Jon Gibbins

Email:
j.m.gibbins@reading.ac.uk
Phone:
+44 (0) 118 378 7082
Job title:
Professor

Responsibilities:

Professor of Cell Biology
Director of the ICMR
Leader of the University of Reading Platelet Biology Research Group

Teaching

Part 3: Cardiovascular Disease

Research centres and groups

Local Collaborators

Dr Chris Jones, School of Biological Sciences
Dr Lucia Stefanini, School of Biological Sciences
Dr Simon Clarke, School of Biological Sciences
Dr Michael Fry, School of Biological Sciences
Professor Julie Lovegrove, Food and Nutritional Sciences
Dr Marcus Tindall, Department of Mathematics and Statistics
Dr Fazil Baksh, Department of Mathematics and Statistics
Dr Keith Foster, School of Biological Sciences
Dr Alexander Edwards, Chemistry

International Collaborators

Extensive international collaborations include colleagues at

Sick Kids Hospital, University of Toronto, Canada
University of British Columbia, Vancouver, Canada
Blood Center of Wisconsin, Milwaukee, USA
Emory University, Atlanta, USA
University of Pennsylvania, Philadelphia, USA
Temple University, Philadelphia, USA
Harvard Medical School, Boston, USA
Kyoto Sangyo University, Kyoto, Japan
Australian Centre for Blood Diseases, Monash University, Australia
School for Cardiovascular Diseases, University of Maastricht, Netherlands
University of Marseille, France
Max Plank Institute for Molecular Biomedicine, Münster, Germany
King Saud University, Riyadh, Saudi Arabia

National Collaborators

Our research is supported by extensive formal and informal collaborations with colleagues at the Wellcome Sanger Institute, Cambridge and at the Universities of

Cambridge
Leicester
Birmingham
Bristol
Hull
Surrey
Nottingham
King's College London
Imperial College London

Research projects

Funding from British Heart Foundation, MRC, BBSRC, Heart Research UK, and pharmaceutical companies
Programme grants from British Heart Foundation and MRC
Understanding of the molecular mechanisms that regulate the function of platelets in haemostasis and thrombosis
Development of new strategies for the prevent of thrombosis
Cell signalling, specialist assays of haematological function, in vivo analysis of thrombosis and its prevention
Development of a mathematical model of platelet signalling and function - the Virtual Platelet - for in silico experimentation, drug discovery and diagnosis.
Founding director of the ICMR, which brings together the distinctive range of research expertise across the University to enable us impact on reducing the burden of cardiovascular diseases and the metabolic conditions from which they develop, through disease prevention and treatment.

Awards and honours

Esteem Factors

Platelet Society - Chair: 2019-present
Heart Research UK- Chair, Novel and Emerging Technologies Panel 2015-present
Royal Society Newton Advanced Fellowships Panel: 2018 - 2021
Full editorial board member, British Journal of Pharmacology: 2014-
Visiting Professor, King Saud University, Riyadh, Saudi Arabia 2011-2014
Full editorial board member, Journal of Biological Chemistry: 2008-2013
British Heart Foundation Project Grants Committee: 2009-2012
John French Lecture 2008 - British Atherosclerosis Society

Selected publications

Clarke SR, Foster SJ. (2006) Surface adhesins of Staphylococcus aureus. Advances in Microbial Physiology. 51:187-224.
Clarke SR, Brummell KJ, Horsburgh MJ, McDowell PW, Mohamad SA, Stapleton MR, Acevedo J, Read RC, Day NP, Peacock SJ, Mond JJ, Kokai-Kun JF, Foster SJ. (2006) Identification of in vivo-expressed antigens of Staphylococcus aureus and their use in vaccinations for protection against nasal carriage. Journal of Infectious Diseases. 193:1098-1108.
Pourmand MR, Clarke SR, Schuman RF, Mond JJ, Foster SJ. (2006) Identification of antigenic components of Staphylococcus epidermidis expressed during human infection. Infection and Immunity. 74:4644-4654.

Impact, enterprise and outreach

Discovery of platelet receptor and associated signalling mechanisms that are the basis of drug discovery programmes by pharmaceutical companies
Collaboration with pharmaceutical sector towards the development of more effective anti-thrombotic agents or strategies
Enterprise Fellow 2005
Extensive worldwide media coverage of research publications
Interviews with local and national print and broadcast media
Public lectures, children's lectures (Reading and Royal Institution), children's workshops, and school visits

Publications

Mitchell, J. , Khan, D. , Rana, R. , Kriek, N. , Unsworth, A. , Sage, T. , Bye, A. ORCID: 0000-0002-2061-2253 , Laffan, M. , Shapiro, S. , Thakurta, A. , Grech, H. , Ramasamy, K. , Gibbins, J. ORCID: 0000-0002-0372-5352 (2023) Multiple myeloma and its treatment contribute to increased platelet reactivity. Platelets , 34 (1). ISSN: 1369-1635 | doi: https://dx.doi.org/10.1080/09537104.2023.2264940
Provenzale, I. , De Simone, I. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Heemskerk, J. , van der Meijden, P. , Jones, C. ORCID: 0000-0001-7537-1509 (2023) Regulation of glycoprotein VI-dependent platelet activation and thrombus formation by heparan sulfate proteoglycan perlecan. International Journal of Molecular Sciences , 24 (17). ISSN: 1422-0067 | doi: https://dx.doi.org/10.3390/ijms241713352
AlOuda, S. , Sasikumar, P. , AlThunayan, T. , Alaajam, F. , Khan, S. , Sahli, K. , Abohassan, M. , Pollitt, A. , Jung, S. , Gibbins, J. ORCID: 0000-0002-0372-5352 (2023) Role of heat shock protein 47 in platelet glycoprotein VI dimerisation and signaling. Research and Practice in Thrombosis and Haemostasis , 7 (6). ISSN: 2475-0379 | doi: https://dx.doi.org/10.1016/j.rpth.2023.102177
Kuravi, S. , Ahmed, N. , Taylor, K. , Capes, E. , Bye, A. , Unsworth, A. , Gibbins, J. , Pugh, N. (2023) Delineating zinc influx mechanisms during platelet activation. International Journal of Molecular Sciences , 24 (14). ISSN: 1422-0067 | doi: https://dx.doi.org/10.3390/ijms241411689
Mitchell, J. , Little, G. , Bye, A. ORCID: 0000-0002-2061-2253 , Gaspar, R. , Unsworth, A. , Kriek, N. , Sage, T. , Stainer, A. , Sangowawa, I. , Morrow, G. , Bastos, R. , Shapiro, S. , Desborough, M. , Curry, N. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Whyte, C. , Mutch, N. , Jones, C. ORCID: 0000-0001-7537-1509 (2023) Platelet factor XIII-A regulates platelet function and promotes clot retraction and stability. Research and Practice in Thrombosis and Haemostasis , 7 (5). ISSN: 2475-0379 | doi: https://dx.doi.org/10.1016/j.rpth.2023.100200
Ranjbar, J. , Njoroge, W. ORCID: 0009-0003-1365-5129 , Gibbins, J. ORCID: 0000-0002-0372-5352 , Roach, P. ORCID: 0000-0003-4135-9733 , Yang, Y. ORCID: 0000-0002-1362-6040 , Harper, A. ORCID: 0000-0003-2413-4823 (2023) Developing biomimetic hydrogels of the arterial wall as a prothrombotic substrate for in vitro human thrombosis models. Gels , 9 (6). pp 1. ISSN: 2310-2861 | doi: https://dx.doi.org/10.3390/gels9060477
Mitchell, J. , Dunster, J. , Kriek, N. , Unsworth, A. , Sage, T. , Mohammed, Y. , De Simone, I. , Taylor, K. , Bye, A. ORCID: 0000-0002-2061-2253 , Ólafsson, G. , Brunton, M. , Mark, S. , Dymott, L. , Whyte, A. , Ruparelia, N. , Mckenna, C. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Jones, C. ORCID: 0000-0001-7537-1509 (2023) The rate of platelet activation determines thrombus size and structure at arterial shear. Journal of Thrombosis and Haemostasis , 21 (8). pp. 2248-2259. ISSN: 1538-7836 | doi: https://dx.doi.org/10.1016/j.jtha.2023.03.044
Cheung, H. , Zou, J. , Tantiwong, C. , Fernandez, D. , Huang, J. , Ahrends, R. , Roest, M. , Cavill, R. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Heemskerk, J. (2023) High-throughput assessment identifying major platelet Ca2+ entry pathways via tyrosine kinase-linked and G protein-coupled receptors. Cell Calcium , 112 ISSN: 0143-4160 | doi: https://dx.doi.org/10.1016/j.ceca.2023.102738
Gibbins, J. ORCID: 0000-0002-0372-5352 (2023) Adding fuel to the flames in pre-eclampsia: the platelet connection. Journal of Thrombosis and Haemostasis , 21 (7). pp. 1750-1752. ISSN: 1538-7933 | doi: https://dx.doi.org/10.1016/j.jtha.2023.03.031
Thienel, M. , Müller-Reif, J. , Zhang, Z. , Ehreiser, V. , Huth, J. , Shchurovska, K. , Kilani, B. , Schweizer, L. , Geyer, P. , Zweibel, M. , Novotny, J. , Lüsebrink, E. , Little, G. , Orban, M. , Nicolai, L. , El Nemr, S. , Titova, A. , Spannagl, M. , Kindberg, J. , Evans, A. , Mach, O. , Vogel, M. , Tiedt, S. , Ormanns, S. , Kessler, B. , Dueck, A. , Friebe, A. , Godsk Jørgensen, P. , Majzoub-Altweck, M. , Blutke, A. , Polzin, A. , Stark, K. , Kääb, S. , Maier, D. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Limper, U. , Frobert, O. , Mann, M. , Massberg, S. , Petzold, T. (2023) Immobility-associated thromboprotection is conserved across mammalian species from bear to human. Science , 380 (6641). pp. 178-187. ISSN: 1095-9203 | doi: https://dx.doi.org/10.1126/science.abo5044
Nelson, M. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Dunster, J. (2023) Platelet-driven routes to chaos in a model of hepatitis. Chaos, Solitons & Fractals , 170 ISSN: 1873-2887 | doi: https://dx.doi.org/10.1016/j.chaos.2023.113338
Tantiwong, C. , Dunster, J. , Cavill, R. , Tomlinson, M. , Wierling, C. , Heemskerk, J. , Gibbins, J. ORCID: 0000-0002-0372-5352 (2023) An agent-based approach for modelling and simulation of glycoprotein VI receptor diffusion, localisation and dimerisation in platelet lipid rafts. Scientific Reports , 13 ISSN: 2045-2322
De Simone, I. , Baaten, C. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Ten Cate, H. , Heemskerk, J. , Jones, C. ORCID: 0000-0001-7537-1509 , van der Meijden, P. (2023) Repeated platelet activation and the potential of previously activated platelets to contribute to thrombus formation. Journal of Thrombosis and Haemostasis , 21 (5). pp. 1289-1306. ISSN: 1538-7933 | doi: https://dx.doi.org/10.1016/j.jtha.2023.01.006
Bye, A. ORCID: 0000-0002-2061-2253 , Kriek, N. , Sage, T. , Rawlings, S. , Prodger, C. , Kesavan, M. , Lees, C. , Booth, S. , Cowen, L. , Shefferd, K. , Desborough, M. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Eyre, T. (2023) Pirtobrutinib results in reversible platelet dysfunction compared to ibrutinib and acalabrutinib. Haematologica , 108 (5). ISSN: 1592-8721 | doi: https://dx.doi.org/10.3324/haematol.2022.281402
Oderberg, D. ORCID: 0000-0001-9585-0515 , Hill, J. , Austin, C. , Bojak, I. ORCID: 0000-0003-1765-3502 , Cinotti, F. , Gibbins, J. ORCID: 0000-0002-0372-5352 (2023) Biological mistakes: what they are and what they mean for the experimental biologist. British Journal for the Philosophy of Science ISSN: 1464-3537 | doi: https://dx.doi.org/10.1086/724444
Dunster, J. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Nelson, M. (2023) Exploring the constituent mechanisms of hepatitis: a dynamical systems approach. Mathematical Medicine and Biology: A Journal of the IMA , 40 (1). pp. 24-48. ISSN: 1477-8599 | doi: https://dx.doi.org/10.1093/imammb/dqac013

