Angela Bithell

Email:
a.bithell@reading.ac.uk
Phone:
+44 (0) 118 378 6570
Job title:
Associate Professor

Responsibilities:

Director of Pharmacology and Therapeutics
Pharmacy Wellbeing, Inclusion, Diversity and Equality Lead
SCFP Wellbeing, Inclusion, Diversity and Equality Committee member (including Athena SWAN)
SCFP Career's Champion (as part of SCFP Athena SWAN)
Main Teaching: MPharm Programme (including PM2A2, PM3A, PM3B, PM4A)
PM3A Module Convenor

Areas of interest

My research interests are in the molecular and cellular mechanisms that underlie normal developmental of the central nervous system (CNS) and CNS-related disorders. A current specific focus in my group is the development and use of 2D and 3D stem cell-derived neuronal-glial in vitro models to investigate the underlying mechanisms of neurodegenerative diseases (including Alzheimer's disease) and as drug discovery and screening platforms. Other work includes combining model systems and 'omics technologies to determine the gene regulatory networks and role of the epigenome in stem cells (pluripotent and neural), neurons and glia in health and disease.

Professional bodies/affiliations

Fellow of the Higher Education Academy (FHEA)
Reading Local Group Representative for the British Neuroscience Association (BNA)
Alzheimer's UK (ARUK) Oxford Network Committee member

Publications

Toman, M. , Wade, J. , Verkhratsky, A. , Dallas, M. ORCID: 0000-0002-5190-0522 , Bithell, A. , Flanagan, B. , Harkin, J. , McDaid, L. (2023) The influence of astrocytic leaflet motility on ionic signalling and homeostasis at active synapses. Scientific Reports , 13 (1). ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-023-30189-8
Day, C. , Silva, J. , Munro, R. , Baker, T. , Wolff, C. , Bithell, A. , Stephens, G. ORCID: 0000-0002-8966-4238 (2023) Anti-AMPA receptor autoantibodies reduce excitatory currents in rat hippocampal neurons. Pharmaceuticals , 16 (1). ISSN: 1424-8247 | doi: https://dx.doi.org/10.3390/ph16010077

Poshtkohi, A. ORCID: 0000-0001-5636-1567 , Wade, J. ORCID: 0000-0003-1300-9429 , McDaid, L. ORCID: 0000-0002-1197-4375 , Liu, J. ORCID: 0000-0002-9790-1571 , Dallas, M. ORCID: 0000-0002-5190-0522 , Bithell, A. ORCID: 0000-0002-0294-078X (2021) Mathematical modelling of human P2X-mediated plasma membrane electrophysiology and calcium dynamics in microglia. PLOS Computational Biology , 17 (11). pp 0. ISSN: 1553-7358 | doi: https://dx.doi.org/10.1371/journal.pcbi.1009520
Fannon, O. , Bithell, A. , Whalley, B. , Delivopoulos, E. ORCID: 0000-0001-6156-1133 (2021) A fibre alginate co-culture platform for the differentiation of mESC and modelling of the neural tube. Frontiers in Neuroscience , 14 ISSN: 1662-453X | doi: https://dx.doi.org/10.3389/fnins.2020.524346

Wade, J. , Breslin, K. , Wong-Lin, K. , Harkin, J. , Flanagan, B. , Van Zalinge, H. , Hall, S. , Dallas, M. , Bithell, A. , Verkhratsky, A. , McDaid, L. (2019) Calcium microdomain formation at the perisynaptic cradle due to NCX reversal: a computational study. Frontiers in Cellular Neuroscience , 13 ISSN: 1662-5102 | doi: https://dx.doi.org/10.3389/fncel.2019.00185
Kang, S. , Hayashi, Y. , Bruyns-Haylett, M. , Baker, D. , Boura, M. , Wang, H. , Karatzas, K. , Serra, I. , Bithell, A. , Williams, C. , Field, D. , Zheng, Y. (2019) Supplemental vitamin B-12 enhances the neural response to sensory stimulation in the barrel cortex of healthy rats but does not affect spontaneous neural activity. Journal of Nutrition , 149 (5). pp. 730-737. ISSN: 1541-6100 | doi: https://dx.doi.org/10.1093/jn/nxz011

Centeno, E. , Cimarosti, H. , Bithell, A. (2018) 2D versus 3D human induced pluripotent stem cell-derived cultures for neurodegenerative disease modelling. Molecular Neurodegeneration , 13 (1). ISSN: 1750-1326 | doi: https://dx.doi.org/10.1186/s13024-018-0258-4

Bhinge, A. , Namboori, S. , Bithell, A. , Soldati, C. , Buckley, N. , Stanton, L. (2016) MiR-375 is essential for human spinal motor neuron development and may be involved in motor neuron degeneration. Stem Cells , 34 (1). pp. 124-134. ISSN: 1066-5099 | doi: https://dx.doi.org/10.1002/stem.2233
Michelucci, A. , Bithell, A. , Burney, M. , Johnston, C. , Wong, K. , Teng, S. , Desai, J. , Gumbleton, N. , Anderson, G. , Stanton, L. , Williams, B. , Buckley, N. (2016) The neurogenic potential of astrocytes is regulated by inflammatory signals. Molecular Neurobiology , 53 (6). pp. 3724-3739. ISSN: 1559-1182 | doi: https://dx.doi.org/10.1007/s12035-015-9296-x

