Professor Rainer Cramer

Krenkel, H. , Brown, J. , Morris, M. , Cramer, R. ORCID: 0000-0002-8037-2511 (2023) The use of salts, buffers and surfactants in LAP-MALDI MS. International Journal of Mass Spectrometry ISSN: 1387-3806 | doi: https://dx.doi.org/10.1016/j.ijms.2023.117134
Lellman, S. , Reynolds, C. ORCID: 0000-0002-4152-1190 , Jones, A. , Taylor, N. , Cramer, R. ORCID: 0000-0002-8037-2511 (2023) LAP-MALDI MS profiling and identification of potential biomarkers for the detection of bovine tuberculosis. Journal of Agricultural and Food Chemistry , 71 (37). pp. 13899-13905. ISSN: 1520-5118 | doi: https://dx.doi.org/10.1021/acs.jafc.3c01879
Challen, B. , Morris, M. , Cramer, R. ORCID: 0000-0002-8037-2511 (2023) Ultra-high-throughput and low-volume analysis of intact proteins with LAP-MALDI MS. Journal of the American Society for Mass Spectrometry , 34 (6). pp. 991-994. ISSN: 1879-1123 | doi: https://dx.doi.org/10.1021/jasms.3c00068
Piras, C. and Cramer, R. ORCID: 0000-0002-8037-2511 (2023) Liquid Atmospheric Pressure (LAP) - MALDI MS(/MS) biomolecular profiling for large-scale detection of animal disease and food adulteration and bacterial identification. In: Shah, H. , Gharbia, S. , Shah, A. , Tranfield, E. , Thompson, C. , (eds.) Microbiological Identification using MALDI-TOF and Tandem Mass Spectrometry: Industrial and Environmental Applications. Wiley ISBN: 9781119814054

Challen, B. and Cramer, R. ORCID: 0000-0002-8037-2511 (2022) Advances in ionisation techniques for mass spectrometry‐based omics research. Proteomics , 22 (15-16). pp 0. ISSN: 1615-9853 | doi: https://dx.doi.org/10.1002/pmic.202100394
Krenkel, H. , Brown, J. , Richardson, K. , Hoyes, E. , Morris, M. , Cramer, R. ORCID: 0000-0002-8037-2511 (2022) Ultrahigh-throughput sample analysis using liquid atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry. Analytical Chemistry , 94 (10). pp. 4141-4145. ISSN: 0003-2700 | doi: https://dx.doi.org/10.1021/acs.analchem.1c05614
Piras, C. , Hale, O. , Reynolds, C. ORCID: 0000-0002-4152-1190 , Jones, A. , Taylor, N. , Morris, M. , Cramer, R. ORCID: 0000-0002-8037-2511 (2022) LAP-MALDI MS coupled with machine learning: an ambient mass spectrometry approach for high-throughput diagnostics. Chemical Science , 13 (6). pp. 1746-1758. ISSN: 1478-6524 | doi: https://dx.doi.org/10.1039/D1SC05171G

Piras, C. , Hale, O. , Reynolds, C. ORCID: 0000-0002-4152-1190 , Jones, A. , Taylor, N. , Morris, M. , Cramer, R. ORCID: 0000-0002-8037-2511 (2021) Speciation and milk adulteration analysis by rapid ambient liquid MALDI mass spectrometry profiling using machine learning. Scientific Reports , 11 (1). ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-021-82846-5

Piras, C. , Greco, V. , Gugliandolo, E. , Soggiu, A. , Tilocca, B. , Bonizzi, L. , Zecconi, A. , Cramer, R. ORCID: 0000-0002-8037-2511 , Britti, D. , Urbani, A. , Roncada, P. (2020) Raw cow milk bacterial consortium as bioindicator of circulating anti-microbial resistance (AMR). Animal Feed Science and Technology , 10 (12). ISSN: 0377-8401 | doi: https://dx.doi.org/10.3390/ani10122378
Piras, C. , Ceniti, C. , Hartmane, E. , Costanzo, N. , Morittu, V. , Roncada, P. , Britti, D. , Cramer, R. (2020) Rapid liquid AP-MALDI MS profiling of lipids and proteins from goat and sheep milk for speciation and colostrum analysis. Proteomes , 8 (3). ISSN: 2227-7382 | doi: https://dx.doi.org/10.3390/proteomes8030020
Cramer, R. (2020) High-speed analysis of large sample sets – how can this key aspect of the omics be achieved?. Molecular and Cellular Proteomics , 19 (11). pp. 1760-1766. ISSN: 1535-9484 | doi: https://dx.doi.org/10.1074/mcp.P120.001997
Castelletto, V. , Seitsonen, J. , Ruokolainen, J. , Piras, C. , Cramer, R. , Edwards-Gayle, C. , Hamley, I. (2020) Peptide nanotubes self-assembled from leucine-rich alpha helical surfactant-like peptides. Chemical Communications , 56 (80). pp. 11977-11980. ISSN: 1359-7345 | doi: https://dx.doi.org/10.1039/D0CC04299D
Scollo, E. , Neville, D. , Oruna-Concha, M. , Trotin, M. , Umaharan, P. , Sukha, D. , Kalloo, R. , Cramer, R. (2020) Proteomic and peptidomic UHPLC-ESI MS/MS analysis of cocoa beans fermented using the Styrofoam-box method. Food Chemistry , 316 ISSN: 0308-8146 | doi: https://dx.doi.org/10.1016/j.foodchem.2020.126350
Krenkel, H. , Hartmane, E. , Piras, C. , Brown, J. , Morris, M. , Cramer, R. (2020) Advancing liquid atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry toward ultra-high-throughput analysis. Analytical Chemistry , 92 (4). pp. 2931-2936. ISSN: 0003-2700 | doi: https://dx.doi.org/10.1021/acs.analchem.9b05202
Scollo, E. , Neville, D. , Oruna-Concha, M. , Trotin, M. , Cramer, R. (2020) UHPLC-MS/MS analysis of cocoa bean proteomes from four different genotypes. Food Chemistry , 303 ISSN: 0308-8146 | doi: https://dx.doi.org/10.1016/j.foodchem.2019.125244
Hale, O. , Ryumin, P. , Brown, J. , Morris, M. , Cramer, R. ORCID: 0000-0002-8037-2511 (2020) Production and analysis of multiply charged negative ions by liquid atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry. Rapid Communications in Mass Spectrometry , 35 (S1). ISSN: 1097-0231 | doi: https://dx.doi.org/10.1002/rcm.8246

