- Identification of new anti-platelet strategies
- Developing platelet risk scores as an intermediate phenotype of cardiovascular disease
- Increasingly sensitive methodology with which to investigate rare bleeding disorders
Chris Jones

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+44 (0) 118 378 4429
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Associate Professor
- Senior Research Fellow
- Director of Diversity, Inclusion and Wellbeing
Areas of interest
- Using genetics and genomics to gain insight into platelet signalling
- Understanding the mechanisms that propagate platelet activation within thrombi
- Identifying how the dynamics of intracellular signalling alter platelet activation and how these temporal changes impact thrombus formation
- Designing methodology from deep phenotyping of platelet function
Teaching
- Part 1: The Living Cell
- Part 3: Medical Genetics
Research centres and groups
National Collaborators
- Prof. Willem Ouwehand, Cambridge
- Dr. Nicole Soranzo, WTSI
- Prof Alison Goodall, Leicester
Awards and honours
Esteem Factors
- Peer review for Journal of Thrombosis and Haemostasis, Vox Sanguinis, and Platelets
Professional bodies/affiliations
- Funding from British Heart Foundation
Impact, enterprise and outreach
Publications
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Mitchell, J.
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Dunster, J.
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Kriek, N.
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Unsworth, A.
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Sage, T.
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Mohammed, Y.
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De Simone, I.
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Taylor, K.
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Bye, A.
ORCID: 0000-0002-2061-2253 , Ólafsson, G. , Brunton, M. , Mark, S. , Dymott, L. , Whyte, A. , Ruparelia, N. , Mckenna, C. , Gibbins, J.
ORCID: 0000-0002-0372-5352 , Jones, C.
ORCID: 0000-0001-7537-1509 (2023) The rate of platelet activation determines thrombus size and structure at arterial shear. Journal of Thrombosis and Haemostasis ISSN: 1538-7836 | doi: https://dx.doi.org/10.1016/j.jtha.2023.03.044
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De Simone, I.
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Baaten, C.
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Gibbins, J.
ORCID: 0000-0002-0372-5352 , Ten Cate, H. , Heemskerk, J. , Jones, C.
ORCID: 0000-0001-7537-1509 , van der Meijden, P. (2023) Repeated platelet activation and the potential of previously activated platelets to contribute to thrombus formation. Journal of Thrombosis and Haemostasis ISSN: 1538-7933 | doi: https://dx.doi.org/10.1016/j.jtha.2023.01.006
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De Simone, I.
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Baaten, C.
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Jandrot-Perrus, M.
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Gibbins, J.
ORCID: 0000-0002-0372-5352 , ten Cate, H. , Heemskerk, J. , Jones, C.
ORCID: 0000-0001-7537-1509 , van der Meijden, P. (2022) Coagulation factor XIIIa and activated protein C activate platelets via GPVI and PAR1. International Journal of Molecular Sciences , 23 (18). ISSN: 1422-0067 | doi: https://dx.doi.org/10.3390/ijms231810203
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Webb, M.
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Tracey, M.
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Harwin, W.
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Tokatli, O.
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Hwang, F.
ORCID: 0000-0002-3243-3869 , Johnson, R. , Barrett, N.
ORCID: 0000-0001-9123-1100 , Jones, C.
ORCID: 0000-0001-7537-1509 (2021) Haptic-enabled collaborative learning in virtual reality for schools. Education and Information Technologies ISSN: 1573-7608 | doi: https://dx.doi.org/10.1007/s10639-021-10639-4
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Dunster, J.
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Mitchell, J.
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Mohammed, Y.
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Taylor, K.
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Gibbins, J.
ORCID: 0000-0002-0372-5352 , Jones, C. (2021) Kinetx: a combined flow cytometry assay and analysis software framework to quantitatively measure and categorize platelet activation in real-time. Journal of Visualized Experiments , 176 ISSN: 1940-087X | doi: https://dx.doi.org/10.3791/62947
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Dunster, J.
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Bye, A.
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Kriek, N.
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Sage, T.
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Mitchell, J.
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Kempster, C.
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Batista, J.
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KcKinney, H.
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Thomas, P.