Wright, J. , Jones, S. , Parvathy, S. , Kaczmarek, L. , Forsythe, I. , Farndale, R. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Mahaut-Smith, M. (2022) The voltage-gated K+ channel Kv1.3 modulates platelet motility and α2β1 integrin-dependent adhesion to collagen. Platelets , 33 (3). pp. 451-461. ISSN: 0953-7104 | doi: https://dx.doi.org/10.1080/09537104.2021.1942818
Waller, A. , Birch, K. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Clarke, S. (2022) Activation of Human Platelets by Staphylococcus aureus Secreted Protease Staphopain A. Pathogens , 11 (11). ISSN: 2076-0817 | doi: https://dx.doi.org/10.3390/pathogens11111237
De Simone, I. , Baaten, C. , Jandrot-Perrus, M. , Gibbins, J. ORCID: 0000-0002-0372-5352 , ten Cate, H. , Heemskerk, J. , Jones, C. ORCID: 0000-0001-7537-1509 , van der Meijden, P. (2022) Coagulation factor XIIIa and activated protein C activate platelets via GPVI and PAR1. International Journal of Molecular Sciences , 23 (18). ISSN: 1422-0067 | doi: https://dx.doi.org/10.3390/ijms231810203
Kriek, N. , Nock, S. , Sage, T. , Khalifa, B. , Bye, A. ORCID: 0000-0002-2061-2253 , Mitchell, J. , Thomson, S. , McLaughlin, M. , Jones, S. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Unsworth, A. ORCID: 0000-0003-3809-5984 (2022) Cucurbitacins elicit anti-platelet activity via perturbation of the cytoskeleton and integrin function. Thrombosis and Haemostasis , 122 (7). pp. 1115-1129. ISSN: 0340-6245 | doi: https://dx.doi.org/10.1055/a-1788-5322
Pycraft Hughes, M. , Kruchek, E. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Griffiths, O. , Abdal, B. , Labeed, F. (2022) The platelet electrome: evidence for a role in regulation of function and surface interaction. Bioelectricity , 4 (3). pp. 153-159. ISSN: 2576-3113 | doi: https://dx.doi.org/10.1089/bioe.2021.0044
Kempster, C. , Butler, G. , Kuznecova, E. , Taylor, K. , Kriek, N. , Little, G. , Sowa, M. , Sage, T. , Johnson, L. ORCID: 0000-0002-0006-1511 , Gibbins, J. ORCID: 0000-0002-0372-5352 , Pollitt, A. (2022) Fully automated platelet differential interference contrast image analysis via deep learning. Scientific Reports , 12 ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-022-08613-2
Hill, J. , Oderberg, D. ORCID: 0000-0001-9585-0515 , Gibbins, J. ORCID: 0000-0002-0372-5352 , Bojak, I. ORCID: 0000-0003-1765-3502 (2022) Mistake-making: a theoretical framework for generating research questions in biology, with illustrative application to blood clotting. Quarterly Review of Biology , 97 (1). ISSN: 0033-5770 | doi: https://dx.doi.org/10.1086/718736
Downes, K. , Zhao, X. , Gleadall, N. , Antanavicius, N. , McKinney, H. , Kempster, C. , Batista, J. , Thomas, P. , Cooper, M. , Michael, J. , Kreuzhuber, R. , Wedderburn, K. , Waller, K. , Varney, B. , Kriek, N. , Ashford, S. , Stirrups, K. , Dunster, J. , McKenzie, S. , Ouwehand, W. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Yang, J. , Astle, W. , Ma, P. (2022) G protein-coupled receptor kinase 5 regulates thrombin signaling in platelets via PAR-1. Blood Advances , 6 (7). pp. 2319-2330. ISSN: 2473-9529 | doi: https://dx.doi.org/10.1182/bloodadvances.2021005453

