Eva Kevei

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+44 (0) 118 378 8932
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Associate Professor
- Director of Internationalisation
- Lecturer in Cell Biology
- Programme Director for Biomedical Sciences.
Research centres and groups
International Collaborators
- Prof Thorsten Hoppe, (University of Cologne, CECAD, Germany)
- Prof Nico Dantuma, (Karolinska Institute in Stockholm, Sweden)
Research projects
Dr. Kevei's research work is focusing on the physiological role of ubiquitylation dependent signaling pathways with emphasis on understanding the cellular and molecular mechanisms of ageing and ageing-related diseases. Her research interest includes:
- investigating the function of different proteins of the ubiquitylation/deubiquitylation system in longevity and stress regulation by using the model organism of C. elegans
- exploring how the different organellar quality control mechanisms, embedded in tissue specific proteostasis network cooperate and communicate in order to maintain organismal health
- generating new C. elegans models for human diseases.
Awards and honours
Esteem Factors
- "Young Scientist Fellowship" of the Hungarian Academy of Sciences, Hungary (2002-2005)
- Book chapter: Phytochrome signal transduction in Photoreceptors and light signalling (Ed.: Batschauer, A.) (2003)
- 1st place awards in the contest of "Qualitas Biologica Foundation" with the PhD dissertation (2007) and with publication (2008)
- Post-doctoral research fellowship of the Alexander von Humboldt-Foundation, Germany (2007-2009)
- Invited speaker at "Decoding the Ubiquitin Chain" meeting, Berlin, Germany (2014)
- Volunteer in organizing the International Meeting of the German Society for Cell Biology (2015)
- Peer reviewer for Cell Death & Disease
Selected publications
2013
- Terecskei, K., Tóth, R., Gyula, P., Kevei, E., Bindics, J., Coupland, G., Nagy, F., Kozma-Bognár, L. (2013) The circadian clock-associated small GTPase LIGHT INSENSITIVE PERIOD1 suppresses light-controlled endoreplication and affects tolerance to salt stress in Arabidopsis. Plant Physiol. 161:278-90. (IF: 7.394)
2011
- Fehér, B., Kozma-Bognár, L., Kevei, E., Hajdu, A., Binkert, M., Davis, S.J., Schäfer, E., Ulm, R., Nagy, F. (2011) Functional interaction of the circadian clock and UV RESISTANCE LOCUS 8-controlled UV-B signaling pathways in Arabidopsis thaliana. Plant J. 67:37-48. (IF: 6.16)
- Kuhlbrodt, K., Janiesch, P.C., Kevei, E., Segref, A., Barikbin, R., Hoppe, T. (2011) The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis. Nat. Cell Biol., 13:273-81. (IF: 19.488)
2010
- Palágyi, A., Terecskei, K., Ádám, E., Kevei, E., Kircher, S., Mérai, Z., Schäfer, E., Nagy, F., Kozma-Bognár, L. (2010) Functional analysis of amino-terminal domains of the photoreceptor phytochrome B. Plant Physiol., 153:1834-45. (IF: 6.451)
2007
- Kevei, E., Schäfer, E., Nagy, F. (2007) Light-regulated nucleo-cytoplasmic partitioning of phytochromes. Journal of Exp. Bot., 58:3113-3124. (IF: 3.917)
- Kevei, E., Gyula, P., Fehér, B., Tóth, R., Viczián, A., Kircher, S., Rea, D., Dorjgotov, D., Schäfer, E., Millar, A.J., Kozma-Bognár, L., Nagy, F. (2007) Arabidopsis thaliana circadian clock is regulated by the small GTPase LIP1. Curr Biol., 17:1456-1464. (IF: 10.539)