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Jones, C.
ORCID: 0000-0001-7537-1509 , Downes, K. , Unsworth, A. , Gibbins, J.
ORCID: 0000-0002-0372-5352 (2021) Multi-parameter phenotyping of platelet reactivity for stratification of human cohorts. Blood Advances , 5 (20). pp. 4017-4030. ISSN: 2473-9529 | doi: https://dx.doi.org/10.1182/bloodadvances.2020003261
- Butcher, G. , Harwin, W. , Jones, C. (2021) An efficient alpha helix model and simulation framework for stationary electrostatic interaction force estimation. Scientific Reports , 11 (1). ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-021-88369-3
- Sahli, K. , Flora, G. , Sasikumar, P. , Maghrabi, A. , Holbrook, L. , AlOuda, S. , Elgheznawy, A. , Sage, T. , Stainer, A. , Adiyaman, R. , AboHassan, M. , Crescente, M. , Kriek, N. , Vaiyapuri, S. , Bye, A. , Unsworth, A. , Jones, C. , McGuffin, L. , Gibbins, J. (2021) Structural, functional and mechanistic insights uncover the fundamental role of orphan connexin-62 in platelets. Blood , 137 (6). pp. 830-843. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood.2019004575
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Ferreira, P.
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Bozbas, E.
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Tannetta, D.
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Alroqaiba, N.
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Zhou, R.
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Crawley, J.
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Gibbins, J.
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Jones, C.
ORCID: 0000-0001-7537-1509 , Ahnstrom, J. , Yaqoob, P. (2020) Mode of induction of platelet-derived extracellular vesicles is a critical determinant of their phenotype and function. Scientific Reports , 10 (1). ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-020-73005-3
- Webb, M. , Tracey, M. , Harwin, W. , Tokatli, O. , Hwang, F. , Barrett, N. , Jones, C. , Johnson, R. , eds. (2019) An investigation of the impact of haptics for promoting understanding of difficult concepts in cell biology. In: Passey, D. , Bottino, R. , Lewin, C. , Sanchez, E. , (eds.) pp. 197-206.
- Webb, M. , Tracey, M. , Harwin, W. , Tokatli, O. , Hwang, F. , Johnson, R. , Barrett, N. , Jones, C. (2019) Design considerations for haptic-enabled virtual reality simulation for interactive learning of nanoscale science in schools. pp. 56-67.
- Bye, A. , Ilkan, Z. , Unsworth, A. , Jones, C. (2018) Immobilization of nonactivated unfixed platelets for real-time single-cell analysis. In: Gibbins, J. and Mahaut-Smith, M. , (eds.) Platelets and Megakaryocytes (Volume 4, Advanced Protocols and Perspectives). Methods in Molecular Biology , 1812. Springer Protocols pp. 1-11. ISBN: 9781493985845
- Stefanini, L. , Lee, R. , Paul, D. , O'Shaughnessy, E. , Ghalloussi, D. , Jones, C. , Boulaftali, Y. , Poe, K. , Piatt, R. , Kechele, D. , Caron, K. , Hahn, K. , Gibbins, J. , Bergmeier, W. (2018) Functional redundancy between RAP1 isoforms in murine platelet production and function. Blood , 132 (18). pp. 1951-1962. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood-2018-03-838714
- Tokatli, O. , Tracey, M. , Hwang, F. , Barrett, N. , Jones, C. , Johnson, R. , Webb, M. , Harwin, W. (2018) A classroom deployment of a haptic system for learning cell biology. (Published in Lecture Notes in Computer Science, volumes 10893 and 10894)
