Sakthi Vaiyapuri

Email:
s.vaiyapuri@reading.ac.uk
Phone:
+44 (0) 118 378 8015
Job title:
Professor in Cardiovascular & Venom Pharmacology

Areas of interest

Our research interests are mainly focussed on the understanding of the orchestrated functions of adhesive molecules in the regulation of cellular interactions and responses during the development of inflammatory diseases. Platelets (small circulating blood cells) are involved in blood clotting to prevent excessive bleeding. However, their inappropriate activation under pathological conditions leads to thrombosis, which can cause major life threatening conditions such as heart attacks and strokes.

Although platelets play an important role in the maintenance of haemostasis and thrombosis, they are known to be critically involved in the development of inflammatory responses. Therefore, our research group is currently investigating the orchestrated functions of adhesive molecules and inflammatory receptors such as formyl peptide and toll-like receptors present on the surface of blood cells such as platelets, monocytes and neutrophils in the regulation of multicellular interactions and their complex functions during inflammatory responses.

As well as this, we are also interested in understanding the pathophysiological functions of snake venom proteins in order to improve the diagnostic and therapeutic approaches to snakebites. Since viper venom components are haemotoxic in nature and target the blood coagulation system, we are able to inter-relate the venom proteins with the coagulation system to understand their mechanisms of action.

Indeed, we have purified several toxic venom proteins including a snaclec, rhinocetin from the venom of Bitis gabonica rhinoceros that was characterised to be a selective inhibitor of integrin α2β1 on the surface of platelets and endothelial cells. We are currently involved in the expression and molecular characterisation of snake venom proteins from plant-based bioreactors and are exploring the therapeutic applications of chemical-based inhibitors as an alternative option for treating snakebites.

Research centres and groups

Membership in Professional Bodies
American Heart Association
International Society on Thrombosis and Haemostasis
British Society for Cardiovascular Research
British Society for Haematology
The Physiological Society

Research projects

Research project funding

University of Reading (2018) BOISP Impact Funding (£20,000) (PI)
Saudi Arabian Cultural Bureau (2017) PhD Studentship, £150,000 (PI)
University of Reading (2016) 2020 Research Fellowship, £5000 (PI)
British Heart Foundation (2016) PhD Studentship, £107,299 (PI)
Saudi Arabian Cultural Bureau (2016) PhD Studentship, £150,000 (PI)
The Wellcome Trust (2016) Seed Award in Science, £98,333 (PI)
British Heart Foundation (2016) Project Grant, £170,397 (PI)
Saudi Arabian Embassy (2016) PhD Studentship, £150,000 (PI)
University of Reading (2016) UROP Summer placement award, £1320 (PI)
The Physiological Society (2015) Research Grant, £9936 (PI)
The Royal Society (2015) Research Grant, £14,999 (PI)
University of Reading (2015) UROP Summer placement award, £1320 (PI)
Saudi Arabian Embassy (2015) PhD Studentship, £138,000 (PI)

Current Group Members

Dr Divya Ravishankar - Postdoctoral Research Associate
Ms Maryam Salamah - PhD
Ms Eman Alzahrani - PhD
Mr Harry Williams - PhD
Mr Kahdr Alatawi - PhD
Mr Thomas Vallance - PhD
Ms Shahtha Alomar - PhD
Ms Medha Sonavane - PhD
Mr Harry Layfield - Research Technician

Impact, Enterprise and Outreach

Snakebite brings social and financial burden among Indian farmers - an article published in 'Rural 21', 03; 2016.
Snakebite Antivenom Development Is Stuck in the 19^th Century. What's Next? - an article published in 'Scientific American' on 17^th November 2015.
Indian's snakebite victims could be offered lifesaving low-cost nasal spray - an article published in 'The Guardian' on 18th July 2014.
Cheap nasal spray may save snakebite victims - an article published in 'SciDevNet' on 17th July 2014.
Universal antidote for snakebite: Experimental trial represents promising step toward - an article published in 'ScienceDaily' on 28th May 2014.
The Killers Underfoot - an article published in 'The New York Times' on 12th April 2014.
Snakebite deaths register rattling surge, finds study - an article published in 'The Times of India' on 12th March 2014.
Clot breakthrough - an article published in an UK newspaper, 'Chronicle' on 10th October 2013.
Food Hospital - Effects of onions in the prevention of cardiovascular diseases- participated in a TV Show for 'Channel 4' in October 2012.
Blood cell breakthrough could help treat heart disease - an article published in 'The Operation Theatre Journal', May 2012: Issue 260; 2.
Blood cell breakthrough could help treat heart disease - an article published in an UK newspaper, 'Reading Post' on 22nd May 2012.
Snakes alive-working with deadly venom - an article published in an UK newspaper, 'Reading Post' on 21st March 2007.