2006
- Locke, J.C.W., Kozma-Bognar, L., Gould, P., Feher, B., Kevei, E., Nagy, F., Turner, M.S., Hall, A., Millar, A.J. (2006) Experimental validation of a predicted feedback loop in the multi-oscillator clock of Arabidopsis. Mol.Syst. Biol., 2:59. (IF: 7.971)
- Kevei, E., Gyula, P., Hall, A., Kozma-Bognar, L., Kim, W-Y., Eriksson, M.E., Toth, R., Hanano, S., Feher, B., Southern, M.M., Bastow, R.M., Viczian, A., Hibberd, V., Davis, S.J., Somers, D.E., Nagy, F., Millar, A.J. (2006) Forward genetic analysis of the circadian clock separates the multiple functions of ZEITLUPE. Plant Physiol., 140:933-945. (IF: 6.125)
2005
- Dodd, A.N., Salathia, N., Hall, A., Kevei, E., Toth, R., Nagy, F., Hibberd, J.M., Millar, A.J., Webb, A.A.R. (2005) Plant circadian clocks increase photosynthesis, growth, survival, and competitive advantage. Science, 309: 630-633. (IF: 30.028)
2003
- Kevei, E., Nagy, F. (2003) Phytochrome controlled signalling cascades in higher plants. Physiologia Plantarum, 117:305-313. (IF: 1.767)
- Nagy, F., Kevei, E., Harter, K., Schäfer, E. (2003) Phytochrome signal transduction. In: EPS book: Photoreceptors and light signalling, (Ed.: Batschauer, A.), 6:1-21.
2001
- Toth, R., Kevei, E., Hall, A., Millar, A., Nagy, F., Kozma-Bognar, L. (2001) Circadian Clock-Regulated Expression of Phytochrome and Cryptochrome Genes in Arabidopsis. Plant Physiol., 127:1607-1616. (IF: 5.105)
2000
- Varga, J., Kevei, E., Toth, B., Kozakiewicz, Z., Hoekstra, R.F. (2000) Molecular analysis of variability within the toxigenic Aspergillus ochraceus species. Can. J. Microbiol., 46:593-599. (IF: 1.105)
- Varga, J., Toth, B., Kevei, E., Palagyi, A., Kozakiewicz, Z. (2000) Analysis of genetic variability within the genus Petromyces. Antonie Van Leeuwenhoek, 771:83-89. (IF: 2.555)
1998
- Varga, J., Rinyu, E., Kevei, E., Toth, B., Kozakiewicz, Z. (1998) Double-stranded RNA mycoviruses in species of Aspergillus sections Circumdati and Fumigati. Can. J. Microbiol., 44:569-574. (IF: 1.134)
1997
- Téren, J., Palagyi, A., Kevei, E., Varga, J. (1997) Isolation of variants of Petromyces albertensis with altered ochratoxin production. Cer. Res. Comm., 25:305-306 (Part 1).
- Varga, J., Kevei, E., Palagyi, A., Toth, B., Teren, J. (1997) Genetic variability within the toxigenic Petromyces genus. Cer. Res. Comm., 25: 285-289 (Part 1).
1996
- Varga, J., Kevei, E., Rinyu, E., Teren, J., Kozakiewicz, Z. (1996) Ochratoxin production by Aspergillus species. Appl. Environ. Microbiol., 62:4461-4464. (IF: 3.129)
Publications
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Jewett, E.
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Arnott, G.
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Connolly, L.
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Vasudevan, N.
ORCID: 0000-0003-4326-3938 , Kevei, E. (2022) Microplastics and their impact on reproduction—can we learn from the C. elegans model?. Frontiers in Toxicology , 4 ISSN: 2673-3080 | doi: https://dx.doi.org/10.3389/ftox.2022.748912
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Chandler, R.
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Cogo, S.
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Lewis, P.
ORCID: 0000-0003-4537-0489 , Kevei, E.