- Unsworth, A. , Bye, A. , Tannetta, D. , Desborough, M. , Kriek, N. , Sage, T. , Allan, H. , Crescente, M. , Yaqoob, P. , Warner, T. , Jones, C. , Gibbins, J. (2017) Farnesoid X receptor and liver X receptor ligands initiate formation of coated platelets. Arteriosclerosis, thrombosis, and vascular biology , 37 (8). pp. 1482-1493. ISSN: 1524-4636 | doi: https://dx.doi.org/10.1161/ATVBAHA.117.309135
- Ilkan, Z. , Wright, J. , Goodall, A. , Gibbins, J. , Jones, C. , Mahaut-Smith, M. (2017) Evidence for shear-mediated Ca2+ entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line. The Journal of Biological Chemistry , 292 (22). pp. 9204-9217. ISSN: 1083-351X | doi: https://dx.doi.org/10.1074/jbc.M116.766196
- Salehe, B. , Jones, C. , Di Fatta, G. , McGuffin, L. , eds. (2017) RAPIDSNPs: A new computational pipeline for rapidly identifying key genetic variants reveals previously unidentified SNPs that are significantly associated with individual platelet responses. In: Colombo, G. , (eds.) PLoS ONE , 12 (4). ISSN: 1932-6203 | doi: https://dx.doi.org/10.1371/journal.pone.0175957
- Webb, M. , Tracey, M. , Harwin, W. , Tokatli, O. , Hwang, F. , Johnson, R. , Barrett, N. , Jones, C. (2017) The potential for haptic-enabled interaction to support collaborative learning in school biology. In: Resta, P. and Smith, S. , (eds.) Proceedings of Society for Information Technology & Teacher Education International Conference 2017. Association for the Advancement of Computing in Education (AACE) , Chesapeake VA. pp. 927-935. ISBN: 9781939797278
- Garner, S. , Furnell, A. , Kahan, B. , Jones, C. , Attwood, A. , Harrison, P. , Kelly, A. , Goodall, A. , Cardigan, R. , Ouwehand, W. (2017) Platelet responses to agonists in a cohort of highly characterised platelet donors are consistent over time. Vox Sanguinis , 112 (1). pp. 18-24. ISSN: 1423-0410 | doi: https://dx.doi.org/10.1111/vox.12468
- Jones, C. (2016) Platelet function and ageing. Mammalian Genome , 27 (7-8). pp. 358-366. ISSN: 1432-1777 | doi: https://dx.doi.org/10.1007/s00335-016-9629-8
- Tannetta, D. , Hunt, K. , Jones, C. , Davidson, N. , Coxon, C. , Ferguson, D. , Redman, C. , Gibbins, J. , Sargent, I. , Tucker, K. (2015) Syncytiotrophoblast extracellular vesicles from pre-eclampsia placentas differentially affect platelet function. PLoS ONE , 10 (11). ISSN: 1932-6203 | doi: https://dx.doi.org/10.1371/journal.pone.0142538
- Mazet, F. , Dunster, J. , Jones, C. , Vaiyapuri, S. , Tindall, M. , Fry, M. , Gibbins, J. (2015) A high-density immunoblotting methodology for quantification of total protein levels and phosphorylation modifications. Scientific Reports , 5 ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/srep16995
- Vaiyapuri, S. , Roweth, H. , Ali, M. , Unsworth, A. , Stainer, A. , Flora, G. , Crescente, M. , Jones, C. , Moraes, L. , Gibbins, J. (2015) Pharmacological actions of nobiletin in the modulation of platelet function. British Journal of Pharmacology , 172 (16). pp. 4133-4145. ISSN: 0007-1188 | doi: https://dx.doi.org/10.1111/bph.13191
- Vaiyapuri, S. , Sage, T. , Rana, R. , Schenk, M. , Ali, M. , Unsworth, A. , Jones, C. , Stainer, A. , Kriek, N. , Moraes, L. , Gibbins, J. (2015) EphB2 regulates contact-dependent and independent signalling to control platelet function. Blood , 125 (4). pp. 720-730. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood-2014-06-585083
