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David Leake

Portrait of David Leake

Management Committee of Institute for Cardiovascular and Metabolic Research  

Areas of interest

  • Mechanisms of low density lipoprotein oxidation in atherosclerosis
  • Use of novel lysosomotropic antioxidant drugs to treat atherosclerosis
  • Atherogenic effects of low extracellular pH on cells found in atherosclerotic lesions 

Postgraduate supervision

Study for a PhD with Professor David Leake


  • Part 1: Pathology: Introduction to Human Disease; Biochemistry and Metabolism
  • Part 2: Pharmacology (module convenor); Clinical Biochemistry (module convenor)
  • Part 3: Cardiovascular Disease (module convenor); Medical Genetics

Research centres and groups

National Collaborators

  • Prof. Peter Weinberg, Imperial College London
  • Dr Grisha Pirianov, Anglia Ruskin University
  • Prof Ronit Shiri-Sverdlov, Maastricht University, The Netherlands
  • Dr Robin Poston, Queen Mary University of London

Awards and honours

Esteem Factors

  • External Examiner for MRes in Biomedical Science at St George's University of London
  • Selected as the 'Scientist of the week' by the Association for Eradication of Heart Attack, USA in July 2002 for 'pioneering work on the low pH of atherosclerotic lesions'.
  • Prize for the best research paper of the year in the Faculty of Life Sciences of the University of Reading in 2009 (for research paper Wen, Y. & Leake, D.S. (2007) Circ. Res. 100, 1337-1343. Low density lipoprotein undergoes oxidation within lysosomes in cells) 

Professional bodies/affiliations

  • Funding from British Heart Foundation

Impact, enterprise and outreach

  • Patent taken out for the change of use of an antioxidant lysosomotropic drug that inhibits atherosclerosis to treat coronary heart disease, strokes and peripheral artery disease
  • Advice on careers in biomedical sciences at Reading School Careers Conference
  • Highly commended image in the British Heart Foundation annual image competition (featured on websites of the BBC, Independent, Guardian and Daily Mail)


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