Angela Bithell

-
+44 (0) 118 378 6570
-
Associate Professor
- Director of Pharmacology and Therapeutics
- Pharmacy Wellbeing, Inclusion, Diversity and Equality Lead
- SCFP Wellbeing, Inclusion, Diversity and Equality Committee member (including Athena SWAN)
- SCFP Career's Champion (as part of SCFP Athena SWAN)
- Main Teaching: MPharm Programme (including PM2A2, PM3A, PM3B, PM4A)
- PM3A Module Convenor
Areas of interest
My research interests are in the molecular and cellular mechanisms that underlie normal developmental of the central nervous system (CNS) and CNS-related disorders. A current specific focus in my group is the development and use of 2D and 3D stem cell-derived neuronal-glial in vitro models to investigate the underlying mechanisms of neurodegenerative diseases (including Alzheimer's disease) and as drug discovery and screening platforms. Other work includes combining model systems and 'omics technologies to determine the gene regulatory networks and role of the epigenome in stem cells (pluripotent and neural), neurons and glia in health and disease.
Professional bodies/affiliations
- Fellow of the Higher Education Academy (FHEA)
- Reading Local Group Representative for the British Neuroscience Association (BNA)
- Alzheimer's UK (ARUK) Oxford Network Committee member
Publications
-
Toman, M.
,
Wade, J.
,
Verkhratsky, A.
,
Dallas, M.
ORCID: 0000-0002-5190-0522 , Bithell, A. , Flanagan, B. , Harkin, J. , McDaid, L. (2023) The influence of astrocytic leaflet motility on ionic signalling and homeostasis at active synapses. Scientific Reports , 13 (1). ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-023-30189-8
-
Day, C.
,
Silva, J.
,
Munro, R.
,
Baker, T.
,
Wolff, C.
,
Bithell, A.
,
Stephens, G.
ORCID: 0000-0002-8966-4238 (2023) Anti-AMPA receptor autoantibodies reduce excitatory currents in rat hippocampal neurons. Pharmaceuticals , 16 (1). ISSN: 1424-8247 | doi: https://dx.doi.org/10.3390/ph16010077
-
Poshtkohi, A.
ORCID: 0000-0001-5636-1567 , Wade, J.
ORCID: 0000-0003-1300-9429 , McDaid, L.
ORCID: 0000-0002-1197-4375 , Liu, J.
ORCID: 0000-0002-9790-1571 , Dallas, M.
ORCID: 0000-0002-5190-0522 , Bithell, A.
ORCID: 0000-0002-0294-078X (2021) Mathematical modelling of human P2X-mediated plasma membrane electrophysiology and calcium dynamics in microglia. PLOS Computational Biology , 17 (11). pp 0. ISSN: 1553-7358 | doi: https://dx.doi.org/10.1371/journal.pcbi.1009520
-
Fannon, O.
,
Bithell, A.
,
Whalley, B.
,
Delivopoulos, E.
ORCID: 0000-0001-6156-1133 (2021) A fibre alginate co-culture platform for the differentiation of mESC and modelling of the neural tube. Frontiers in Neuroscience , 14 ISSN: 1662-453X | doi: https://dx.doi.org/10.3389/fnins.2020.524346
- Wade, J. , Breslin, K. , Wong-Lin, K. , Harkin, J. , Flanagan, B. , Van Zalinge, H. , Hall, S. , Dallas, M. , Bithell, A. , Verkhratsky, A. , McDaid, L. (2019) Calcium microdomain formation at the perisynaptic cradle due to NCX reversal: a computational study. Frontiers in Cellular Neuroscience , 13 ISSN: 1662-5102 | doi: https://dx.doi.org/10.3389/fncel.2019.00185
- Kang, S. , Hayashi, Y. , Bruyns-Haylett, M. , Baker, D. , Boura, M. , Wang, H. , Karatzas, K. , Serra, I. , Bithell, A. , Williams, C. , Field, D. , Zheng, Y. (2019) Supplemental vitamin B-12 enhances the neural response to sensory stimulation in the barrel cortex of healthy rats but does not affect spontaneous neural activity. Journal of Nutrition , 149 (5). pp. 730-737. ISSN: 1541-6100 | doi: https://dx.doi.org/10.1093/jn/nxz011
- Centeno, E. , Cimarosti, H. , Bithell, A. (2018) 2D versus 3D human induced pluripotent stem cell-derived cultures for neurodegenerative disease modelling. Molecular Neurodegeneration , 13 (1). ISSN: 1750-1326 | doi: https://dx.doi.org/10.1186/s13024-018-0258-4
- Bhinge, A. , Namboori, S. , Bithell, A. , Soldati, C. , Buckley, N. , Stanton, L. (2016) MiR-375 is essential for human spinal motor neuron development and may be involved in motor neuron degeneration. Stem Cells , 34 (1). pp. 124-134. ISSN: 1066-5099 | doi: https://dx.doi.org/10.1002/stem.2233
- Michelucci, A. , Bithell, A. , Burney, M. , Johnston, C. , Wong, K. , Teng, S. , Desai, J. , Gumbleton, N. , Anderson, G. , Stanton, L. , Williams, B. , Buckley, N. (2016) The neurogenic potential of astrocytes is regulated by inflammatory signals. Molecular Neurobiology , 53 (6). pp. 3724-3739. ISSN: 1559-1182 | doi: https://dx.doi.org/10.1007/s12035-015-9296-x