ORCID: 0000-0002-0560-9208 (2021) Modelling the functional genomics of Parkinson’s disease in Caenorhabditis elegans: LRRK2 and beyond. Bioscience Reports , 41 (9). pp 0. ISSN: 0144-8463 | doi: https://dx.doi.org/10.1042/bsr20203672
- Chandler, R. , Cogo, S. , Lewis, P. , Kevei, E. (2021) Modelling the functional genomics of Parkinson’s in Caenorhabditis elegans: LRRK2 and beyond. Bioscience Reports , 41 (9). ISSN: 0144-8463 | doi: https://dx.doi.org/10.1042/BSR20203672
- Herzog, L. , Kevei, É. , Marchante, R. , Böttcher, C. , Bindesbøll, C. , Lystad, A. , Pfeiffer, A. , Gierisch, M. , Salomons, F. , Simonsen, A. , Hoppe, T. , Dantuma, N. (2020) The Machado–Joseph disease deubiquitylase ataxin‐3 interacts with LC3C/GABARAP and promotes autophagy. Aging Cell , 19 (1). ISSN: 1474-9718 | doi: https://dx.doi.org/10.1111/acel.13051
- Kevei, E. , Pokrzywa, W. , Hoppe, T. (2017) Repair or destruction: an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasis. FEBS Letters , 591 (17). pp. 2616-2635. ISSN: 0014-5793 | doi: https://dx.doi.org/10.1002/1873-3468.12750
- Tawo, R. , Pokrzywa, W. , Kevei, É. , Akyuz, M. , Balaji, V. , Adrian, S. , Höhfeld, J. , Hoppe, T. (2017) The ubiquitin ligase CHIP integrates proteostasis and aging by regulation of insulin receptor turnover. Cell , 169 (3). pp. 470-482.e13. ISSN: 1097-4172 | doi: https://dx.doi.org/10.1016/j.cell.2017.04.003
- Ackermann, L. , Schell, M. , Pokrzywa, W. , Kevei, E. , Gartner, A. , Schumacher, B. , Hoppe, T. (2016) E4 ligase–specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis. Nature structural & molecular biology , 23 (11). pp. 995-1002. ISSN: 1545-9985 | doi: https://dx.doi.org/10.1038/nsmb.3296
- Franz, A. , Kevei, É. , Hoppe, T. (2015) Double-edged alliance: mitochondrial surveillance by the UPS and autophagy. Current Opinion in Cell Biology , 37 pp. 18-27. ISSN: 0955-0674 | doi: https://dx.doi.org/10.1016/j.ceb.2015.08.004
- Livnat-Levanon, N. , Kevei, É. , Kleifeld, O. , Krutauz, D. , Segref, A. , Rinaldi, T. , Erpapazoglou, Z. , Cohen, M. , Reis, N. , Hoppe, T. , Glickman, M. (2014) Reversible 26S proteasome disassembly upon mitochondrial stress. Cell reports , 7 (5). pp. 1371-1380. ISSN: 2211-1247 | doi: https://dx.doi.org/10.1016/j.celrep.2014.04.030
- Kevei, E. and Hoppe, T. (2014) Ubiquitin sets the timer: impacts on aging and longevity. Nature structural & molecular biology , 21 (4). pp. 290-292. ISSN: 1545-9985 | doi: https://dx.doi.org/10.1038/nsmb.2806
- Segref, A. , Kevei, É. , Pokrzywa, W. , Schmeisser, K. , Mansfeld, J. , Livnat-Levanon, N. , Ensenauer, R. , Glickman, M. , Ristow, M. , Hoppe, T. (2014) Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system.. Cell Metabolism , 19 (4). pp. 642-652. ISSN: 1550-4131 | doi: https://dx.doi.org/10.1016/j.cmet.2014.01.016
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Varga, J.
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Tóth, B.
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Kevei, É.
ORCID: 0000-0002-0560-9208 , Palágyi, A. , Kozakiewicz, Z. (2000) Analysis of genetic variability within the genus Petromyces. Antonie van Leeuwenhoek , 77 (1). pp. 83-89. ISSN: 1572-9699 | doi: https://dx.doi.org/10.1023/A:1002475816014