Local Collaborators

Professor Jonathan Gibbins, School of Biological Sciences
Professor Ketan Patel, School of Biological Sciences
Professor Ben Whalley, School of Pharmacy
Professor Gary Stephens, School of Pharmacy
Professor Helen Osborn, School of Pharmacy
Dr Alistair McNeish, School of Pharmacy
Dr Darius Widera, School of Pharmacy
Dr Katrina Bicknell, School of Pharmacy
Dr Katja Strohfeldt, School of Pharmacy
Dr Andrew Bicknell, School of Biological Sciences
Dr Keith Foster, School of Biological Sciences
Dr Michael Fry, School of Biological Sciences
Dr David Leake, School of Biological Sciences
Dr Kim Watson, School of Biological Sciences
Dr Chris Jones, School of Biological Sciences
Dr Fazil Baksh, Department of Mathematics and Statistics

National Collaborators

Professor Sue Brain, Kings College London, UK
Dr Robert Harrison, Liverpool School of Tropical Medicine, UK
Professor Martyn Mahaut-Smith, University of Leicester, UK
Professor Mauro Perretti, William Harvey Research Institute, London, UK
Dr Stephen Paul Samuel, Queen Elizabeth Hospital, King's Lynn, UK
Researching For A Bright Future - an article published in the University of Reading alumni magazine in 2006

International Collaborators

Dr Matthew Lewin, California Academy of Sciences, USA
Dr Alexander Simon, University of Arizona, USA
Dr Leonardo Moraes, National University of Singapore, Singapore
Dr Prabu Gajjeraman, Karpagam University, India
Dr C Soundara Raj, TCR Multispeciality Hospital, Tamil Nadu, India

Awards and honours

2018: Winner of 'Research Engagement and Impact Awards 2018' for Embark Category

2018: 'Best Undergraduate Project Award' at the University of Reading from The Physiological Society for Chi Ut Kitty Iun for her research project in our laboratory

2016: 2020 Research Fellowship from the University of Reading

2016: 'Research Inspired Teaching Excellence Award' by the Reading University Students' Union

2016: 'Best Undergraduate Dissertation Award' for the Faculty of Life sciences for 'Muhammad Javed' for his MPharm research project in our laboratory

2015: 'Best UROP Project award' for Health Research Theme at the University of Reading for 'Ghalib Masood' for his summer project in our laboratory.

2014: Research Travel Grant from the University of Reading.

2014: Travel Award from the American Heart Association.

2014: Best Cover Art Award of 2013 at ATVB Conference in Toronto.

2013: Best Research Output Award for the Faculty of Life Sciences, University of Reading.

2013: Travel award from British Society for Haemostasis and Thrombosis.

2010: ICMR Research Development Award, University of Reading.

2007: Leonard Sutton Scholarship Award for research assistantship, University of Reading.

2007: Special research award from the Felix Trust, London.

2002: Gnanam Endowment Fellowship for Research at University of Madras, Chennai, India.

2000: 'Best Student Award' received at Thanthai Hans Roever College, Tamil Nadu, India.

Publications

Williams, J. and Vaiyapuri, S. ORCID: 0000-0002-6006-6517 (2023) The value of venom. Biologist , 70 (1). pp. 14-17. ISSN: 0006-3347
Senthilkumaran, S. , Patel, K. , Rajan, E. , Vijayakumar, P. , Miller, S. , Rucavado, A. , Gilabadi, S. , Sonavane, M. , Richards, N. , Williams, J. , Williams, H. , Trim, S. , Thirumalaikolundusubramanian, P. , Gutiérrez, J. , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 (2023) Peripheral arterial thrombosis following Russell’s viper bites. TH Open ISSN: 2512-9465
Senthilkumaran, S. , Arathisenthil, S. , Williams, J. , Almeida, J. , Williams, H. , Rajan, E. , Thirumalaikolundusubramanian, P. , Patel, K. , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 (2023) Neutrophil-mediated erythrophagocytosis following Russell's viper (Daboia russelii) bite. Toxicon , 228 ISSN: 0041-0101 | doi: https://dx.doi.org/10.1016/j.toxicon.2023.107111
Williams, H. , Moejes, K. , Williams, J. , Almeida, J. , Savania, R. , Senthilkumaran, S. , Patel, K. , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 (2023) Ashes to eye: a skilled snake handler’s experience with ophthalmic envenomation. PLoS Neglected Tropical Diseases , 17 (4). ISSN: 1935-2735 | doi: https://dx.doi.org/10.1371/journal.pntd.0011264
Senthilkumaran, S. , Salim, A. , Almeida, J. , Williams, J. , Vijayakumar, P. , Thirunavukarasu, A. , Christopoulos, M. , Williams, H. , Thirumalaikolundusubramanian, P. , Patel, K. , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 (2023) The effectiveness of antibiotics in managing bacterial infections on bite sites following snakebite envenomation. Toxins , 15 (3). ISSN: 2072-6651 | doi: https://dx.doi.org/10.3390/toxins15030190
Senthilkumaran, S. , Almeida, J. , Williams, J. , Williams, H. , Thirumalaikolundusubramanian, P. , Patel, K. , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 (2023) Rapid identification of bilateral adrenal and pituitary haemorrhages induced by Russell's viper envenomation results in positive patient outcome. Toxicon , 225 ISSN: 0041-0101 | doi: https://dx.doi.org/10.1016/j.toxicon.2023.107068
Samy, R. , Mackessy, S. , Jeyasankar, A. , Ponraj, M. , Franco, O. , Cooper, M. , Kandasamy, M. , Mohanta, T. , Bhagavathsingh, J. , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 (2023) Purification of PaTx-II from the venom of Australian King Brown Snake and characterization of its antimicrobial and wound healing activities. International Journal of Molecular Sciences , 24 (5). ISSN: 1422-0067 | doi: https://dx.doi.org/10.3390/ijms24054359
Zharkova, O. , Salamah, M. , Babak, M. , Rajan, E. , Lim, L. , Andrade, F. , Gil, C. , Oliani, S. , Moraes, L. , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 (2023) Deletion of annexin A1 in mice upregulates the expression of its receptor, Fpr2/3, and reactivity to the AnxA1 mimetic peptide in platelets. International Journal of Molecular Sciences , 24 (4). ISSN: 1422-0067 | doi: https://dx.doi.org/10.3390/ijms24043424
Senthilkumaran, S. , Almeida, J. , Williams, J. , Salim, A. , Williams, H. , Thirumalaikolundusubramanian, P. , Patel, K. , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 (2023) Russell's viper envenomation induces rectus sheath haematoma. Toxicon , 224 ISSN: 0041-0101 | doi: https://dx.doi.org/10.1016/j.toxicon.2023.107037
Vaiyapuri, S. ORCID: 0000-0002-6006-6517 , Kadam, P. , Chandrasekharuni, G. , Oliveira, I. , Senthilkumaran, S. , Salim, A. , Patel, K. , Sachett, J. , Pucca, M. (2023) Multifaceted community health education programs as powerful tools to mitigate snakebite-induced deaths, disabilities, and socioeconomic burden. Toxicon: X , 17 ISSN: 2590-1710 | doi: https://dx.doi.org/10.1016/j.toxcx.2022.100147

