- Frontiers loop:https://loop.frontiersin.org/people/456082/overview
- Research gate: https://www.researchgate.net/scientific-contributions/Viridiana-Alcantara-Alonso-2080192477
- ORCID iD: 0000-0002-9782-2398
Viridiana Alcantara-Alonso
Areas of interest
- Atherosclerosis
- Cardiovascular disease
- Metabolism
- Neuroendocrinology
Expertise
- Western-Blotting
- ELISA
- Real-time qPCR
- Confocal microscopy
Background
As part of my master’s and PhD studies at the Universidad Nacional Autonoma de Mexico, I investigated some of the molecular mechanisms involved in stress responses and metabolism. Currently, I am exploring the effects of a potential treatment for atherosclerosis using in vitro methods. I am analysing the intracellular pathways implicated in the formation of the atherosclerotic lesion and the possibility of regression with cysteamine and cysteamine-related molecules. The effectiveness of these treatments is crucial for the management of cardiovascular disease, one of the main causes of death and disability worldwide.
Selected publications
- Alvarez-Salas E, Alcántara-Alonso V, Matamoros-Trejo G, Vargas MA, Morales-Mulia M, de Gortari P. Mediobasal hypothalamic and adenohypophyseal TRH-degrading enzyme (PPII) is down-regulated by zinc deficiency. International Journal of Developmental Neuroscience 2015,46:115-124. DOI: 10.1016/j.ijdevneu.2015.08.001
- Puga L, Alcántara-Alonso V, Coffeen U, Jaimes O, de Gortari P. TRH injected into the nucleus accumbens shell releases dopamine and reduces feeding motivation in rats.Behav Brain Res 2016, 306:128-136. DOI: 10.1016/j.bbr.2016.03.031
- Valdés-Moreno MI, Alcántara-Alonso V, Estrada-Camarena E, Mengod G, Amaya MI, Matamoros-Trejo G, de Gortari P. Phosphodiesterase-7 inhibition affects accumbal and hypothalamic thyrotropin-releasing hormone expression, feeding and anxiety behavior of rats. Behav Brain Res. 2017 Feb 15;319:165-173. DOI: 10.1016/j.bbr.2016.11.027
- Alcántara-Alonso V, Amaya MI, Matamoros-Trejo G, de Gortari P. Altered functionality of the corticotrophin-releasing hormone receptor-2 in the hypothalamic paraventricular nucleus of hyperphagic maternally separated rats.Neuropeptides. 2017 Jun; 63:75-82. DOI: 10.1016/j.npep.2017.01.006
- Alcántara-Alonso V, Panetta P, de Gortari P, Grammatopoulos DK. Corticotropin-Releasing Hormone As the Homeostatic Rheostat of Feto-Maternal Symbiosis and Developmental ProgrammingIn Uteroand Neonatal Life.Front Endocrinol (Lausanne). 2017 Jul 11;8:161. DOI: 10.3389/fendo.2017.00161
- Alcántara-Alonso V, Alvarez-Salas E, Matamoros-Trejo G, de Gortari P. Intrauterine Zn Deficiency Favors Thyrotropin-Releasing Hormone-Increasing Effects on Thyrotropin Serum Levels and Induces Subclinical Hypothyroidism in Weaned Rats. Nutrients. 2017 Oct 18;9:1139. DOI: 10.3390/nu9101139
- de Gortari P., Alcántara-Alonso V., Matamoros-Trejo G., Amaya M.I.,Alvarez-Salas E. Differential effects of leptin administration on feeding and HPT axis function in early-life overfed adult rats. Peptides. 2020 Feb 24;127:170285. DOI: 10.1016/j.peptides.2020.170285
- Meijles DN, Cull JJ, Cooper STE, Markou T, Hardyman MA, Fuller SJ, Alharbi HO, Haines ZHR, Alcántara-Alonso V, Glennon PE, Sheppard MN, Sugden PH, Clerk A. The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension. Clin Sci (Lond). 2021 Jul 30;135(14):1631-1647. DOI: 10.1042/CS20210192
- Alcántara-Alonso E, Molinar-Ramos F, González-López JA, Alcántara-Alonso V, Muñoz-Pérez MA, Lozano-Nuevo JJ, Benítez-Maldonado DR, Mendoza-Portillo E. High triglyceride to HDL-cholesterol ratio as a biochemical marker of severe outcomes in COVID-19 patients. Clin Nutr ESPEN. 2021 Aug;44:437-444.DOI: 10.1016/j.clnesp.2021.04.020
- Chávez J, Alcántara-Alonso V, García-Luna C, Soberanes-Chávez P, Grammatopoulos D, de Gortari P.Hypothalamic TRH mediates anorectic effects of serotonin in rats. eNeuro. 2022 May 11;9(3):ENEURO.0077-22.2022. DOI: 10.1523/ENEURO.0077-22.2022
Connections
Publications
-
Chávez, J.