Lellman, S. and Cramer, R. (2019) Bacterial identification by lipid profiling using liquid atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry. Clinical Chemistry and Laboratory Medicine , 58 (6). pp. 930-938. ISSN: 1437-4331 | doi: https://dx.doi.org/10.1515/cclm-2019-0908
Lambertucci, S. , Orman, K. , Das Gupta, S. , Fisher, J. , Gazal, S. , Williamson, R. , Cramer, R. , Bindschedler, L. (2019) Analysis of barley leaf epidermis and extrahaustorial proteomes during powdery mildew infection reveals that the PR5 thaumatin-like protein TLP5 is required for susceptibility towards Blumeria graminis f. sp. hordei. Frontiers in Plant Science , 10 pp 0. ISSN: 1664-462X | doi: https://dx.doi.org/10.3389/fpls.2019.01138
Hale, O. and Cramer, R. (2019) Atmospheric pressure ultraviolet laser desorption and ionization from liquid samples for native mass spectrometry. Analytical Chemistry , 91 (22). pp. 14192-14197. ISSN: 0003-2700 | doi: https://dx.doi.org/10.1021/acs.analchem.9b03875
Hale, O. , Morris, M. , Jones, B. , Reynolds, C. , Cramer, R. (2019) Liquid atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry adds enhanced functionalities to MALDI MS profiling for disease diagnostics. ACS Omega , 4 (7). pp. 12759-12765. ISSN: 2470-1343 | doi: https://dx.doi.org/10.1021/acsomega.9b01476
Hutchinson, J. , Hamley, I. , Edwards-Gayle, C. , Castelletto, V. , Piras, C. , Cramer, R. , Kowalczyk, R. , Seitsonen, J. , Ruokolainen, J. , Rambo, R. (2019) Melanin production by tyrosinase activity on a tyrosine-rich peptide fragment and pH-dependent self-assembly of its lipidated analogue. Organic & Biomolecular Chemistry , 17 pp. 4543-4553. ISSN: 1477-0520 | doi: https://dx.doi.org/10.1039/C9OB00550A

Ryumin, P. and Cramer, R. (2018) The composition of liquid atmospheric pressure matrix-assisted laser desorption/ionization matrices and its effect on ionization in mass spectrometry. Analytica Chimica Acta , 1013 pp. 43-53. ISSN: 1873-4324 | doi: https://dx.doi.org/10.1016/j.aca.2018.01.070
Scollo, E. , Neville, D. , Oruna-Concha, M. ORCID: 0000-0001-7916-1592 , Trotin, M. , Cramer, R. ORCID: 0000-0002-8037-2511 (2018) Characterization of the proteome of Theobroma cacao beans by nano-UHPLC-ESI MS/MS. Proteomics , 18 (3-4). ISSN: 1615-9853 | doi: https://dx.doi.org/10.1002/pmic.201700339
Hale, O. and Cramer, R. (2018) Collision-induced dissociation of doubly-charged barium-cationized lipids generated from liquid samples by atmospheric pressure matrix-assisted laser desorption/ionization provides structurally diagnostic product ions. Analytical and Bioanalytical Chemistry , 410 (5). pp. 1435-1444. ISSN: 1618-2650 | doi: https://dx.doi.org/10.1007/s00216-017-0788-6

Brown, J. , Morris, M. , Cramer, R. (2017) Liquid AP-MALDI: ion signal intensity and persistence at laser repetition rates between 1 Hz and 5 kHz.
Hale, O. , Morris, M. , Cramer, R. (2017) AP-MALDI-Q-IMS-TOF MS as a liquid sample mass profiling platform for food authenticity tests.
Torma, A. , Groves, K. , Biesenbruch, S. , Mussell, C. , Reid, A. , Ellison, S. , Cramer, R. , Quaglia, M. (2017) A candidate liquid chromatography mass spectrometry reference method for the quantification of the cardiac marker 1-32 B-type natriuretic peptide. Clinical Chemistry and Laboratory Medicine , 55 (9). pp. 1434-6621. ISSN: 1437-4331 | doi: https://dx.doi.org/10.1515/cclm-2016-1054
Castelletto, V. , Ryumin, P. , Cramer, R. , Hamley, I. , Taylor, M. , Allsop, D. , Reza, M. , Ruokolainen, J. , Arnold, T. , Hermida-Merino, D. , Garcia, C. , Leal, M. , Castaño, E. (2017) Self-assembly and anti-amyloid cytotoxicity activity of amyloid beta peptide derivatives. Scientific Reports , 7 ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/srep43637
Ryumin, P. , Brown, J. , Morris, M. , Cramer, R. (2017) Protein identification using a nanoUHPLC-AP-MALDI MS/MS workflow with CID of multiply charged proteolytic peptides. International Journal of Mass Spectrometry , 416 pp. 20-28. ISSN: 1387-3806 | doi: https://dx.doi.org/10.1016/j.ijms.2016.12.006