Hernández-Altamirano, J. , Salazar-Valenzuela, D. , Medina-Villamizar, E. , Quirola, D. , Patel, K. , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 , Lomonte, B. , Almeida, J. (2022) First insights into the venom composition of two Ecuadorian coral snakes. International Journal of Molecular Sciences , 23 (23). ISSN: 1422-0067 | doi: https://dx.doi.org/10.3390/ijms232314686
Senthilkumaran, S. , Arathisenthil, S. , Williams, J. , Williams, H. , Thirumalaikolundusubramanian, P. , Patel, K. , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 (2022) An unnecessary Russell’s Viper bite on the tongue due to live snake worship and dangerous first aid emphasise the urgent need for stringent policies. Toxins , 14 (12). ISSN: 2072-6651 | doi: https://dx.doi.org/10.3390/toxins14120817
Senthilkumaran, S. , Miller, S. , Williams, H. , Thirumalaikolundusubramanian, P. , Patel, K. , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 (2022) Bilateral simultaneous optic neuritis following envenomations by Indian cobra and common krait. Toxins , 14 (11). ISSN: 2072-6651 | doi: https://dx.doi.org/10.3390/toxins14110805
Ramprasath, T. , Natarajan, N. , Gopas, J. , Subbiah, R. , Rajendran, P. , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 , eds. (2022) Development of novel small molecules as therapeutics for inflammatory diseases and delineating their molecular mechanisms. Frontiers in Pharmacology Frontiers (In Press)
Senthilkumaran, S. , Miller, S. , Williams, H. , Thirumalaikolundusubramanian, P. , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 , Patel, K. (2022) Hirata’s disease (insulin autoimmune syndrome) following envenomation by a common krait. Toxicon , 219 ISSN: 0041-0101 | doi: https://dx.doi.org/10.1016/j.toxicon.2022.09.009
Senthilkumaran, S. , Miller, S. , Williams, H. , Savania, R. , Thirumalaikolundusubramanian, P. , Patel, K. , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 (2022) Development of Wunderlich Syndrome following a Russell’s viper bite. Toxicon , 215 pp. 11-16. ISSN: 0041-0101 | doi: https://dx.doi.org/10.1016/j.toxicon.2022.06.004
Alqallaf, A. , Engelbeen, S. , Palo, A. , Cutrupi, F. , Tanganyika-de Winter, C. , Plomp, J. , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 , Aartsma-Rus, A. , Patel, K. , Putten, M. (2022) The therapeutic potential of soluble activin type IIB receptor treatment in a limb girdle muscular dystrophy type 2D mouse model. Neuromuscular Disorders , 32 (5). pp. 419-435. ISSN: 0960-8966 | doi: https://dx.doi.org/10.1016/j.nmd.2022.03.002
Senthilkumaran, S. , Miller, S. , Williams, H. , Vaiyapuri, R. , Savania, R. , Elangovan, N. , Thirumalaikolundusubramanian, P. , Patel, K. , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 (2022) Ultrasound-guided compression method effectively counteracts Russell’s viper bite-induced pseudoaneurysm. Toxins , 14 (4). ISSN: 2072-6651 | doi: https://dx.doi.org/10.3390/toxins14040260
Albadawi, D. , Ravishankar, D. , Vallance, T. , Patel, K. , Osborn, H. , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 (2022) Impacts of commonly used edible plants on the modulation of platelet function. International Journal of Molecular Sciences , 23 (2). ISSN: 1422-0067 | doi: https://dx.doi.org/10.3390/ijms23020605
Arathisenthil, S. , Senthilkumaran, S. , Vijayakumar, P. , Savania, R. , Williams, H. , Elangovan, N. , Bicknell, A. , Patel, K. , Trim, S. , Thirumalaikolundusubramanian, P. , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 (2022) Rapid development of a salivary calculus in submandibular gland and its potential causes in a young victim following Russell’s viper bite. Toxicon , 206 pp. 85-89. ISSN: 0041-0101 | doi: https://dx.doi.org/10.1016/j.toxicon.2021.12.018

