Kim Watson
-
+44 (0) 118 378 6640
-
Professor
- Professor in Structural Biochemistry
Building location
HLS Room 2.02Teaching
- Part 1: Foundation Biology
- Part 2: Protein Structure and Function
- Part 3: Structural Proteomics and Synthetic Biology
Research centres and groups
Member of
- Institute for Cardiovascular & Metabolic Research
- Molecular & Cellular Medicine Group
Research projects
- Funding from BBSRC, Lister Institute of Preventive Medicine, Diamond Light Source, Industry
- Unravelling sequence-structure-function relationships of proteins
- Drug discovery using computer-aided and structure-based approaches
- Protein engineering for industry
- Understanding molecular mechanisms of disease
- Bile acid metabolism, lipid profiling and health
- Gut-liver-brain axis and health
Awards and honours
Esteem Factors
- Fellow of the Royal Society of Chemistry
- Fellow of the Royal Society of Biology and Chartered Biologist
- Fellow Member, Lister Institute of Preventive Medicine
- Fellow of the Higher Education Academy
- Visiting Scientist, MRC Harwell International Centre for Mouse Genetics
- Visiting Scientist, Diamond Light Source
Professional bodies/affiliations
Impact, Enterprise and Outreach
- Consultant to Industry for computational and structural biology for drug discovery and engineering enzymes for biotechnology
- Development of lead compounds and pharmacophores for drug discovery
- Development and delivery of biopharma skills training for Industry
- Experience of working with a number of Government organisations
- Numerous outreach activities to promote student awareness of STEM research
- Highlighted in 'Women in Research', a photographic exhibition to celebrate women in research at the University of Reading
International Collaborators
- Prof. Gabriele Cruciani, University of Perugia, Italy
- Dr. Edda Battaglia, Gastroenterology, Cardinal Massaia Hospital, Asti, Italy
National Collaborators
- Prof. Glenn Gibson, Food Biosciences, University of Reading
- Dr. Eva Kevei, Biological Sciences, University of Reading
- Prof. Heather Mortiboys, Sheffield Institute of Translational Neuroscience
- Prof. Oliver Bandmann, Consultant Neurologist, Sheffield Institute of Translational Neuroscience
- Dr. Roger Cox, MRC Harwell International Centre for Mouse Genetics
Websites/blogs
Study for a PhD with Professor Kim Watson
Selected publications
Pre 2005
Watson KA, Johnson LNJ, Leoffen P, Gillham D, Eggleston D, Collins P, Moynihan JM, DTI government report (2004) "Structural Genomics in Japan and China" following invitation to coordinate and lead a fully funded DTI mission. The report describes the findings from a DTI funded mission to China and Japan to explore emerging HTP technologies and provide opportunities for UK collaboration/technology transfer.
Brown, K., Carpenter E., Watson, KA, Coggins, JR, Hawkins, AR, Koch, MH, Svergun, DI. (2003) "Twists and turns: a tale of two shikimate-pathway enzymes." Biochem. Soc. Trans., 31, 543-547.
Nathalie Marchand-Geneste, Kimberly A. Watson, Bjorn K. Alsberg, and Ross D. King, (2002) "New Approach to Pharmacophore Mapping and QSAR Analysis Using Inductive Logic Programming. Application to Thermolysin Inhibitors and Glycogen Phosphorylase b Inhibitors".J. Med. Chem., 45, 399-409.
Katerina Tsitsanou, Nikos G. Oikonomakos, Spiros E. Zographos, V. Skamnaki, Mary Gregoriou, Kimberly A. Watson, Louise N. Johnson, George W.J. Fleet, Protein Science, 1999, 8, 741-749. "Effect of commonly used cryoprotectants on glycogen phosphorylase activity and structure"
Kimberly A. Watson, Claire McCleverty, Silvano Geremia, Silvain Cottaz, Hughes Driguez, Louise N. Johnson, The EMBO Journal, 1999, 18, 4619. "Phosphorylase recognition and phosphorylysis of its oligosaccharide substrate: Answers to a long outstanding question"
Mark O'Reilly, Kimberly A. Watson, Louise N. Johnson, Biochemistry, 1999, 38, 5337-5345. "The crystal structure of the E.coli maltodextrin phosphorylase-acarbose complex"
Marc O'Reilly, Kimberly A. Watson, Reinhard Schinzel, Dieter Palm and Louise N. Johnson, Nature Structural Biology, 1997, 4, 405-412. "Oligosaccharide substrate binding in Escherichia colimaltodextrin phosphorylase"
Manuel Pastor, Gabriele Cruciani and Kimberly A. Watson, J. Med. Chem., 1997, 40, 4089-4102. "A Strategy for the Incorporation of Water Molecules Present in a Ligand-Binding Site into a 3D-QSAR Analysis"
Kimberly A. Watson, Reinhard Schinzel, Deiter Palm and Louise N. Johnson, The EMBO Journal, 1997, 16, 1-14. "The crystal structure of Escherichia coli maltodextrin phosphorylase provides an explanation for the activity without control in this basic archetype of a phosphorylase"
Publications
-
Khater, M.