Wiangnon, K. and Cramer, R. (2016) Liquid MALDI MS analysis of complex peptide and proteome samples. Journal of Proteome Research , 15 (9). pp. 2998-3008. ISSN: 1535-3907 | doi: https://dx.doi.org/10.1021/acs.jproteome.6b00148
Timms, J. , Hale, O. , Cramer, R. (2016) Advances in mass spectrometry-based cancer research and analysis: from cancer proteomics to clinical diagnostics. Expert Review of Proteomics , 13 (6). pp. 593-607. ISSN: 1478-9450 | doi: https://dx.doi.org/10.1080/14789450.2016.1182431
Bryant, L. , Patole, C. , Cramer, R. (2016) Proteomic analysis of the medicinal plant Artemisia annua: data from leaf and trichome extracts. Data In Brief , 7 pp. 325-331. ISSN: 2352-3409 | doi: https://dx.doi.org/10.1016/j.dib.2016.02.038
Pennington, H. , Gheorghe, D. , Damerum, A. , Pliego, C. , Spanu, P. , Cramer, R. , Bindschedler, L. (2016) Interactions between the powdery mildew effector BEC1054 and barley proteins identify candidate host targets. Journal of Proteome Research , 15 (3). pp. 826-839. ISSN: 1535-3907 | doi: https://dx.doi.org/10.1021/acs.jproteome.5b00732
Ryumin, P. , Brown, J. , Morris, M. , Cramer, R. (2016) Investigation and optimization of parameters affecting the multiply charged ion yield in AP-MALDI MS. Methods , 104 pp. 11-20. ISSN: 1046-2023 | doi: https://dx.doi.org/10.1016/j.ymeth.2016.01.015
Wiangnon, K. and Cramer, R. (2016) Coupling liquid MALDI MS to liquid chromatography. In: Cramer, R. , (eds.) Advances in MALDI and Laser-Induced Soft Ionization Mass Spectrometry. Springer pp. 65-76. ISBN: 9783319048185 | doi: https://dx.doi.org/10.1007/978-3-319-04819-2_4
Towers, M. and Cramer, R. (2016) Ionic liquids and other liquid matrices for sensitive MALDI MS analysis. In: Cramer, R. , (eds.) Advances in MALDI and Laser-Induced Soft Ionization Mass Spectrometry. Springer pp. 51-64. ISBN: 9783319048185 | doi: https://dx.doi.org/10.1007/978-3-319-04819-2_3
Cramer, R. (2016) Preface. In: Cramer, R. , (eds.) Advances in MALDI and Laser-Induced Soft Ionization Mass Spectrometry. Springer ISBN: 9783319048185
Ryumin, P. and Cramer, R. (2016) Efficient production of multiply charged MALDI ions. In: Cramer, R. , (eds.) Advances in MALDI and Laser-Induced Soft Ionization Mass Spectrometry. Springer pp. 37-47. ISBN: 9783319048185 | doi: https://dx.doi.org/10.1007/978-3-319-04819-2_2
Cramer, R. , eds. (2016) Advances in MALDI and laser-induced soft ionization mass spectrometry. Springer ISBN: 9783319048185

Nouretdinov, I. , Devetyarov, D. , Vovk, V. , Burford, B. , Camuzeaux, S. , Gentry-Maharaj, A. , Tiss, A. , Smith, C. , Luo, Z. , Chervonenkis, A. , Hallett, R. , Waterfield, M. , Cramer, R. , Timms, J. , Jacobs, I. , Menon, U. , Gammerman, A. (2015) Multiprobabilistic prediction in early medical diagnoses. Annals of Mathematics and Artificial Intelligence , 74 (1-2). pp. 203-222. ISSN: 1573-7470 | doi: https://dx.doi.org/10.1007/s10472-013-9367-5
Flatley, B. , Quaye, C. , Johnson, E. , Freeman, A. , Muneer, A. , Minhas, S. , Paterson, J. , Musa, F. , Malone, P. , Cramer, R. (2015) Distribution analysis of the putative cancer marker S100A4 across invasive squamous cell carcinoma penile tissue. EuPA Open Proteomics , 7 pp. 1-10. ISSN: 2212-9685 | doi: https://dx.doi.org/10.1016/j.euprot.2015.02.001
Bryant, L. , Flatley, B. , Patole, C. , Brown, G. , Cramer, R. (2015) Proteomic analysis of Artemisia annua – towards elucidating the biosynthetic pathways of the antimalarial pro-drug artemisinin. BMC Plant Biology , 15 (1). ISSN: 1471-2229 | doi: https://dx.doi.org/10.1186/s12870-015-0565-7
Wiangnon, K. and Cramer, R. (2015) Sample preparation: a crucial factor for the analytical performance of rationally designed MALDI matrices. Analytical Chemistry , 87 (3). pp. 1485-1488. ISSN: 0003-2700 | doi: https://dx.doi.org/10.1021/ac504412p

