Mike Fry
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+44 (0) 118 378 7028
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Associate Professor
Associate Professor in Biomedical Sciences
Teaching
- Part 1: The living Cell, The Living Cell 2, Laboratory and Study Skills for Biomedicine
- Part 2: Science Communication, Life and Death of a Cell, Molecular Biology of the Gene, Protein Structure and Function.
- Part 3: Cell Communication and Disease, Cancer
Research centres and groups
Member of Impact, Enterprise and Outreach
- Joint Inventor on several patents linked to phosphoinositide 3-kinase research
- Host annual training day for British Biology Olympiad Finalists, Hosted BBO UK finals in 2013
- Local Ambassador for the Biochemical Society
Research projects
- Funding from British Heart Foundation
- Development of a mathematical model of platelet signalling and function - the Virtual Platelet - for in silico experimentation, drug discovery and diagnosis.
- Analysis of the non-genomic functions of histone deacetylases in cellular signalling using proteomic approaches - platelets as a model system.
- Analysis of phosphoinositide 3-kinases in cancer
- Evolution of cellular signalling systems
Professional bodies/affiliations
Local Collaborators
- Prof. Jon Gibbins, School of Biological Sciences
- Dr Chris Jones, School of Biological Sciences
- Dr Marcus Tindall, Department of Mathematics and Statistics
- Dr Fazil Baksh, Department of Mathematics and Statistics
- Dr Philippa Darbre, School of Biological Sciences
International Collaborators
- Dr Bernard Payrastre, Inserm U1048, I2MC and Université Paul Sabatier, Toulouse, France
National Collaborators
- Prof. Marco Falasca, Queen Mary University, London
- Dr Tania Maffuccci, Queen Mary University, London
Selected publications
Pre 2003
Fry MJ. Phosphoinositide 3-kinase signalling in breast cancer: how big a role might it play? (2001) Breast Cancer Res. 3: 304-12.
Publications
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Jackson, K.
ORCID: 0000-0002-0070-3203
,
Newens, K.
,
Fry, M.
,
Thompson, A.
,
Williams, C.
(2022)
Differential effects of single fatty acids and fatty acid mixtures on the phosphoinositide 3-kinase/Akt/eNOS pathway in endothelial cells.
European Journal of Nutrition
, 61
pp.
2463-2473.
ISSN:
1436-6215
|
doi:
https://dx.doi.org/10.1007/s00394-022-02821-2
- Mazet, F. , Tindall, M. , Gibbins, J. , Fry, M. (2020) A model of the PI cycle reveals the regulating roles of lipid-binding proteins and pitfalls of using mosaic biological data. Scientific Reports , 10 (1). pp 0. ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-020-70215-7
- Mazet, F. and Fry, M. (2018) Precise quantification of platelet proteins and their phosphorylation states. In: Gibbins, J. and Mahaut-Smith, M. , (eds.) Platelets and Megakaryocytes: Volume 4, Advanced Protocols and Perspectives. , 1812. Methods in molecular biology (Clifton, N.J.) , 1812 pp. 113-125. ISSN: 1940-6029 ISBN: 9781493985845 | doi: https://dx.doi.org/10.1007/978-1-4939-8585-2_7
- Mazet, F. , Dunster, J. , Jones, C. , Vaiyapuri, S. , Tindall, M. , Fry, M. , Gibbins, J. (2015) A high-density immunoblotting methodology for quantification of total protein levels and phosphorylation modifications. Scientific Reports , 5 ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/srep16995
- Dunster, J. , Mazet, F. , Fry, M. , Gibbins, J. , Tindall, M. (2015) Regulation of early steps of GPVI signal transduction by phosphatases: a systems biology approach. PLoS Computational Biology , 11 (11). ISSN: 1553-734X | doi: https://dx.doi.org/10.1371/journal.pcbi.1004589
- Bye, A. , Unsworth, A. , Vaiyapuri, S. , Stainer, A. , Fry, M. , Gibbins, J. (2015) Ibrutinib inhibits platelet integrin αIIbβ3 outside-in signaling and thrombus stability but not adhesion to collagen. Arteriosclerosis Thrombosis and Vascular Biology , 35 (11). pp. 2326-2335. ISSN: 1524-4636 | doi: https://dx.doi.org/10.1161/ATVBAHA.115.306130
- Ray, S. , Fry, M. , Darbre, P. (2011) Enhanced sensitivity to rapamycin following long-term oestrogen deprivation in MCF-7, T-47-D and ZR-75-1 human breast cancer cells. Journal of Endocrinology , 208 pp. 21-29. ISSN: 0022-0795 | doi: https://dx.doi.org/10.1677/JOE-10-0137
- Fry, . (2009) Phosphoinositide (PI) 3-kinase assays. Methods in Molecular Biology , 462 pp. 345-362. ISSN: 1064-3745 | doi: https://dx.doi.org/10.1007/978-1-60327-115-8
- Traer, . , Foster, . , Abraham, . , Fry, . (2006) Are class II phosphoinositide 3-kinases potential targets for anticancer therapies?. Bull Cancer , 93 (5). pp. E53-8. ISSN: 1769-6917
- Pendaries, . , Tronchere, . , Arbibe, . , Mounier, . , Gozani, . , Cantley, . , Fry, . , Gaits-Iacovoni, . , Sansonetti, . , Payrastre, . (2006) PtdIns(5)P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection. Embo Journal , 25 (5). pp. 1024-1034. ISSN: 0261-4189 | doi: https://dx.doi.org/10.1038/sj.emboj.7601001
- Maffucci, . , Cooke, . , Foster, . , Traer, . , Fry, . , Falasca, . (2005) Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration. Journal of Cell Biology , 169 (5). pp. 789-799. ISSN: 0021-9525 | doi: https://dx.doi.org/10.1083/jcb.200408005
- Foster, . , Traer, . , Abraham, . , Fry, . (2003) The phosphoinositide (PI) 3-kinase family. Journal of Cell Science , 116 (15). pp. 3037-3040. ISSN: 0021-9533 | doi: https://dx.doi.org/10.1242/jcs.00609
- Barry, . , Graham, . , Fry, . , Gibbins, . (2003) Regulation of glycogen synthase kinase 3 in human platelets: a possible role in platelet function?. FEBS Letters , 553 (1-2). pp. 173-178. ISSN: 0014-5793 | doi: https://dx.doi.org/10.1016/s0014-5793(03)01015-9