,
Watson, K.
ORCID: 0000-0002-9987-8539
,
Boateng, S.
,
Greco, F.
,
Osborn, H.
(2022)
Halogenated flavonoid derivatives display antiangiogenic activity.
Molecules
, 27
(15).
ISSN:
1420-3049
|
doi:
https://dx.doi.org/10.3390/molecules27154757
-
Rajasekaran, M.
,
Hussain, R.
,
Siligardi, G.
,
Andrews, S.
,
Watson, K.
ORCID: 0000-0002-9987-8539
(2022)
Crystal structure and metal binding properties of the periplasmic iron component EfeM from Pseudomonas syringae EfeUOB/M iron-transport system.
BioMetals
ISSN:
0966-0844
|
doi:
https://dx.doi.org/10.1007/s10534-022-00389-2
-
Chamata, Y.
,
Jackson, K.
ORCID: 0000-0002-0070-3203
,
Watson, K.
,
Jauregi, P.
(2021)
Whey-derived peptides at the heart of the COVID-19 pandemic.
International Journal of Molecular Sciences
, 22
(21).
ISSN:
1422-0067
|
doi:
https://dx.doi.org/10.3390/ijms222111662
-
Baltulionis, G.
,
Blight, M.
,
Robin, A.
,
Charalampopoulos, D.
ORCID: 0000-0003-1269-8402
,
Watson, K.
(2021)
The role of propeptide-mediated autoinhibition and intermolecular chaperone in the maturation of cognate catalytic domain in leucine aminopeptidase.
Journal of Structural Biology
, 213
(3).
ISSN:
1047-8477
|
doi:
https://dx.doi.org/10.1016/j.jsb.2021.107741
- Danson, A. , McStea, A. , Wang, L. , Pollitt, A. , Martin-Fernandez, M. , Moraes, I. , Walsh, M. , MacIntyre, S. , Watson, K. (2020) Super-resolution fluorescence microscopy reveals clustering behaviour of Chlamydia pneumoniae’s major outer membrane protein. Biology , 9 (10). ISSN: 2079-7737 | doi: https://dx.doi.org/10.3390/biology9100344
- Natfji, A. , Nikitin, D. , Semina, I. , Moustafine, R. , Khutoryanskiy, V. , Lin, H. , Stephens, G. , Watson, K. , Osborn, H. , Greco, F. (2020) Conjugation of haloperidol to PEG allows peripheral localisation of haloperidol and eliminates CNS extrapyramidal effects. Journal of Controlled Release , 322 pp. 227-235. ISSN: 0168-3659 | doi: https://dx.doi.org/10.1016/j.jconrel.2020.02.037
- Chamata, Y. , Watson, K. , Jauregi, P. (2020) Whey-derived peptides interactions with ACE by molecular docking as a potential predictive tool of natural ACE inhibitors. International Journal of Molecular Sciences , 21 (3). pp 0. ISSN: 1422-0067 | doi: https://dx.doi.org/10.3390/ijms21030864
- Ravishankar, D. , Albadawi, D. , Chaggar, V. , Patra, P. , Williams, H. , Salamah, M. , Vaiyapuri, R. , Dash, P. , Patel, K. , Watson, K. , Vaiyapuri, S. (2019) Isorhapontigenin, a resveratrol analogue selectively inhibits ADP-stimulated platelet activation. European Journal of Pharmacology , 862 ISSN: 0014-2999 | doi: https://dx.doi.org/10.1016/j.ejphar.2019.172627
- Salamah, M. , Ravishankar, D. , Kodji, X. , Moraes, L. , Williams, H. , Vallance, T. , Albadawi, D. , Vaiyapuri, R. , Watson, K. , Gibbins, J. , Brain, S. , Perretti, M. , Vaiyapuri, S. (2018) The endogenous antimicrobial cathelicidin LL37 induces platelet activation and augments thrombus formation. Blood Advances , 2 (21). pp. 2973-2985. ISSN: 2473-9529 | doi: https://dx.doi.org/10.1182/bloodadvances.2018021758