Smith, I. , Haag, M. , Ugbode, C. , Tams, D. , Rattray, M. , Przyborski, S. , Bithell, A. , Whalley, B. (2015) Neuronal-glial populations form functional networks in a biocompatible 3D scaffold. Neuroscience Letters , 609 pp. 198-202. ISSN: 0304-3940 | doi: https://dx.doi.org/10.1016/j.neulet.2015.10.044
Raposo, A. , Vasconcelos, F. , Drechsel, D. , Marie, C. , Johnston, C. , Dolle, D. , Bithell, A. , Gillotin, S. , van den Berg, D. , Ettwiller, L. , Flicek, P. , Crawford, G. , Parras, C. , Berninger, B. , Buckley, N. , Guillemot, F. , Castro, D. (2015) Ascl1 coordinately regulates gene expression and the chromatin landscape during neurogenesis. Cell reports , 10 (9). pp. 1544-1556. ISSN: 2211-1247 | doi: https://dx.doi.org/10.1016/j.celrep.2015.02.025
Soldati, C. , Caramanica, P. , Burney, M. , Toselli, C. , Bithell, A. , Augusti-Tocco, G. , Stanton, L. , Biagioni, S. , Buckley, N. , Cacci, E. (2015) RE1 silencing transcription factor/neuron-restrictive silencing factor regulates expansion of adult mouse subventricular zone-derived neural stem/progenitor cells in vitro. Journal of Neuroscience Research , 93 (8). pp. 1203-1214. ISSN: 1097-4547 | doi: https://dx.doi.org/10.1002/jnr.23572

Soldati, C. , Bithell, A. , Johnston, C. , Wong, K. , Stanton, L. , Buckley, N. (2013) Dysregulation of REST-regulated coding and non-coding RNAs in a cellular model of Huntington's disease. Journal of Neurochemistry , 124 (3). pp. 418-30. ISSN: 0022-3042 | doi: https://dx.doi.org/10.1111/jnc.12090
Denk, F. , Huang, W. , Sidders, B. , Bithell, A. , Crow, M. , Grist, J. , Sharma, S. , Ziemek, D. , Rice, A. , Buckley, N. , McMahon, S. (2013) HDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain. Pain , 154 (9). pp. 1668-1679. ISSN: 0304-3959 | doi: https://dx.doi.org/10.1016/j.pain.2013.05.021
Burney, M. , Johnston, C. , Wong, K. , Teng, S. , Beglopoulos, V. , Stanton, L. , Williams, B. , Bithell, A. , Buckley, N. (2013) An epigenetic signature of developmental potential in neural stem cells and early neurons.. Stem Cells , 31 (9). pp. 1868-1880. ISSN: 1066-5099 | doi: https://dx.doi.org/10.1002/stem.1431

Soldati, C. , Bithell, A. , Johnston, C. , Wong, K. , Teng, S. , Beglopoulos, V. , Stanton, L. , Buckley, N. (2012) Repressor element 1 silencing transcription factor couples loss of pluripotency with neural induction and neural differentiation. Stem Cells , 30 (3). pp. 425-434. ISSN: 1066-5099 | doi: https://dx.doi.org/10.1002/stem.1004

Soldati, C. , Bithell, A. , Conforti, P. , Cattaneo, E. , Buckley, N. (2011) Rescue of gene expression by modified REST decoy oligonucleotides in a cellular model of Huntington's disease. Journal of Neurochemistry , 116 (3). pp. 415-425. ISSN: 0022-3042 | doi: https://dx.doi.org/10.1111/j.1471-4159.2010.07122.x
Castro, D. , Martynoga, B. , Parras, C. , Ramesh, V. , Pacary, E. , Johnston, C. , Drechsel, D. , Lebel-Potter, M. , Garcia, L. , Hunt, C. , Dolle, D. , Bithell, A. , Ettwiller, L. , Buckley, N. , Guillemot, F. (2011) A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets. Genes & Development , 25 (9). pp. 930-945. ISSN: 1549-5477 | doi: https://dx.doi.org/10.1101/gad.627811
Bithell, A. (2011) REST: transcriptional and epigenetic regulator. Epigenomics , 3 (1). pp. 47-58. ISSN: 1750-192X | doi: https://dx.doi.org/10.2217/EPI.10.76

Buckley, N. , Johnson, R. , Zuccato, C. , Bithell, A. , Cattaneo, E. (2010) The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease. Neurobiology of Disease , 39 (1). pp. 28-39. ISSN: 1095-953x | doi: https://dx.doi.org/10.1016/j.nbd.2010.02.003
Bithell, A. , Hsu, T. , Kandanearatchi, A. , Landau, S. , Everall, I. , Tsuang, M. , Chana, G. , Williams, B. (2010) Expression of the Rap1 guanine nucleotide exchange factor, MR-GEF, is altered in individuals with bipolar disorder. PLoS ONE , 5 (4). ISSN: 1932-6203 | doi: https://dx.doi.org/10.1371/journal.pone.0010392

Bithell, A. , Finch, S. , Hornby, M. , Williams, B. (2008) Fibroblast growth factor 2 maintains the neurogenic capacity of embryonic neural progenitor cells in vitro but changes their neuronal subtype specification. Stem Cells , 26 (6). pp. 1565-1674. ISSN: 1066-5099 | doi: https://dx.doi.org/10.1634/stemcells.2007-0832

Bithell, A. and Williams, B. (2005) Neural stem cells and cell replacement therapy: making the right cells. Clinical Science , 108 (1). pp. 13-22. ISSN: 0143-5221

Bithell, A. , Alberta, J. , Hornby, F. , Stiles, C. , Williams, B. (2003) Expression of the guanine nucleotide exchange factor, mr-gef, is regulated during the differentiation of specific subsets of telencephalic neurons. Brain Research , 146 (1-2). pp. 107-18. ISSN: 0006-8993 | doi: https://dx.doi.org/10.1016/j.devbrainres.2003.09.017

Angela Bithell

Areas of interest

Professional bodies/affiliations

Publications

2023

2021

2019

2018

2016

2015

2013

2012

2011

2010

2008

2005

2003