Gary Stephens

Email:
g.j.stephens@reading.ac.uk
Phone:
+44 (0) 118 378 6156
Job title:
Professor of Pharmacology

Responsibilities:

Director of Pharmacology

Areas of interest

Functional effects of CACHD1 on calcium channels (external collaborators: Manoj Patel, University of Virginia, USA; Gerald Obermair, Krems University, Austria)
Targeting calcium channels in pain (with Maria Maiaru, University of Reading)
Psychedelic drugs in pain (with Maria Maiaru, University of Reading)
Role of plant cannabinoids in hyperexcitability in the CNS
Modulation of inhibitory neurotransmission in the cerebellum

Research centres and groups

Memberships:

British Journal of Pharmacology Editorial Board: Senior Editor
Pharmaceuticalsjournal: Section EdiTor in Chief Pharmacology
Fellow of British Pharmacological Society
Fellow of The Physiological Society
The Calcium Channel Network
Ion Channel Research @ Reading
Centre for Neuroscience and Neurodynamics

Background

Our group uses patch clamp electrophysiology to investigate presynaptic mechanisms in synaptic transmission. In particular, we are interested in modulation of presynaptic calcium channels and G protein-coupled receptor (GPCR) in disease conditions, with work on pain, epilepsy and ataxia. We are also investigating the effect of psychedelic drugs in pain. We investigate molecular determinants of ion channel and receptor modulation in native neurones and recombinant cells and synaptic transmission in mammalian cerebellum and hippocampal brain slices. We have previously investigated plant derived cannabinoids as therapeutic agents.

Selected publications

Other Publications

Harvey, V.L & Stephens, G.J. (2004) Mechanism of GABA_B receptor-mediated inhibition of spontaneous GABA release onto cerebellar Purkinje cells. Eur. J. Neurosci. 20: 684-690

Bardo, S., Robertson, B. & Stephens, G.J. (2002) Presynaptic internal Ca²⁺ stores contribute to inhibitory neurotransmitter release onto mouse cerebellar Purkinje cells. Br. J. Pharmacol. 137: 529-537

Stephens, G.J., Morris, N. P., Fyffe, R. E.W. & Robertson B. (2001) The Ca_V2.1/α1A (P/Q-type) voltage-dependent calcium channel mediates inhibitory neurotransmission onto mouse cerebellar Purkinje cells. Eur. J. Neurosci. 13: 1902-1912

Southan, A.P., Morris, N.P., Stephens, G.J. & Robertson, B. (2000) Hyperpolarization-activated currents in presynaptic terminals of mouse cerebellar basket cells. J. Physiol. 526: 91-97

Stephens, G.J., Page, K.M., Bogdanov Y. & Dolphin, A.C. (2000). The a1B Ca²⁺ channel amino terminus contributes determinants for β subunit-mediated voltage-dependent inactivation properties. J. Physiol. 525: 377-390

Meir, A., Bell, D.C. Stephens, G.J., Page K.M. & Dolphin, A.C (2000) Calcium channel β subunit promotes voltage-dependent modulation of α1B by Gβγ. Biophys. J. 79: 731-746

Canti, C., Page, K.M., Stephens, G.J., & Dolphin, A.C (1999) Identification of amino acids in the N terminus of the rabbit α1B voltage-dependent calcium channel required for inhibition by G proteins. J. Neurosci. 19:6855-6884

Page, K.M., Canti C., Stephens, G.J., Berrow, N.S. & Dolphin, A.C. (1998) Identification of the amino terminus of neuronal Ca²⁺ channel α1 subunits α1B and α1E as an essential determinant of G protein modulation. J. Neurosci. 18: 4815-4824

Stephens, G.J., Canti C., Page, K.M. & Dolphin, A.C. (1998) Role of domain I of neuronal Ca²⁺ channel a1 subunits in G protein modulation. J. Physiol. 509: 163-169.