Senthilkumaran, S. , Patel, K. , Salim, A. , Vijayakumar, P. , Williams, H. , Vaiyapuri, R. , Savania, R. , Elangovan, N. , Thirumalaikolundusubramanian, P. , Baksh, M. ORCID: 0000-0003-3107-8815 , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 (2021) Neutrophil gelatinase-associated lipocalin acts as a robust early diagnostic marker for renal replacement therapy in patients with Russell’s viper bite-induced acute kidney injuries. Toxins , 13 (11). ISSN: 2072-6651 | doi: https://dx.doi.org/10.3390/toxins13110797
Senthilkumaran, S. , Vijayakumar, P. , Savania, R. , Vaiyapuri, R. , Elangovan, N. , Patel, K. , Trim, S. , Thirumalaikolundusubramanian, P. , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 (2021) Splenic rupture and subsequent splenectomy in a young healthy victim following Russell’s viper bite. Toxicon , 204 pp. 9-13. ISSN: 0041-0101 | doi: https://dx.doi.org/10.1016/j.toxicon.2021.10.010
Alatawi, K. , Ravishankar, D. , Patra, P. , Bye, A. , Stainer, A. , Patel, K. , Widera, D. ORCID: 0000-0003-1686-130X , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 (2021) 1,8-cineole affects agonists-induced platelet activation, thrombus formation and haemostasis. Cells , 10 (10). ISSN: 2073-4409 | doi: https://dx.doi.org/10.3390/cells10102616
Suarez-Berumen, K. , Collins-Hooper, H. , Gormova, A. , Meech, R. , Sacco, A. , Dash, P. , Mitchell, R. , Shestopalov, V. , Woolley, T. , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 , Patel, K. , Makarenkova, H. (2021) Pannexin 1 regulates skeletal muscle regeneration by promoting bleb-based myoblast migration and fusion through a novel lipid based signaling mechanism. Frontiers in Cell and Developmental Biology ISSN: 2296-634X | doi: https://dx.doi.org/10.3389/fcell.2021.736813
Senthilkumaran, S. , Williams, H. , Patel, K. , Trim, S. , Thirumalaikolundusubramanian, P. , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 (2021) Priapism following a juvenile Russell’s viper bite: an unusual case report. PLoS Neglected Tropical Diseases , 15 (3). ISSN: 1935-2735 | doi: https://dx.doi.org/10.1371/journal.pntd.0009242
Vaughan, D. , Mitchell, R. , Kretz, O. , Chambers, D. , Lalowski, M. , Amthor, H. , Ritvos, O. , Pasternack, A. , Matsakas, A. , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 , Huber, T. , Denecke, B. , Mukherjee, A. , Widera, D. ORCID: 0000-0003-1686-130X , Patel, K. (2021) A muscle growth promoting treatment based on the attenuation of activin/myostatin signalling in young mice results in long-term testicular abnormalities. Disease Models & Mechanisms , 14 (2). ISSN: 1754-8411 | doi: https://dx.doi.org/10.1242/dmm.047555
Majeed, K. , Al-Fahad, D. , Jalood, H. , Hantosh, H. , Ali, M. , Sakthivel, S. , Williams, H. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Patel, K. , Baksh, M. , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 (2021) RhD blood type significantly influences susceptibility to contract COVID-19 among a study population in Iraq. F1000Research ISSN: 2046-1402 | doi: https://dx.doi.org/10.12688/f1000research.27777.1
Vallance, T. , Sheard, J. , Meng, Y. , Torre, E. , Patel, K. , Widera, D. ORCID: 0000-0003-1686-130X , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 (2021) Development and characterisation of a novel, megakaryocyte NF-κB reporter cell line for investigating inflammatory responses. Journal of Thrombosis and Haemostasis , 19 (1). pp. 107-120. ISSN: 1538-7933 | doi: https://dx.doi.org/10.1111/jth.15118
Sahli, K. , Flora, G. , Sasikumar, P. , Maghrabi, A. , Holbrook, L. , AlOuda, S. , Elgheznawy, A. , Sage, T. , Stainer, A. , Adiyaman, R. , AboHassan, M. , Crescente, M. , Kriek, N. , Vaiyapuri, S. , Bye, A. , Unsworth, A. , Jones, C. , McGuffin, L. , Gibbins, J. (2021) Structural, functional and mechanistic insights uncover the fundamental role of orphan connexin-62 in platelets. Blood , 137 (6). pp. 830-843. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood.2019004575

