Nandini Vasudevan
-
01183787035
-
Associate Professor
- Associate Professor in Endocrinology
- Research Division Lead, Biomedical Sciences and Biomedical Engineering.
- Supervision of research done by post-graduate and undergraduate students.
- Undergraduate advising.
- Mentorship of Post-Doctoral Research Fellows.
Areas of interest
Neuroendocrinology and Molecular Endocrinology with an emphasis on behaviour using physiologically relevant model systems.Teaching
- Part 1: Pathology and Histology
- Part 2: Physiological Biochemistry
- Part 2: Practical Animal Behaviour
- Part 3: Medical Genetics
- Part 3: Special Topics in Endocrinology
- Part 3: Neurobiology (Module Convenor)
Research centres and groups
Member of the Impact, Enterprise and Outreach
- Director of Outreach, SBS (2016-2019); revamped the UoR Scholars Programme and other science outreach events in local school with collaborators within the development.
- Novel mechanisms of estrogen action and estrogen production in the brain can be used to discover new drug targets in diseases impacted by estrogen, such as breast cancer.
- Control of social behaviours can lead to better welfare of managed animals.
- Steroid synthesis in the brain can lead to better understanding of sexually dimorphic traits.
- Target discovery for alleviation of symptoms of hypothyroidism.
- Led yearly mini-courses, consisting of lectures and experiments on Brain and Behavior for high school students and for at-risk students in New Orleans, USA.
- Participated in Brain Awareness Day activities, Soapbox Science, Pint of Science, School Career Days and Big Bang Fair to increase knowledge of the brain and STEM research amongst members of the public.
Research projects
- Mechanisms of estrogen action in neuronal cells, including an emphasis on non-genomic and non-transcriptional signalling and their relevance to behaviour.
- Mechanisms by which GPR30, a putative membrane Estrogen Receptor (mER) signals in neurons and the relevance to behaviour.
- Role of locally synthesized steroids and their relevance to social behaviors.
- Role of thyroid hormones in the regulation of anxiety and cognition.
- Role of nuclear receptors and neuropeptides in C.elegans social behaviours and ageing.
Awards and honours
Esteem Factors
- Was PI on a NSF CAREER (USA) grant "Role of nongenomic estrogen signaling in neuromorphology and behavior (April 2011- Dec 2015; 1 million USD).
- Co-investigator on NIH R01 Grant "Short term estradiol in middle age: implications for female cognitive aging" (2012-2017; 1,388,365 USD; PI: Dr. Daniels).
- Co-investigator on MRC grant "The Mouth Gut Brain Model" 2017-2019; 188983 GBP; PI: Dr. Lisa Methven, UoR.
- Reviewer for endocrine and molecular endocrine journals.
- Reviewer for National Science Foundation (NSF), USA and for ALW, MRC, BBSRC grants.
- Editorial Board Member, Nuclear Receptor Research.
Professional bodies/affiliations
International and National Collaborators
- Dr Kiran Soma, University of British Columbia, Canada
- Dr Jeffrey Tasker, Dr Gary Dohanich & Dr Jill Daniels, Tulane University, USA
- Dr Sonoko Ogawa, Tsukuba University, Japan
- Dr. Shinji Tsukahara, Saitama University.
- Dr. Eva Kevei, Dr. Francesco Tamagnini, Dr. Evangelos Delivopoulos, Dr. Yoshikatsu Hayashi, Dr. Zuowei Wang, Professor Claire Williams, Professor Slawomir Nasuto and Professor Bhisma Chakrabarti: from either SBS, Psychology, Pharmacy or Mathematics, University of Reading.
Publications
-
Davis, D.
,
Vajaria, R.
,
Delivopoulos, E.
ORCID: 0000-0001-6156-1133
,
Vasudevan, N.
ORCID: 0000-0003-4326-3938
(2022)
Localisation of oestrogen receptors in stem cells and in stem cell derived neurons of the mouse.
Journal of Neuroendocrinology
ISSN:
0953-8194
|
doi:
https://dx.doi.org/10.1111/jne.13220
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Chaudry, S.
and
Vasudevan, N.
ORCID: 0000-0003-4326-3938
(2022)
mTOR-dependent spine dynamics in autism.
Frontiers in Molecular Neuroscience
, 15
ISSN:
1662-5099
|
doi:
https://dx.doi.org/10.3389/fnmol.2022.877609
-
Jewett, E.
,
Arnott, G.
,
Connolly, L.
,
Vasudevan, N.
ORCID: 0000-0003-4326-3938
,
Kevei, E.
(2022)
Microplastics and their impact on reproduction—can we learn from the C. elegans model?.