Stephens, G.J., Brice N.L., Berrow, N.S. & Dolphin, A.C. (1998) Facilitation of α1B calcium channels: involvement of endogenous Gβγ subunits. J. Physiol. 509: 15-27

Owen, D.G., Hall, A., Stephens, G.J., Stow, J. & Robertson, B. (1997) The relative potencies of dendrotoxins as blockers of the cloned voltage-gated K⁺ channel, mKv1.1 (MK-1), when stably expressed in Chinese hamster ovary cells. Br. J. Pharmacol. 120: 1029-1034

Page, K.M., Stephens, G.J., Berrow, N. & Dolphin, A.C. (1997) The intracellular loop between domains I and II of the B-type calcium channel confers aspects of G protein sensistivity to the E-type calcium channel. J. Neurosci. 17: 1330-1338

Stephens, G.J., Page, K.M, Burley, J.R., Berrow, N. & Dolphin, A.C. (1997) Functional expression of rat brain cloned α1E calcium channels in COS-7. Pflügers Archives Eur. J. Physiol 433:523-532

Owen DG,, Hall A, Stephens GJ, Stow J & Robertson B (1997). The relative potencies of dendrotoxins as blockers of the cloned voltage-gated K+ channel, mKv1.1 (MK-1), when stably expressed in Chinese hamster ovary cells. Br. J. Pharmacol. 120:1029-1034

Stephens, G.J., Owen, D.G., Opalko, A., Pisano, M. R., MacGregor, W. H. & Robertson, B. (1996) Studies on the blocking action of human Kv3.4 inactivation peptide variants in the mouse cloned Kv1.1 K+ channel. J. Physiol. 496:145-154

Stephens, G.J., Owen, D.G. & Robertson, B. (1996) Cysteine-modifying reagents alter the gating of the rat cloned potassium channel Kv1.4. Pflügers Archives Eur. J. Physiol. 431:435-442

Stephens, G.J., Cockett, M. I., Nawoschik, S.P., Schechter, L.E. & Owen, D.G. (1996). The modulation of the rate of inactivation of the mKv1.1 K⁺ channel by the β subunit, Kvβ1 and lack of effect of a Kv_1 N-terminal peptide. FEBS Letts. 378:250-252

Stephens, G.J. & Robertson, B. (1995). Inactivation of the cloned potassium channel, mouse Kv1.1 by the human Kv3.4 'ball' peptide and its chemical modification. J. Physiol. 484:1-13

Grimes JA., Fraser SP, Stephens GJ, Downing JEG, Laniado ME,, Foster CS, Abel PD & Djamgo, MBA (1995). Differential expression of voltage-activated Na+ currents in two prostatic tumour cell lines: contribution to invasiness in vitro. FEBS Letts. 369:290-294

Stephens, G.J., Garratt, J. C., Robertson, B. & Owen, D.G. (1994). On the mechanism of 4-aminopyridine action on the cloned mouse brain potassium channel, mKv1.1. J. Physiol. 477:187-196

Stephens, G.J., Marriott, D.R., Djamgoz, M.B.A. & Wilkin, G.P. (1993) Electrophysiological and biochemical evidence for bradykinin receptors on cultured cortical oligodendrocytes. Neurosci. Lett., 153:223-226

Stephens, G.J., Djamgoz, M.B.A. & Wilkin, G.P. (1993) A patch clamp study of excitatory amino acid effects on cortical astrocyte subtypes in culture. Receptors Channels, 1:39-52

Stephens, G.J., Cholewinski, A.J., Wilkin, G.P. & Djamgoz, M.B.A. (1993) Calcium-mobilizing and electrophysiological effects of bradykinin on cortical astrocyte subtypes in culture. Glia 9:269-279

Wilkin, G.P., Marriott, D.R., Cholewinski, A.J., Wood, J.N., Taylor, G.W., Stephens, G.J. & Djamgoz, M.B.A. (1991) Receptor activation and its biochemical consequences in astrocytes. In: Glial-Neuronal Interaction, Vol. 633. N.J. Abbott, ed. Ann. N. Y. Acad. Sci., New York, pp. 475-488

Cholewinski, A.J., Stephens, G.J., McDermott, A.M. & Wilkin, G.P. (1991) Identification of bradykinin B2 binding sites on cultured cortical astrocytes. J. Neurochem., 57:1456-1458

