Philip Dash
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+44 (0) 118 378 7400
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Head of School
Professor of Cancer Biology
Teaching
I'm involved with teaching at all levels, from Foundation to Masters level, with a focus on cell biology and cancer.
- Module convenor of Building Blocks of Life (Part 1) and Venoms & Poisons (Part 2).
- Teach on Foundation Biology (Part 0), Pathology (Part 1), Cells & Immunity (Part 2), Cancer & Cell Communication (Part 3) and Biology of Cancer (MSc) among other modules.
- Programme Director for the MSc by Research in Biomedicine programme.
- Supervise undergraduate, MSc and PhD research projects.
Research projects
My lab is focused on understanding the mechanisms of how cancer spreads, a process called metastasis. We are particularly interested in metastatic colonisation - the adaptation of cancer cells to a new site after they've spread from their primary site. This involves studying interactions between cancer cells, the extracellular matrix and the other cells in the tumour microenvironment. We are currently studying how a range of different cancer types adapt to the brain and the liver.Publications
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Barnawi, I.
,
Hawsawi, Y.
,
Dash, P.
,
Oyouni, A.
,
Mustafa, S.
,
Hussien, N.
,
Al-Amer, O.
,
Alomar, S.
,
Mansour, L.
ORCID: 0000-0002-9415-9383
(2022)
Nitric Oxide Synthase potentiates the resistance of cancer cell lines to anticancer chemotherapeutics.
Anti-cancer agents in medicinal chemistry
, 22
(7).
pp.
1397-1406.
ISSN:
1871-5206
|
doi:
https://dx.doi.org/10.2174/1871520621666210623094526
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Suarez-Berumen, K.
,
Collins-Hooper, H.
,
Gormova, A.
,
Meech, R.
,
Sacco, A.
,
Dash, P.
,
Mitchell, R.
,
Shestopalov, V.
,
Woolley, T.
,
Vaiyapuri, S.
ORCID: 0000-0002-6006-6517
,
Patel, K.
,
Makarenkova, H.
(2021)
Pannexin 1 regulates skeletal muscle regeneration by promoting bleb-based myoblast migration and
fusion through a novel lipid based signaling mechanism.
Frontiers in Cell and Developmental Biology
ISSN:
2296-634X
|
doi:
https://dx.doi.org/10.3389/fcell.2021.736813
- Chawsheen, M. and Dash, P. (2021) mTOR modulates resistance to gemcitabine in lung cancer in an MTORC2 dependent mechanism.. Cellular Signalling , 81 pp 0. ISSN: 0898-6568 | doi: https://dx.doi.org/10.1016/j.cellsig.2021.109934
- Dhurgham, A. , Alharethi, S. , Alharbi, B. , Mawlood, K. , Dash, P. (2020) Ptdins(4,5)p2 and ptdins(3,4,5)p3 dynamics during focal adhesions assembly and disassembly in a cancer cell line. Turkish Journal of Biology , 44 (6). pp. 381-392. ISSN: 1303-829X | doi: https://dx.doi.org/10.3906/biy-2004-108
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Butler, G.
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Keeton, S.
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Johnson, L.
ORCID: 0000-0002-0006-1511
,
Dash, P.
(2020)
A phenotypic switch in the dispersal strategy of breast cancer cells selected for metastatic colonization.
Proceedings of the Royal Society B: Biological Sciences
, 287
(1940).