Dunster, J. , Mitchell, J. , Mohammed, Y. , Taylor, K. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Jones, C. (2021) Kinetx: a combined flow cytometry assay and analysis software framework to quantitatively measure and categorize platelet activation in real-time. Journal of Visualized Experiments , 176 ISSN: 1940-087X | doi: https://dx.doi.org/10.3791/62947
Bye, A. , Hoepel, W. , Mitchell, J. , Jegouic, S. , Loureiro, S. , Sage, T. , Vidarsson, G. , Nouta, J. , Wuhrer, M. , de Taeye, S. , van Gils, M. , Kriek, N. , Cooper, N. , Jones, I. ORCID: 0000-0002-7738-2516 , den Dunnen, J. , Gibbins, J. ORCID: 0000-0002-0372-5352 (2021) Aberrant glycosylation of anti-SARS-CoV-2 spike IgG is a pro-thrombotic stimulus for platelets. Blood , 138 (16). pp. 1481-1489. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood.2021011871
Gaspar, R. , Mansilla, S. , Vieira, V. , da Silva, L. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Castro, L. , Trostchansky, A. , de A. Paes, A. (2021) The protein disulphide isomerase inhibitor CxxCpep modulates oxidative burst and mitochondrial function in platelets. Free Radical Biology and Medicine , 172 pp. 668-674. ISSN: 0891-5849 | doi: https://dx.doi.org/10.1016/j.freeradbiomed.2021.07.011
Cai, H. , Sasikumar, P. , Little, G. , Bihan, D. , Hamaia, S. , Zhou, A. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Farndale, R. (2021) Identification of HSP47 binding site on native collagen and its implications on the development of HSP47 inhibitors. Biomolecules , 11 (7). ISSN: 2218-273X | doi: https://dx.doi.org/10.3390/biom11070983
Dunster, J. , Bye, A. , Kriek, N. , Sage, T. , Mitchell, J. , Kempster, C. , Batista, J. , KcKinney, H. , Thomas, P. , Jones, C. ORCID: 0000-0001-7537-1509 , Downes, K. , Unsworth, A. , Gibbins, J. ORCID: 0000-0002-0372-5352 (2021) Multi-parameter phenotyping of platelet reactivity for stratification of human cohorts. Blood Advances , 5 (20). pp. 4017-4030. ISSN: 2473-9529 | doi: https://dx.doi.org/10.1182/bloodadvances.2020003261
Simoes Gaspar, R. and Gibbins, J. ORCID: 0000-0002-0372-5352 (2021) Thiol isomerases orchestrate thrombosis and haemostasis. Antioxidants & Redox Signaling , 35 (13). ISSN: 1523-0864 | doi: https://dx.doi.org/10.1089/ars.2021.0086
Simoes Gaspar, R. , Sage, T. , Little, G. , Kriek, N. , Pula, G. , Gibbins, J. ORCID: 0000-0002-0372-5352 (2021) Protein disulphide isomerase and NADPH oxidase 1 cooperate to control platelet function and are associated with cardiometabolic disease risk factors. Antioxidants , 10 (3). ISSN: 2076-3921 | doi: https://dx.doi.org/10.3390/antiox10030497
Taylor, K. , Little, G. , Gibbins, J. ORCID: 0000-0002-0372-5352 (2021) Mind the gap: connexins and pannexins in platelet function. Platelets , 32 (7). pp. 888-894. ISSN: 0953-7104 | doi: https://dx.doi.org/10.1080/09537104.2021.1902971
Soriano Jerez, E. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Hughes, C. ORCID: 0000-0002-9790-5820 (2021) Targeting platelet inhibition receptors for novel therapies: PECAM-1 and G6b-B. Platelets , 32 (6). pp. 761-769. ISSN: 0953-7104 | doi: https://dx.doi.org/10.1080/09537104.2021.1882668
Gaspar, R. , Ferreira, P. , Mitchell, J. , Pula, G. , Gibbins, J. ORCID: 0000-0002-0372-5352 (2021) Platelet-derived extracellular vesicles express NADPH oxidase-1 (Nox-1), generate superoxide and modulate platelet function. Free Radical Biology and Medicine , 165 pp. 395-400. ISSN: 0891-5849 | doi: https://dx.doi.org/10.1016/j.freeradbiomed.2021.01.051
Gaspar, R. , Unsworth, A. , Al-Dibouni, A. , Bye, A. , Sage, T. , Stewart, M. , Cox, R. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Sellayah, D. , Hughes, C. ORCID: 0000-0002-9790-5820 (2021) Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring. Scientific Reports , 11 ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-020-80373-3
Majeed, K. , Al-Fahad, D. , Jalood, H. , Hantosh, H. , Ali, M. , Sakthivel, S. , Williams, H. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Patel, K. , Baksh, M. , Vaiyapuri, S. ORCID: 0000-0002-6006-6517 (2021) RhD blood type significantly influences susceptibility to contract COVID-19 among a study population in Iraq. F1000Research ISSN: 2046-1402 | doi: https://dx.doi.org/10.12688/f1000research.27777.1
Holbrook, L. , Keeton, S. , Sasikumar, P. , Nock, S. , Gelzinis, J. , Brunt, E. , Ryan, S. , Pantos, M. , Verbetsky, C. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Kennedy, D. (2021) Zafirlukast is a broad-spectrum thiol isomerase inhibitor that inhibits thrombosis without altering bleeding times. British Journal of Pharmacology , 178 (3). pp. 550-563. ISSN: 1476-5381 | doi: https://dx.doi.org/10.1111/bph.15291
Sahli, K. , Flora, G. , Sasikumar, P. , Maghrabi, A. , Holbrook, L. , AlOuda, S. , Elgheznawy, A. , Sage, T. , Stainer, A. , Adiyaman, R. , AboHassan, M. , Crescente, M. , Kriek, N. , Vaiyapuri, S. , Bye, A. , Unsworth, A. , Jones, C. , McGuffin, L. , Gibbins, J. (2021) Structural, functional and mechanistic insights uncover the fundamental role of orphan connexin-62 in platelets. Blood , 137 (6). pp. 830-843. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood.2019004575
Unsworth, A. , Bye, A. , Sage, T. , Gaspar, R. , Eaton, N. , Drew, C. , Stainer, A. , Kriek, N. , Volberding, P. , Hutchinson, J. , Riley, R. , Jones, S. , Mundell, S. , Cui, W. , Falet, H. , Gibbins, J. (2021) Anti-platelet properties of Pim kinase inhibition is mediated through disruption of thromboxane A2 receptor signalling. Haematologica , 106 (7). ISSN: 1592-8721 | doi: https://dx.doi.org/10.3324/haematol.2019.223529

Ferreira, P. , Bozbas, E. , Tannetta, D. , Alroqaiba, N. , Zhou, R. , Crawley, J. , Gibbins, J. , Jones, C. ORCID: 0000-0001-7537-1509 , Ahnstrom, J. , Yaqoob, P. (2020) Mode of induction of platelet-derived extracellular vesicles is a critical determinant of their phenotype and function. Scientific Reports , 10 (1). ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-020-73005-3
Mazet, F. , Tindall, M. , Gibbins, J. , Fry, M. (2020) A model of the PI cycle reveals the regulating roles of lipid-binding proteins and pitfalls of using mosaic biological data. Scientific Reports , 10 (1). pp 0. ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-020-70215-7
Al-Dibouni, A. , Gaspar, R. , Ige, S. , Boateng, S. , Cagampang, F. , Gibbins, J. , Cox, R. , Sellayah, D. (2020) Unique genetic and histological signatures of mouse pericardial adipose tissue. Nutrients , 12 (6). ISSN: 2072-6643 | doi: https://dx.doi.org/10.3390/nu12061855
Martyanov, A. , Balabin, F. , Dunster, J. , Panteleev, M. , Gibbins, J. , Sveshnikov, A. (2020) Control of platelet CLEC-2-mediated activation by receptor clustering and tyrosine kinase signalling. Biophysical Journal , 118 (11). ISSN: 0006-3495 | doi: https://dx.doi.org/10.1016/j.bpj.2020.04.023
lopes Pires, M. , Ahmed, N. , Vara, D. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Pula, G. , Pugh, N. (2020) Zinc regulates reactive oxygen species generation in platelets. Platelets , 32 (3). pp. 368-377. ISSN: 0953-7104 | doi: https://dx.doi.org/10.1080/09537104.2020.1742311
Gaspar, R. , da Silva, S. , Stapleton, J. , Fontelles, J. , Sousa, H. , Chagas, V. , Alsufyani, S. , Trostchansky, A. , Gibbins, J. , Paes, A. (2020) Myricetin, the main flavonoid in Syzygium cumini leaf, is a novel inhibitor of platelet thiol isomerases PDI and ERp5. Frontiers in Pharmacology , 10 ISSN: 1663-9812 | doi: https://dx.doi.org/10.3389/fphar.2019.01678
Bye, A. , Gibbins, J. , Mahaut-Smith, M. (2020) Ca2+ waves coordinate purinergic receptor–evoked integrin activation and polarization. Science Signaling , 13 (615). ISSN: 1937-9145 | doi: https://dx.doi.org/10.1126/scisignal.aav7354
Darling, T. , Schenk, M. , Zhou, C. , Maloba, F. , Mimche, P. , Gibbins, J. , Jobe, S. , Lamb, T. (2020) Platelet alpha-granules contribute to organ-specific pathologies in a mouse model of severe malaria. Blood Advances , 4 (1). pp. 1-8. ISSN: 2473-9529 | doi: https://dx.doi.org/10.1182/bloodadvances.2019000773
Dunster, J. , Unsworth, A. , Bye, A. , Haining, E. , Sowa, M. , Di, Y. , Sage, T. , Pallini, C. , Pike, J. , Hardy, A. , Nieswandt, B. , García, Á. , Watson, S. , Poulter, N. , Gibbins, J. , Pollitt, A. (2020) Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation. Journal of Thrombosis and Haemostasis , 18 (2). pp. 485-496. ISSN: 1538-7836 | doi: https://dx.doi.org/10.1111/jth.14673

Flora, G. , Sahli, K. , Sasikumar, P. , Holbrook, L. , Stainer, A. , Alouda, S. , Crescente, M. , Sage, T. , Unsworth, A. , Gibbins, J. (2019) Non-genomic effects of the Pregnane X Receptor negatively regulate platelet functions, thrombosis and haemostasis. Scientific Reports , 9 (1). ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-019-53218-x
Stainer, A. , Sasikumar, P. , Bye, A. , Unsworth, A. , Holbrook, L. , Tindall, M. , Lovegrove, J. , Gibbins, J. (2019) The metabolites of the dietary flavonoid quercetin possess potent antithrombotic activity, and interact with aspirin to enhance antiplatelet effects. TH Open , 3 (3). pp. e244-e258. ISSN: 2512-9465 | doi: https://dx.doi.org/10.1055/s-0039-1694028
Stainer, A. , Sasikumar, P. , Bye, A. , Unsworth, A. , Holbrook, L. , Tindall, M. , Lovegrove, J. , Gibbins, J. (2019) Quercetin and its methylated metabolites possess anti-thrombotic properties that interact with aspirin to enhance its anti-platelet effects. TH Open , 3 (3). pp. e244-e258. ISSN: 2512-9465 | doi: https://dx.doi.org/10.1055/s-0039-1694028
Salamah, M. , Ravishankar, D. , Vaiyapuri, R. , Moraes, L. , Patel, K. , Perretti, M. , Gibbins, J. , Vaiyapuri, S. (2019) The formyl peptide fMLF primes platelet activation and augments thrombus formation. Journal of Thrombosis and Haemostasis , 17 (7). pp. 1120-1133. ISSN: 1538-7836 | doi: https://dx.doi.org/10.1111/jth.14466
Macwan, A. , Boknas, N. , Ntzouni, M. , Ramstrom, S. , Gibbins, J. , Faxalv, L. , Lindahl, T. (2019) Gradient-dependent inhibition of stimulatory signaling from platelet G protein-coupled receptors. Haematologica , 104 (7). pp. 1482-1492. ISSN: 1592-8721 | doi: https://dx.doi.org/10.3324/haematol.2018.205815
Unsworth, A. , Bye, A. , Kriek, N. , Sage, T. , Osborne, A. , Donaghy, D. , Gibbins, J. (2019) Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction. Platelets , 30 (6). pp. 762-772. ISSN: 0953-7104 | doi: https://dx.doi.org/10.1080/09537104.2018.1514107