- Taylor, L. , Vasudevan, S. , Jones, C. , Gibbins, J. , Churchill, G. , Campbell, R. , Coxon, C. (2014) Discovery of novel GPVI receptor antagonists by structure-based repurposing.. PLoS ONE , 9 (6). ISSN: 1932-6203 | doi: https://dx.doi.org/10.1371/journal.pone.0101209
- Jones, C. , Tucker, K. , Sasikumar, P. , Sage, T. , Kaiser, W. , Moore, C. , Emerson, M. , Gibbins, J. (2014) Integrin-linked kinase regulates the rate of platelet activation and is essential for the formation of stable thrombi. Journal of Thrombosis and Haemostasis , 12 (8). pp. 1342-1352. ISSN: 1538-7933 | doi: https://dx.doi.org/10.1111/jth.12620
- Jones, C. , Sage, T. , Moraes, L. , Vaiyapuri, S. , Hussain, U. , Tucker, K. , Barrett, N. , Gibbins, J. (2014) Platelet endothelial cell adhesion molecule-1 inhibits platelet response to thrombin and von Willebrand factor by regulating the internalization of glycoprotein Ib via AKT/glycogen synthase kinase-3/dynamin and integrin αIIbβ3. Arteriosclerosis Thrombosis and Vascular Biology , 34 (9). pp. 1968-1976. ISSN: 1079-5642 | doi: https://dx.doi.org/10.1161/ATVBAHA.114.304097
- Ambily, A. , Kaiser, W. , Pierro, C. , Chamberlain, E. , Li, Z. , Jones, C. , Kassouf, N. , Gibbins, J. , Authi, K. (2014) The role of plasma membrane STIM1 and Ca(2+)entry in platelet aggregation. STIM1 binds to novel proteins in human platelets.. Cellular Signalling , 26 (3). pp. 502-511. ISSN: 0898-6568 | doi: https://dx.doi.org/10.1016/j.cellsig.2013.11.025
- Vaiyapuri, S. , Ali, M. , Moraes, L. , Sage, T. , Lewis, K. , Jones, C. , Gibbins, J. (2013) Tangeretin regulates platelet function through inhibition of phosphoinositide 3-Kinase and cyclic nucleotide signaling. Arteriosclerosis Thrombosis and Vascular Biology , 33 (12). pp. 2740-2749. ISSN: 1079-5642 | doi: https://dx.doi.org/10.1161/ATVBAHA.113.301988
- McMahon, G. , Jones, C. , Hayes, P. , Naylor, A. , Goodall, A. (2013) Transient heparin-induced platelet activation linked to generation of platelet 12-lipoxygenase: findings from a randomised controlled trial. Thrombosis and haemostasis , 109 (6). pp. 977-1185. ISSN: 0340-6245 | doi: https://dx.doi.org/10.1160/TH12-11-0793
- Vaiyapuri, S. , Jones, C. , Sasikumar, P. , Moraes, L. , Munger, S. , Wright, J. , Ali, M. , Sage, T. , Kaiser, W. , Tucker, K. , Stain, C. , Bye, A. , Jones, S. , Oviedo-Orta, E. , Simon, A. , Mahaut-Smith, M. , Gibbins, J. (2012) Gap junctions and connexin hemichannels underpin hemostasis and thrombosis. Circulation , 125 (20). pp. 2479-2491. ISSN: 0009-7322 | doi: https://dx.doi.org/10.1161/CIRCULATIONAHA.112.101246
- Jones, C. , Moraes, L. , Gibbins, J. (2012) Regulation of platelet biology by platelet endothelial cell adhesion molecule-1. . Platelets , 23 (5). pp. 331-335. ISSN: 1369-1635 | doi: https://dx.doi.org/10.3109/09537104.2011.626091
- Jones, C. , Barrett, N. , Moraes, L. , Gibbins, J. , Jackson, D. (2011) Endogenous inhibitory mechanisms and the regulation platelet function. In: Gibbins, J. and Mahaut-Smith, M. , (eds.) Platelets and Megakaryocytes. vol. 3, Additional Protocols and Perspectives. Methods in Molecular Biology, vol. 788 Humana Press pp. 341-366. ISBN: 9781617793066
- Spyridon, M. , Moraes, L. , Jones, C. , Sage, T. , Sasikumar, P. , Bucci, G. , Gibbins, J. (2011) LXR as a novel antithrombotic target. Blood , 117 (21). pp. 5751-5761. ISSN: 1528-0020 | doi: https://dx.doi.org/10.1182/blood-2010-09-306142