,
Alcantara Alonso, V.
ORCID: 0000-0002-9782-2398
,
García-Luna, C.
,
Soberanes-Chávez, P.
,
Grammatopoulos, D.
,
de Gortari, P.
(2022)
Hypothalamic TRH mediates anorectic effects of serotonin in rats.
eNeuro
, 9
(3).
ISSN:
2373-2822
|
doi:
https://dx.doi.org/10.1523/ENEURO.0077-22.2022
-
Alcántara-Alonso, E.
ORCID: 0000-0002-2481-3298
,
Molinar-Ramos, F.
,
González-López, J.
,
Alcantara Alonso, V.
ORCID: 0000-0002-9782-2398
,
Muñoz-Pérez, M.
,
Lozano-Nuevo, J.
,
Benítez-Maldonado, D.
,
Mendoza-Portillo, E.
(2021)
High triglyceride to HDL-cholesterol ratio as a biochemical marker of severe outcomes in COVID-19 patients.
Clinical Nutrition ESPEN
, 44
pp.
437-444.
ISSN:
2405-4577
|
doi:
https://dx.doi.org/10.1016/j.clnesp.2021.04.020
-
Meijles, D.
,
Cull, J.
,
Cooper, S.
,
Markou, T.
,
Hardyman, M.
,
Fuller, S.
,
Alharbi, H.
,
Haines, Z.
,
Alcantara Alonso, V.
,
Glennon, P.
,
Sheppard, M.
,
Sugden, P.
,
Clerk, A.
ORCID: 0000-0002-5658-0708
(2021)
The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension.
Clinical Science
, 135
(14).
pp.
1631-1647.
ISSN:
0143-5221
|
doi:
https://dx.doi.org/10.1042/CS20210192
- de Gortari, P. , Alcántara-Alonso, V. , Matamoros-Trejo, G. , Amaya, M. , Alvarez-Salas, E. (2020) Differential effects of leptin administration on feeding and HPT axis function in early-life overfed adult rats. Peptides , 127 (1). ISSN: 0196-9781 | doi: https://dx.doi.org/10.1016/j.peptides.2020.170285
- Valdés-Moreno, M. , Alcántara-Alonso, V. , Estrada-Camarena, E. , Mengod, G. , Amaya, M. , Matamoros-Trejos, G. , de Gortari, P. (2017) Phosphodiesterase-7 inhibition affects accumbal and hypothalamic thyrotropin-releasing hormone expression, feeding and anxiety behavior of rats. Behavioural Brain Research , 319 pp. 165-173. ISSN: 0166-4328 | doi: https://dx.doi.org/10.1016/j.bbr.2016.11.027
- Alcántara-Alonso, V. , Amaya, M. , Matamoros-Trejo, G. , de Gortari, P. (2017) Altered functionality of the corticotrophin-releasing hormone receptor-2 in the hypothalamic paraventricular nucleus of hyperphagic maternally separated rats. Neuropeptides , 63 pp. 75-82. ISSN: 0143-4179 | doi: https://dx.doi.org/10.1016/j.npep.2017.01.006
- Alcántara-Alonso, V. , Panetta, P. , de Gortari, P. , Grammatopoulos, D. (2017) Corticotropin-releasing hormone as the homeostatic rheostat of feto-maternal symbiosis and developmental programming In utero and neonatal life. Frontiers in Endocrinology , 8 ISSN: 1664-2392 | doi: https://dx.doi.org/10.3389/fendo.2017.00161
- Alcántara-Alonso, V. , Alvarez-Salas, E. , Matamoros-Trejo, G. , De Gortari, P. (2017) Intrauterine Zn deficiency favors thyrotropin-releasing hormone-increasing effects on thyrotropin serum levels and induces subclinical hypothyroidism in weaned rats. Nutrients , 9 (10). ISSN: 2072-6643 | doi: https://dx.doi.org/10.3390/nu9101139
- Puga, L. , Alcantara Alonso, V. , Coffeen, U. , Jaimes, O. , de Gortari, P. (2016) TRH injected into the nucleus accumbens shell releases dopamine and reduces feeding motivation in rats. Behavioural Brain Research , 306 pp. 128-136. ISSN: 0166-4328 | doi: https://dx.doi.org/10.1016/j.bbr.2016.03.031
- Alvarez-Salas, E. , Alcántara-Alonso, V. , Matamoros-Trejo, G. , Angel Vargas, M. , Morales-Mulia, M. , de Gortari, P. (2015) Mediobasal hypothalamic and adenohypophyseal TRH-degrading enzyme (PPII) is down-regulated by zinc deficiency. International Journal of Developmental Neuroscience , 46 pp. 115-124. ISSN: 0736-5748 | doi: https://dx.doi.org/10.1016/j.ijdevneu.2015.08.001