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Dyan Sellayah

Email:
d.sellayah@reading.ac.uk
Phone:
100
Job title:
Associate Professor

Responsibilities:

Module convenor for BI3BA7-Medical Genetics (year 3), BI3EM1-Evolutionary Medicine (year 3)
Admissions Tutor & Program Director for Medical Sciences

Teaching

Part 3: Medical Genetics

Research centres and groups

National Collaborators

Prof Roger Cox (MRC Harwell)
Dr Felino Cagampang (University of Southampton)
Prof Dame Frances Ashcroft (University of Oxford)

Research projects

Dr. Sellayah's research aims to investigate the molecular mechanisms that govern fat (adipose) tissue development and function in the context of obesity. His specific focus is in:

Investigating the developmental programming of brown adipose tissue thermogenesis.
Assessing the Impact of maternal nutrition during development on offspring adipose tissue development and function.
Elucidating the function of FTO in adipogenesis
Establishing the therapeutic potential of metformin's effects on adipose tissue
Evolutionary origins of obesity

Awards and honours

Esteem Factors

Recipient of the MRC New Investigator Research Grant award (2017) of £409,989
Junior Research Fellow, Linacre College, University of Oxford 2014-2015
Paper selected in top 5 basic research articles of 2014 in the journal Endocrinology
Research highlight, Nature Medicine:17:1356, 2011

Impact, enterprise and outreach

School Director for Outreach
Project co-founder of ReadiLab Initiative
Contributor to Reading Scholars' Program

Publications

Gaspar, R. , Unsworth, A. , Al-Dibouni, A. , Bye, A. , Sage, T. , Stewart, M. , Cox, R. , Gibbins, J. ORCID: 0000-0002-0372-5352 , Sellayah, D. , Hughes, C. ORCID: 0000-0002-9790-5820 (2021) Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring. Scientific Reports , 11 ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-020-80373-3

Al-Dibouni, A. , Gaspar, R. , Ige, S. , Boateng, S. , Cagampang, F. , Gibbins, J. , Cox, R. , Sellayah, D. (2020) Unique genetic and histological signatures of mouse pericardial adipose tissue. Nutrients , 12 (6). ISSN: 2072-6643 | doi: https://dx.doi.org/10.3390/nu12061855

Sellayah, D. , Thomas, H. , Lanham, S. , Cagampang, F. (2019) Maternal obesity during pregnancy and lactation influences offspring obesogenic adipogenesis but not developmental adipogenesis in mice. Nutrients , 11 (3). ISSN: 2072-6643 | doi: https://dx.doi.org/10.3390/nu11030495
Sellayah, D. (2019) The impact of early human migration on brown adipose tissue evolution and its relevance to the modern obesity pandemic. Journal of the Endocrine Society , 3 (2). pp. 372-386. ISSN: 2472-1972 | doi: https://dx.doi.org/10.1210/js.2018-00363

Sellayah, D. and Cagampang, F. (2018) The divergent effect of maternal protein restriction during pregnancy and postweaning high-fat diet feeding on blood pressure and adiposity in adult mouse offspring. Nutrients , 10 (12). ISSN: 2072-6643 | doi: https://dx.doi.org/10.3390/nu10121832

Merkestein, M. and Sellayah, D. (2015) Role of FTO in adipocyte development and function: recent insights. International Journal of Endocrinology , 2015 ISSN: 1687-8337 | doi: https://dx.doi.org/10.1155/2015/521381
Merkestein, M. , Laber, S. , McMurray, F. , Andrew, D. , Gregor, S. , Sanderson, J. , Li, M. , Usher, S. , Sellayah, D. , Ashcroft, F. , Cox, R. (2015) FTO influences adipogenesis by regulating mitotic clonal expansion. Nature Communications , 6 ISSN: 2041-1723 | doi: https://dx.doi.org/10.1038/ncomms7792

Sellayah, D. and Sikder, D. (2014) Orexin restores aging-related brown adipose tissue dysfunction in male mice. Endocrinology , 155 (2). pp. 485-501. ISSN: 1945-7170 | doi: https://dx.doi.org/10.1210/en.2013-1629
Sellayah, D. , Dib, L. , Anthony, F. , Watkins, A. , Flemming, T. , Hanson, M. , Cagampang, F. (2014) Effect of maternal protein restriction during pregnancy and postweaning high-fat feeding of diet-induced thermogenesis in adult mouse offspring. European Journal of Nutrition , 53 (7). pp. 1523-1531. ISSN: 1436-6215 | doi: https://dx.doi.org/10.1007/s00394-014-0657-4
Sellayah, D. , Cagampang, F. , Cox, R. (2014) On the evolutionary origins of obesity: a new hypothesis. Endocrinology , 155 (5). pp. 1573-1588. ISSN: 1945-7170 | doi: https://dx.doi.org/10.1210/en.2013-2103
Merkestein, M. , Cagampang, F. , Sellayah, D. (2014) Fetal programming of adipose tissue function: an evolutionary perspective. Mammalian Genome , 25 (9-10). pp. 413-423. ISSN: 1432-1777 | doi: https://dx.doi.org/10.1007/s00335-014-9528-9