Flatley, B. , Malone, P. , Cramer, R. (2014) MALDI mass spectrometry in prostate cancer biomarker discovery. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics , 1844 (5). pp. 940-949. ISSN: 1570-9639 | doi: https://dx.doi.org/10.1016/j.bbapap.2013.06.015
Flatley, B. , Wilmott, K. , Malone, P. , Cramer, R. (2014) MALDI MS profiling of post-DRE urine samples highlights the potential of b-Microseminoprotein as a marker for prostatic diseases. The Prostate , 74 (1). pp. 103-111. ISSN: 1097-0045 | doi: https://dx.doi.org/10.1002/pros.22736

Cramer, R. , Karas, M. , Jaskolla, T. (2013) Enhanced MALDI MS sensitivity by weak base additives and glycerol sample coating. Analytical Chemistry , 86 (1). pp. 744-751. ISSN: 0003-2700 | doi: https://dx.doi.org/10.1021/ac403228d
Kovaleva, V. , Cramer, R. , Krynytskyy, H. , Gout, I. , Gout, R. (2013) Analysis of tyrosine phosphorylation and phosphotyrosine-binding proteins in germinating seeds from Scots pine. Plant Physiology and Biochemistry , 67 pp. 33-40. ISSN: 0981-9428 | doi: https://dx.doi.org/10.1016/j.plaphy.2013.02.008
Agrawal, G. , Sarkar, A. , Righetti, P. , Pedreschi, R. , Carpentier, S. , Wang, T. , Barkla, B. , Kohli, A. , Ndimba, B. , Bykova, N. , Rampitsch, C. , Zolla, L. , Rafudeen, M. , Cramer, R. , Bindschedler, L. , Tsakirpaloglou, N. , Job, D. , Kikuchi, S. , Rakwal, R. (2013) A decade of plant proteomics and mass spectrometry: translation of technical advancements to food security and safety issues. Mass Spectrometry Reviews , 32 (5). pp. 335-365. ISSN: 1098-2787 | doi: https://dx.doi.org/10.1002/mas.21365
Cramer, R. , Pirkl, A. , Hillenkamp, F. , Dreisewerd, K. (2013) AP-UV-MALDI mit flüssigen Matrizes: stabile Ionenausbeuten von mehrfach geladenen Peptid- und Proteinionen für die empfindliche Massenspektrometrie. Angewandte Chemie-International Edition , 125 (8). pp. 2420-2424. ISSN: 1521-3773 | doi: https://dx.doi.org/10.1002/ange.201208628
Greenland, B. , Bird, M. , Burattini, S. , Cramer, R. , O'Reilly, R. , Patterson, J. , Hayes, W. , Cardin, C. , Colquhoun, H. (2013) Mutual binding of polymer end-groups by complementary π–π-stacking: a molecular “Roman Handshake”. Chemical Communications , 49 (5). pp. 454-456. ISSN: 1359-7345 | doi: https://dx.doi.org/10.1039/C2CC35965K
Cramer, R. , Pirkl, A. , Hillenkamp, F. , Dreisewerd, K. (2013) Liquid AP-UV-MALDI enables stable ion yields of multiply charged peptide and protein ions for sensitive analysis by mass spectrometry. Angewandte Chemie-International Edition , 52 (8). pp. 2364-2367. ISSN: 1521-3773 | doi: https://dx.doi.org/10.1002/anie.201208628

Cramer, R. and Westermeier, R. , eds. (2012) Difference Gel Electrophoresis (DIGE). Humana Press ISBN: 9781617795725 | doi: https://dx.doi.org/10.1007/978-1-61779-573-2
Pedersen, C. , van Themaat, E. , McGuffin, L. , Abbott, J. , Burgis, T. , Barton, G. , Bindschedler, L. , Lu, X. , Maekawa, T. , Weßling, R. , Cramer, R. , Thordal-Christensen, H. , Panstruga, R. , Spanu, P. (2012) Structure and evolution of barley powdery mildew effector candidates. BMC Genomics , 13 (1). pp. 694. ISSN: 1471-2164 | doi: https://dx.doi.org/10.1186/1471-2164-13-694
Smith, C. , Mills, D. , Cramer, R. (2012) Application of DIGE and mass spectrometry in the study of type 2 Diabetes Mellitus (T2DM) mouse models. In: Cramer, R. and Westermeier, R. , (eds.) Difference Gel Electrophoresis (DIGE). Methods in molecular biology Methods in Molecular Biology (854). pp. 299-318. ISSN: 1064-3745 ISBN: 9781617795725 | doi: https://dx.doi.org/10.1007/978-1-61779-573-2_21
Sarsby, J. , Towers, M. , Stain, C. , Cramer, R. , Koroleva, O. (2012) Mass spectrometry imaging of glucosinolates in arabidopsis flowers and siliques. Phytochemistry , 77 pp. 110-118. ISSN: 0031-9422 | doi: https://dx.doi.org/10.1016/j.phytochem.2012.01.026
Agrawal, G. , Sarkar, A. , Agrawal, R. , Ndimba, B. , Tanou, G. , Dunn, M. , Kieselbach, T. , Cramer, R. , Weinkoop, S. , Chen, S. , Rafudeen, M. , Deswal, R. , Barkla, B. , Weckwerth, W. , Heazlewood, J. , Renaut, J. , Job, D. , Chakraborty, N. , Rakwal, R. (2012) Boosting the globalization of plant proteomics through INPPO: current developments 3 and future prospects. Proteomics , 12 (3). pp. 359-368. ISSN: 1615-9853 | doi: https://dx.doi.org/10.1002/pmic.201290018