Trim, S. , Trim, C. , Williams, H. , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 (2020) The failures of ethnobotany and phytomedicine in delivering novel treatments for snakebite envenomation. Toxins , 12 (12). ISSN: 2072-6651 | doi: https://dx.doi.org/10.3390/toxins12120774
Miller, S. , Osterhoudt, K. , Korenoski, A. , Patel, K. , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 (2020) Exotic snakebites reported to Pennsylvania poison control centers: lessons learned on the demographics, clinical effects, and treatment of these cases. Toxins , 12 (12). ISSN: 2072-6651 | doi: https://dx.doi.org/10.3390/toxins12120755
Samuel, S. , Chinnaraju, S. , Williams, H. , Pichamuthu, E. , Subharao, M. , Vaiyapuri, M. , Arumugam, S. , Vaiyapuri, R. , Baksh, F. , Patel, K. , Trim, S. , Duncombe, T. ORCID: 0000-0003-4746-4470 , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 (2020) Venomous snakebites: rapid action saves lives - a multifaceted community education programme increases awareness about snakes and snakebites among the rural population of Tamil Nadu, India. PLoS Neglected Tropical Diseases , 14 (12). ISSN: 1935-2735 | doi: https://dx.doi.org/10.1371/journal.pntd.0008911
Salamah, M. , Vallance, T. , Kodji, X. , Ravishankar, D. , Williams, H. , Brain, S. , Vaiyapuri, S. (2020) The antimicrobial cathelicidin CRAMP augments platelet activation during psoriasis in mice. Biomolecules , 10 (9). ISSN: 2218-273X | doi: https://dx.doi.org/10.3390/biom10091267
Knudsen, C. , Casewell, N. , Lomonte, B. , Gutiérrez, J. , Vaiyapuri, S. , Laustsen, A. (2020) Novel snakebite therapeutics must be tested in appropriate rescue models to robustly assess their preclinical efficacy. Toxins , 12 (9). ISSN: 2072-6651 | doi: https://dx.doi.org/10.3390/toxins12090528
Layfield, H. , Williams, H. , Ravishankar, D. , Mehmi, A. , Sonavane, M. , Salim, A. , Vaiyapuri, R. , Lakshminarayanan, K. , Vallance, T. , Bicknell, A. , Trim, S. , Patel, K. , Vaiyapuri, S. (2020) Repurposing cancer drugs, batimastat and marimastat, to inhibit the activity of a group I metalloprotease from the venom of the Western Diamondback rattlesnake, Crotalus atrox. Toxins , 12 (5). ISSN: 2072-6651 | doi: https://dx.doi.org/10.3390/toxins12050309
Vaughan, D. , Kretz, O. , Alqallaf, A. , Mitchell, R. , Vaiyapuri, S. , Matsakas, A. , Pasternack, A. , Collins-Hooper, H. , Ritvos, O. , Ballesteros, R. , Huber, T. , Amthor, H. , Mukherjee, A. , Patel, K. (2020) Diminution in sperm quantity and quality in mouse models of Duchenne Muscular Dystrophy induced by a myostatin-based muscle growth-promoting intervention. European Journal of Translational Myology , 30 (2). pp. 276-285. ISSN: 2037-7452 | doi: https://dx.doi.org/10.4081/ejtm.2019.8904