Frontiers in Toxicology
, 4
ISSN:
2673-3080
|
doi:
https://dx.doi.org/10.3389/ftox.2022.748912
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Clark, S.
,
Pollard, K.
,
Rainville, J.
,
Vasudevan, N.
ORCID: 0000-0003-4326-3938
(2022)
Immunoblot Detection of the Phosphorylation of the Estrogen Receptor α as an Outcome of GPR30 /GPER1 Activation..
In:
Eyster, K.
, (eds.)
Estrogen Receptors: Methods and Protocols.
Methods in Molecular Biology
, 2418.
Methods in molecular biology (Clifton, N.J.)
, 2418
pp.
25-39.
ISSN:
1940-6029
ISBN:
9781071619193
|
doi:
https://dx.doi.org/10.1007/978-1-0716-1920-9_2
-
Geher-Herczegh, T.
,
Wang, Z.
,
Masuda, T.
,
Yoshida, R.
,
Vasudevan, N.
ORCID: 0000-0003-4326-3938
,
Hayashi, Y.
(2021)
Delayed mechanical response to chemical kinetics in self-
oscillating hydrogels driven by the Belousov−Zhabotinsky
reaction.
Macromolecules
, 54
(13).
pp.
6430-6439.
ISSN:
0024-9297
|
doi:
https://dx.doi.org/10.1021/acs.macromol.1c00402
- Dovey, J. and Vasudevan, N. (2020) Does GPER1 play a role in sexual dimorphism?. Frontiers in Endocrinology , 11 ISSN: 1664-2392 | doi: https://dx.doi.org/10.3389/fendo.2020.595895
- Ogawa, S. , Tsukahara, S. , Choleris, E. , Vasudevan, N. (2020) Estrogenic regulation of social behavior and sexually dimorphic brain formation. Neuroscience and Biobehavioral Reviews , 110 pp. 46-59. ISSN: 0149-7634 | doi: https://dx.doi.org/10.1016/j.neubiorev.2018.10.012
- Rainville, J. , Weiss, G. , Evanson, N. , Herman, J. , Vasudevan, N. , Tasker, J. (2019) Membrane-initiated nuclear trafficking of the glucocorticoid receptor in hypothalamic neurons. Steroids , 142 pp. 55-64. ISSN: 0039-128X | doi: https://dx.doi.org/10.1016/j.steroids.2017.12.005
- Vajaria, R. and Vasudevan, N. (2018) Is the membrane estrogen receptor, GPER1, a promiscuous receptor that modulates nuclear estrogen receptor-mediated functions in the brain?. Hormones and Behavior pp 0. ISSN: 0018-506X | doi: https://dx.doi.org/10.1016/j.yhbeh.2018.06.012
- Hadjimarkou, M. and Vasudevan, N. (2018) GPER1/GPR30 in the brain: crosstalk with classical estrogen receptors and implications for behavior. Journal of Steroid Biochemistry and Molecular Biology , 176 pp. 57-64. ISSN: 0960-0760 | doi: https://dx.doi.org/10.1016/j.jsbmb.2017.04.012
- Rainville, J. , Pollard, K. , Vasudevann, N. (2015) Membrane-initiated non-genomic signaling by estrogens in the hypothalamus: cross-talk with glucocorticoids with implications for behavior. Frontiers in Endocrinology , 6 ISSN: 1664-2392 | doi: https://dx.doi.org/10.3389/fendo.2015.00018
- Fisher, M. and Vasudevan, N. (2015) Cognition and anxiety are regulated by thyroid hormone signaling. Immunology‚ Endocrine and Metabolic Agents in Medicinal Chemistry , 15 (1). pp. 60-70. ISSN: 1875-5844 | doi: https://dx.doi.org/10.2174/187152221501150710130829
- Clark, S. , Pollard, K. , Rainville, J. , Vasudevan, N. (2015) Detection of the phosphorylation of the estrogen receptor alpha as an outcome of GPR30 activation. In: Eyster, K. , (eds.) Estrogen receptors: methods and protocols. Methods in Molecular Biology , 1366. Humana Press , New York. pp. 457-470. ISBN: 9781493931262 | doi: https://dx.doi.org/10.1007/978-1-4939-3127-9_36
- Hawley, W. , Grissom, E. , Moody, N. , Dohanich, G. , Vasudevan, N. (2014) Activation of G-protein-coupled receptor 30 is sufficient to enhance spatial recognition memory in ovariectomized rats. Behavioural Brain Research , 262 pp. 68-73. ISSN: 0166-4328 | doi: https://dx.doi.org/10.1016/j.bbr.2014.01.006