Cramer, R. (2011) Editorial for “Advances in Biological Mass Spectrometry and Proteomics”. Methods , 54 (4). pp. 349-350. ISSN: 1046-2023 | doi: https://dx.doi.org/10.1016/j.ymeth.2011.07.007
Timms, J. , Menon, U. , Devetyarov, D. , Tiss, A. , Camuzeaux, S. , McCurrie, K. , Nouretdinov, I. , Burford, B. , Smith, C. , Gentry-Maharaj, A. , Hallett, R. , Ford, J. , Luo, Z. , Vovk, V. , Gammerman, A. , Cramer, R. , Jacobs, I. (2011) Early detection of ovarian cancer in samples pre-diagnosis using CA125 and MALDI-MS peaks. Cancer Genomics and Proteomics , 8 (6). pp. 289-305. ISSN: 1790-6245
Koroleva, O. and Cramer, R. (2011) Single-cell proteomic analysis of glucosinolate-rich S-cells in Arabidopsis thaliana. Methods , 54 (4). pp. 413-423. ISSN: 1046-2023 | doi: https://dx.doi.org/10.1016/j.ymeth.2011.06.005
Bauer, C. , Kleinjung, F. , Smith, C. , Towers, M. , Tiss, A. , Chadt, A. , Dreja, T. , Beule, D. , Al-Hasani, H. , Reinert, K. , Schuchhardt, J. , Cramer, R. (2011) Biomarker discovery and redundancy reduction towards classification using a multi-factorial MALDI-TOF MS T2DM mouse model dataset. BMC Bioinformatics , 12 ISSN: 1471-2105 | doi: https://dx.doi.org/10.1186/1471-2105-12-140
Bindschedler, L. and Cramer, R. (2011) Fully automated software solution for protein quantitation by global metabolic labeling with stable isotopes. Rapid Communications in Mass Spectrometry , 25 (11). pp. 1461-1471. ISSN: 1097-0231 | doi: https://dx.doi.org/10.1002/rcm.4872
Bindschedler, L. and Cramer, R. (2011) Quantitative plant proteomics. PROTEOMICS , 11 (4). pp. 756-775. ISSN: 1615-9861 | doi: https://dx.doi.org/10.1002/pmic.201000426
Stringano, E. , Cramer, R. , Hayes, W. , Smith, C. , Gibson, T. , Mueller-Harvey, I. (2011) Deciphering the complexity of sainfoin (Onobrychis viciifolia) proanthocyanidins by MALDI-TOF mass spectrometry with a judicious choice of isotope patterns and matrixes. Analytical Chemistry , 83 (11). pp. 4147-4153. ISSN: 0003-2700 | doi: https://dx.doi.org/10.1021/ac2003856
Bindschedler, L. , McGuffin, L. , Burgis, T. , Spanu, P. , Cramer, R. (2011) Proteogenomics and in silico structural and functional annotation of the barley powdery mildew Blumeria graminis f. sp. hordei. Methods , 54 (4). pp. 432-441. ISSN: 1046-2023 | doi: https://dx.doi.org/10.1016/j.ymeth.2011.03.006
Bauer, C. , Cramer, R. , Schuchhardt, J. (2011) Evaluation of peak-picking algorithms for protein mass spectrometry. In: Hamacher, M. , Eisenacher, M. , Stephan, C. , (eds.) Data mining in proteomics: from standards to applications. Methods in molecular biology , 696. Humana Press , USA. pp. 341-352. ISBN: 9781607619864 | doi: https://dx.doi.org/10.1007/978-1-60761-987-1_22
Tiss, A. , Smith, C. , Cramer, R. (2011) MALDI MS-based biomarker profiling of blood samples. In: Ivanov, A. and Lazarev, A. , (eds.) Sample preparation in biological mass spectrometry. Springer , New York. pp. 733-747. ISBN: 9789400707580
Bindschedler, L. , Smith, C. , Cramer, R. (2011) Quantitative plant proteomics using hydroponic isotope labeling of entire plants (HILEP). In: Ivanov, A. and Lazarev, A. , (eds.) Sample preparation in biological mass spectrometry. , XVI. Springer , New York. ISBN: 9789400707580