Vallance, T. , Ravishankar, D. , Albadawi, D. , Layfield, H. , Sheard, J. , Vaiyapuri, R. , Dash, P. , Patel, K. , Widera, D. , Vaiyapuri, S. (2019) Effect of ultrapure lipopolysaccharides derived from diverse bacterial species on the modulation of platelet activation. Scientific Reports , 9 ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-019-54617-w
Patel, K. , Simbi, B. , Ritvos, O. , Vaiyapuri, S. , Dhoot, G. (2019) Dysregulated cell signalling and reduced satellite cell potential in ageing muscle. Experimental Cell Research , 385 (2). ISSN: 0014-4827 | doi: https://dx.doi.org/10.1016/j.yexcr.2019.111685
Ravishankar, D. , Albadawi, D. , Chaggar, V. , Patra, P. , Williams, H. , Salamah, M. , Vaiyapuri, R. , Dash, P. , Patel, K. , Watson, K. , Vaiyapuri, S. (2019) Isorhapontigenin, a resveratrol analogue selectively inhibits ADP-stimulated platelet activation. European Journal of Pharmacology , 862 ISSN: 0014-2999 | doi: https://dx.doi.org/10.1016/j.ejphar.2019.172627
Vallance, T. , Ravishankar, D. , Albadawi, D. , Osborn, H. , Vaiyapuri, S. (2019) Synthetic flavonoids as novel modulators of platelet function and thrombosis. International Journal of Molecular Sciences , 20 (12). ISSN: 1422-0067 | doi: https://dx.doi.org/10.3390/ijms20123106
Williams, H. , Layfield, H. , Vallance, T. , Patel, K. , Bicknell, A. , Trim, S. , Vaiyapuri, S. (2019) The urgent need to develop novel strategies for the diagnosis and treatment of snakebites. Toxins , 11 (6). ISSN: 2072-6651 | doi: https://dx.doi.org/10.3390/toxins11060363
Salamah, M. , Ravishankar, D. , Vaiyapuri, R. , Moraes, L. , Patel, K. , Perretti, M. , Gibbins, J. , Vaiyapuri, S. (2019) The formyl peptide fMLF primes platelet activation and augments thrombus formation. Journal of Thrombosis and Haemostasis , 17 (7). pp. 1120-1133. ISSN: 1538-7836 | doi: https://dx.doi.org/10.1111/jth.14466
Omairi, S. , Hua, K. , Collins-Hooper, H. , Scott, C. , Vaiyapuri, S. , Torelli, S. , Montanero, F. , Matsakas, A. , Patel, K. (2019) Regulation of the dystrophin-associated glycoprotein complex composition by the metabolic properties of muscle fibres. Scientific Reports , 9 ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-019-39532-4
Williams, H. , Mellows, B. , Mitchell, R. , Sfyri, P. , Layfield, H. , Salamah, M. , Vaiyapuri, R. , Collins-Hooper, H. , Bicknell, A. , Matsakas, A. , Patel, K. , Vaiyapuri, S. (2019) Mechanisms underpinning the permanent muscle damage induced by snake venom metalloprotease. PLoS Neglected Tropical Diseases , 13 (1). ISSN: 1935-2735 | doi: https://dx.doi.org/10.1371/journal.pntd.0007041

Williams, H. , Hayter, P. , Ravishankar, D. , Baines, A. , Layfield, H. , Croucher, L. , Wark, C. , Bicknell, A. , Trim, S. , Vaiyapuri, S. (2018) Impact of Naja nigricollis venom on the production of methaemoglobin. Toxins , 10 (12). ISSN: 2072-6651 | doi: https://dx.doi.org/10.3390/toxins10120539
Salamah, M. , Ravishankar, D. , Kodji, X. , Moraes, L. , Williams, H. , Vallance, T. , Albadawi, D. , Vaiyapuri, R. , Watson, K. , Gibbins, J. , Brain, S. , Perretti, M. , Vaiyapuri, S. (2018) The endogenous antimicrobial cathelicidin LL37 induces platelet activation and augments thrombus formation. Blood Advances , 2 (21). pp. 2973-2985. ISSN: 2473-9529 | doi: https://dx.doi.org/10.1182/bloodadvances.2018021758
Ravishankar, D. , Salamah, M. , Akimbaev, A. , Williams, H. , Albadawi, D. , Vaiyapuri, R. , Greco, F. , Osborn, H. , Vaiyapuri, S. (2018) Impact of specific functional groups in flavonoids on the modulation of platelet activation. Scientific Reports , 8 ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-018-27809-z
Paolini, A. , Omairi, S. , Mitchell, R. , Vaughan, D. , Matsakas, A. , Vaiyapuri, S. , Ricketts, T. , Rubinsztein, D. , Patel, K. (2018) Attenuation of autophagy impacts on muscle fibre development, starvation induced stress and fibre regeneration following acute injury. Scientific Reports , 8 ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-018-27429-7

Vallance, T. , Zeuner, M. , Williams, H. , Widera, D. , Vaiyapuri, S. (2017) Toll-like receptor 4 signalling and its impact on platelet function, thrombosis, and haemostasis. Mediators of inflammation , 2017 ISSN: 0962-9351 | doi: https://dx.doi.org/10.1155/2017/9605894
Zeuner, M. , Vallance, T. , Vaiyapuri, S. , Cottrell, G. , Widera, D. (2017) Development and characterisation of a novel NF-κB reporter cell line for investigation of neuroinflammation. Mediators of inflammation , 2017 ISSN: 0962-9351 | doi: https://dx.doi.org/10.1155/2017/6209865
Ravishankar, D. , Salamah, M. , Attina, A. , Pothi, R. , Vallance, T. , Javed, M. , Williams, H. , Alzahrani, E. , Kabova, E. , Vaiyapuri, R. , Shankland, K. , Gibbins, J. , Strohfeldt, K. , Greco, F. , Osborn, H. , Vaiyapuri, S. (2017) Ruthenium-conjugated chrysin analogues modulate platelet activity, thrombus formation and haemostasis with enhanced efficacy. Scientific Reports , 7 ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-017-05936-3
Williams, H. , Vaiyapuri, R. , Gajjeraman, P. , Hutchinson, G. , Gibbins, J. , Bicknell, A. , Vaiyapuri, S. (2017) Challenges in diagnosing and treating snakebites in a rural population of Tamil Nadu, India: the views of clinicians. Toxicon , 130 pp. 44-46. ISSN: 0041-0101 | doi: https://dx.doi.org/10.1016/j.toxicon.2017.02.025