Publications

Stephens, G. ORCID: 0000-0002-8966-4238 and Bell, D. (2023) 19th World Congress of Basic and Clinical Pharmacology, July 2nd–7th, 2023, Glasgow. Mary Ann Liebert, Inc. | doi: https://dx.doi.org/10.1089/bioe.2023.0029
Stanford, S. , Alexander, S. , Cirino, G. , George, C. , Insel, P. , Kendall, D. , Ji, Y. , Panettieri Jr., R. , Patel, H. , Sobey, C. , Stefanska, B. , Stephens, G. ORCID: 0000-0002-8966-4238 , Teixeira, M. , Vergnolle, N. , Ferdinandy, P. , Ahluwalia, A. (2023) Considering and reporting sex as an experimental variable II: an update on progress in the British Journal of Pharmacology. British Journal of Pharmacology , 180 (9). pp. 1191-1196. ISSN: 1476-5381 | doi: https://dx.doi.org/10.1111/bph.16049
Panettieri, R. , Stanford, S. , Alexander, S. , Cirino, G. , George, C. , Insel, P. , Kendall, D. , Ji, Y. , Patel, H. , Sobey, C. , Stefanska, B. , Stephens, G. ORCID: 0000-0002-8966-4238 , Teixeira, M. , Vergnolle, N. , Ferdinandy, P. , Ahluwalia, A. (2023) BJP recommendations for publishing research on tobacco smoke and environmental tobacco smoke exposure. British Journal of Pharmacology , 180 (12). pp. 1537-1541. ISSN: 0007-1188 | doi: https://dx.doi.org/10.1111/bph.16089
Stephens, G. ORCID: 0000-0002-8966-4238 (2023) Cannabinoids. In: Gruol, D. , Koibuchi, N. , Manto, M. , Molinari, M. , Schmahmann, J. , Shen, Y. , (eds.) Essentials of Cerebellum and Cerebellar Disorders. A Primer for Graduate Students. 2nd edition. Springer pp. 221-224. ISBN: 9783031150692 | doi: https://dx.doi.org/10.1007/978-3-031-15070-8_34
Day, C. , Silva, J. , Munro, R. , Baker, T. , Wolff, C. , Bithell, A. , Stephens, G. ORCID: 0000-0002-8966-4238 (2023) Anti-AMPA receptor autoantibodies reduce excitatory currents in rat hippocampal neurons. Pharmaceuticals , 16 (1). ISSN: 1424-8247 | doi: https://dx.doi.org/10.3390/ph16010077
Ingrande, J. , Patel, H. , Kendall, D. , Stefanska, B. , Alexander, S. , Bakhle, M. , Cirino, G. , Docherty, J. , George, C. , Insel, P. , Ji, Y. , King, B. , Lilley, E. , Panettieri, R. , Ramage, A. , Sobey, C. , Stanford, S. , Stephens, G. ORCID: 0000-0002-8966-4238 , Teixeira, M. , Vergnolle, N. , Ahluwalia, A. (2023) Guidance for the use and reporting of anaesthetic agents in BJP manuscripts involving work with animals. British Journal of Pharmacology , 180 (3). pp. 255-263. ISSN: 0007-1188 | doi: https://dx.doi.org/10.1111/bph.15992