Salamah, M. , Ravishankar, D. , Kodji, X. , Moraes, L. , Williams, H. , Vallance, T. , Albadawi, D. , Vaiyapuri, R. , Watson, K. , Gibbins, J. , Brain, S. , Perretti, M. , Vaiyapuri, S. (2018) The endogenous antimicrobial cathelicidin LL37 induces platelet activation and augments thrombus formation. Blood Advances , 2 (21). pp. 2973-2985. ISSN: 2473-9529 | doi: https://dx.doi.org/10.1182/bloodadvances.2018021758
Dunster, J. , Panteleev, M. , Gibbins, J. , Sveshnikova, A. (2018) Mathematical techniques for understanding platelet regulation and the development of new pharmacological approaches. In: Gibbins, J. and Mahaut-Smith, M. , (eds.) Platelets and Megakaryocytes: Volume 4, Advanced Protocols and Perspectives. Methods in Molecular Biology , 1812. Methods in molecular biology (Clifton, N.J.) , 1812 pp. 255-279. ISSN: 1940-6029 ISBN: 9781493985845 | doi: https://dx.doi.org/10.1007/978-1-4939-8585-2_15
Bye, A. , Unsworth, A. , Gibbins, J. (2018) Screening and high-throughput platelet assays. In: Gibbins, J. and Mahaut-Smith, M. , (eds.) Platelets and Megakaryocytes: Volume 4, Advanced Protocols and Perspectives. , 1812. Methods in molecular biology (Clifton, N.J.) , 1812 pp. 81-94. ISSN: 1940-6029 ISBN: 9781493985845 | doi: https://dx.doi.org/10.1007/978-1-4939-8585-2_5
Gibbins, J. and Mahaut-Smith, M. , eds. (2018) Platelets and Megakaryocytes. Volume 4, Advanced Protocols and Perspectives. Methods in Molecular Biology , 1812. Humana Press pp 304. ISBN: 9781493985845 | doi: https://dx.doi.org/10.1007/978-1-4939-8585-2
Stefanini, L. , Lee, R. , Paul, D. , O'Shaughnessy, E. , Ghalloussi, D. , Jones, C. , Boulaftali, Y. , Poe, K. , Piatt, R. , Kechele, D. , Caron, K. , Hahn, K. , Gibbins, J. , Bergmeier, W. (2018) Functional redundancy between RAP1 isoforms in murine platelet production and function. Blood , 132 (18). pp. 1951-1962. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood-2018-03-838714
Huang, Z. , Barker, D. , Gibbins, J. , Dash, P. (2018) Talin is a substrate for SUMOylation in migrating cancer cells. Experimental Cell Research , 370 (2). pp. 417-425. ISSN: 0014-4827 | doi: https://dx.doi.org/10.1016/j.yexcr.2018.07.005
Bye, A. and Gibbins, J. (2018) Move along, nothing to see here: Btk inhibitors stop platelets sticking to plaques. Journal of Thrombosis and Haemostasis , 16 (8). pp. 1461-1463. ISSN: 1538-7933 | doi: https://dx.doi.org/10.1111/jth.14201
Molica, F. , Figueroa, X. , Kwak, B. , Isakson, B. , Gibbins, J. (2018) Connexins and pannexins in vascular function and disease. International Journal of Molecular Sciences , 19 (6). ISSN: 1422-0067 | doi: https://dx.doi.org/10.3390/ijms19061663
Fuentos, E. , Gibbins, J. , Holbrook, L. , Palomo, I. (2018) NADPH oxidase 2 (NOX2): a key target of oxidative stress-mediated platelet activation and thrombosis. Trends in Cardiovascular Medicine , 28 (7). pp. 429-434. ISSN: 1050-1738 | doi: https://dx.doi.org/10.1016/j.tcm.2018.03.001
Belyaev, A. , Dunster, J. , Gibbins, J. , Panteleev, M. , Volpert, V. (2018) Modelling thrombosis in silico: frontiers, challenges, unresolved problems and milestones. Physics of Life Reviews , 26-27 pp. 57-95. ISSN: 1571-0645 | doi: https://dx.doi.org/10.1016/j.plrev.2018.02.005
Sasikumar, P. , AlOuda, K. , Kaiser, W. , Holbrook, L. , Kriek, N. , Unsworth, A. , Bye, A. , Sage, T. , Ushioda, R. , Nagata, K. , Farndale, R. , Gibbins, J. (2018) The chaperone protein HSP47: a platelet collagen binding protein that contributes to thrombosis and haemostasis. Journal of Thrombosis and Haemostasis , 16 (5). pp. 946-959. ISSN: 1538-7933 | doi: https://dx.doi.org/10.1111/jth.13998
Unsworth, A. , Flora, G. , Gibbins, J. (2018) Non-genomic effects of nuclear receptors: insights from the anucleate platelet. Cardiovascular Research , 114 (5). pp. 645-655. ISSN: 0008-6363 | doi: https://dx.doi.org/10.1093/cvr/cvy044
Holbrook, L. , Sandhar, G. , Sasikumar, P. , Schenk, M. , Stainer, A. , Sahli, K. , Flora, G. , Bicknell, A. , Gibbins, J. (2018) A humanized monoclonal antibody that inhibits platelet-surface ERp72 reveals a role for ERp72 in thrombosis. Journal of Thrombosis and Haemostasis , 16 (2). pp. 367-377. ISSN: 1538-7836 | doi: https://dx.doi.org/10.1111/jth.13878

Lopes Pires, M. , Clarke, S. , Marcondes, S. , Gibbins, J. (2017) Lipopolysaccharide potentiates platelet responses via toll-like receptor 4-stimulated Akt-Erk-PLA2 signalling. PLoS ONE , 12 (11). ISSN: 1932-6203 | doi: https://dx.doi.org/10.1371/journal.pone.0186981
Bye, A. , Unsworth, A. , Desborough, M. , Hildyard, C. , Appleby, N. , Bruce, D. , Kriek, N. , Nock, S. , Sage, T. , Hughes, C. , Gibbins, J. (2017) Severe platelet dysfunction in NHL patients receiving ibrutinib is absent in patients receiving acalabrutinib. Blood Advances , 1 (26). pp. 2610-2623. ISSN: 2473-9529 | doi: https://dx.doi.org/10.1182/bloodadvances.2017011999
Unsworth, A. , Bye, A. , Tannetta, D. , Desborough, M. , Kriek, N. , Sage, T. , Allan, H. , Crescente, M. , Yaqoob, P. , Warner, T. , Jones, C. , Gibbins, J. (2017) Farnesoid X receptor and liver X receptor ligands initiate formation of coated platelets. Arteriosclerosis, thrombosis, and vascular biology , 37 (8). pp. 1482-1493. ISSN: 1524-4636 | doi: https://dx.doi.org/10.1161/ATVBAHA.117.309135
Ravishankar, D. , Salamah, M. , Attina, A. , Pothi, R. , Vallance, T. , Javed, M. , Williams, H. , Alzahrani, E. , Kabova, E. , Vaiyapuri, R. , Shankland, K. , Gibbins, J. , Strohfeldt, K. , Greco, F. , Osborn, H. , Vaiyapuri, S. (2017) Ruthenium-conjugated chrysin analogues modulate platelet activity, thrombus formation and haemostasis with enhanced efficacy. Scientific Reports , 7 ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-017-05936-3
Ilkan, Z. , Wright, J. , Goodall, A. , Gibbins, J. , Jones, C. , Mahaut-Smith, M. (2017) Evidence for shear-mediated Ca2+ entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line. The Journal of Biological Chemistry , 292 (22). pp. 9204-9217. ISSN: 1083-351X | doi: https://dx.doi.org/10.1074/jbc.M116.766196
Williams, H. , Vaiyapuri, R. , Gajjeraman, P. , Hutchinson, G. , Gibbins, J. , Bicknell, A. , Vaiyapuri, S. (2017) Challenges in diagnosing and treating snakebites in a rural population of Tamil Nadu, India: the views of clinicians. Toxicon , 130 pp. 44-46. ISSN: 0041-0101 | doi: https://dx.doi.org/10.1016/j.toxicon.2017.02.025
Unsworth, A. , Flora, G. , Sasikumar, P. , Bye, A. , Sage, T. , Kriek, N. , Crescente, M. , Gibbins, J. (2017) RXR ligands negatively regulate thrombosis and hemostasis. Arteriosclerosis Thrombosis and Vascular Biology , 37 (5). pp. 812-822. ISSN: 1524-4636 | doi: https://dx.doi.org/10.1161/ATVBAHA.117.309207
Unsworth, A. , Kriek, N. , Bye, A. , Naran, K. , Sage, T. , Flora, G. , Gibbins, J. (2017) PPARγ agonists negatively regulate αIIbβ3 integrin outside-in signalling and platelet function through upregulation of protein kinase A activity. Journal of Thrombosis and Haemostasis , 15 (2). pp. 356-369. ISSN: 1538-7933 | doi: https://dx.doi.org/10.1111/jth.13578