- Moir, L. , Bochukova, E. , Dumbell, R. , Banks, G. , Bains, R. , Nolan, P. , Scudamore, C. , Simon, M. , Watson, K. , Keogh, J. , Henning, E. , Hendricks, A. , O'Rahilly, S. , Barroso, I. , UK10K, C. , Sullivan, A. , Bersten, D. , Whitelaw, M. , Kirsch, S. , Bentley, E. , Farooqi, I. , Cox, R. (2017) Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety. Molecular Metabolism , 6 (11). pp. 1419-1428. ISSN: 2212-8778 | doi: https://dx.doi.org/10.1016/j.molmet.2017.08.006
- Ravishankar, D. , Watson, K. , Greco, F. , Osborn, H. (2016) Novel synthesised flavone derivatives provide significant insight into the structural features required for enhanced anti-proliferative activity. RSC Advances , 6 (69). pp. 64544-64556. ISSN: 2046-2069 | doi: https://dx.doi.org/10.1039/C6RA11041J
- Swioklo, S. , Watson, K. , Williamson, E. , Farrimond, J. , Putnam, S. , Bicknell, K. (2015) Defining key structural determinants for the pro-osteogenic activity of flavonoids. Journal of Natural Products , 78 (11). pp. 2598-2608. ISSN: 1520-6025 | doi: https://dx.doi.org/10.1021/acs.jnatprod.5b00075
- Wright, B. , Watson, K. , McGuffin, L. , Lovegrove, J. , Gibbins, J. (2015) GRID and docking analyses reveal a molecular basis for flavonoid inhibition of src-family kinase activity. Journal of Nutritional Biochemistry , 26 (11). pp. 1156-1165. ISSN: 0955-2863 | doi: https://dx.doi.org/10.1016/j.jnutbio.2015.05.004
- Ravishankar, D. , Watson, K. , Boateng, S. , Green, R. , Greco, F. , Osborn, H. (2015) Exploring quercetin and luteolin derivatives as antiangiogenic agents. European Journal of Medicinal Chemistry , 97 pp. 259-274. ISSN: 0223-5234 | doi: https://dx.doi.org/10.1016/j.ejmech.2015.04.056
- Osman, A. , Symeou, S. , Trisse, V. , Watson, K. , Tzortzis, G. , Charalampopoulos, D. (2014) Synthesis of prebiotic galactooligosaccharides from lactose using bifidobacterial β-galactosidase (BbgIV) immobilised on DEAE-Cellulose, Q-Sepharose and amino-ethyl agarose. Biochemical Engineering Journal , 82 pp. 188-199. ISSN: 1369-703X | doi: https://dx.doi.org/10.1016/j.bej.2013.11.020
- Antaloae, A. , Montigny, C. , le Maire, M. , Watson, K. , Sorensen, T. (2013) Optimisation of recombinant production of active human cardiac SERCA2a ATPase. PLoS ONE , 8 (8). ISSN: 1932-6203 | doi: https://dx.doi.org/10.1371/journal.pone.0071842
- Atanu, F. , Oviedo-Orta, E. , Watson, K. (2013) A novel transport mechanism for MOMP in Chlamydophila pneumoniae and its putative role in immune-therapy. PLoS ONE , 8 (4). ISSN: 1932-6203 | doi: https://dx.doi.org/10.1371/journal.pone.0061139
- Sarsam, S. , Nutt, D. , Strohfeldt, K. , Watson, K. (2011) Titanocene anticancer complexes and their binding mode of action to human serum albumin: a computational study. Metallomics , 3 (2). pp. 152-161. ISSN: 1756-5901 | doi: https://dx.doi.org/10.1039/c0mt00041h
- Zhou, H. , Standfuss, J. , Watson, K. , Krasel, C. (2010) Structure of full-length arrestin2 in a dimeric crystal form.