Stringano, E. , Hayot, C. , Smith, L. , Theodoridou, K. , Aufrere, J. , Brown, R. , Hayes, W. , Cramer, R. , Mueller-Harvey, I. (2010) Thiolytic screening method for exploring condensed tannin variation in a unique sainfoin germplasm bank. Planta Medica , 76 (12). ISSN: 1439-0221 | doi: https://dx.doi.org/10.1055/s-0030-1264189
Stringano, E. , Gea, A. , Cramer, R. , Hayes, W. , Mueller-Harvey, I. (2010) Structural diversity of sainfoin (Onobrychis viciifolia) tannins.
Tiss, A. , Timms, J. , Smith, C. , Devetyarov, D. , Gentry-Maharaj, A. , Camuzeaux, S. , Burford, B. , Nouretdinov, I. , Ford, J. , Luo, Z. , Jacobs, I. , Menon, U. , Gammerman, A. , Cramer, R. (2010) Highly accurate detection of ovarian cancer using CA125 but limited improvement with serum matrix-assisted laser desorption/ionization time-of-flight mass spectrometry profiling. International Journal of Gynecological Cancer , 20 (9). pp. 1518-1524. ISSN: 1048-891x | doi: https://dx.doi.org/10.1111/IGC.0b013e3181fc1990
Spanu, P. , Abbott, J. , Amselem, J. , Burgis, T. , Soanes, D. , Stuber, K. , Loren van Themaat, E. , Brown, J. , Butcher, S. , Gurr, S. , Lebrun, M. , Ridout, C. , Schulze-Lefert, P. , Talbot, N. , Ahmadinejad, N. , Ametz, C. , Barton, G. , Benjdia, M. , Bidzinski, P. , Bindschedler, L. , Both, M. , Brewer, M. , Cadle-Davidson, L. , Cadle-Davidson, M. , Collemare, J. , Cramer, R. , Frenkel, O. , Godfrey, D. , Harriman, J. , Hoede, C. , King, B. , Klages, S. , Kleemann, J. , Knoll, D. , Koti, P. , Kreplak, J. , Lopez-Ruiz, F. , Lu, X. , Maekawa, T. , Mahanil, S. , Micali, C. , Milgroom, M. , Montana, G. , Noir, S. , O'Connell, R. , Oberhaensli, S. , Parlange, F. , Pedersen, C. , Quesneville, H. , Reinhardt, R. , Rott, M. , Sacristan, S. , Schmidt, S. , Schon, M. , Skamnioti, P. , Sommer, H. , Stephens, A. , Takahara, H. , Thordal-Christensen, H. , Vigouroux, M. , Wessling, R. , Wicker, T. , Panstruga, R. (2010) Genome expansion and gene loss in powdery mildew fungi reveal tradeoffs in extreme parasitism. Science , 330 (6010). pp. 1543-1546. ISSN: 1095-9203 | doi: https://dx.doi.org/10.1126/science.1194573
Flatley, B. , Malone, P. , Cramer, R. (2010) MS-based clinical proteomics: biomarker discovery in men’s cancer . European Pharmaceutical Review (5). pp. 53-56. ISSN: 1360-8606
Timms, J. , Cramer, R. , Camuzeaux, S. , Tiss, A. , Smith, C. , Burford, B. , Nouretdinov, I. , Devetyarov, D. , Gentry-Maharaj, A. , Ford, J. , Luo, Z. , Gammerman, A. , Menon, U. , Jacobs, I. (2010) Peptides generated ex vivo from serum proteins by tumor-specific exopeptidases are not useful biomarkers in ovarian cancer. Clinical Chemistry , 56 (2). pp. 262-271. ISSN: 1530-8561 | doi: https://dx.doi.org/10.1373/clinchem.2009.133363
Towers, M. , McKendrick, J. , Cramer, R. (2010) Introduction of 4-chloro-alpha-cyanocinnamic acid liquid matrices for high sensitivity UV-MALDI MS. Journal of Proteome Research , 9 (4). pp. 1931-1940. ISSN: 1535-3893 | doi: https://dx.doi.org/10.1021/pr901089j
Fenton, T. , Gwalter, J. , Cramer, R. , Gout, I. (2010) S6K1 is acetylated at lysine 516 in response to growth factor stimulation. Biochemical and biophysical research communications , 398 (3). pp. 400-405. ISSN: 1090-2104 | doi: https://dx.doi.org/10.1016/j.bbrc.2010.06.081
Koroleva, O. , Gibson, T. , Cramer, R. , Stain, C. (2010) Glucosinolate-accumulating S-cells in Arabidopsis leaves and flower stalks undergo programmed cell death at early stages of differentiation. The Plant Journal , 64 (3). pp. 456-469. ISSN: 0960-7412 | doi: https://dx.doi.org/10.1111/j.1365-313X.2010.04339.x
Tiss, A. , Smith, C. , Menon, U. , Jacobs, I. , Timms, J. , Cramer, R. (2010) A well-characterised peak identification list of MALDI MS profile peaks for human blood serum. Proteomics , 10 (18). pp. 3388-3392. ISSN: 1615-9853 | doi: https://dx.doi.org/10.1002/pmic.201000100

