About the servers

This is the main page for the McGuffin bioinformatics group web servers. Several protein structure and function prediction methods are freely available for academic use. Please cite the relevant publications for each method. References for methods can be found on each server home page.

IntFOLD

An integrated server providing a single interface for the prediction of structure and function from sequence with interactive graphical output.

ModFOLD

Assess the quality of predicted 3D models.

ReFOLD

Fix the errors in 3D models of proteins.

FunFOLD

Predict protein-ligand interactions.

DISOclust

Predict the intrinsically disordered regions within a protein sequence.

DomFOLD

Predict the domain boundaries within a protein sequence.

nFOLD3

Our older unsupported method for building 3D models of a protein from sequence using fold recognition.

Downloads

Download standalone verisons of the methods.
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News and Updates

  • Apr 2017: ModFOLD6 server paper accepted by Nucleic Acids Research - Publications
  • Apr 2017: ReFOLD server paper accepted by Nucleic Acids Research - Publications
  • Apr 2017: PLOS ONE paper accepted - Publications
  • Dec 2016: Success at CASP12 (among the top few ranked in TBM and QA)! Two talks and three posters presented on our new methods and servers. The ReFOLD and ModFOLD6 servers are now online.
  • Nov 2016: Two new PhD students to start - People
  • Sep 2016: CASP12 prediction season complete. 5 abstracts submitted for Dec conference describing IntFOLD4, ModFOLD6, ReFOLD, MultiFOLD and ModFOLDIA. New servers and downloads coming soon...
  • May-Aug 2016: CASP12 prediction season! New servers and methods will be benchmarked.
  • Apr 2016: Methods in Mol. Biol. paper published - Publications
  • Feb 2016: Won the University Best Research Output prize in the Health Theme for paper in J. Clin. Invest. Pubmed
  • Feb 2016: Nature Sci. Rep. paper published - Publications
  • Jan 2016: Methods in Mol. Biol. paper published - Publications
  • Dec 2015: Int. J. Mol. Sci. paper accepted - Publications
  • Oct 2015: New PhD student started - People
  • Aug 2015: Int. J. Mol. Sci. paper accepted - Publications
  • May 2015: J. Nutr. Biochem. paper accepted - Publications
  • Apr 2015: New PhD student started - People
  • Mar 2015: New IntFOLD server paper accepted by Nucleic Acids Research - Publications
  • Feb 2015: Science paper published containing results from the IntFOLD server - Press release
  • Jan 2015: New PhD student started - People
  • Dec 2014: Success at CASP11, especially in the Quality Assessment category and with Contact Assisted (Tp) modelling
  • Oct 2014: Veterinary Dermatology paper published.
  • Jul-Oct 2014: New PhD students started.
  • Aug 2014: CASP11 prediction season complete. Participation in refinement and contact assisited categories for the first time.
  • May 2014: CASP11 starts! New servers and methods will be benchmarked.
  • Apr 2014: New PhD students appointed
  • Mar 2014: Methods Mol. Biol. chapter published
  • Feb 2014: Paper accepted by the Journal of Clinical Investigation - Publications

Contact

Tel: 0118 378 6332

Email: l.j.mcguffin
@reading.ac.uk

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