- Smith, I. , Haag, M. , Ugbode, C. , Tams, D. , Rattray, M. , Przyborski, S. , Bithell, A. , Whalley, B. (2015) Neuronal-glial populations form functional networks in a biocompatible 3D scaffold. Neuroscience Letters , 609 pp. 198-202. ISSN: 0304-3940 | doi: https://dx.doi.org/10.1016/j.neulet.2015.10.044
- Raposo, A. , Vasconcelos, F. , Drechsel, D. , Marie, C. , Johnston, C. , Dolle, D. , Bithell, A. , Gillotin, S. , van den Berg, D. , Ettwiller, L. , Flicek, P. , Crawford, G. , Parras, C. , Berninger, B. , Buckley, N. , Guillemot, F. , Castro, D. (2015) Ascl1 coordinately regulates gene expression and the chromatin landscape during neurogenesis. Cell reports , 10 (9). pp. 1544-1556. ISSN: 2211-1247 | doi: https://dx.doi.org/10.1016/j.celrep.2015.02.025
- Soldati, C. , Caramanica, P. , Burney, M. , Toselli, C. , Bithell, A. , Augusti-Tocco, G. , Stanton, L. , Biagioni, S. , Buckley, N. , Cacci, E. (2015) RE1 silencing transcription factor/neuron-restrictive silencing factor regulates expansion of adult mouse subventricular zone-derived neural stem/progenitor cells in vitro. Journal of Neuroscience Research , 93 (8). pp. 1203-1214. ISSN: 1097-4547 | doi: https://dx.doi.org/10.1002/jnr.23572
- Soldati, C. , Bithell, A. , Johnston, C. , Wong, K. , Stanton, L. , Buckley, N. (2013) Dysregulation of REST-regulated coding and non-coding RNAs in a cellular model of Huntington's disease. Journal of Neurochemistry , 124 (3). pp. 418-30. ISSN: 0022-3042 | doi: https://dx.doi.org/10.1111/jnc.12090
- Denk, F. , Huang, W. , Sidders, B. , Bithell, A. , Crow, M. , Grist, J. , Sharma, S. , Ziemek, D. , Rice, A. , Buckley, N. , McMahon, S. (2013) HDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain. Pain , 154 (9). pp. 1668-1679. ISSN: 0304-3959 | doi: https://dx.doi.org/10.1016/j.pain.2013.05.021
- Burney, M. , Johnston, C. , Wong, K. , Teng, S. , Beglopoulos, V. , Stanton, L. , Williams, B. , Bithell, A. , Buckley, N. (2013) An epigenetic signature of developmental potential in neural stem cells and early neurons.. Stem Cells , 31 (9). pp. 1868-1880. ISSN: 1066-5099 | doi: https://dx.doi.org/10.1002/stem.1431
- Soldati, C. , Bithell, A. , Johnston, C. , Wong, K. , Teng, S. , Beglopoulos, V. , Stanton, L. , Buckley, N. (2012) Repressor element 1 silencing transcription factor couples loss of pluripotency with neural induction and neural differentiation. Stem Cells , 30 (3). pp. 425-434. ISSN: 1066-5099 | doi: https://dx.doi.org/10.1002/stem.1004
- Soldati, C. , Bithell, A. , Conforti, P. , Cattaneo, E. , Buckley, N. (2011) Rescue of gene expression by modified REST decoy oligonucleotides in a cellular model of Huntington's disease. Journal of Neurochemistry , 116 (3). pp. 415-425. ISSN: 0022-3042 | doi: https://dx.doi.org/10.1111/j.1471-4159.2010.07122.x
- Castro, D. , Martynoga, B. , Parras, C. , Ramesh, V. , Pacary, E. , Johnston, C. , Drechsel, D. , Lebel-Potter, M. , Garcia, L. , Hunt, C. , Dolle, D. , Bithell, A. , Ettwiller, L. , Buckley, N. , Guillemot, F. (2011) A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets. Genes & Development , 25 (9). pp. 930-945. ISSN: 1549-5477 | doi: https://dx.doi.org/10.1101/gad.627811
- Bithell, A. (2011) REST: transcriptional and epigenetic regulator. Epigenomics , 3 (1). pp. 47-58. ISSN: 1750-192X | doi: https://dx.doi.org/10.2217/EPI.10.76
- Buckley, N. , Johnson, R. , Zuccato, C. , Bithell, A. , Cattaneo, E. (2010) The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease. Neurobiology of Disease , 39 (1). pp. 28-39. ISSN: 1095-953x | doi: https://dx.doi.org/10.1016/j.nbd.2010.02.003
- Bithell, A. , Hsu, T. , Kandanearatchi, A. , Landau, S. , Everall, I. , Tsuang, M. , Chana, G. , Williams, B. (2010) Expression of the Rap1 guanine nucleotide exchange factor, MR-GEF, is altered in individuals with bipolar disorder. PLoS ONE , 5 (4). ISSN: 1932-6203 | doi: https://dx.doi.org/10.1371/journal.pone.0010392
- Bithell, A. , Finch, S. , Hornby, M. , Williams, B. (2008) Fibroblast growth factor 2 maintains the neurogenic capacity of embryonic neural progenitor cells in vitro but changes their neuronal subtype specification. Stem Cells , 26 (6). pp. 1565-1674. ISSN: 1066-5099 | doi: https://dx.doi.org/10.1634/stemcells.2007-0832
- Bithell, A. and Williams, B. (2005) Neural stem cells and cell replacement therapy: making the right cells. Clinical Science , 108 (1). pp. 13-22. ISSN: 0143-5221
- Bithell, A. , Alberta, J. , Hornby, F. , Stiles, C. , Williams, B. (2003) Expression of the guanine nucleotide exchange factor, mr-gef, is regulated during the differentiation of specific subsets of telencephalic neurons. Brain Research , 146 (1-2). pp. 107-18. ISSN: 0006-8993 | doi: https://dx.doi.org/10.1016/j.devbrainres.2003.09.017