Francesco Tamagnini
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+44 (0) 118 378 4745
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Lecturer in Pharmacology
Areas of interest
I am a neurophysiologist. My research is focused on the characterization of functional correlates of dementia. My lab work is complemented by my teaching experience and public outreach commitment.
- Characterization of epileptic-like single cell membrane excitability alterations and synaptic plasticity impairments in the temporal lobe of mouse models of dementia.
- Characterization of electrophysiological maturity of stem-cell derived neurons grown onto 2D (e.g. diamond) and 3D (e.g. designed hydrogels) substrates.
- Development and validation of computer-based models of neuronal function.
- Development of non-invasive, EEG-based diagnostic and prognostic tools for Alzheimer's disease.
My outreach commitment is aimed at two main objectives:
- Raise awareness on Alzheimer's and dementia, while describing the fascinating machinery of the brain and its role in high cognitive functions.
- Promote an informed debate on animal research with a focus on its ethical, legislative and practical aspects.
Research centres and groups
School of Pharmacy, Pharmacology GroupPublications
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Bercea, C.
,
Limbu, R.
,
Behnam, K.
,
Ng, K.
,
Aziz, Q.
,
Tinker, A.
,
Tamagnini, F.
ORCID: 0000-0002-8741-5094
,
Cottrell, G.
ORCID: 0000-0001-9098-7627
,
McNeish, A.
(2022)
Omega-3 polyunsaturated fatty acid-induced vasodilation in mouse aorta and mesenteric arteries is not mediated by ATP-sensitive potassium channels.
Frontiers in Physiology
, 13
ISSN:
1664-042X
|
doi:
https://dx.doi.org/10.3389/fphys.2022.1033216
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Barberio, C.
,
Saez, J.
,
Withers, A.
,
Nair, M.
,
Tamagnini, F.
ORCID: 0000-0002-8741-5094
,
Owens, R.
(2022)
Conducting polymer-ECM scaffolds for human neuronal cell differentiation.
Advanced HEalthcare Materials
, 11
(20).
ISSN:
2192-2659
|
doi:
https://dx.doi.org/10.1002/adhm.202200941
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Torre, E.
,
Bicer, M.
,
Cottrell, G.
ORCID: 0000-0001-9098-7627
,
Widera, D.
ORCID: 0000-0003-1686-130X
,
Tamagnini, F.
ORCID: 0000-0002-8741-5094
(2021)
Time-dependent reduction of calcium oscillations in adipose-derived stem cells differentiating towards adipogenic and osteogenic lineage.
Biomolecules
, 11
(10).
ISSN:
2218-273X
|
doi:
https://dx.doi.org/10.3390/biom11101400
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Bercea, C.
,
Cottrell, G.
ORCID: 0000-0001-9098-7627
,
Tamagnini, F.
ORCID: 0000-0002-8741-5094
,
McNeish, A.
(2021)
Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and hypertension: a review of vasodilatory mechanisms of DHA and EPA.
British Journal of Pharmacology
, 178
(4).
pp.
860-877.
ISSN:
0007-1188
|
doi:
https://dx.doi.org/10.1111/bph.15336
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Tamagnini, F.
ORCID: 0000-0002-8741-5094
(2020)
Nucleated, outside-out, somatic, macropatch recordings in native neurons.
In:
Mark, D.
and
Damian, B.
, (eds.)
Patch Clamp Electrophysiology Methods and Protocols.
Humana
, New York, NY.
pp.
229-242.