Moraes, L. , Unsworth, A. , Vaiyapuri, S. , Ali, M. , Sasikumar, P. , Sage, T. , Flora, G. , Bye, A. , Kriek, N. , Dorchies, E. , Molendi-Coste, O. , Dombrowicz, D. , Staels, B. , Bishop-Bailey, D. , Gibbins, J. (2016) Farnesoid X Receptor and its ligands inhibit the function of platelets. Arteriosclerosis Thrombosis and Vascular Biology , 36 (12). pp. 2324-2333. ISSN: 1524-4636 | doi: https://dx.doi.org/10.1161/ATVBAHA.116.308093
Crescente, M. , Pluthero, F. , Li, L. , Lo, R. , Walsh, T. , Schenk, M. , Holbrook, L. , Loureiro, S. , Ali, M. , Vaiyapuri, S. , Falet, H. , Jones, I. , Poole, A. , Kahr, W. , Gibbins, J. (2016) Intracellular trafficking, localization, and mobilization of platelet-borne thiol isomerases. Arteriosclerosis Thrombosis and Vascular Biology , 36 (6). pp. 1164-1173. ISSN: 1079-5642 | doi: https://dx.doi.org/10.1161/ATVBAHA.116.307461

Mazet, F. , Dunster, J. , Jones, C. , Vaiyapuri, S. , Tindall, M. , Fry, M. , Gibbins, J. (2015) A high-density immunoblotting methodology for quantification of total protein levels and phosphorylation modifications. Scientific Reports , 5 ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/srep16995
Bye, A. , Unsworth, A. , Vaiyapuri, S. , Stainer, A. , Fry, M. , Gibbins, J. (2015) Ibrutinib inhibits platelet integrin αIIbβ3 outside-in signaling and thrombus stability but not adhesion to collagen. Arteriosclerosis Thrombosis and Vascular Biology , 35 (11). pp. 2326-2335. ISSN: 1524-4636 | doi: https://dx.doi.org/10.1161/ATVBAHA.115.306130
Vaiyapuri, S. , Flora, G. , Gibbins, J. (2015) Gap junctions and connexin hemichannels in the regulation of haemostasis and thrombosis. Biochemical Society Transactions , 43 (3). pp. 489-494. ISSN: 1470-8752 | doi: https://dx.doi.org/10.1042/BST20150055
Vaiyapuri, S. , Sunagar, K. , Gibbins, J. , Jackson, T. , Reeks, T. , Fry, B. (2015) Kallikrein enzymes. In: Fry, B. , (eds.) Venomous reptiles and their toxins: evolution, pathophysiology and biodiscovery. Oxford University Press , New York. pp. 267-280. ISBN: 9780199309399
Vaiyapuri, S. , Roweth, H. , Ali, M. , Unsworth, A. , Stainer, A. , Flora, G. , Crescente, M. , Jones, C. , Moraes, L. , Gibbins, J. (2015) Pharmacological actions of nobiletin in the modulation of platelet function. British Journal of Pharmacology , 172 (16). pp. 4133-4145. ISSN: 0007-1188 | doi: https://dx.doi.org/10.1111/bph.13191
Vaiyapuri, S. , Sage, T. , Rana, R. , Schenk, M. , Ali, M. , Unsworth, A. , Jones, C. , Stainer, A. , Kriek, N. , Moraes, L. , Gibbins, J. (2015) EphB2 regulates contact-dependent and independent signalling to control platelet function. Blood , 125 (4). pp. 720-730. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood-2014-06-585083

Jones, C. , Sage, T. , Moraes, L. , Vaiyapuri, S. , Hussain, U. , Tucker, K. , Barrett, N. , Gibbins, J. (2014) Platelet endothelial cell adhesion molecule-1 inhibits platelet response to thrombin and von Willebrand factor by regulating the internalization of glycoprotein Ib via AKT/glycogen synthase kinase-3/dynamin and integrin αIIbβ3. Arteriosclerosis Thrombosis and Vascular Biology , 34 (9). pp. 1968-1976. ISSN: 1079-5642 | doi: https://dx.doi.org/10.1161/ATVBAHA.114.304097
Lewin, M. , Samuel, S. , Wexler, D. , Bickler, P. , Vaiyapuri, S. , Mensh, B. (2014) Early treatment with intranasal neostigmine reduces mortality in a mouse model of Naja naja (Indian Cobra) envenomation. Journal of Tropical Medicine , 2014 ISSN: 1687-9686 | doi: https://dx.doi.org/10.1155/2014/131835