Gibbins, J. (2016) Platelets stop us leaking. Blood , 127 (12). pp. 1528-1529. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood-2016-01-692186
Moraes, L. , Unsworth, A. , Vaiyapuri, S. , Ali, M. , Sasikumar, P. , Sage, T. , Flora, G. , Bye, A. , Kriek, N. , Dorchies, E. , Molendi-Coste, O. , Dombrowicz, D. , Staels, B. , Bishop-Bailey, D. , Gibbins, J. (2016) Farnesoid X Receptor and its ligands inhibit the function of platelets. Arteriosclerosis Thrombosis and Vascular Biology , 36 (12). pp. 2324-2333. ISSN: 1524-4636 | doi: https://dx.doi.org/10.1161/ATVBAHA.116.308093
Crescente, M. , Pluthero, F. , Li, L. , Lo, R. , Walsh, T. , Schenk, M. , Holbrook, L. , Loureiro, S. , Ali, M. , Vaiyapuri, S. , Falet, H. , Jones, I. , Poole, A. , Kahr, W. , Gibbins, J. (2016) Intracellular trafficking, localization, and mobilization of platelet-borne thiol isomerases. Arteriosclerosis Thrombosis and Vascular Biology , 36 (6). pp. 1164-1173. ISSN: 1079-5642 | doi: https://dx.doi.org/10.1161/ATVBAHA.116.307461
Bye, A. , Unsworth, A. , Gibbins, J. (2016) Platelet signaling: a complex interplay between inhibitory and activatory networks. Journal of Thrombosis and Haemostasis , 14 (5). pp. 918-930. ISSN: 1538-7933 | doi: https://dx.doi.org/10.1111/jth.13302

Tannetta, D. , Hunt, K. , Jones, C. , Davidson, N. , Coxon, C. , Ferguson, D. , Redman, C. , Gibbins, J. , Sargent, I. , Tucker, K. (2015) Syncytiotrophoblast extracellular vesicles from pre-eclampsia placentas differentially affect platelet function. PLoS ONE , 10 (11). ISSN: 1932-6203 | doi: https://dx.doi.org/10.1371/journal.pone.0142538
Mazet, F. , Dunster, J. , Jones, C. , Vaiyapuri, S. , Tindall, M. , Fry, M. , Gibbins, J. (2015) A high-density immunoblotting methodology for quantification of total protein levels and phosphorylation modifications. Scientific Reports , 5 ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/srep16995
Dunster, J. , Mazet, F. , Fry, M. , Gibbins, J. , Tindall, M. (2015) Regulation of early steps of GPVI signal transduction by phosphatases: a systems biology approach. PLoS Computational Biology , 11 (11). ISSN: 1553-734X | doi: https://dx.doi.org/10.1371/journal.pcbi.1004589
Bye, A. , Unsworth, A. , Vaiyapuri, S. , Stainer, A. , Fry, M. , Gibbins, J. (2015) Ibrutinib inhibits platelet integrin αIIbβ3 outside-in signaling and thrombus stability but not adhesion to collagen. Arteriosclerosis Thrombosis and Vascular Biology , 35 (11). pp. 2326-2335. ISSN: 1524-4636 | doi: https://dx.doi.org/10.1161/ATVBAHA.115.306130
Wright, B. , Watson, K. , McGuffin, L. , Lovegrove, J. , Gibbins, J. (2015) GRID and docking analyses reveal a molecular basis for flavonoid inhibition of src-family kinase activity. Journal of Nutritional Biochemistry , 26 (11). pp. 1156-1165. ISSN: 0955-2863 | doi: https://dx.doi.org/10.1016/j.jnutbio.2015.05.004
Vaiyapuri, S. , Flora, G. , Gibbins, J. (2015) Gap junctions and connexin hemichannels in the regulation of haemostasis and thrombosis. Biochemical Society Transactions , 43 (3). pp. 489-494. ISSN: 1470-8752 | doi: https://dx.doi.org/10.1042/BST20150055
Vaiyapuri, S. , Sunagar, K. , Gibbins, J. , Jackson, T. , Reeks, T. , Fry, B. (2015) Kallikrein enzymes. In: Fry, B. , (eds.) Venomous reptiles and their toxins: evolution, pathophysiology and biodiscovery. Oxford University Press , New York. pp. 267-280. ISBN: 9780199309399
Vaiyapuri, S. , Roweth, H. , Ali, M. , Unsworth, A. , Stainer, A. , Flora, G. , Crescente, M. , Jones, C. , Moraes, L. , Gibbins, J. (2015) Pharmacological actions of nobiletin in the modulation of platelet function. British Journal of Pharmacology , 172 (16). pp. 4133-4145. ISSN: 0007-1188 | doi: https://dx.doi.org/10.1111/bph.13191
Vaiyapuri, S. , Sage, T. , Rana, R. , Schenk, M. , Ali, M. , Unsworth, A. , Jones, C. , Stainer, A. , Kriek, N. , Moraes, L. , Gibbins, J. (2015) EphB2 regulates contact-dependent and independent signalling to control platelet function. Blood , 125 (4). pp. 720-730. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood-2014-06-585083

Taylor, L. , Vasudevan, S. , Jones, C. , Gibbins, J. , Churchill, G. , Campbell, R. , Coxon, C. (2014) Discovery of novel GPVI receptor antagonists by structure-based repurposing.. PLoS ONE , 9 (6). ISSN: 1932-6203 | doi: https://dx.doi.org/10.1371/journal.pone.0101209
Dannoura, A. , Giraldo, A. , Pereira, I. , Gibbins, J. , Dash, P. , Bicknell, K. , Brooks, G. (2014) Ibuprofen inhibits migration and proliferation of human coronary artery smooth muscle cells by inducing a differentiated phenotype: role of peroxisome proliferator-activated receptor y. Journal of Pharmacy and Pharmacology , 66 (6). pp. 779-792. ISSN: 0022-3573 | doi: https://dx.doi.org/10.1111/jphp.12203
Jones, C. , Tucker, K. , Sasikumar, P. , Sage, T. , Kaiser, W. , Moore, C. , Emerson, M. , Gibbins, J. (2014) Integrin-linked kinase regulates the rate of platelet activation and is essential for the formation of stable thrombi. Journal of Thrombosis and Haemostasis , 12 (8). pp. 1342-1352. ISSN: 1538-7933 | doi: https://dx.doi.org/10.1111/jth.12620
Jones, C. , Sage, T. , Moraes, L. , Vaiyapuri, S. , Hussain, U. , Tucker, K. , Barrett, N. , Gibbins, J. (2014) Platelet endothelial cell adhesion molecule-1 inhibits platelet response to thrombin and von Willebrand factor by regulating the internalization of glycoprotein Ib via AKT/glycogen synthase kinase-3/dynamin and integrin αIIbβ3. Arteriosclerosis Thrombosis and Vascular Biology , 34 (9). pp. 1968-1976. ISSN: 1079-5642 | doi: https://dx.doi.org/10.1161/ATVBAHA.114.304097
Ambily, A. , Kaiser, W. , Pierro, C. , Chamberlain, E. , Li, Z. , Jones, C. , Kassouf, N. , Gibbins, J. , Authi, K. (2014) The role of plasma membrane STIM1 and Ca(2+)entry in platelet aggregation. STIM1 binds to novel proteins in human platelets.. Cellular Signalling , 26 (3). pp. 502-511. ISSN: 0898-6568 | doi: https://dx.doi.org/10.1016/j.cellsig.2013.11.025