ISBN:
9781071608173
|
doi:
https://dx.doi.org/10.1007/978-1-0716-0818-0_11
- Tait, L. , Tamagnini, F. , Stothart, G. , Barvas, E. , Monaldini, C. , Frusciante, R. , Volpini, M. , Guttmann, S. , Coulthard, E. , Brown, J. , Kazanina, N. , Goodfellow, M. (2020) EEG microstate complexity for aiding early diagnosis of Alzheimer’s disease. Scientific Reports , 10 ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-020-74790-7
- Bianchi, R. , Eilers, W. , Pellati, F. , Corsi, L. , Foster, H. , Foster, K. , Tamagnini, F. (2020) Hippocampal synaptic and membrane function in the DBA/2J-mdx mouse model of Duchenne muscular dystrophy. Molecular and Cellular Neuroscience , 104 ISSN: 1044-7431 | doi: https://dx.doi.org/10.1016/j.mcn.2020.103482
- Stephen, T. , Tamagnini, F. , Piegsa, J. , Sung, K. , Harvey, J. , Oliver-Evans, A. , Murray, T. , Ahmed, Z. , Hutton, M. , Randall, A. , O' Neill, M. , Jackson, J. (2019) Imbalance in the response of pre- and post-synaptic components to amyloidopathy. Scientific Reports , 9 ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-019-50781-1
- Palombo, F. , Masia, F. , Mattana, S. , Tamagnini, F. , Borri, P. , Langbein, W. , Fioretto, D. (2018) Hyperspectral analysis applied to micro-Brillouin maps of amyloid-beta plaques in Alzheimer’s disease brains. Analysis , 143 (24). pp. 6095-6102. ISSN: 1467-8284 | doi: https://dx.doi.org/10.1039/C8AN01291A
- Tamagnini, F. , Cotton, M. , Goodall, O. , Harrison, G. , Jeynes, C. , Palombo, F. , Tomkow, J. , Tomkow, T. , Wedgwood, K. (2018) ‘Of Mice and Dementia’: A filmed conversation on the use of animals in dementia research. Dementia , 17 (8). pp. 1055-1063. ISSN: 1741-2684 | doi: https://dx.doi.org/10.1177/1471301218789560
- Palombo, F. , Tamagnini, F. , Jeynes, C. , Mattana, S. , Swift, I. , Nallala, J. , Hancock, J. , Brown, J. , Randall, A. , Stone, N. (2018) Detection of Aβ plaque-associated astrogliosis in Alzheimer’s disease brain by spectroscopic imaging and immunohistochemistry. Analyst , 143 (4). pp. 850-857. ISSN: 0003-2654 | doi: https://dx.doi.org/10.1039/c7an01747b
- Mattana, S. , Caponi, S. , Tamagnini, F. , Fioretto, D. , Palombo, F. (2017) Viscoelasticity of amyloid plaques in transgenic mouse brain studied by Brillouin microspectroscopy and correlative Raman analysis. Journal of Innovative Optical Health Sciences , 10 (6). ISSN: 1793-7205 | doi: https://dx.doi.org/10.1142/S1793545817420019
- Tamagnini, F. , Walsh, D. , Brown, J. , Bondulich, M. , Hanger, D. , Randall, A. (2017) Hippocampal neurophysiology is modified by a disease-associated C-terminal fragment of tau protein. Neurobiology of Aging , 60 pp. 44-56. ISSN: 0197-4580 | doi: https://dx.doi.org/10.1016/j.neurobiolaging.2017.07.005
- Mehrban, N. , Zhu, B. , Tamagnini, F. , Young, F. , Wasmuth, A. , Hudson, K. , Thomson, A. , Birchall, M. , Randall, A. , Song, B. , Woolfson, D. (2015) Functionalized α-helical peptide hydrogels for neural tissue engineering. ACS Biomaterials Science & Engineering , 1 (6). pp. 431-439. ISSN: 2373-9878 | doi: https://dx.doi.org/10.1021/acsbiomaterials.5b00051
- Tamagnini, F. , Novelia, J. , Kerrigan, T. , Brown, J. , Tsaneva-Atanasova, K. , Randall, A. (2015) Altered intrinsic excitability of hippocampal CA1 pyramidal neurons in aged PDAPP mice. Frontiers in Cellular Neuroscience , 9 ISSN: 1662-5102 | doi: https://dx.doi.org/10.3389/fncel.2015.00372
- Nistor, P. , May, P. , Tamagnini, F. , Randall, A. , Caldwell, M. (2015) Long-term culture of pluripotent stem-cell-derived human neurons on diamond – a substrate for neurodegeneration research and therapy. Biomaterial , 61 pp. 139-149. ISSN: 0142-9612 | doi: https://dx.doi.org/10.1016/j.biomaterials.2015.04.050
- Tamagnini, F. , Scullion, S. , Brown, J. , Randall, A. (2015) Intrinsic excitability changes induced by acute treatment of hippocampal CA1 pyramidal neurons with exogenous amyloid β peptide. Hippocampus , 25 (7). pp. 786-797. ISSN: 1050-9631 | doi: https://dx.doi.org/10.1002/hipo.22403
- Tamagnini, F. , Scullion, S. , Brown, J. , Randall, A. (2014) Low concentrations of the solvent dimethyl sulphoxide alter intrinsic excitability properties of cortical and hippocampal pyramidal cells. PLoS ONE , 9 (3). ISSN: 1932-6203 | doi: https://dx.doi.org/10.1371/journal.pone.0092557