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Liam McGuffin

Portrait of Liam McGuffin
  • Admissions Tutor for BSc Biological Sciences with Industrial Experience
  • Director of Impact and Enterprise  


  • Part 1:
    • The Living Cell 
    • Key Skills in Biological Sciences 
    • Building Blocks of Life 
  • Part 2:
    • Molecular Biology of the Gene: Expression, Function and Analysis 
    • Molecular Genetics 
    • Protein Structure and Function 
    • Introduction to Bioinformatics and Computational Biology 
    • Professional Careers Development 
  • Part 3:
    • Projects in Bioinformatics and Systems Biology
    • MRes Biomedical Research 
    • MSc in Molecular Medicine

Research centres and groups

Member of the Impact, Enterprise and Outreach

  • STEM Ambassador working with local secondary schools 
  • Science & Engineering Ambassador at Science Oxford for various events during National Science and Engineering Week and the Oxford Science Festival 
  • Scientific consultancy, software development and data mining work for various biotech companies

Research projects

  • Funding from the BBSRC, MRC, Diamond Light Source, RCUK and International Governments 
  • Development of novel computational tools for the prediction of protein structures, functions and interactions from amino acid sequences. See: McGuffin Group Web servers
  • Prediction and experimental verification of the effects of mutations on protein folding and function 
  • Application of computational methods for understanding the molecular mechanisms of cardiovascular function and disease 
  • Development of algorithms for the evaluation of the quality of 3D models of proteins and setting data standards for theoretical model validation 
  • High performance computing for the large scale structure and functional annotation of the proteomes of organisms relevant to food security 
  • Participation in the biennial experiments for the Critical Assessment of Techniques for Protein Structure Prediction (CASP)

Awards and honours

Esteem Factors

  • RCUK Academic Fellowship (held from 2006-2011) 
  • Invited speaker at the 8th, 9th and 10th Community Wide Experiments on the Critical Assessment of Techniques for Protein Structure Prediction 
  • Member of the MRC College of Experts for Special Training Fellowships in Biomedical Informatics 
  • Member of the program committee for the European Conference on Computational Biology  

Professional bodies/affiliations

International Collaborators

  • Professor Dr Filiz Gurel, Istanbul University, Turkey 
  • Dr Luis V. Monteagudo, University of Zaragoza, Spain 
  • Dr Valter Tucci, Istituto Italiano di Tecnologia, Genova, Italy 
  • Dr Daniel Roche, The French National Sequencing Center (Genoscope), Évry, France 
  • Dr Carsten Pedersen, University of Copenhagen, Denmark 
  • Prof. Hans Thordal-Christensen University of Copenhagen, Denmark 
  • Prof. Ralph Panstruga, Max-Planck Institute for Plant Breeding Research, Cologne, Germany 
  • Dr Emiel Ver Loren van Themaat, Max-Planck Institute for Plant Breeding Research, Cologne, Germany 
  • Prof. Gerd Pfeifer, City of Hope National Medical Center, California, USA 
  • Dr Thomas Dunwell, City of Hope National Medical Center, California, USA 
  • Dr Paulo Teixeira, University of Campinas, Brazil

National Collaborators

  • Dr Anne-Marie Mallon, MRC Harwell, Oxfordshire 
  • Dr Pat Nolan, MRC Harwell, Oxfordshire 
  • Dr Michelle Simon, MRC Harwell, Oxfordshire 
  • Dr Rohannah Hussain, Diamond Light Source, Oxfordshire 
  • Dr Laurence Bindschedler, Royal Holloway, University of London 
  • Dr Tim Burgis, Imperial College London 
  • Dr Pietro Spanu, Imperial College London 
  • Dr Kevin Bryson, University College London 
  • Dr Soren Sorensen, University College London 
  • Prof David T. Jones, University College London 
  • Prof Christine Oregno, University College London 
  • Prof Mike Sternberg, Imperial College London 
  • Prof Janet Thornton, European Bioinformatics Institute 
  • Lorenz Wernisch, University College London 
  • Dr Stefano Lise, University of Oxford 
  • Dr Michael Sadowski, Synthace, London