Francesco Tamagnini

Email:
f.tamagnini@reading.ac.uk
Phone:
+44 (0) 118 378 4745
Job title:
Lecturer in Pharmacology

Areas of interest

I am a neurophysiologist. My research is focused on the characterization of functional correlates of dementia. My lab work is complemented by my teaching experience and public outreach commitment.

Characterization of epileptic-like single cell membrane excitability alterations and synaptic plasticity impairments in the temporal lobe of mouse models of dementia.
Characterization of electrophysiological maturity of stem-cell derived neurons grown onto 2D (e.g. diamond) and 3D (e.g. designed hydrogels) substrates.
Development and validation of computer-based models of neuronal function.
Development of non-invasive, EEG-based diagnostic and prognostic tools for Alzheimer's disease.

My outreach commitment is aimed at two main objectives:

Raise awareness on Alzheimer's and dementia, while describing the fascinating machinery of the brain and its role in high cognitive functions.
Promote an informed debate on animal research with a focus on its ethical, legislative and practical aspects.

Research centres and groups

School of Pharmacy, Pharmacology Group

Publications

Brady, E. , Griffiths, J. , Andrianova, L. , Bielska, M. , Saito, T. , Saido, T. , Randall, A. , Tamagnini, F. ORCID: 0000-0002-8741-5094 , Witton, J. , Craig, M. (2023) Alterations to parvalbumin-expressing interneuron function and associated network oscillations in the hippocampal – medial prefrontal cortex circuit during natural sleep in AppNL-G-F/NL-G-F mice. Neurobiology of disease , 182 pp 0. ISSN: 1095-953X | doi: https://dx.doi.org/10.1016/j.nbd.2023.106151

Bercea, C. , Limbu, R. , Behnam, K. , Ng, K. , Aziz, Q. , Tinker, A. , Tamagnini, F. ORCID: 0000-0002-8741-5094 , Cottrell, G. ORCID: 0000-0001-9098-7627 , McNeish, A. (2022) Omega-3 polyunsaturated fatty acid-induced vasodilation in mouse aorta and mesenteric arteries is not mediated by ATP-sensitive potassium channels. Frontiers in Physiology , 13 ISSN: 1664-042X | doi: https://dx.doi.org/10.3389/fphys.2022.1033216
Barberio, C. , Saez, J. , Withers, A. , Nair, M. , Tamagnini, F. ORCID: 0000-0002-8741-5094 , Owens, R. (2022) Conducting polymer-ECM scaffolds for human neuronal cell differentiation. Advanced HEalthcare Materials , 11 (20). ISSN: 2192-2659 | doi: https://dx.doi.org/10.1002/adhm.202200941

Torre, E. , Bicer, M. , Cottrell, G. ORCID: 0000-0001-9098-7627 , Widera, D. ORCID: 0000-0003-1686-130X , Tamagnini, F. ORCID: 0000-0002-8741-5094 (2021) Time-dependent reduction of calcium oscillations in adipose-derived stem cells differentiating towards adipogenic and osteogenic lineage. Biomolecules , 11 (10). ISSN: 2218-273X | doi: https://dx.doi.org/10.3390/biom11101400
Bercea, C. , Cottrell, G. ORCID: 0000-0001-9098-7627 , Tamagnini, F. ORCID: 0000-0002-8741-5094 , McNeish, A. (2021) Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and hypertension: a review of vasodilatory mechanisms of DHA and EPA. British Journal of Pharmacology , 178 (4). pp. 860-877. ISSN: 0007-1188 | doi: https://dx.doi.org/10.1111/bph.15336

Tamagnini, F. ORCID: 0000-0002-8741-5094 (2020) Nucleated, outside-out, somatic, macropatch recordings in native neurons. In: Mark, D. and Damian, B. , (eds.) Patch Clamp Electrophysiology Methods and Protocols. Humana , New York, NY. pp. 229-242. ISBN: 9781071608173 | doi: https://dx.doi.org/10.1007/978-1-0716-0818-0_11
Tait, L. , Tamagnini, F. , Stothart, G. , Barvas, E. , Monaldini, C. , Frusciante, R. , Volpini, M. , Guttmann, S. , Coulthard, E. , Brown, J. , Kazanina, N. , Goodfellow, M. (2020) EEG microstate complexity for aiding early diagnosis of Alzheimer’s disease. Scientific Reports , 10 ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-020-74790-7
Bianchi, R. , Eilers, W. , Pellati, F. , Corsi, L. , Foster, H. , Foster, K. , Tamagnini, F. (2020) Hippocampal synaptic and membrane function in the DBA/2J-mdx mouse model of Duchenne muscular dystrophy. Molecular and Cellular Neuroscience , 104 ISSN: 1044-7431 | doi: https://dx.doi.org/10.1016/j.mcn.2020.103482

