Simon Clarke
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+44 (0) 118 378 8895
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Associate Professor
Teaching
- Part 1: Introductory Microbiology, Pathology: Introduction to Human Disease, Practical Biochemistry
- Part 2: Function of the Bacterial Cell, Immunology
- Part 3: Bacterial Pathogens, Mechanisms of Microbial Function, Use and Abuse of the Microbial World, Microbiology Field Trip
Research projects
- Funding from British Heart Foundation, The Royal Society, The Felix Scholarship
- Pathogenicity and virulence in Gram positive bacteria
- Staphylococcal infections of the cardiovascular system
- Survival and colonisation of Staphylococcus aureus in the gut
Background
- Microbiology Research Group
- Institute for Cardiovascular & Metabolic Research
Expert advisor for a Wellcome Trust Health Innovation Challenge Fund committee meeting and member of interview panel
Member of:
Selected publications
Clarke SR, Foster SJ. (2006) Surface adhesins of Staphylococcus aureus. Advances in Microbial Physiology. 51:187-224.
Clarke SR, Brummell KJ, Horsburgh MJ, McDowell PW, Mohamad SA, Stapleton MR, Acevedo J, Read RC, Day NP, Peacock SJ, Mond JJ, Kokai-Kun JF, Foster SJ. (2006) Identification of in vivo-expressed antigens of Staphylococcus aureus and their use in vaccinations for protection against nasal carriage. Journal of Infectious Diseases. 193:1098-1108.
Pourmand MR, Clarke SR, Schuman RF, Mond JJ, Foster SJ. (2006) Identification of antigenic components of Staphylococcus epidermidis expressed during human infection. Infection and Immunity. 74:4644-4654.
Publications
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Alsultan, A.
,
Walton, G.
ORCID: 0000-0001-5426-5635
,
Andrews, S.
ORCID: 0000-0003-4295-2686
,
Clarke, S.
(2023)
Staphylococcus aureus FadB is a dehydrogenase that mediates cholate resistance and survival under human colonic conditions.
Microbiology
, 169
(3).
ISSN:
1465-2080
|
doi:
https://dx.doi.org/10.1099/mic.0.001314
- Alsallami, D. , Alsultan, A. , Abbas, K. , Clarke, S. (2023) Evaluation of efflux pump inhibitory activity of some plant extracts and using them as adjuvants to potentiate the inhibitory activity of some antibiotics against Staphylococcus aureus. Open Veterinary Journal , 13 (1). pp. 42-47. ISSN: 2226-4485 | doi: https://dx.doi.org/10.5455/OVJ.2023.v13.i1.5
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Waller, A.
,
Birch, K.
,
Gibbins, J.
ORCID: 0000-0002-0372-5352
,
Clarke, S.
(2022)
Activation of Human Platelets by Staphylococcus aureus
Secreted Protease Staphopain A.
Pathogens
, 11
(11).
ISSN:
2076-0817
|
doi:
https://dx.doi.org/10.3390/pathogens11111237
- Lopes Pires, M. , Clarke, S. , Marcondes, S. , Gibbins, J. (2017) Lipopolysaccharide potentiates platelet responses via toll-like receptor 4-stimulated Akt-Erk-PLA2 signalling. PLoS ONE , 12 (11). ISSN: 1932-6203 | doi: https://dx.doi.org/10.1371/journal.pone.0186981
- Sannasiddappa, T. , Lund, P. , Clarke, S. (2017) In vitro antibacterial activity of unconjugated and conjugated bile salts on Staphylococcus aureus. Frontiers in Microbiology , 8 ISSN: 1664-302X | doi: https://dx.doi.org/10.3389/fmicb.2017.01581
- Sannasiddappa, T. , Hood, G. , Hanson, K. , Costabile, A. , Gibson, G. , Clarke, S. (2015) Staphylococcus aureus MnhF mediates cholate efflux and facilitates survival under human colonic conditions. Infection and Immunity , 83 (6). pp. 2350-2357. ISSN: 0019-9567 | doi: https://dx.doi.org/10.1128/IAI.00238-15