Kaisis, E. , Thei, L. , Stephens, G. ORCID: 0000-0002-8966-4238 , Dallas, M. ORCID: 0000-0002-5190-0522 (2022) Protofibrillar amyloid beta modulation of recombinant hCaV2.2 (N-type) voltage-gated channels. Pharmaceuticals , 15 (12). ISSN: 1424-8247 | doi: https://dx.doi.org/10.3390/ph15121459
Banazadeh, M. , Olangian-Tehrani, S. , Sharifi, M. , Malek- Ahmadi, M. , Nikzad, F. , Doozandeh- Nargesi, N. , Mohammadi, A. , Stephens, G. ORCID: 0000-0002-8966-4238 , Shabani, M. (2022) Mechanisms of COVID-19-induced cerebellitis. Current medical research and opinion , 38 (12). pp. 2109-2118. ISSN: 0300-799 | doi: https://dx.doi.org/10.1080/03007995.2022.2141963
Ablinger, C. , Eibl, C. , Geisler, S. , Campiglio, M. , Stephens, G. ORCID: 0000-0002-8966-4238 , Missler, M. , Obermair, G. (2022) α2δ-4 and Cachd1 proteins are regulators of presynaptic functions. International Journal of Molecular Sciences , 23 (17). ISSN: 1422-0067 | doi: https://dx.doi.org/10.3390/ijms23179885
Curtis, M. , Alexander, S. , Cirino, G. , George, C. , Kendall, D. , Insel, P. , Izzo, A. , Ji, Y. , Panettieri, R. , Patel, H. , Sobey, C. , Stanford, S. , Stanley, P. , Stefanska, B. , Stephens, G. ORCID: 0000-0002-8966-4238 , Teixeira, M. , Vergnolle, N. , Ahluwalia, A. (2022) Planning experiments: updated guidance on experimental design and analysis and their reporting III. British Journal of Pharmacology , 179 (15). pp. 3907-3913. ISSN: 0007-1188 | doi: https://dx.doi.org/10.1111/bph.15868
Stephens, G. ORCID: 0000-0002-8966-4238 and Shukla, A. (2022) Targeting the cell's gatekeepers for novel drug discovery. British Journal of Pharmacology , 179 (14). pp. 3485-3486. ISSN: 0007-1188 | doi: https://dx.doi.org/10.1111/bph.15831

George, C. , Alexander, S. , Cirino, G. , Insel, P. , Izzo, A. , JI, Y. , Kendall, D. , Panettieri, R. , Patel, H. , Sobey, C. , Stanford, S. , Stefanska, B. , Stephens, G. ORCID: 0000-0002-8966-4238 , Teixeira, M. , Ahluwalia, A. (2021) Editorial policy regarding the citation of preprints in the British Journal of Pharmacology (BJP). British Journal of Pharmacology , 178 (18). pp. 3605-3610. ISSN: 0007-1188 | doi: https://dx.doi.org/10.1111/bph.15589
Silveirinha, V. , Lin, H. , Tanifuji, S. , Mochida, S. , Cottrell, G. ORCID: 0000-0001-9098-7627 , Cimarosti, H. , Stephens, G. ORCID: 0000-0002-8966-4238 (2021) CaV2.2 (N-type) voltage-gated calcium channels are activated by SUMOylation pathways. Cell Calcium , 93 ISSN: 0143-4160 | doi: https://dx.doi.org/10.1016/j.ceca.2020.102326

Williams, C. ORCID: 0000-0003-4452-671X and Stephens, G. ORCID: 0000-0002-8966-4238 (2020) Development of cannabidiol as a treatment for severe childhood epilepsies. British Journal of Pharmacology , 177 (24). pp. 5509-5517. ISSN: 0007-1188 | doi: https://dx.doi.org/10.1111/bph.15274
Lilley, E. , Stanford, S. , Kendall, D. , Alexander, S. , Cirino, G. , Docherty, J. , George, C. , Insel, P. , Izzo, A. , Ji, Y. , Panettieri, R. , Sobey, C. , Stefanska, B. , Stephens, G. , Teixeira, M. , Ahluwalia, A. (2020) ARRIVE 2.0 and the British Journal of Pharmacology: updated guidance for 2020. British Journal of Pharmacology , 177 (16). pp. 3611-3616. ISSN: 0007-1188 | doi: https://dx.doi.org/10.1111/bph.15178
Izzo, A. , Teixeira, M. , Alexander, S. , Cirino, G. , Docherty, J. , George, C. , Insel, P. , Ji, Y. , Kendall, D. , Panattieri, R. , Sobey, C. , Stanford, S. , Stefanska, B. , Stephens, G. , Ahluwalia, A. (2020) A practical guide for transparent reporting of research on natural products in the British Journal of Pharmacology: reproducibility of natural product research. British Journal of Pharmacology , 177 (10). pp. 2169-2178. ISSN: 0007-1188 | doi: https://dx.doi.org/10.1111/bph.15054
Natfji, A. , Nikitin, D. , Semina, I. , Moustafine, R. , Khutoryanskiy, V. , Lin, H. , Stephens, G. , Watson, K. , Osborn, H. , Greco, F. (2020) Conjugation of haloperidol to PEG allows peripheral localisation of haloperidol and eliminates CNS extrapyramidal effects. Journal of Controlled Release , 322 pp. 227-235. ISSN: 0168-3659 | doi: https://dx.doi.org/10.1016/j.jconrel.2020.02.037