Stephen, T. , Tamagnini, F. , Piegsa, J. , Sung, K. , Harvey, J. , Oliver-Evans, A. , Murray, T. , Ahmed, Z. , Hutton, M. , Randall, A. , O' Neill, M. , Jackson, J. (2019) Imbalance in the response of pre- and post-synaptic components to amyloidopathy. Scientific Reports , 9 ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-019-50781-1

Palombo, F. , Masia, F. , Mattana, S. , Tamagnini, F. , Borri, P. , Langbein, W. , Fioretto, D. (2018) Hyperspectral analysis applied to micro-Brillouin maps of amyloid-beta plaques in Alzheimer’s disease brains. Analysis , 143 (24). pp. 6095-6102. ISSN: 1467-8284 | doi: https://dx.doi.org/10.1039/C8AN01291A
Tamagnini, F. , Cotton, M. , Goodall, O. , Harrison, G. , Jeynes, C. , Palombo, F. , Tomkow, J. , Tomkow, T. , Wedgwood, K. (2018) ‘Of Mice and Dementia’: A filmed conversation on the use of animals in dementia research. Dementia , 17 (8). pp. 1055-1063. ISSN: 1741-2684 | doi: https://dx.doi.org/10.1177/1471301218789560
Palombo, F. , Tamagnini, F. , Jeynes, C. , Mattana, S. , Swift, I. , Nallala, J. , Hancock, J. , Brown, J. , Randall, A. , Stone, N. (2018) Detection of Aβ plaque-associated astrogliosis in Alzheimer’s disease brain by spectroscopic imaging and immunohistochemistry. Analyst , 143 (4). pp. 850-857. ISSN: 0003-2654 | doi: https://dx.doi.org/10.1039/c7an01747b

Mattana, S. , Caponi, S. , Tamagnini, F. , Fioretto, D. , Palombo, F. (2017) Viscoelasticity of amyloid plaques in transgenic mouse brain studied by Brillouin microspectroscopy and correlative Raman analysis. Journal of Innovative Optical Health Sciences , 10 (6). ISSN: 1793-7205 | doi: https://dx.doi.org/10.1142/S1793545817420019
Tamagnini, F. , Walsh, D. , Brown, J. , Bondulich, M. , Hanger, D. , Randall, A. (2017) Hippocampal neurophysiology is modified by a disease-associated C-terminal fragment of tau protein. Neurobiology of Aging , 60 pp. 44-56. ISSN: 0197-4580 | doi: https://dx.doi.org/10.1016/j.neurobiolaging.2017.07.005

Mehrban, N. , Zhu, B. , Tamagnini, F. , Young, F. , Wasmuth, A. , Hudson, K. , Thomson, A. , Birchall, M. , Randall, A. , Song, B. , Woolfson, D. (2015) Functionalized α-helical peptide hydrogels for neural tissue engineering. ACS Biomaterials Science & Engineering , 1 (6). pp. 431-439. ISSN: 2373-9878 | doi: https://dx.doi.org/10.1021/acsbiomaterials.5b00051
Tamagnini, F. , Novelia, J. , Kerrigan, T. , Brown, J. , Tsaneva-Atanasova, K. , Randall, A. (2015) Altered intrinsic excitability of hippocampal CA1 pyramidal neurons in aged PDAPP mice. Frontiers in Cellular Neuroscience , 9 ISSN: 1662-5102 | doi: https://dx.doi.org/10.3389/fncel.2015.00372
Nistor, P. , May, P. , Tamagnini, F. , Randall, A. , Caldwell, M. (2015) Long-term culture of pluripotent stem-cell-derived human neurons on diamond – a substrate for neurodegeneration research and therapy. Biomaterial , 61 pp. 139-149. ISSN: 0142-9612 | doi: https://dx.doi.org/10.1016/j.biomaterials.2015.04.050
Tamagnini, F. , Scullion, S. , Brown, J. , Randall, A. (2015) Intrinsic excitability changes induced by acute treatment of hippocampal CA1 pyramidal neurons with exogenous amyloid β peptide. Hippocampus , 25 (7). pp. 786-797. ISSN: 1050-9631 | doi: https://dx.doi.org/10.1002/hipo.22403

Tamagnini, F. , Scullion, S. , Brown, J. , Randall, A. (2014) Low concentrations of the solvent dimethyl sulphoxide alter intrinsic excitability properties of cortical and hippocampal pyramidal cells. PLoS ONE , 9 (3). ISSN: 1932-6203 | doi: https://dx.doi.org/10.1371/journal.pone.0092557

Francesco Tamagnini

Areas of interest

Research centres and groups

Publications

2023

2022

2021

2020

2019

2018

2017

2015

2014