Bindschedler, L. , Towers, M. , Cramer, R. (2009) Hydroponic isotope labeling of entire plants (HILEP) for quantitative plant proteomics.
Bindschedler, L. , Burgis, T. , Mills, D. , Ho, J. , Spanu, P. , Cramer, R. (2009) In planta proteomics and proteogenomics of the biotrophic barley fungal pathogen blumeria f.sp. hordei.
Ortiz-Chao, . , Gomez-Ruiz, . , Rastall, . , Mills, D. , Cramer, . , Pihlanto, . , Korhonen, . , Jauregi, . (2009) Production of novel ACE inhibitory peptides from beta-lactoglobulin using Protease N Amano . International Dairy Journal , 19 (2). pp. 69-76. ISSN: 0958-6946 | doi: https://dx.doi.org/10.1016/j.idairyj.2008.07.011
Palmblad, . , Tiss, . , Cramer, . (2009) Mass spectrometry in clinical proteomics - from the present to the future. Proteomics Clinical Applications , 3 (1). pp. 6-17. ISSN: 1862-8346 | doi: https://dx.doi.org/10.1002/prca.200800090
Kovaleva, . , Kiyamova, . , Cramer, . , Krynytskyy, . , Gout, . , Filonenko, . , Gout, . (2009) Purification and molecular cloning of antimicrobial peptides from Scots pine seedlings. Peptides , 30 (12). pp. 2136-2143. ISSN: 0196-9781 | doi: https://dx.doi.org/10.1016/j.peptides.2009.08.007
Gammerman, . , Vovk, . , Burford, . , Nouretdinov, . , Luo, . , Chervonenkis, . , Waterfield, . , Cramer, . , Tempst, . , Villanueva, . , Kabir, . , Camuzeaux, . , Timms, . , Menon, . , Jacobs, . (2009) Serum proteomic abnormality predating screen detection of ovarian cancer. Computer Journal , 52 (3). pp. 326-333. ISSN: 0010-4620 | doi: https://dx.doi.org/10.1093/comjnl/bxn021
Bindschedler, L. , Burgis, T. , Mills, D. , Ho, J. , Cramer, R. , Spanu, P. (2009) In planta proteomics and proteogenomics of the biotrophic barley fungal pathogen blumeria graminis f. sp hordei. Molecular & Cellular Proteomics , 8 (10). pp. 2368-2381. ISSN: 1535-9476 | doi: https://dx.doi.org/10.1074/mcp.M900188-MCP200
Towers, . , Rollin, . , Tiss, . , Cramer, . (2009) Is liquid UV-MALDI a real alternative to solid state UV-MALDI?.
Towers, . , McKendrick, J. , Cramer, . (2009) High Sensitivity α-cyano-4-Chlorocinnamic Acid Liquid Matrices for UV-MALDI MS.
Tiss, . , Smith, . , Menon, . , Jacobs, . , Timms, . , Cramer, . (2009) An extensive peptide identification list of MALDI MS profile peaks from the analysis of human blood serum.
Cramer, . (2009) MALDI MS. In: Reinders, . and Sickmann, . , (eds.) Proteomics: methods and protocols. Methods in molecular biology , 564. Humana Press , Totowa, New Jersey. pp. 85-103. ISBN: 9781607611561 | doi: https://dx.doi.org/10.1007/978-1-60761-157-8_5

Timms, . and Cramer, . (2008) Difference gel electrophoresis. Proteomics , 8 (23-24). pp. 4886-4897. ISSN: 1615-9853 | doi: https://dx.doi.org/10.1002/pmic.200800298
Huang, H. , Cendan, C. , Roza, C. , Okuse, K. , Cramer, R. , Timms, J. , Wood, J. (2008) Proteomic profiling of neuromas reveals alterations in protein composition and local protein synthesis in hyper-excitable nerves. Molecular Pain , 4 pp. 33. ISSN: 1744-8069 | doi: https://dx.doi.org/10.1186/1744-8069-4-33
Bindschedler, . , Palmblad, . , Cramer, . (2008) Hydroponic isotope labelling of entire plants (HILEP) for quantitative plant proteomics; an oxidative stress case study. Phytochemistry , 69 (10). pp. 1962-1972. ISSN: 0031-9422 | doi: https://dx.doi.org/10.1016/j.phytochem.2008.04.007
Towers, . and Cramer, . (2008) High-sensitivity liquid UV-MALDI-MS analysis. pp. TP 047.
Tiss, . , Smith, . , Timms, . , Luo, . , Gammerman, . , Waterfield, . , Menon, . , Jacobs, . , Cramer, . (2008) A robust and sensitive automated method for MS-based serum pattern diagnostics using well-established ZipTip technology and ultrafiltration. pp. MP 624.
Bindschedler, . and Cramer, . (2008) Equalisation of protein amounts for overcoming the high dynamic protein expression range in the analysis of plant proteomes. pp. MP 573.

Palmblad, M. , Towers, M. , Cramer, R. (2007) Multiplexed quantitative proteomics using differential metabolic 15N-labeling.
Palmbland, M. , Towers, M. , Cramer, R. (2007) Investigation of liquid MALDI and optimization for instrument tuning and quantitative measurements.
Cramer, R. and Dreisewerd, K. (2007) UV matrix-assisted laser desorption ionization: principles instrumentation and applications. In: Gross, M. and Capriolo, R. , (eds.) The encyclopedia of mass spectrometry. , 6. Elsevier ISBN: 9780080438016
Tiss, A. , Smith, C. , Camuzeaux, S. , Kabir, M. , Gayther, S. , Menon, U. , Waterfield, M. , Timms, J. , Jacobs, I. , Cramer, R. (2007) Serum peptide profiling using MALDI mass spectrometry. Proteomics , 7 (S1). pp. 77-89. ISSN: 1615-9853 | doi: https://dx.doi.org/10.1002/pmic.200700746
Towers, . and Cramer, . (2007) Liquid matrices for analyses by UV-MALDI mass spectrometry. Spectroscopy , 22 (11). pp. 29-. ISSN: 0887-6703
Palmblad, . , Mills, D. , Bindschedler, . , Cramer, . (2007) Chromatographic alignment of LC-MS and LC-MS/MS datasets by genetic algorithm feature extraction. Journal of the American Society for Mass Spectrometry , 18 (10). pp. 1835-1843. ISSN: 1044-0305 | doi: https://dx.doi.org/10.1016/j.jasms.2007.07.018
Palmblad, . , Bindschedler, . , Cramer, . (2007) Quantitative proteomics using uniform N-15-labeling, MASCOT, and the trans-proteomic pipeline. Proteomics , 7 (19). pp. 3462-3469. ISSN: 1615-9853 | doi: https://dx.doi.org/10.1002/pmic.200700180
Palmblad, M. and Cramer, R. (2007) Liquid matrix deposition on conductive hydrophobic surfaces for tuning and quantitation in UV-MALDI mass spectrometry. Journal of the American Society of Mass Spectrometry , 18 (4). pp. 693-697. ISSN: 1044-0305 | doi: https://dx.doi.org/10.1016/j.jasms.2006.11.013