- Goodall, A. , Burns, P. , Salles, I. , Macaulay, I. , Jones, C. , Ardissino, D. , de Bono, B. , Bray, S. , Deckmyn, H. , Dudbridge, F. , Fitzgerald, D. , Garner, S. , Gusnanto, A. , Koch, K. , Langford, C. , O'Connor, M. , Rice, C. , Stemple, D. , Stephens, J. , Trip, M. , Zwaginga, J. , Samani, N. , Watkins, N. , Maguire, P. , Ouwehand, W. (2010) Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function. Blood , 116 (22). pp. 4646-4656. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood-2010-04-280925
- Moraes, L. , Barrett, N. , Jones, C. , Holbrook, L. , Spyridon, M. , Sage, T. , Newman, D. , Gibbins, J. (2010) Platelet endothelial cell adhesion molecule-1 regulates collagen-stimulated platelet function by modulating the association of phosphatidylinositol 3-kinase with Grb-2-associated binding protein-1 and linker for activation of T cells. Journal of Thrombosis and Haemostasis , 8 (11). pp. 2530-2541. ISSN: 1538-7933 | doi: https://dx.doi.org/10.1111/j.1538-7836.2010.04025.x
- Holbrook, L. , Watkins, N. , Simmonds, A. , Jones, C. , Ouwehand, W. , Gibbins, J. (2010) Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation. British Journal of Haematology , 148 (4). pp. 627-637. ISSN: 0007-1048 | doi: https://dx.doi.org/10.1111/j.1365-2141.2009.07994.x
- Moraes, L. , Spyridon, M. , Kaiser, W. , Jones, C. , Sage, T. , Atherton, R. , Gibbins, J. (2010) Non-genomic effects of PPARgamma ligands: inhibition of GPVI-stimulated platelet activation. Journal of Thrombosis and Haemostasis , 8 (3). pp. 577-587. ISSN: 1538-7933 | doi: https://dx.doi.org/10.1111/j.1538-7836.2009.03732.x
- Soranzo, . , Rendon, . , Gieger, . , Jones, . , Watkins, . , Menzel, . , Doring, . , Stephens, . , Prokisch, . , Erber, . , Potter, . , Bray, . , Burns, . , Jolley, . , Falchi, . , Kuhnel, . , Erdmann, . , Schunkert, . , Samani, . , Illig, . , Garner, . , Rankin, . , Meisinger, . , Bradley, . , Thein, . , Goodall, . , Spector, . , Deloukas, . , Ouwehand, . (2009) A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function. Blood , 113 (16). pp. 3831-3837. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood-2008-10-184234
- O'Connor, . , Salles, . , Cvejic, . , Watkins, . , Walker, . , Garner, . , Jones, . , Macaulay, . , Steward, . , Zwaginga, . , Bray, . , Dudbridge, . , de Bono, . , Goodall, . , Deckmyn, . , Stemple, . , Ouwehand, . (2009) Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins. Blood , 113 (19). pp. 4754-62. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood-2008-06-162693
- McMahon, . , Webster, . , Hayes, . , Jones, . , Goodall, . , Naylor, . (2009) Low molecular weight heparin significantly reduces embolisation after carotid endarterectomy - a randomised controller trial. European Journal of Vascular and Endovascular Surgery , 37 (6). pp. 633-9. ISSN: 1078-5884 | doi: https://dx.doi.org/10.1016/j.ejvs.2009.02.009
- Jones, . , Garner, . , Moraes, . , Kaiser, . , Rankin, . , Bloodomics Consortium , Ouwehand, . , Goodall, . , Gibbins, . (2009) PECAM-1 expression and activity negatively regulate multiple platelet signaling pathways. FEBS Letters , 583 (22). pp. 3618-3624. ISSN: 0014-5793 | doi: https://dx.doi.org/10.1016/j.febslet.2009.10.037
- Jones, . , Bray, . , Garner, . , Stephens, . , de Bono, . , Angenent, . , Bentley, . , Burns, . , Coffey, . , Deloukas, . , Earthrow, . , Farndale, . , Hoylaerts, . , Koch, . , Rankin, . , Rice, . , Rogers, . , Samani, . , Steward, . , Walker, . , N.A., . , Akkerman, . , Dudbridge, . , Goodall, . , Ouwehand, . (2009) A functional genomics approach reveals novel quantitative trait loci associated with platelet signalling pathways. Blood , 114 (7). pp. 1405-16. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood-2009-02-202614