- Hart, D. , Nilges, M. , Pollard, K. , Lynn, T. , Patsos, O. , Shiel, C. , Clark, S. , Vasudevan, N. (2014) Activation of the G-protein coupled receptor 30 (GPR30) has different effects on anxiety in male and female mice. Steroids , 81 pp. 49-56. ISSN: 0039-128X | doi: https://dx.doi.org/10.1016/j.steroids.2013.11.004
- Clark, S. , Rainville, J. , Zhao, X. , Katzenellenbogen, B. , Pfaff, D. , Vasudevan, N. (2014) Estrogen receptor-mediated transcription involves the activation of multiple kinase pathways in neuroblastoma cells. Journal of Steroid Biochemistry and Molecular Biology , 139 pp. 45-53. ISSN: 0960-0760 | doi: https://dx.doi.org/10.1016/j.jsbmb.2013.09.010
- Buras, A. , Battle, L. , Landers, E. , Nguyen, T. , Vasudevan, N. (2014) Thyroid hormones regulate anxiety in the male mouse. Hormones and Behavior , 65 (2). pp. 88-96. ISSN: 0018-506X | doi: https://dx.doi.org/10.1016/j.yhbeh.2013.11.008
- Anchan, D. , Gafur, A. , Sano, K. , Ogawa, S. , Vasudevan, N. (2014) Activation of the GPR30 receptor promotes lordosis in female mice. Neuroendocrinology , 100 (1). pp. 71-80. ISSN: 1423-0194 | doi: https://dx.doi.org/10.1159/000365574
- Anchan, D. , Clark, S. , Pollard, K. , Vasudevan, N. (2014) GPR30 activation decreases anxiety in the open field test but not in the elevated plus maze test in female mice. Brain and behaviour , 4 (1). pp. 51-59. ISSN: 2162-3279 | doi: https://dx.doi.org/10.1002/brb3.197
- Vasudevan, N. , Morgan, M. , Pfaff, D. , Ogawa, S. (2013) Distinct behavioral phenotypes in male mice lacking the thyroid hormone receptor alpha1 or beta isoforms. Hormones and Behavior , 63 (5). pp. 742-751. ISSN: 0018-506X | doi: https://dx.doi.org/10.1016/j.yhbeh.2013.03.015
- Vasudevan, N. and Pfaff, D. (2008) Non-genomic actions of estrogens and their interaction with genomic actions in the brain. Frontiers in Neuroendocrinology , 29 (2). pp. 238-57. ISSN: 1095-6808 | doi: https://dx.doi.org/10.1016/j.yfrne.2007.08.003
- Vasudevan, N. and Pfaff, D. (2007) Membrane-initiated actions of estrogens in neuroendocrinology: emerging principles. Endocr Rev , 28 (1). pp. 1-19. ISSN: 0163-769X (Print)
- Bahadur, U. , Ganjam, G. , Vasudevan, N. , Kondaiah, P. (2005) Estrogen regulation of chicken riboflavin carrier protein gene is mediated by ERE half sites without direct binding of estrogen receptor. Molecular and Cellular Endocrinology , 231 (1-2). pp. 1-11. ISSN: 3037207 | doi: https://dx.doi.org/10.1016/j.mce.2004.12.007
- Zhao, X. , Pfaff, D. , Vasudevan, N. (2005) Estrogens and thyroid hormone: Non-genomic effects are coupled to transcription.. Current Medicinal Chemistry - Immunology, Endocrine and Metabolic agents , 6 pp. 267-280.
- Zhao, X. , Macbride, M. , Peterson, B. , Pfaff, D. , Vasudevan, N. (2005) Calcium Flux in Neuroblastoma Cells Is a Coupling Mechanism between Non-Genomic and Genomic Modes of Estrogens. Neuroendocrinology , 81 (3). pp. 174-182.
- Zhao, X. , Lorenc, H. , Stephenson, H. , Wang, Y. , Witherspoon, D. , Katzenellenbogen, B. , Pfaff, D. , Vasudevan, N. (2005) Thyroid hormone can increase estrogen-mediated transcription from a consensus estrogen response element in neuroblastoma cells. Proc Natl Acad Sci U S A , 102 (13). pp. 4890-5.
- Vasudevan, N. and Pfaff, D. (2005) Molecular mechanisms of crosstalk between thyroid hormones and estrogens. Current Opinion in Endocrinology and Diabetes , 12 (5). pp. 381-88.
- Vasudevan, N. , Kow, L. , Pfaff, D. (2005) Integration of steroid hormone initiated membrane action to genomic function in the brain. Steroids , 70 (5-7). pp. 388-96.