Vaiyapuri, S. ORCID: 0000-0002-6006-6517 (2013) Sequence and functional analysis of viper venom proteolytic enzymes. Lambert Academic Publishing , Saarbrucken. ISBN: 9783659399183
Vaiyapuri, S. , Vaiyapuri, R. , Ashokan, R. , Ramasamy, K. , Nattamaisundar, K. , Jeyaraj, A. , Chandran, V. , Gajjeraman, P. , Baksh, M. , Gibbins, J. , Hutchinson, E. (2013) Snakebite and its socio-economic impact on the rural population of Tamil Nadu, India. PLoS ONE , 8 (11). pp. e80090. ISSN: 1932-6203 | doi: https://dx.doi.org/10.1371/journal.pone.0080090
Vaiyapuri, S. , Ali, M. , Moraes, L. , Sage, T. , Lewis, K. , Jones, C. , Gibbins, J. (2013) Tangeretin regulates platelet function through inhibition of phosphoinositide 3-Kinase and cyclic nucleotide signaling. Arteriosclerosis Thrombosis and Vascular Biology , 33 (12). pp. 2740-2749. ISSN: 1079-5642 | doi: https://dx.doi.org/10.1161/ATVBAHA.113.301988
Vaiyapuri, S. , Moraes, L. , Sage, T. , Ali, M. , Lewis, K. , Mayhaut-Smith, M. , Oviedo-Orta, E. , Simon, A. , Gibbins, J. (2013) Connexin40 regulates platelet function. Nature Communications , 4 pp. 2564-2572. ISSN: 2041-1723 | doi: https://dx.doi.org/10.1038/ncomms3564
Moraes, L. , Vaiyapuri, S. , Sasikumar, P. , Ali, M. , Kriek, N. , Sage, T. , Gibbins, J. (2013) Antithrombotic actions of statins involve PECAM-1 signalling. Blood , 122 (18). pp. 3188-3196. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood-2013-04-491845

Vaiyapuri, S. , Thiyagarajan, N. , Hutchinson, E. , Gibbins, J. (2012) Sequence and phylogenetic analysis of viper venom serine proteases. Bioinformation , 8 (16). pp. 763-772. ISSN: 0973-2063
Vaiyapuri, S. , Hutchinson, E. , Ali, M. , Dannoura, A. , Stanley, R. , Harrison, R. , Bicknell, A. , Gibbins, J. (2012) Rhinocetin, a venom-derived integrin-specific antagonist inhibits collagen-induced platelet and endothelial cell functions . The Journal of Biological Chemistry , 287 (31). pp. 26235-26244. ISSN: 1083-351X | doi: https://dx.doi.org/10.1074/jbc.M112.381483
Vaiyapuri, S. , Jones, C. , Sasikumar, P. , Moraes, L. , Munger, S. , Wright, J. , Ali, M. , Sage, T. , Kaiser, W. , Tucker, K. , Stain, C. , Bye, A. , Jones, S. , Oviedo-Orta, E. , Simon, A. , Mahaut-Smith, M. , Gibbins, J. (2012) Gap junctions and connexin hemichannels underpin hemostasis and thrombosis. Circulation , 125 (20). pp. 2479-2491. ISSN: 0009-7322 | doi: https://dx.doi.org/10.1161/CIRCULATIONAHA.112.101246
Elashry, M. , Collins-Hooper, H. , Vaiyapuri, S. , Patel, K. (2012) Characterisation of connective tissue from the hypertrophic skeletal muscle of myostatin null mice. Journal of Anatomy , 220 (6). pp. 603-611. ISSN: 0021-8782 | doi: https://dx.doi.org/10.1111/j.1469-7580.2012.01503.x

Vaiyapuri, S. , Wagstaff, S. , Harrison, R. , Gibbins, J. , Hutchinson, G. (2011) Evolutionary analysis of novel serine proteases in the venom gland transcriptome of Bitis gabonica rhinoceros. PLoS ONE , 6 (6). ISSN: 1932-6203 | doi: https://dx.doi.org/10.1371/journal.pone.0021532

Vaiyapuri, S. , Harrison, R. , Bicknell, A. , Gibbins, J. , Hutchinson, E. (2010) Purification and functional characterisation of Rhinocerase, a novel serine protease from the venom of Bitis gabonica rhinoceros. PLoS ONE , 5 (3). ISSN: 1932-6203 | doi: https://dx.doi.org/10.1371/journal.pone.0009687
Vaiyapuri, S. , Wagstaff, S. , Watson, K. , Harrison, R. , Gibbins, J. , Hutchinson, E. (2010) Purification and functional characterisation of rhiminopeptidase A, a novel aminopeptidase from the venom of Bitis gabonica rhinoceros. PLoS Neglected Tropical Diseases , 4 (8). ISSN: 1935-2735 | doi: https://dx.doi.org/10.1371/journal.pntd.0000796

Vaiyapuri, S. ORCID: 0000-0002-6006-6517 (2008) Sequence, Structure and Functional Studies of Viper Venom Proteolytic Enzymes.

Sakthi Vaiyapuri

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