- Murray, E. , Crowley, R. , Truman, A. , Clarke, S. , Cottam, J. , Jadhav, G. , Steele, V. , O'Shea, P. , Lindholm, C. , Cockayne, A. , Chhabra, R. , Chan, W. , Williams, P. (2014) Targeting Staphylococcus aureus quorum sensing with non-peptidic small molecule inhibitors. Journal of Medicinal Chemistry , 57 (6). pp. 2813-2819. ISSN: 0022-2623 | doi: https://dx.doi.org/10.1021/jm500215s
- Waller, A. , Sage, T. , Kumar, C. , Carr, T. , Gibbins, J. , Clarke, S. (2013) Staphylococcus aureus lipoteichoic acid inhibits platelet activation and thrombus formation via the Paf receptor. Journal of Infectious Diseases , 208 (12). pp. 2046-2057. ISSN: 1537-6613 | doi: https://dx.doi.org/10.1093/infdis/jit398
- Sannasiddappa, T. , Costabile, A. , Gibson, G. , Clarke, S. (2011) The influence of Staphylococcus aureus on gut microbial ecology in an in vitro continuous culture human colonic model system. PLoS ONE , 6 (8). ISSN: 1932-6203
- Jackson, R. , Johnson, L. , Clarke, S. , Arnold, D. (2011) Bacterial pathogen evolution: breaking news. Trends in Genetics , 27 (1). pp. 32-40. ISSN: 0168-9525 | doi: https://dx.doi.org/10.1016/j.tig.2010.10.001
- Clarke, S. (2010) Phenol-soluble modulins of Staphylococcus aureus lure neutrophils into battle. Cell Host and Microbe , 7 (6). pp. 423-424. ISSN: 1931-3128 | doi: https://dx.doi.org/10.1016/j.chom.2010.05.015
- Clarke, . , Andre, . , Walsh, . , Dufrene, . , Foster, . , Foster, . (2009) Iron-regulated surface determinant protein a mediates adhesion of staphylococcus aureus to human corneocyte envelope proteins. Infection and Immunity , 77 (6). pp. 2408-2416. ISSN: 0019-9567 | doi: https://dx.doi.org/10.1128/iai.01304-08
- Clarke, S. and Foster, S. (2008) IsdA protects Staphylococcus aureus against the bactericidal protease activity of apolactoferrin. Infection and Immunity , 76 (4). pp. 1518-1526. ISSN: 0019-9567 | doi: https://dx.doi.org/10.1128/IAI.01530-07
- Jensen, R. , Winzer, K. , Clarke, S. , Chan, W. , Williams, P. (2008) Differential recognition of Staphylococcus aureus quorum-sensing signals depends on both extracellular loops 1 and 2 of the transmembrane sensor AgrC.. Journal of Molecular Biology , 381 (2). pp. 300-309. ISSN: 0022-2836 | doi: https://dx.doi.org/10.1016/j.jmb.2008.06.018
- Tiyawisutsri, . , Holden, . , Tumapa, . , Rengpipat, . , Clarke, . , Foster, . , Nierman, . , Day, . , Peacock, . (2007) Burkholderia Hep_Hag autotransporter (BuHA) proteins elicit a strong antibody response during experimental glanders but not human melioidosis. BMC Microbiology , 7 (19). pp. 19. ISSN: 1471-2180 | doi: https://dx.doi.org/10.1186/1471-2180-7-19
- Clarke, . , Mohamed, . , Bian, . , Routh, . , Kokai-Kun, . , Mond, . , Tarkowski, . , Foster, . (2007) The staphylococcus aureus surface protein IsdA mediates resistance to the innate defenses of human skin. Cell Host and Microbe , 1 (3). pp. 192-212. ISSN: 1931-3128 | doi: https://dx.doi.org/10.1016/j.chom.2007.04.005
- Wright, A. , Cole, J. , Newport, R. , Fisher, C. , Clarke, S. , Sinclair, R. , Fischer, H. , Cuello, G. (2007) The Neutron Diffraction Anomalous Dispersion Technique and its Application to Sm2O3.4P2O5. Nuclear Instruments & Methods in Physics Research. Section A. , 571 (3). pp. 622-635. ISSN: 0168-9002 | doi: https://dx.doi.org/10.1016/j.nima.2006.11.045