Docherty, J. , Stanford, S. , Panattieri, R. , Alexander, S. , Cirino, G. , George, C. , Hoyer, D. , Izzo, A. , Ji, Y. , Lilley, E. , Sobey, C. , Stanley, P. , Stefanska, B. , Stephens, G. , Teixeira, M. , Ahluwalia, A. (2019) Sex: a change in our guidelines to authors to ensure that this is no longer an ignored experimental variable. British Journal of Pharmacology , 176 (21). pp. 4081-4086. ISSN: 0007-1188 | doi: https://dx.doi.org/10.1111/bph.14761
Tabatabaee, S. , Baker, D. , Selwood, D. , Whalley, B. , Stephens, G. (2019) The Cannabinoid-Like Compound, VSN16R, Acts on Large Conductance, Ca2+-Activated K+ Channels to Modulate Hippocampal CA1 Pyramidal Neuron Firing. Pharmaceuticals , 12 (3). pp 0. ISSN: 1424-8247 | doi: https://dx.doi.org/10.3390/ph12030104
Stephens, G. and Cottrell, G. (2019) CACHD1: a new activity-modifying protein for voltage-gated calcium channels. Channels , 13 (1). pp. 120-123. ISSN: 1933-6969 | doi: https://dx.doi.org/10.1080/19336950.2019.1600968
Whalley, B. , Lin, H. , Bell, L. , Hill, T. , Patel, A. , Gray, R. , Roberts, E. , Devinsky, O. , Bazelot, M. , Williams, C. , Stephens, G. (2019) Species-specific susceptibility to cannabis-induced convulsions. British Journal of Pharmacology , 176 (10). pp. 1506-1523. ISSN: 0007-1188 | doi: https://dx.doi.org/10.1111/bph.14165

Cottrell, G. , Soubrane, C. , Hounshell, J. , Lin, H. , Owenson, V. , Rigby, M. , Cox, P. , Barker, B. , Ottolini, M. , Ince, S. , Bauer, C. , Perez-Reyes, E. , Patel, M. , Stevens, E. , Stephens, G. (2018) CACHD1 is an α2δ-like protein that modulates CaV3 voltage-gated calcium channel activity. The Journal of Neuroscience , 38 (4). pp. 9186-9201. ISSN: 1529-2401 | doi: https://dx.doi.org/10.1523/JNEUROSCI.3572-15.2018
Stevens, E. and Stephens, G. , eds. (2018) Recent advances in targeting ion channels to treat chronic pain. British Journal of Pharmacology , 175. British Journal of Pharmacology , 175 (12). pp. 2133-2137. ISSN: 0007-1188 | doi: https://dx.doi.org/10.1111/bph.14215
Arjmand, S. , Behzadi, M. , Stephens, G. , Ezzatabadipou, S. , Seifaddini, R. , Arjmand, S. , Shabani, M. (2018) A brain on a roller coaster: can the dopamine reward system act as a protagonist to subdue the ups and downs of bipolar disorder?. The Neuroscientist , 24 (5). pp. 423-439. ISSN: 1073-8584 | doi: https://dx.doi.org/10.1177/1073858417714226

Coelho-Silva, L. , Stephens, G. , Cimarosti, H. (2017) SUMOylation and calcium signalling: potential roles in the brain and beyond. Neuronal Signaling , 1 (3). ISSN: 2059-6553 | doi: https://dx.doi.org/10.1042/NS20160010
Barker, B. , Young , G. , Soubrane, C. , Stephens, G. , Stevens, E. , Patel , M. (2017) Ion channels. In: Conn, P. , (eds.) Conn's Translational Neuroscience 1st Edition. Elsevier Academic Press , London. pp. 11-43. ISBN: 9780128023815 | doi: https://dx.doi.org/10.1016/B978-0-12-802381-5.00002-6

