Sheila MacIntyre
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8898 or 7887
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Associate Professor
Programme advisor for Microbiology
Areas of interest
- Cell surfaces of Gram negative bacteria
- Secretion via the chaperone: usher pathway
- Assembly of surface F1 antigen of the plague pathogen, Yersinia pestis
- Secretion of proteins by fish pathogens belonging to Aeromonas spp
- Genomics of rodent associated Campylobacter
Teaching
- Part 1: Introductory Microbiology
- Part 2: Microbiology- a medical perspective; Medical microbiology (Pharmacy); Function of the Bacterial Cell
- Part 3: Bacterial pathogens; Use and abuse of the Microbial world
Research centres and groups
Microbiome and Iron Research Group
International Collaborators
- Professor Stefan Knight, Swedish University of Agricultural Sciences, Uppsala, Sweden
- Dr Anton Zavialov, SUAS, Uppsala and University of Turku, Finland
National Collaborators
- Professor Martin Maiden , Dept Zoology, Oxford University
- Dr Noel MacCarthy, Oxford University /PHE Didcot
- Professor Haroun Shah, PHE Microbiology services, Colindale, London
Background
Member of the Microbiology Research GroupSelected publications
Kersley, J., Zavialov, A. V., Moslehi, E. , Knight, S. D. and MacIntyre, S. (2003) Mutagenesis elucidates the assembly pathway and structure of Yersinia pestis F1 polymer Adv Exp Med Biol 529: 113-116
Zavialov, A.V. Kersley, J., Korpela, T., Zav'yalov, V.P., MacIntyre, S. and Knight, S. (2002) Donor strand complementation mechanism in the biogenesis of non-pilus system. Mol. Microbiol. 45, 983-995
MacIntyre, S., Zyrianova, I.M., Chernovskaya, T.V., Leonard, M., Rudenko,E.G., Zav'yalov, V.P. and Chapman, D.A.G. (2001) An extended hydrophobic interactive surface of Yersinia pestis Caf1M chaperone is essential for subunit binding and F1 capsule assembly Mol. Microbiol. 39, 12-25.
Publications
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Gahlot, D.
ORCID: 0000-0001-6963-0009
,
Taheri, N.
ORCID: 0000-0001-9139-8744
,
MacIntyre, S.
(2023)
Diversity in genetic regulation of bacterial fimbriae assembled by the Chaperone Usher pathway.
International Journal of Molecular Sciences
, 24
(1).
pp
0.
ISSN:
1422-0067
|
doi:
https://dx.doi.org/10.3390/ijms24010161
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Gahlot, D.
ORCID: 0000-0001-6963-0009
,
Ifill, G.
,
MacIntyre, S.
(2021)
Optimised heterologous expression and functional analysis of the Yersinia pestis F1-Capsular antigen regulator Caf1R.
International Journal of Molecular Sciences
, 22
(18).
pp
0.
ISSN:
1422-0067
|
doi:
https://dx.doi.org/10.3390/ijms22189805
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Withey, Z.
,
Goodall, T.
,
MacIntyre, S.
,
Gweon, S.
ORCID: 0000-0002-6218-6301
(2021)
Characterization of communal sink drain communities of a university campus.
Environmental DNA
, 3
(5).
ISSN:
2637-4943
|
doi:
https://dx.doi.org/10.1002/edn3.196
- Danson, A. , McStea, A. , Wang, L. , Pollitt, A. , Martin-Fernandez, M. , Moraes, I. , Walsh, M. , MacIntyre, S. , Watson, K. (2020) Super-resolution fluorescence microscopy reveals clustering behaviour of Chlamydia pneumoniae’s major outer membrane protein. Biology , 9 (10). ISSN: 2079-7737 | doi: https://dx.doi.org/10.3390/biology9100344
- Vegge, C. , Jansen van Rensburg, M. , Rasmussen, J. , Maiden, M. , Johnsen, L. , Danielsen, M. , MacIntyre, S. , Ingmer, H. , Kelly, D. (2016) Glucose metabolism via the Entner-Doudoroff pathway in Campylobacter: a rare trait that enhances survival and promotes biofilm formation in some isolates. Frontiers in Microbiology , 7 ISSN: 1664-302X | doi: https://dx.doi.org/10.3389/fmicb.2016.01877
- Di Yu, X. , Dubnovitsky, A. , Pudney, A. , MacIntyre, S. , Knight, S. , Zavialov, A. (2012) Allosteric mechanism controls traffic in the chaperone/usher pathway. Structure , 20 (11). pp. 1861-1871. ISSN: 0969-2126 | doi: https://dx.doi.org/10.1016/j.str.2012.08.016
- Yu, X. , Fooks, L. , Moslehi-Mohebi, E. , Tischenko, V. , Askarieh, G. , Knight, S. , MacIntyre, S. , Zavialov, A. (2012) Large is fast, small is tight: determinants of speed and affinity in subunit capture by a periplasmic chaperone. Journal of molecular biology , 417 (4). pp. 294-308. ISSN: 1089-8638 | doi: https://dx.doi.org/10.1016/j.jmb.2012.01.020
- Stuart, A. , Prescott, C. , MacIntyre, S. , Sethar, A. , Neuman, B. , McCarthy, N. , Wimalarathna, H. , Maiden, M. (2011) The role of rodents as carriers of disease on UK farms: a preliminary investigation. pp. 198-199. (Proceedings of the 8th European Vertebrate Pest Management Conference)
- Dubnovitsky, A. , Duck, Z. , Kersley , J. , Hard, J. , MacIntyre, S. , Knight, S. (2010) Conserved hydrophobic clusters on the surface of the Caf1A usher C-terminal domain are important for F1 antigen assembly. Journal of Molecular Biology , 403 (2). pp. 243-259. ISSN: 0022-2836 | doi: https://dx.doi.org/10.1016/j.jmb.2010.08.034
- Yu, . , Visweswaran, . , Duck, . , Marupakula, . , MacIntyre, . , Knight, . , Zavialov, . (2009) Caf1A usher possesses a Caf1 subunit-like domain that is crucial for Caf1 fibre secretion. Biochemical Journal , 418 pp. 541-551. ISSN: 0264-6021 | doi: https://dx.doi.org/10.1042/bj20080992
- Zavialvo, . , Tischenko, . , Fooks, . , Brandsdal, . , Aqvist, . , Zav'Yalov, . , MacIntyre, . , Knight, . (2005) Resolving the energy paradox of chaperone/usher-mediated fibre assembly. Biochemical Journal , 389 pp. 685-694. ISSN: 0264-6021
- MacIntyre, . , Knight, . , Fooks, . (2004) Structure and function of F1 capsule. In: Carniel, . and Hinnenbusch, . , (eds.) Yersinia: Molecular and Cellular Biology. Horizon Bioscience pp. 363-407. ISBN: 9781904933069
- Zavialov, . , Berglund, . , Pudney, . , Fooks, . , Ibrahim, . , MacIntyre, . , Knight, . (2003) Structure and biogenesis of the capsular F1 antigen from Yersinia pestis: Preserved folding energy drives fiber formation. Cell , 113 (5). pp. 587-596. ISSN: 0092-8674 | doi: https://dx.doi.org/10.1016/S0092-8674(03)00351-9
- Gunasena, . , Komrower, . , MacIntyre, . (2003) The fish pathogen Yersinia ruckeri possesses a TTS system. Advances in Experimental Medicine and Biology , 529 pp. 105-7. ISSN: 0065-2598 | doi: https://dx.doi.org/10.1007/b100541