- Vasudevan, N. , Kia, H. , Hadjimarkou, M. , Koibuchi, N. , Chin, W. , Forrest, D. , Vennstrom, B. , Pfaff, D. (2005) Retinoid-Related Receptor (ROR) alpha mRNA Expression Is Altered in the Brain of Male Mice Lacking All Ligand-Binding Thyroid Hormone Receptor (TR) Isoforms. Endocrine , 26 (1). pp. 25-32.
- Kow, L. , Vasudevan, N. , Devidze, N. , Pfaff, D. (2004) Mechanisms of steroid hormone action on developing and adult hypothalamic nerve cells: biophysical and molecular studies relevant for hormone-dependent behaviors. In: Kordon, C. , Christen, Y. , Gaillard, R. , (eds.) Hormones and the Brain. Research and Perspectives in Endocrine Interactions , 3. Springer Verlag , Heidelberg. pp. 73-78.
- Vasudevan, N. , Ogawa, S. , Pfaff, D. (2002) Estrogen and thyroid hormone receptor interactions: physiological flexibility by molecular specificity. Physiol Rev , 82 (4). pp. 923-44. ISSN: 0031-9333 (Print) | doi: https://dx.doi.org/10.1152/physrev.00014.2002
- Vasudevan, N. , Kia, H. , Inoue, S. , Muramatsu, M. , Pfaff, D. (2002) Isoform specificity for oestrogen receptor and thyroid hormone receptor genes and their interactions on the NR2D gene promoter. J Neuroendocrinol , 14 (10). pp. 836-42. ISSN: 0953-8194 (Print)
- Pfaff, D. , Ogawa, S. , Kia, H. , Vasudevan, N. , Krebs, C. , Frohlich, J. , Kow, L. (2002) Genetic mechanisms in neural and hormonal controls over female reproductive behaviors. In: Pfaff, D. , Arnold, A. , Etgen, A. , Fahrbach, S. , Rubin, R. , (eds.) Hormones, Brain and Behavior. , 3. Academic Press , San Diego. pp. 441-460.
- Vasudevan, N. , Zhu, Y. , Daniel, S. , Koibuchi, N. , Chin, W. , Pfaff, D. (2001) Crosstalk between oestrogen receptors and thyroid hormone receptor isoforms results in differential regulation of the preproenkephalin gene. Journal of Neuroendocrinology , 13 (9). pp. 779-90. ISSN: 0953-8194
- Vasudevan, N. , Kow, L. , Pfaff, D. (2001) Early membrane estrogenic effects required for full expression of slower genomic actions in a nerve cell line.. Proc Natl Acad Sci U S A. , 98 (21). pp. 12267-71.
- Vasudevan, N. , Koibuchi, N. , Chin, W. , Pfaff, D. (2001) Differential crosstalk between estrogen receptor (ER) alpha and ER beta and the thyroid hormone receptor isoforms results in flexible regulation of the consensus ERE. Mol Brain Res , 95 (1-2). pp. 9-17.
- Vasudevan, N. , Davidkova, G. , Zhu, Y. , Koibuchi, N. , Chin, W. , Pfaff, D. (2001) Differential interaction of estrogen receptor and thyroid hormone receptor isoforms on the rat oxytocin receptor promoter leads to differences in transcriptional regulation. Neuroendocrinology , 74 (5). pp. 309-24. ISSN: 0028-3835
- Vasudevan, N. , Bahadur, U. , Kondaiah, P. (2001) Characterisation of chicken riboflavin carrier protein gene structure and promoter regulation by estrogen. J. Biosci , 26 (1). pp. 39-46..
- Pfaff, D. , Vasudevan, N. , Kia, H. , Zhu, Y. , Chan, J. , Garey, J. , Morgan, M. , Ogawa, S. (2000) Estrogens, brain and behavior: studies in fundamental neurobiology and observations related to women's health. J Steroid Biochem Mol Biol , 74 (5). pp. 365-73. ISSN: 0960-0760 (Print)
- Kia, H. , Vasudevan, N. , Pfaff, D. (2000) New concepts in the neuroendocrine regulation of female reproductive behavior. In: Filicori, M. , (eds.) Endocrine basis of reproductive behavior. Monduzzi , Bologna. pp. 69-76.
- Pfaff, D. , Vasudevan, N. , Attardi, B. (1999) Neuroendocrine Regulation of Sexual Behavior. In: Conn, P. and Freeman, M. , (eds.) Neuroendocrinology in Physiology and Medicine. Humana Press , Totowa NJ. pp. 287-299.