- Vaiyapuri, S. , Wagstaff, S. , Watson, K. , Harrison, R. , Gibbins, J. , Hutchinson, E. (2010) Purification and functional characterisation of rhiminopeptidase A, a novel aminopeptidase from the venom of Bitis gabonica rhinoceros. PLoS Neglected Tropical Diseases , 4 (8). ISSN: 1935-2735 | doi: https://dx.doi.org/10.1371/journal.pntd.0000796
- Rajasekaran, M. , Mitchell, S. , Gibson, T. , Hussain, R. , Siligardi, G. , Andrews, S. , Watson, K. (2010) Isolation and characterisation of EfeM, a periplasmic component of the putative EfeUOBM iron transporter of Pseudomonas syringae pv. syringae. Biochemical and Biophysical Research Communications , 398 (3). pp. 366-371. ISSN: 0006-291X | doi: https://dx.doi.org/10.1016/j.bbrc.2010.06.072
- Rajasekaran, M. , Nilapwar, S. , Andrews, S. , Watson, K. (2010) EfeO-cupredoxins: major new members of the cupredoxin superfamily with roles in bacterial iron transport. BioMetals , 23 (1). pp. 1-17. ISSN: 0966-0844 | doi: https://dx.doi.org/10.1007/s10534-009-9262-z
- Bamford, V. , Armour, M. , Mitchell, S. , Cartron, M. , Andrews, S. , Watson, K. (2008) Preliminary X-ray diffraction analysis of YqjH from Escherichia coli: a putative cytoplasmic ferri-siderophore reductase. Acta Crystallographica Section F-Structural Biology and Crystallization Communications , 64 (9). pp. 792-796. ISSN: 1744-3091 | doi: https://dx.doi.org/10.1107/S174430910802352X
- Pugazhendhi, . , Watson, . , Mills, . , Botting, . , Pope, . , Darbre, . (2008) Effect of sulphation on the oestrogen agonist activity of the phytoestrogens genistein and daidzein in MCF-7 human breast cancer cells. Journal of Endocrinology , 197 (3). pp. 503-515. ISSN: 0022-0795 | doi: https://dx.doi.org/10.1677/joe-07-0384
- Baba-Dikwa, . , Thompson, . , Spencer, N. , Andrews, . , Watson, . (2008) Overproduction, purification and preliminary X-ray diffraction analysis of YncE, an iron-regulated Sec-dependent periplasmic protein from Escherichia coli. Acta Crystallographica Section F-Structural Biology and Crystallization Communications , 64 pp. 966-969. ISSN: 1744-3091 | doi: https://dx.doi.org/10.1107/s1744309108029515
- Lamanna, . , Catalano, . , Carocci, . , Di Mola, . , Franchini, . , Tortorella, . , Vanderheyden, . , Sinicropi, . , Watson, . , Sciabola, . (2007) AT(1) receptor ligands: virtual-screening-based design with TOPP descriptors, synthesis, and biological evaluation of pyrrolidine derivatives. ChemMedChem , 2 (9). pp. 1298-310. ISSN: 1860-7179 | doi: https://dx.doi.org/10.1002/cmdc.200700082
- Cartron, . , Mitchell, S. , Woodhall, . , Andrews, . , Watson, . (2007) Preliminary X-ray diffraction analysis of YcdB from Escherichia coli: a novel haem-containing and Tat-secreted periplasmic protein with a potential role in iron transport. Acta Crystallographica Section F-Structural Biology and Crystallization Communications , 63 pp. 37-41. ISSN: 1744-3091 | doi: https://dx.doi.org/10.1107/s174430910604509x
- Armour, . , Cartron, . , Mitchell, . , Bamford, . , Watson, . , Andrews, . (2007) YqjH: a novel cytopolasmic siderophore reductase found in eschericia coli. American Journal of Hematology , 82 (6). pp. 582-582. ISSN: 0361-8609
- Watson, . (2005) How China and Japan are solving the protein puzzle. Global Watch , 44 pp. 4-7.
- Watson, . , Chrysina, . , Tsitsanou, . , Zographos, . , Archontis, . , Fleet, . , Oikonomakos, . (2005) Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase. Proteins: Structure, Function and Bioinformatics , 61 (4). pp. 966-83. ISSN: 0887-3585 | doi: https://dx.doi.org/10.1002/prot.20653
- Archontis, . , Watson, . , Xie, . , Andreou, . , Chrysina, . , Zographos, . , Oikonomakos, . , Karplus, . (2005) Glycogen phosphorylase inhibitors: a free energy perturbation analysis of glucopyranose spirohydantoin analogues. Proteins , 61 (4). pp. 984-98. ISSN: 0887-3585
- Browning, K. , Carpenter, E. , Watson, K. , Coggins, J. , Hawkins, A. , Koch, M. , Svergun, D. (2003) Twists and turns: a tale of two shikimate-pathway enzymes. Biochemical Society Transactions , 31 (3). pp. 543-547. ISSN: 1470-8752