ISSN:
0962-8452
|
doi:
https://dx.doi.org/10.1098/rspb.2020.2523
- Wass, A. , Butler, G. , Taylor, T. , Dash, P. , Johnson, L. (2020) Cancer cell lines show high heritability for motility but not generation time. Royal Society Open Science , 7 (4). ISSN: 2054-5703 | doi: https://dx.doi.org/10.1098/rsos.191645
- Vallance, T. , Ravishankar, D. , Albadawi, D. , Layfield, H. , Sheard, J. , Vaiyapuri, R. , Dash, P. , Patel, K. , Widera, D. , Vaiyapuri, S. (2019) Effect of ultrapure lipopolysaccharides derived from diverse bacterial species on the modulation of platelet activation. Scientific Reports , 9 ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-019-54617-w
- Butler, G. , Rudge, J. , Dash, P. (2019) Mathematical modelling of cell migration. Essays in Biochemistry , 63 (5). pp. 631-637. ISSN: 0071-1365 | doi: https://dx.doi.org/10.1042/EBC20190020
- Ravishankar, D. , Albadawi, D. , Chaggar, V. , Patra, P. , Williams, H. , Salamah, M. , Vaiyapuri, R. , Dash, P. , Patel, K. , Watson, K. , Vaiyapuri, S. (2019) Isorhapontigenin, a resveratrol analogue selectively inhibits ADP-stimulated platelet activation. European Journal of Pharmacology , 862 ISSN: 0014-2999 | doi: https://dx.doi.org/10.1016/j.ejphar.2019.172627
- Huang, Z. , Barker, D. , Gibbins, J. , Dash, P. (2018) Talin is a substrate for SUMOylation in migrating cancer cells. Experimental Cell Research , 370 (2). pp. 417-425. ISSN: 0014-4827 | doi: https://dx.doi.org/10.1016/j.yexcr.2018.07.005
- Keeton, S. , Delalande, J. , Cranfield, M. , Burns, A. , Dash, P. (2018) Compressed collagen and decellularized tissue: novel components in a pipeline approach for the study of cancer metastasis. BMC Cancer , 18 (622). ISSN: 1471-2407 | doi: https://dx.doi.org/10.1186/s12885-018-4533-0
- Taylor, T. , Wass, A. , Johnson, L. , Dash, P. (2017) Resource competition promotes tumour expansion in experimentally evolved cancer. BMC Evolutionary Biology , 17 ISSN: 1471-2148 | doi: https://dx.doi.org/10.1186/s12862-017-1117-6
- Dannoura, A. , Giraldo, A. , Pereira, I. , Gibbins, J. , Dash, P. , Bicknell, K. , Brooks, G. (2014) Ibuprofen inhibits migration and proliferation of human coronary artery smooth muscle cells by inducing a differentiated phenotype: role of peroxisome proliferator-activated receptor y. Journal of Pharmacy and Pharmacology , 66 (6). pp. 779-792. ISSN: 0022-3573 | doi: https://dx.doi.org/10.1111/jphp.12203
- Collins-Hooper, H. , Sartori, R. , Macharia, R. , Visanuvimol, K. , Foster, K. , Matsakas, A. , Flasskamp, H. , Ray, S. , Dash, P. , Sandri, M. , Patel, K. (2014) Propeptide-mediated inhibition of myostatin increases muscle mass through inhibiting proteolytic pathways in aged mice. Journals of Gerontology Series A: Biological and Medical Sciences , 69 (9). pp. 1049-1059. ISSN: 1079-5006 | doi: https://dx.doi.org/10.1093/gerona/glt170
- Khanna, S. , Dash, P. , Darbre, P. (2014) Exposure to parabens at the concentration of maximal proliferative response increases migratory and invasive activity of human breast cancer cells in vitro. Journal of Applied Toxicology , 34 (9). pp. 1051-1059. ISSN: 0260-437X | doi: https://dx.doi.org/10.1002/jat.3003
- Hooper, C. , Paudyal, A. , Dash, P. , Boateng, S. (2013) Modulation of stretch-induced myocyte remodeling and gene expression by nitric oxide: a novel role for lipoma preferred partner in myofibrillogenesis. American Journal of Physiology - Heart and Circulatory Physiology , 304 (10). pp. H1302-H1313. ISSN: 1522-1539 | doi: https://dx.doi.org/10.1152/ajpheart.00004.2013
- Taylor, T. , Johnson, L. , Jackson, R. , Brockhurst, M. , Dash, P. (2013) First steps in experimental cancer evolution. Evolutionary Applications , 6 (3). pp. 535-548. ISSN: 1752-4571 | doi: https://dx.doi.org/10.1111/eva.12041