Gibbins, J. (2013) Platelets using proteins creatively.. Blood , 122 (22). pp. 3553-3554. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood-2013-09-527663
Wright, B. , Tindall, M. , Lovegrove, J. , Gibbins, J. (2013) Investigating flavonoids as molecular templates for the design of small-molecule inhibitors of cell signaling. Journal of Food Science , 78 (12). pp. N1921-N1928. ISSN: 1750-3841 | doi: https://dx.doi.org/10.1111/1750-3841.12293
Vaiyapuri, S. , Vaiyapuri, R. , Ashokan, R. , Ramasamy, K. , Nattamaisundar, K. , Jeyaraj, A. , Chandran, V. , Gajjeraman, P. , Baksh, M. , Gibbins, J. , Hutchinson, E. (2013) Snakebite and its socio-economic impact on the rural population of Tamil Nadu, India. PLoS ONE , 8 (11). pp. e80090. ISSN: 1932-6203 | doi: https://dx.doi.org/10.1371/journal.pone.0080090
Wright, B. , Spencer, J. , Lovegrove, J. , Gibbins, J. (2013) Flavonoid inhibitory pharmacodynamics on platelet function in physiological environments. Food & Function , 4 (12). pp. 1803-1810. ISSN: 2042-650X | doi: https://dx.doi.org/10.1039/C3FO60272A
Vaiyapuri, S. , Ali, M. , Moraes, L. , Sage, T. , Lewis, K. , Jones, C. , Gibbins, J. (2013) Tangeretin regulates platelet function through inhibition of phosphoinositide 3-Kinase and cyclic nucleotide signaling. Arteriosclerosis Thrombosis and Vascular Biology , 33 (12). pp. 2740-2749. ISSN: 1079-5642 | doi: https://dx.doi.org/10.1161/ATVBAHA.113.301988
Vaiyapuri, S. , Moraes, L. , Sage, T. , Ali, M. , Lewis, K. , Mayhaut-Smith, M. , Oviedo-Orta, E. , Simon, A. , Gibbins, J. (2013) Connexin40 regulates platelet function. Nature Communications , 4 pp. 2564-2572. ISSN: 2041-1723 | doi: https://dx.doi.org/10.1038/ncomms3564
Moraes, L. , Vaiyapuri, S. , Sasikumar, P. , Ali, M. , Kriek, N. , Sage, T. , Gibbins, J. (2013) Antithrombotic actions of statins involve PECAM-1 signalling. Blood , 122 (18). pp. 3188-3196. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood-2013-04-491845
Waller, A. , Sage, T. , Kumar, C. , Carr, T. , Gibbins, J. , Clarke, S. (2013) Staphylococcus aureus lipoteichoic acid inhibits platelet activation and thrombus formation via the Paf receptor. Journal of Infectious Diseases , 208 (12). pp. 2046-2057. ISSN: 1537-6613 | doi: https://dx.doi.org/10.1093/infdis/jit398
Kim, K. , Hahm, E. , Li, J. , Holbrook, L. , Sasikumar, P. , Stanley, R. , Ushio-Fukai, M. , Gibbins, J. , Cho, J. (2013) Platelet protein disulfide isomerase is required for thrombus formation but not essential for hemostasis in mice. Blood , 122 (6). pp. 1052-1061. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood-2013-03-492504
Wright, B. , Spencer, J. , Lovegrove, J. , Gibbins, J. (2013) Insights into dietary flavonoids as molecular templates for the design of anti-platelet drugs. Cardiovascular Research , 97 (1). pp. 13-22. ISSN: 0008-6363 | doi: https://dx.doi.org/10.1093/cvr/cvs304
Wright, B. , Stanley, R. , Kaiser, W. , Gibbins, J. (2013) The integration of proteomics and systems approaches to map regulatory mechanisms underpinning platelet function.. Proteomics, Clinical Applications , 7 (1-2). pp. 144-154. ISSN: 1862-8354 | doi: https://dx.doi.org/10.1002/prca.201200095

Mitchell, H. , Gibbins, J. , Griffin, B. , Lovegrove, J. , Stowell, J. , Foot, E. (2012) Food and Health Forum meeting - nutritional approaches to cardiovascular health: workshop report. Nutrition Bulletin , 37 (3). pp. 270-284. ISSN: 1471-9827 | doi: https://dx.doi.org/10.1111/j.1467-3010.2012.01984.x
Gibbins, J. (2012) JAMming the signals. Blood , 119 (14). pp. 3197-3198. ISSN: 1528-0020 | doi: https://dx.doi.org/10.1182/blood-2012-02-409060
Vaiyapuri, S. , Thiyagarajan, N. , Hutchinson, E. , Gibbins, J. (2012) Sequence and phylogenetic analysis of viper venom serine proteases. Bioinformation , 8 (16). pp. 763-772. ISSN: 0973-2063
Vaiyapuri, S. , Hutchinson, E. , Ali, M. , Dannoura, A. , Stanley, R. , Harrison, R. , Bicknell, A. , Gibbins, J. (2012) Rhinocetin, a venom-derived integrin-specific antagonist inhibits collagen-induced platelet and endothelial cell functions . The Journal of Biological Chemistry , 287 (31). pp. 26235-26244. ISSN: 1083-351X | doi: https://dx.doi.org/10.1074/jbc.M112.381483
Bertling, A. , Niemann, S. , Hussain, M. , Holbrook, L. , Stanley, R. , Brodde, M. , Pohl, S. , Schifferdecker, T. , Roth, J. , Jurk, K. , Müller, A. , Lahav, J. , Peters, G. , Heilmann, C. , Gibbins, J. , Kehrel, B. (2012) Staphylococcal extracellular adherence protein induces platelet activation by stimulation of thiol isomerases. Arteriosclerosis Thrombosis and Vascular Biology , 32 pp. 1979-1990. ISSN: 1079-5642 | doi: https://dx.doi.org/10.1161/ATVBAHA.112.246249
Vaiyapuri, S. , Jones, C. , Sasikumar, P. , Moraes, L. , Munger, S. , Wright, J. , Ali, M. , Sage, T. , Kaiser, W. , Tucker, K. , Stain, C. , Bye, A. , Jones, S. , Oviedo-Orta, E. , Simon, A. , Mahaut-Smith, M. , Gibbins, J. (2012) Gap junctions and connexin hemichannels underpin hemostasis and thrombosis. Circulation , 125 (20). pp. 2479-2491. ISSN: 0009-7322 | doi: https://dx.doi.org/10.1161/CIRCULATIONAHA.112.101246
Jones, C. , Moraes, L. , Gibbins, J. (2012) Regulation of platelet biology by platelet endothelial cell adhesion molecule-1. . Platelets , 23 (5). pp. 331-335. ISSN: 1369-1635 | doi: https://dx.doi.org/10.3109/09537104.2011.626091
Coxon, C. , Lewis, A. , Sadler, A. , Vasudevan, S. , Thomas, A. , Dundas, K. , Taylor, L. , Campbell, R. , Gibbins, J. , Churchill, G. , Tucker, K. (2012) NAADP regulates human platelet function. . Biochemical Journal , 441 (1). pp. 435-442. ISSN: 0264-6021 | doi: https://dx.doi.org/10.1042/BJ20111175
Holbrook, L. , Sasikumar, P. , Stanley, R. , Simmonds, A. , Bicknell, A. , Gibbins, J. (2012) The platelet-surface thiol isomerase enzyme ERp57 modulates platelet function. Journal of Thrombosis and Haemostasis , 10 (2). pp. 278-288. ISSN: 1538-7933 | doi: https://dx.doi.org/10.1111/j.1538-7836.2011.04593.x

Wright, B. , Stanley, R. , Kaiser, W. , Mills, D. , Gibbins, J. (2011) Analysis of protein networks in resting and collagen receptor (GPVI)-stimulated platelet sub-proteomes. . Proteomics , 11 (23). pp. 4588-4592. ISSN: 1615-9853 | doi: https://dx.doi.org/10.1002/pmic.201100410
Stanley, R. , Tucker, K. , Barrett, N. , Gibbins, J. (2011) Platelets and their role in thrombotic and cardiovascular disease: the impact of proteomic analysis. In: Garcia, A. and Senis, Y. , (eds.) Platelet Proteomics: Principles, Analysis and Applications. Mass Spectrometry Wiley pp. 3-26. ISBN: 9780470463376
Tucker, K. , Sage, T. , Gibbins, J. (2011) Clot retraction. In: Gibbins, J. and Mahaut-Smith, M. , (eds.) Platelets and Megakaryocytes. vol. 3, Additional Protocols and Perspectives. Methods in Molecular Biology , vol. 788. Humana Press pp. 101-108. ISBN: 9781617793066
Jones, C. , Barrett, N. , Moraes, L. , Gibbins, J. , Jackson, D. (2011) Endogenous inhibitory mechanisms and the regulation platelet function. In: Gibbins, J. and Mahaut-Smith, M. , (eds.) Platelets and Megakaryocytes. vol. 3, Additional Protocols and Perspectives. Methods in Molecular Biology, vol. 788 Humana Press pp. 341-366. ISBN: 9781617793066
Vaiyapuri, S. , Wagstaff, S. , Harrison, R. , Gibbins, J. , Hutchinson, G. (2011) Evolutionary analysis of novel serine proteases in the venom gland transcriptome of Bitis gabonica rhinoceros. PLoS ONE , 6 (6). ISSN: 1932-6203 | doi: https://dx.doi.org/10.1371/journal.pone.0021532
Spyridon, M. , Moraes, L. , Jones, C. , Sage, T. , Sasikumar, P. , Bucci, G. , Gibbins, J. (2011) LXR as a novel antithrombotic target. Blood , 117 (21). pp. 5751-5761. ISSN: 1528-0020 | doi: https://dx.doi.org/10.1182/blood-2010-09-306142