Stephens, G. (2016) Cerebellar circuits: biochemistry, neurotransmitters and neuromodulators: cannabinoids as modulators in the cerebellum. In: Gruol, D. , Koibuchi, N. , Manto, M. , Molinari, M. , Schmahmann, J. , Shen, Y. , (eds.) Essentials of Cerebellum and Cerebellar Disorders: A Primer For Graduate Students. Springer , Dordrecht. pp. 255-259. ISBN: 9783319245492 | doi: https://dx.doi.org/10.1007/978-3-319-24551-5_33
Heath, F. , Newman, A. , Clementi, C. , Pasut, G. , Lin, H. , Stephens, G. , Whalley, B. , Osborn, H. , Greco, F. (2016) A novel PEG–haloperidol conjugate with a non-degradable linker shows the feasibility of using polymer–drug conjugates in a non-prodrug fashion. Polymer Chemistry , 7 (47). pp. 7204-7210. ISSN: 1759-9954 | doi: https://dx.doi.org/10.1039/c6py01418f
Stephens, G. (2016) Does modulation of the endocannabinoid system have potential therapeutic utility in cerebellar ataxia?. Journal of Physiology , 594 (16). pp. 4631-4641. ISSN: 1469-7793 | doi: https://dx.doi.org/10.1113/JP271106

Arjmand, S. , Vaziri, Z. , Behzadi, M. , Abbassian, H. , Stephens, G. , Shabani, M. (2015) Cannabinoids and tremor induced by motor-related disorders: friend or foe?. Neurotherapeutics , 12 (4). pp. 778-787. ISSN: 1933-7213 | doi: https://dx.doi.org/10.1007/s13311-015-0367-5
Ronzitti, G. , Bucci, G. , Stephens, G. , Chieregatti, E. (2015) Raft-partitioning of calcium channels regulates their function. Channels , 9 (4). pp. 169-170. ISSN: 1933-6969 | doi: https://dx.doi.org/10.1080/19336950.2015.1063285
Vogl, C. , Tanifuji, S. , Danis, B. , Daniels, V. , Foerch, P. , Wolff, C. , Whalley, B. , Mochida, S. , Stephens, G. (2015) Synaptic vesicle glycoprotein 2A modulates vesicular release and calcium channel function at peripheral sympathetic synapses. The European Journal of Neuroscience , 41 (4). pp. 398-409. ISSN: 0953-816X | doi: https://dx.doi.org/10.1111/ejn.12799

Ronzitti, G. , Bucci, G. , Emanuele, M. , Leo, D. , Sotnikova, T. , Mus, L. , Soubrane, C. , Dallas, M. , Thalhammer, A. , Cingolani, L. , Mochida, S. , Gainetdinov, R. , Stephens, G. , Chieregatti, E. (2014) Exogenous alpha-Synuclein decreases raft partitioning of Cav2.2 channels inducing dopamine release. Journal of Neuroscience , 34 (32). pp. 10603-10615. ISSN: 1529-2401 | doi: https://dx.doi.org/10.1523/JNEUROSCI.0608-14.2014
Iannotti, F. , Hill, C. , Leo, A. , Alhusaini, A. , Soubrane, C. , Mazzarella, E. , Russo, E. , Whalley, B. , Di Marzo, V. , Stephens, G. (2014) Nonpsychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability. ACS Chemical Neuroscience , 5 (11). pp. 1131-1141. ISSN: 1948-7193 | doi: https://dx.doi.org/10.1021/cn5000524
Hill, A. , Jones, N. , Smith, I. , Hill, C. , Williams, C. , Stephens, G. , Whalley, B. (2014) Voltage-gated sodium (NaV) channel blockade by plant cannabinoids does not confer anticonvulsant effects per se. Neuroscience Letters , 566 pp. 269-274. ISSN: 0304-3940 | doi: https://dx.doi.org/10.1016/j.neulet.2014.03.013

