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Liam McGuffin

Portrait of Liam McGuffin

Professor of Bioinformatics


  • Key Skills in Biological Sciences
  • Molecular Genetics
  • Introduction to Bioinformatics and Computational Biology
  • Part 3 Projects in Bioinformatics
  • MSc by Research in Molecular Medicine

Research projects

  • Funding from the BBSRC, MRC, Diamond Light Source, RCUK and International Governments 
  • Development of novel computational tools for the prediction of protein structures, functions and interactions from amino acid sequences. See: McGuffin Group Web servers
  • Prediction and experimental verification of the effects of mutations on protein folding and function 
  • Application of computational methods for understanding the molecular mechanisms of cardiovascular function and disease 
  • Development of algorithms for the evaluation of the quality of 3D models of proteins and setting data standards for theoretical model validation 
  • High performance computing for the large scale structure and functional annotation of the proteomes of organisms relevant to food security 
  • Participation in the biennial experiments for the Critical Assessment of Techniques for Protein Structure Prediction (CASP)

Awards and honours

Esteem Factors

  • RCUK Academic Fellowship (held from 2006-2011) 
  • Invited speaker at numerous Community Wide Experiments on the Critical Assessment of Techniques for Protein Structure Prediction 
  • Member of the MRC College of Experts for Special Training Fellowships in Biomedical Informatics 
  • Member of the program committee for the European Conference on Computational Biology  


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