- Hooper, C. , Dash, P. , Boateng, S. (2012) Lipoma preferred partner is a mechanosensitive protein regulated by nitric oxide in the heart. FEBS Open Bio , 2 pp. 135-144. ISSN: 2211-5463 | doi: https://dx.doi.org/10.1016/j.fob.2012.05.005
- Collins-Hooper, H. , Woolley, T. , Dyson, L. , Patel, A. , Potter, P. , Baker, R. , Gaffney, E. , Maini, P. , Dash, P. , Patel, K. (2012) Age related changes in speed and mechanism of adult skeletal muscle stem cell migration. Stem Cells , 30 (6). pp. 1182-1195. ISSN: 1066-5099 | doi: https://dx.doi.org/10.1002/stem.1088
- Patel, A. and Dash, P. (2012) Formation of atypical podosomes in extravillous trophoblasts regulates extracellular matrix degradation. European Journal of Cell Biology , 91 (3). pp. 171-179. ISSN: 0171-9335 | doi: https://dx.doi.org/10.1016/j.ejcb.2011.11.006
- Otto, A. , Collins-Hooper, H. , Patel, A. , Dash, P. , Patel, K. (2011) Adult skeletal muscle stem cell migration is mediated by a blebbing/amoeboid mechanism. Rejuvenation Research , 14 (3). pp. 249-260. ISSN: 1549-1684 | doi: https://dx.doi.org/10.1089/rej.2010.1151
- Arias, M. , Loxley, A. , Eatmon, C. , Van Roey, G. , Fairhurst, D. , Mitchnick, M. , Dash, P. , Cole, T. , Wegmann, F. , Sattentau, Q. , Shattock, R. (2011) Carnauba wax nanoparticles enhance strong systemic and mucosal cellular and humoral immune responses to HIV-gp140 antigen. Vaccine , 29 (6). pp. 1258-1269. ISSN: 0264-410X | doi: https://dx.doi.org/10.1016/j.vaccine.2010.11.084
- Bommer, U. , Heng, C. , Perrin, A. , Dash, P. , Lobov, S. , Elia, A. , Clemens, M. (2010) Roles of the translationally controlled tumour protein (TCTP) and the double-stranded RNA-dependent protein kinase, PKR, in cellular stress responses. Oncogene , 29 pp. 763-773. ISSN: 0950-9232 | doi: https://dx.doi.org/10.1038/onc.2009.380
- LaMarca, . , Dash, . , Vishnuthevan, . , Harvey, . , Sullivan, . , Morris, . , Whitley, . (2008) Epidermal growth factor-stimulated extravillous cytotrophoblast motility is mediated by the activation of PI3-K, Akt and both p38 and p42/44 mitogen-activated protein kinases. Human Reproduction , 23 (8). pp. 1733-1741. ISSN: 0268-1161 | doi: https://dx.doi.org/10.1093/humrep/den178
- Harris, . , McCormick, . , Cartwright, . , Whitley, . , Dash, . (2008) S-nitrosylation of proteins at the leading edge of migrating trophoblasts by inducible nitric oxide synthase promotes trophoblast invasion. Exp Cell Res , 314 (8). pp. 1765-76. ISSN: 0014-4827 | doi: https://dx.doi.org/10.1016/j.yexcr.2008.02.010
- Wong, . , Portmann, . , Sherwood, . , Niemela, . , Koivisto, . , Parkkila, . , Trick, . , L'Abbe, . , Wilson, . , Dash, . , Srirajaskanthan, . , Preedy, . , Wiseman, . (2007) The cytoprotective effect of alpha-tocopherol and daidzein against d-galactosamine-induced oxidative damage in the rat liver. Metabolism , 56 (7). pp. 865-75. ISSN: 0026-0495 | doi: https://dx.doi.org/10.1016/j.metabol.2007.01.005
- Whitley, . , Dash, . , Ayling, . , Prefumo, . , Thilaganathan, . , Cartwright, . (2007) Increased apoptosis in first trimester extravillous trophoblasts from pregnancies at higher risk of developing preeclampsia. American Journal of Pathology , 170 (6). pp. 1903-9. ISSN: 0002-9440 | doi: https://dx.doi.org/10.2353/ajpath.2007.070006
- Ganapathy, . , Whitley, . , Cartwright, . , Dash, . , Thilaganathan, . (2007) Effect of heparin and fractionated heparin on trophoblast invasion. Human Reproduction , 22 (9). pp. 2523-7. ISSN: 0268-1161
- Dash, . , McCormick, . , Thomson, . , Johnstone, . , Cartwright, . , Whitley, . (2007) Fas ligand-induced apoptosis is regulated by nitric oxide through the inhibition of fas receptor clustering and the nitrosylation of protein kinase Cepsilon. Exp Cell Res , 313 (16). pp. 3421-3431. ISSN: 0014-4827