Silveirinha, V. , Stephens, G. , Cimarosti, H. (2013) Molecular targets underlying SUMO-mediated neuroprotection in brain ischemia. Journal of Neurochemistry , 127 (5). pp. 580-591. ISSN: 0022-3042 | doi: https://dx.doi.org/10.1111/jnc.12347
Wang, X. , Whalley, B. , Stephens, G. (2013) The du2J mouse model of ataxia and absence epilepsy has deficient cannabinoid CB1 receptor-mediated signalling. Journal of Physiology , 591 (16). pp. 3919-3933. ISSN: 1469-7793 | doi: https://dx.doi.org/10.1113/jphysiol.2012.244947
Bucci, G. , Mochida, S. , Stephens, G. (2013) Use of synthetic CaV2.2 Ca2+ channel peptides to study presynaptic function. In: Stephens, G. and Mochida, S. , (eds.) Modulation of Presynaptic Calcium Channels. Springer , Dordrecht. pp. 223-240. ISBN: 9789400763333 | doi: https://dx.doi.org/10.1007/978-94-007-6334-0
Baillie, G. , Horswill, J. , Anavi-Goffer,, S. , Reggio, P. , Bolognini , D. , Abood, M. , McAllister, S. , Strange, P. , Stephens, G. , Pertwee, R. , Ross, R. (2013) CB1 receptor allosteric modulators display both agonist and signaling pathway specificity . Molecular Pharmacology , 82 (2). pp. 322-338. ISSN: 1521-0111 | doi: https://dx.doi.org/10.1124/mol.112.080879

Hill, A. , Mercier, M. , Hill, T. , Glyn, S. , Jones, N. , Yamasaki, Y. , Futamura, T. , Duncan, M. , Stott, C. , Stephens, G. , Williams, C. , Whalley, B. (2012) Cannabidivarin is anticonvulsant in mouse and rat in vitro and in seizure models. British Journal of Pharmacology , 167 (8). pp. 1629-1642. ISSN: 0007-1188 | doi: https://dx.doi.org/10.1111/j.1476-5381.2012.02207.x
Jones, N. , Glyn, S. , Akiyama, S. , Hill, T. , Hill, A. , Weston, S. , Burnett, M. , Yamasaki, Y. , Stephens, G. , Whalley, B. , Williams, C. (2012) Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures. Seizure , 21 (5). pp. 344-352. ISSN: 1059-1311 | doi: https://dx.doi.org/10.1016/j.seizure.2012.03.001
Vogl, C. , Mochida, S. , Wolff, C. , Whalley, B. , Stephens, G. (2012) The SV2A ligand levetiracetam inhibits presynaptic Ca2+ channels via an intracellular pathway. Molecular Pharmacology , 82 (2). pp. 199-208. ISSN: 1521-0111 | doi: https://dx.doi.org/10.1124/mol.111.076687
Hill, A. , Williams, C. , Whalley, B. , Stephens, G. (2012) Phytocannabinoids as novel therapeutic agents in CNS disorders. Pharmacology & Therapeutics , 133 (1). pp. 79-97. ISSN: 0163-7258 | doi: https://dx.doi.org/10.1016/j.pharmthera.2011.09.002

Bucci, G. , Mochida, S. , Stephens, G. (2011) Inhibition of synaptic transmission and G protein modulation by synthetic CaV2.2 Ca2+ channel peptides. Journal of Physiology , 589 (13). pp. 3085-3101. ISSN: 0022-3751 | doi: https://dx.doi.org/10.1113/jphysiol.2010.204735
Wang, X. , Horswill, J. , Whalley, B. , Stephens, G. (2011) Effects of the Allosteric Antagonist 1-(4-Chlorophenyl)-3-[3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl]urea (PSNCBAM-1) on CB1 Receptor Modulation in the Cerebellum. Molecular Pharmacology , 79 (4). pp. 758-767. ISSN: 1521-0111 | doi: https://dx.doi.org/10.1124/mol.110.068197

Hill, A. , Weston, S. , Jones, N. , Smith, I. , Bevan , S. , Williamson, E. , Stephens, G. , Williams, C. , Whalley, B. (2010) Δ9-tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rat. Epilepsia , 51 (8). pp. 1522-1532. ISSN: 0013-9580 | doi: https://dx.doi.org/10.1111/j.1528-1167.2010.02523.x
Hill, A. , Jones, N. , Williams, C. , Stephens, G. , Whalley, B. (2010) Development of multi-electrode array screening for anticonvulsants in acute rat brain slices. Journal of Neuroscience Methods , 185 (2). pp. 246 -256 . ISSN: 0165-0270 | doi: https://dx.doi.org/10.1016/j.jneumeth.2009.10.007
Jones, N. , Hill, A. , Smith, I. , Bevan, S. , Williams, C. , Whalley, B. , Stephens, G. (2010) Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo. Journal of Pharmacology and Experimental Therapeutics , 332 (2). pp. 569-577. ISSN: 0022-3565 | doi: https://dx.doi.org/10.1124/jpet.109.159145