Glen, A. , Evans, C. , Gan, C. , Cross, S. , Hamdy, F. , Gibbins, J. , Lippitt, J. , Eaton, C. , Noirel, J. , Wright, P. , Rehman, I. (2010) Eight-plex iTRAQ analysis of variant metastatic human prostate cancer cells identifies candidate biomarkers of progression: an exploratory study. . The Prostate , 70 (12). pp. 1313-1332. ISSN: 1097-0045 | doi: https://dx.doi.org/10.1002/pros.21167
Moraes, L. , Barrett, N. , Jones, C. , Holbrook, L. , Spyridon, M. , Sage, T. , Newman, D. , Gibbins, J. (2010) Platelet endothelial cell adhesion molecule-1 regulates collagen-stimulated platelet function by modulating the association of phosphatidylinositol 3-kinase with Grb-2-associated binding protein-1 and linker for activation of T cells. Journal of Thrombosis and Haemostasis , 8 (11). pp. 2530-2541. ISSN: 1538-7933 | doi: https://dx.doi.org/10.1111/j.1538-7836.2010.04025.x
Holbrook, L. , Watkins, N. , Simmonds, A. , Jones, C. , Ouwehand, W. , Gibbins, J. (2010) Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation. British Journal of Haematology , 148 (4). pp. 627-637. ISSN: 0007-1048 | doi: https://dx.doi.org/10.1111/j.1365-2141.2009.07994.x
Moraes, L. , Spyridon, M. , Kaiser, W. , Jones, C. , Sage, T. , Atherton, R. , Gibbins, J. (2010) Non-genomic effects of PPARgamma ligands: inhibition of GPVI-stimulated platelet activation. Journal of Thrombosis and Haemostasis , 8 (3). pp. 577-587. ISSN: 1538-7933 | doi: https://dx.doi.org/10.1111/j.1538-7836.2009.03732.x
Vaiyapuri, S. , Harrison, R. , Bicknell, A. , Gibbins, J. , Hutchinson, E. (2010) Purification and functional characterisation of Rhinocerase, a novel serine protease from the venom of Bitis gabonica rhinoceros. PLoS ONE , 5 (3). ISSN: 1932-6203 | doi: https://dx.doi.org/10.1371/journal.pone.0009687
Vaiyapuri, S. , Wagstaff, S. , Watson, K. , Harrison, R. , Gibbins, J. , Hutchinson, E. (2010) Purification and functional characterisation of rhiminopeptidase A, a novel aminopeptidase from the venom of Bitis gabonica rhinoceros. PLoS Neglected Tropical Diseases , 4 (8). ISSN: 1935-2735 | doi: https://dx.doi.org/10.1371/journal.pntd.0000796
Wright, B. , Moraes, L. , Kemp, C. , Mullen, W. , Crozier, A. , Lovegrove, J. , Gibbins, J. (2010) A structural basis for the inhibition of collagen-stimulated platelet function by quercetin and structurally related flavonoids. British Journal of Pharmacology , 159 pp. 1312-1325. ISSN: 1476-5381 | doi: https://dx.doi.org/10.1111/j.1476-5381.2009.00632.x
Wright, B. , Gibson, T. , Spencer, J. , Lovegrove, J. , Gibbins, J. (2010) Platelet-mediated metabolism of the common dietary flavonoid, quercetin.. PLoS ONE , 5 (3). ISSN: 1932-6203 | doi: DOI:10.1371/journal.pone.0009673

Tucker, . , Kaiser, . , Bergeron, . , Hu, . , Dong, . , Tan, . , Gibbins, . (2009) Proteomic analysis of resting and thrombin-stimulated platelets reveals the translocation and functional relevance of HIP-55 in platelets. Proteomics , 9 (18). pp. 4340-4354. ISSN: 1615-9853 | doi: https://dx.doi.org/10.1002/pmic.200900024
Kaiser, . , Holbrook, . , Tucker, . , Stanley, . , Gibbins, . (2009) A functional proteomic method for the enrichment of peripheral membrane proteins reveals the collagen binding protein Hsp47 is exposed on the surface of activated human platelets. Journal of Proteome Research , 8 (6). pp. 2903-2914. ISSN: 1535-3893 | doi: https://dx.doi.org/10.1021/pr900027j
Jones, . , Garner, . , Moraes, . , Kaiser, . , Rankin, . , Bloodomics Consortium , Ouwehand, . , Goodall, . , Gibbins, . (2009) PECAM-1 expression and activity negatively regulate multiple platelet signaling pathways. FEBS Letters , 583 (22). pp. 3618-3624. ISSN: 0014-5793 | doi: https://dx.doi.org/10.1016/j.febslet.2009.10.037
Gibbins, . (2009) Tweaking the gain on platelet regulation: The tachykinin connection. Atherosclerosis , 206 (1). pp. 1-7. ISSN: 0021-9150 | doi: https://dx.doi.org/10.1016/j.atherosclerosis.2008.12.010

Tucker, . , Sage, . , Stevens, . , Jordan, . , Jones, . , Barrett, . , St-Arnaud, . , Frampton, . , Dedhar, . , Gibbins, . (2008) A dual role for integrin-linked kinase in platelets: regulating integrin function and alpha-granule secretion. Blood , 112 (12). pp. 4523-4531. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood-2008-03-148502
Jones, S. , Tucker, K. , Sage, T. , Kaiser, W. , Barrett, N. , Lowry, P. , Zimmer, A. , Hunt, S. , Emerson, M. , Gibbins, J. (2008) Peripheral tachykinins and the neurokinin receptor NK1 are required for platelet thrombus formation. Blood , 111 (2). pp. 605-612. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood-2007-07-103424
Jones, . and Gibbins, . (2008) The neurokinin 1 receptor: a potential new target for anti-platelet therapy?. Current Opinion in Pharmacology , 8 (2). pp. 114-119. ISSN: 1471-4892 | doi: https://dx.doi.org/10.1016/j.coph.2008.01.004
Barrett, . , Holbrook, . , Jones, . , Kaiser, . , Moraes, . , Rana, . , Sage, . , Stanley, . , Tucker, . , Wright, . , Gibbins, . (2008) Future innovations in anti-platelet therapies. British Journal of Pharmacology , 154 (5). pp. 918-939. ISSN: 0007-1188 | doi: https://dx.doi.org/10.1038/bjp.2008.151

Moraes, . , Swales, . , Wray, . , Damazo, . , Gibbins, . , Warner, . , Bishop-Bailey, . (2007) Nongenomic signaling of the retinoid X receptor through binding and inhibiting Gq in human platelets. Blood , 109 (9). pp. 3741-3744. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood-2006-05-022566
Moraes, . , Bishop-Bailey, . , Gibbins, . (2007) Non-genomic signalling of the retinoic X receptor through inhibition of Gq signalling in human platelets. Heart , 93 (11). pp. 371-374. ISSN: 1355-6037
Gumireddy, . , Sun, . , Klein-Szanto, . , Gibbins, . , Gimotty, . , Saunders, . , Schultz, . , Huang, . (2007) In vivo selection for metastasis promoting genes in the mouse. Proceedings of the National Academy of Sciences of the United States of America , 104 (16). pp. 6696-6701. ISSN: 0027-8424 | doi: https://dx.doi.org/10.1073/pnas.0701145104
Guerrero, . , Navarro-Nunez, . , Lozano, . , Martinez, . , Vicente, . , Gibbins, . , Rivera, . (2007) Flavonoids inhibit the platelet TxA(2) signalling pathway and antagonize TxA(2) receptors (TP) in platelets and smooth muscle cells. British Journal of Clinical Pharmacology , 64 (2). pp. 133-144. ISSN: 0306-5251 | doi: https://dx.doi.org/10.1111/j.1365-2125.2007.02881.x

Patel, . , Sharifi, . , Milward, . , Oberprieler, . , Gibbins, . , Parkin, . , Naseem, . (2006) Platelet nitric oxide synthase is activated by tyrosine dephosphorylation: possible role for SHP-1 phosphatase. Journal of Thrombosis and Haemostasis , 4 (11). pp. 2423-2432. ISSN: 1538-7933 | doi: https://dx.doi.org/10.1111/j.1538-7836.2006.02160.x
Jordan, . and Gibbins, . (2006) Extracellular disulfide exchange and the regulation of cellular function. Antioxidants & Redox Signaling , 8 (3-4). pp. 312-324. ISSN: 1523-0864
Hubbard, . , Wolffram, . , de Vos, . , Bovy, . , Gibbins, . , Lovegrove, J. (2006) Ingestion of onion soup high in quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in man: a pilot study. British Journal of Nutrition , 96 (3). pp. 482-488. ISSN: 0007-1145
Falati, . , Patil, . , Gross, . , Stapleton, . , Merrill-Skoloff, . , Barrett, . , Pixton, . , Weiler, . , Cooley, . , Newman, . , Newman, . , Furie, . , Furie, . , Gibbins, . (2006) Platelet PECAM-1 inhibits thrombus formation in vivo. Blood , 107 (2). pp. 535-541. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood-2005-04-1512