Bindschedler, L. , Palmblad, M. , Cramer, R. (2006) First-dimension separation with the MicroRotoforTM cell prior to SDS-PAGE and LC-MS/MS analysis. Bio-Rad Bulletin , 5451 pp. 1-4.
Palmblad, M. , Bindschedler, L. , Gibson, T. , Cramer, R. (2006) Comparison of bottom-up protein identification methods.
Jacob, . and Cramer, . (2006) PIGOK: linking protein identity to gene ontology and function. Journal of Proteome Research , 5 (12). pp. 3429-3432. ISSN: 1535-3893 | doi: https://dx.doi.org/10.1021/pr0601537
Palmblad, . , Bindschedler, . , Gibson, T. , Cramer, . (2006) Automatic internal calibration in liquid chromatography/Fourier transform ion cyclotron resonance mass spectrometry of protein digests. Rapid Communications in Mass Spectrometry , 20 (20). pp. 3076-3080. ISSN: 0951-4198 | doi: https://dx.doi.org/10.1002/rcm.2707
Nagano, . , Bornhauser, . , Warnasuriya, . , Entwistle, . , Cramer, . , Lindholm, . , Naaby-Hansen, . (2006) PDGF regulates the actin cytoskeleton through hnRNP-K-mediated activation of the ubiquitin E-3-ligase MIR. EMBO Journal , 25 (9). pp. 1871-1882. ISSN: 0261-4189 | doi: https://dx.doi.org/10.1038/sj.emboj.7601059

Jacob, R. , Thompson, A. , Cramer, R. (2005) A preliminary comparative analysis of the H. sapiens saliva proteome between cysteine fractionation,performic acid oxidation LC/MALDI/MS/MS and LC/ESI/MS/MS.
Weeks, . , Sinclair, . , Jacob, . , Saxton, . , Kirby, . , Jones, . , Waterfield, . , Cramer, . , Timms, . (2005) Stress-induced changes in the Schizosaccharomyces pombe proteome using two-dimensional difference gel electrophoresis, mass spectrometry and a novel integrated robotics platform. Proteomics , 5 (6). pp. 1669-1685. ISSN: 1615-9853 | doi: https://dx.doi.org/10.1002/pmic.200401241
Hastie, . , Saxton, . , Akpan, . , Cramer, . , Masters, . , Naaby-Hans, . (2005) Combined affinity labelling and mass spectrometry analysis of differential cell surface protein expression in normal and prostate cancer cells. Oncogene , 24 (38). pp. 5905-5913. ISSN: 0950-9232 | doi: https://dx.doi.org/10.1038/sj.onc.1208747
de Graauw, . , Tijdens, . , Cramer, . , Corless, . , Timms, . , van de Water, . (2005) Heat shock protein 27 is the major differentially phosphorylated protein involved in renal epithelial cellular stress response and controls focal adhesion organization and apoptosis. The Journal of Biological Chemistry , 280 (33). pp. 29885-29898. ISSN: 1083-351X | doi: https://dx.doi.org/10.1074/jbc.M412708200
Cutillas, . , Biber, . , Marks, . , Jacob, . , Stieger, . , Cramer, . , Waterfield, . , Burlingame, . , Unwin, . (2005) Proteomic analysis of plasma membrane vesicles isolated from the rat renal cortex. Proteomics , 5 (1). pp. 101-112. ISSN: 1615-9853
Cramer, . , Gobom, . , Nordhoff, . (2005) High-throughput proteomics using matrix-assisted laser desorption/ionization mass spectrometry. Expert Review of Proteomics , 2 (3). pp. 407-420. ISSN: 1478-9450 | doi: https://dx.doi.org/10.1586/14789450.2.3.407
Cramer, . and Corless, . (2005) Liquid ultraviolet matrix-assisted laser desorption/ionization mass spectrometry for automated proteomic analysis. Proteomics , 5 (2). pp. 360-370. ISSN: 1615-9853 | doi: https://dx.doi.org/10.1002/pmic.200400956
Chan, . , Gharbi, . , Gaffney, . , Cramer, . , Waterfield, . , Timms, . (2005) Proteomic analysis of redox- and ErbB2-dependent changes in mammary luminal epithelial cells using cysteine- and lysine-labelling two-dimensional difference gel electrophoresis. Proteomics , 5 (11). pp. 2908-2926. ISSN: 1615-9853 | doi: https://dx.doi.org/10.1002/pmic.200401300
Barnouin, . , Hart, . , Thompson, . , Okuyama, . , Waterfield, . , Cramer, . (2005) Enhanced phosphopeptide isolation by Fe(III)-IMAC using 1,1,1,3,3,3-hexafluoroisopropanol. Proteomics , 5 (17). pp. 4376-4388. ISSN: 1615-9853 | doi: https://dx.doi.org/10.1002/pmic.200401323
Naaby-Hansen, . , Warnasuriya, . , Hastie, . , Gallney, . , Cramer, . (2005) Proteomic approaches in the analysis of hypertension. In: Fennell, . and Baker, . , (eds.) Hypertension: methods and protocols . Methods in molecular medicine , 108. Humana Press , New Jersey. pp. 275-296. ISBN: 9781588293237

Professor Rainer Cramer

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Professor Rainer Cramer

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