Stephens, G. (2009) G-protein-coupled-receptor-mediated presynaptic inhibition in the cerebellum. Trends in Pharmacological Sciences , 30 (8). pp. 421-430 . ISSN: 1656147 | doi: https://dx.doi.org/10.1016/j.tips.2009.05.008
Yang, L. and Stephens, G. (2009) Effects of neuropathy on high-voltage-activated Ca2+ current in sensory neurones. Cell Calcium , 46 (4). pp. 248-256 . ISSN: 1434160 | doi: https://dx.doi.org/10.1016/j.ceca.2009.08.001
Long, P. , Mercer, A. , Begum, R. , Stephens, G. , Sihra, T. , Jovanovic, J. (2009) Nerve terminal GABAA receptors activate Ca2+/calmodulin-dependent signaling to inhibit voltage-gated Ca2+ influx and glutamate release. The Journal of Biological Chemistry , 284 (13). pp. 8717-8728. ISSN: 1083-351X | doi: https://dx.doi.org/10.1074/jbc.M805322200
Farrimond, J. , Hill, A. , Jones, N. , Stephens, G. , Whalley, B. , Williams, C. (2009) A cost-effective high-throughput digital system for observation and acquisition of animal behavioral data. Behavior Research Methods , 41 (2). pp. 446-451. ISSN: 1554-351X | doi: https://dx.doi.org/10.3758/BRM.41.2.446
Whalley, B. , Stephens, G. , Constanti, A. (2009) Investigation of the effects of the novel anticonvulsant compound carisbamate(RWJ-333369) on rat piriform cortical neurones in vitro. British Journal of Pharmacology , 156 (6). pp. 994-1008. ISSN: 0007-1188 | doi: https://dx.doi.org/10.1111/j.1476-5381.2008.00110.x

Ma, . , Weston, . , Whalley, . , Stephens, . (2008) The phytocannabinoid Δ9-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum . British Journal of Pharmacology , 154 (1). pp. 204-215. ISSN: 0007-1188 | doi: https://dx.doi.org/10.1038/bjp.2008.57
Dennis, I. , Whalley, B. , Stephens, G. (2008) Effects of Delta9-tetrahydrocannabivarin on [35S]GTPgammaS binding in mouse brain cerebellum and piriform cortex membranes. British Journal of Pharmacology , 154 (6). pp. 1349-58. ISSN: 0007-1188 | doi: https://dx.doi.org/10.1038/bjp.2008.190

Matthews, . , Bee, . , Stephens, . , Dickenson, . (2007) The Ca(v)2.3 calcium channel antagonist SNX-482 reduces dorsal horn neuronal responses in a rat model of chronic neuropathic pain. European Journal of Neuroscience , 25 (12). pp. 3561-3569. ISSN: 0953-816X | doi: https://dx.doi.org/10.1111/j.1460-9568.2007.05605.x

Harvey, . , Duguid, . , Krasel, . , Stephens, . (2006) Evidence that GABA rho subunits contribute to functional ionotropic GABA receptors in mouse cerebellar Purkinje cells. Journal of Physiology-London , 577 (1). pp. 127-139. ISSN: 0022-3751 | doi: https://dx.doi.org/10.1113/jphysiol.2006.112482
Weston, S. , Williamson, E. , Constanti, A. , Stephens, G. , Whalley, B. (2006) Tetrahydrocannabivarin exhibits anticonvulsant effects in a piriform cortical brain slice model of epileptiform activity. Proceedings of the British Pharmacological Society at http://www.pa2online.org/abstract/abstract.jsp?abid=28533.

Stephens, . and Mochida, . (2005) G protein ss gamma subunits mediate presynaptic inhibition of transmitter release from rat superior cervical ganglion neurones in culture. Journal of Physiology , 563 (3). pp. 765-776. ISSN: 0022-3751 | doi: https://dx.doi.org/10.1113/jphysiol.2004.080192

Gary Stephens

Areas of interest

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Background

Selected publications

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