Jordan, . , Stevens, . , Hubbard, . , Barrett, . , Sage, . , Authi, . , Gibbins, . (2005) A role for the thiol isomerase. protein ERP5 in platelet function. Blood , 105 (4). pp. 1500-1507. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood-2004-02-0608

Hubbard, . , Wolffram, . , Lovegrove, . , Gibbins, J. (2004) Ingestion of quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in humans. Journal of Thrombosis and Haemostasis , 2 (12). pp. 2138-2145. ISSN: 1538-7933 | doi: https://dx.doi.org/10.1111/j.1538-7836.2004.01067.x
Stevens, . , Jordan, . , Sage, . , Gibbins, . (2004) The regulation of integrin-linked kinase in human platelets: evidence for involvement in the regulation of integrin alpha(2)beta(1). Journal of Thrombosis and Haemostasis , 2 (8). pp. 1443-1452. ISSN: 1538-7933 | doi: https://dx.doi.org/10.1111/j.1538-7836.2004.00870.x
Jones, . , Craik, . , Gibbins, . , Poole, . (2004) Regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C terminus. The Journal of Biological Chemistry , 279 (39). pp. 40475-40483. ISSN: 1083-351X | doi: https://dx.doi.org/10.1074/jbc.M402970200
Graham, . , Stevens, . , Page, . , Grant, . , Brain, . , Lowry, . , Gibbins, . (2004) Tachykinins regulate the function of platelets. Blood , 104 (4). pp. 1058-1065. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood-2003-11-3979
Gibbins, . (2004) Platelet adhesion signalling and the regulation of thrombus formation. Journal of Cell Science , 117 (16). pp. 3415-3425. ISSN: 0021-9533 | doi: https://dx.doi.org/10.1242/jcs.01325
Gibbins, . (2004) Techniques for analysis of proteins by SDS-polyacrylamide gel electrophoresis and Western blotting. Methods in Molecular Biology , 273 pp. 139-152. ISSN: 1064-3745 | doi: https://dx.doi.org/10.1385/1592597831
Gibbins, . (2004) Study of tyrosine kinases and protein tyrosine phosphorylation. Methods in Molecular Biology , 273 pp. 153-168. ISSN: 1064-3745 | doi: https://dx.doi.org/10.1385/1-59259-783-1:153
Coffey, . , Jarvis, . , Gibbins, . , Coles, . , Barrett, . , Wylie, . , O'Donnell, . (2004) Platelet 12-lipoxygenase activation via glycoprotein VI: involvement of multiple signaling pathways in agonist control of H(P)ETE synthesis . Circulation Research , 94 (12). pp. 1598-1605. ISSN: 0009-7330 | doi: https://dx.doi.org/10.1161/01.RES.0000132281.78948.65
Batuwangala, . , Leduc, . , Gibbins, . , Bon, . , Jones, . (2004) Structure of the snake-venom toxin convulxin. Acta Crystallographica Section D- Biological Crystallography , 60 (1). pp. 46-53. ISSN: 0907-4449 | doi: https://dx.doi.org/10.1107/s0907444903021620

Hubbard, . , Stevens, . , Cicmil, . , Sage, . , Jordan, . , Williams, . , Lovegrove, . , Gibbins, J. (2003) Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway. Journal of Thrombosis and Haemostasis , 1 (5). pp. 1079-1088. ISSN: 1538-7933 | doi: https://dx.doi.org/10.1046/j.1538-7836.2003.00212.x
Polanowska-Grabowska, . , Gibbins, . , Gear, . (2003) Platelet adhesion to collagen and collagen-related peptide under flow. Roles of the alpha(2)beta(1) integrin, GPVI, and Src tyrosine kinases. Arteriosclerosis Thrombosis and Vascular Biology , 23 (10). pp. 1934-1940. ISSN: 1079-5642 | doi: 01.ATV.0000086937.46974.70v1
Hubbard, . , Wolffram, . , Lovegrove, J. , Gibbins, J. (2003) The role of polyphenolic compounds in the diet as inhibitors of platelet function. Proceedings of the Nutrition Society , 62 (2). pp. 469-478. ISSN: 0029-6651 | doi: https://dx.doi.org/10.1079/pns2003253
Barry, . , Graham, . , Fry, . , Gibbins, . (2003) Regulation of glycogen synthase kinase 3 in human platelets: a possible role in platelet function?. FEBS Letters , 553 (1-2). pp. 173-178. ISSN: 0014-5793 | doi: https://dx.doi.org/10.1016/s0014-5793(03)01015-9

Gibbins, J. (2002) The negative regulation of platelet function: extending the role of the ITIM. Trends in Cardiovascular Medicine , 12 (5). pp. 213-219. ISSN: 1050-1738
Cicmil, M. , Thomas, J. , Leduc, M. , Bon, C. , Gibbins, J. (2002) Platelet endothelial cell adhesion molecule-1 signaling inhibits the activation of human platelets. Blood , 99 (1). pp. 137-144. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood.V99.1.137
Barry, F. and Gibbins, J. (2002) Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI. The Journal of Biological Chemistry , 277 (15). pp. 12874-12878. ISSN: 1083-351X | doi: https://dx.doi.org/10.1074/jbc.M200482200

Berlanga, O. , Bobe, R. , Becker, M. , Murphy, G. , Leduc, M. , Bon, C. , Barry, F. , Gibbins, J. , Garcia, P. , Frampton, J. , Watson, S. (2000) Expression of the collagen receptor glycoprotein VI during megakaryocyte differentiation. Blood , 96 (8). pp. 2740-2745. ISSN: 0006-4971
Cicmil, M. , Thomas, J. , Sage, T. , Barry, F. , Leduc, M. , Bon, C. , Gibbins, J. (2000) Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases. The Journal of biological chemistry , 275 (35). pp. 27339-27347. ISSN: 0021-9258 | doi: https://dx.doi.org/10.1074/jbc.M003196200

Mountford, J. , Melford, S. , Bunce, C. , Gibbins, J. , Watson, S. (1999) Collagen or collagen-related peptide cause (Ca2+)i elevation and increased tyrosine phosphorylation in human megakaryocytes.. Thrombosis and haemostasis , 82 (3). pp. 1153-1159. ISSN: 0340-6245

Watson, S. and Gibbins, J. (1998) Collagen receptor signalling in platelets: extending the role of the ITAM.. Immunology today , 19 (6). pp. 260-264. ISSN: 0167-5699
Gibbins, J. , Briddon, S. , Shutes, A. , van Vugt, M. , van de Winkel, J. , Saito, T. , Watson, S. (1998) The p85 subunit of phosphatidylinositol 3-kinase associates with the Fc receptor gamma-chain and linker for activitor of T cells (LAT) in platelets stimulated by collagen and convulxin.. The Journal of biological chemistry , 273 (51). pp. 34437-34443. ISSN: 0021-9258

Asselin, J. , Gibbins, J. , Achison, M. , Lee, Y. , Morton, L. , Farndale, R. , Barnes, M. , Watson, S. (1997) A collagen-like peptide stimulates tyrosine phosphorylation of syk and phospholipase C gamma2 in platelets independent of the integrin alpha2beta1.. Blood , 89 (4). pp. 1235-1242. ISSN: 0006-4971
Poole, A. , Gibbins, J. , Turner, M. , van Vugt, M. , van de Winkel, J. , Saito, T. , Tybulewicz, V. , Watson, S. (1997) The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen.. The EMBO journal , 16 (9). pp. 2333-2341. ISSN: 0261-4189
Gibbins, J. , Okuma, M. , Farndale, R. , Barnes, M. , Watson, S. (1997) Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain.. FEBS letters , 413 (2). pp. 255-259. ISSN: 0014-5793

Woods, R. , David, J. , Baigent, S. , Gibbins, J. , Lowry, P. (1996) Elevated levels of corticotrophin-releasing factor binding protein in the blood of patients suffering from arthritis and septicaemia and the presence of novel ligands in synovial fluid.. British journal of rheumatology , 35 (2). pp. 120-124. ISSN: 0263-7103
Gibbins, J. , Woods, R. , Lowry, P. (1996) Affinity purification of 61- and 65-kDa rat brain corticotropin-releasing factor receptors and receptor-associated G proteins.. The international journal of biochemistry & cell biology , 28 (9). pp. 1017-1029. ISSN: 1357-2725
Robinson, A. , Gibbins, J. , Rodríguez-Liñares, B. , Finan, P. , Wilson, L. , Kellie, S. , Findell, P. , Watson, S. (1996) Characterization of Grb2-binding proteins in human platelets activated by Fc gamma RIIA cross-linking.. Blood , 88 (2). pp. 522-530. ISSN: 0006-4971
Gibbins, J. , Asselin, J. , Farndale, R. , Barnes, M. , Law, C. , Watson, S. (1996) Tyrosine phosphorylation of the Fc receptor gamma-chain in collagen-stimulated platelets.. The Journal of biological chemistry , 271 (30). pp. 18095-18099. ISSN: 0021-9258

Woods, R. , Kennedy, K. , Gibbins, J. , Behan, D. , Vale, W. , Lowry, P. (1994) Corticotropin-releasing factor binding protein dimerizes after association with ligand.. Endocrinology , 135 (2). pp. 768-773. ISSN: 0013-7227

Jon Gibbins

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