- Garner, S. , Jones, C. , Stephens, J. , Burns, P. , Walton, J. , Bernard, A. , Angenent, W. , Ouwehand, W. , Goodall, A. (2008) Apheresis donors and platelet function: inherent platelet responsiveness influences platelet quality. Transfusion , 48 (4). pp. 673-680. ISSN: 0041-1132 | doi: https://dx.doi.org/10.1111/j.1537-2995.2007.01591.x
- Jones, C. , Payne, D. , Hayes, P. , Naylor, A. , Bell, P. , Thompson, M. , Goodall, A. (2008) The antithrombotic effect of dextran-40 in man is due to enhanced fibrinolysis in vivo. Journal of Vascular Research , 48 (3). pp. 715-722. ISSN: 1018-1172 | doi: https://dx.doi.org/10.1016/j.jvs.2008.04.008
- Payne, D. , Jones, C. , Hayes, P. , Naylor, A. , Goodall, A. (2007) Therapeutic benefit of low-dose clopidogrel in patients undergoing carotid surgery is linked to variability in the platelet adenosine diphosphate response and patients' weight. Stroke , 38 (9). pp. 2464-2469. ISSN: 0039-2499 | doi: https://dx.doi.org/10.1161/STROKEAHA.107.486787
- Jones, C. , Garner, S. , Angenent, W. , Bernard, A. , Berzuini, C. , Burns, P. , Farndale, R. , Hogwood, J. , Rankin, A. , Stephens, J. , Tom, B. , Walton, J. , Dudbridge, F. , Ouwehand, W. , Goodall, A. (2007) Mapping the platelet profile for functional genomic studies and demonstration of the effect size of the GP6 locus. Journal of Thrombosis and Haemostasis , 5 (8). pp. 1756-1765. ISSN: 1538-7933 | doi: https://dx.doi.org/10.1111/j.1538-7836.2007.02632.x
- Horsley, . , Burkitt, . , Jones, . , Patterson, . , Harris, . , Moss, . , del Rio, . , Leake, . (2007) Mechanism of the antioxidant to pro-oxidant switch in the behavior of dehydroascorbate during LDL oxidation by copper(II) ions. Archives of Biochemistry and Biophysics , 465 (2). pp. 303-314. ISSN: 0003-9861 | doi: https://dx.doi.org/10.1016/j.abb.2007.07.005
- Toff, W. , Jones, C. , Ford, I. , Pearse, R. , Watson, H. , Watt, S. , Ross, J. , Gradwell, D. , Batchelor, A. , Abrams, K. , Meijers, J. , Goodall, A. , Greaves, M. (2006) Effect of hypobaric hypoxia, simulating conditions during long-haul air travel, on coagulation, fibrinolysis, platelet function, and endothelial activation. Jama-Journal of the American Medical Association , 295 (19). pp. 2251-2261. ISSN: 0098-7484 | doi: https://dx.doi.org/10.1001/jama.295.19.2251
- Webster, S. , Payne, D. , Jones, C. , Hayes, P. , Bell, P. , Goodall, A. , Naylor, A. (2004) Anti-platelet effect of aspirin is substantially reduced after administration of heparin during carotid endarterectomy. Journal of Vascular Research , 40 (3). pp. 463-468. ISSN: 1018-1172 | doi: https://dx.doi.org/10.1016/j.jvs.2004.06.022
- Nicoll, . , Jones, . , Norris, . (2004) Comparison of survival rates of captive-reared and wild-bred Mauritius kestrels (falco punctatus) in a re-introduced population. Biological Conservation , 118 (4). pp. 539-548. ISSN: 0006-3207 | doi: https://dx.doi.org/10.1016/j.biocon.2003.09.028
- Nicoll, . , Jones, . , Norris, . (2003) Declining survival rates in a reintroduced population of the Mauritius kestrel: evidence for non-linear density dependence and environmental stochasticity. Journal of Animal Ecology , 72 (6). pp. 917-926. ISSN: 0021-8790