wijeyesekera

Office

Building location

Areas of interest

Research centres and groups

Academic qualifications

Publications

2023

2022

2021

2020

2019

2018

2017

2016

2015

2014