Ying Zheng
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+44 (0) 118 378 7635
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Professor in Systems Engineering and Neuroscience
Areas of interest
Professor Ying Zhen has been working in the interface of systems engineering and neuroscience for over 10 years. The main direction of her research is to develop mathematical models to understand neural and haemodynamic signals obtained from neuroimaging techniques such as microelectrodes, EEG, laser-Doppler flowmetry, optical imaging spectroscopy and fMRI. The mathematical models are based on physiological measurements (neural and haemodynamic), with the model parameters reflecting aspects of the underlying physiological processes. These mathematical models also generate testable hypotheses to guide the design of further physiological experiments and the refinement of these models.Postgraduate supervision
Research projects
Professor Zheng is currently working on the development of:
- Spatio-temporal models of local field potential recordings based on the balanced nature of neural excitation and inhibition, with potential applications to the interpretation of EEG recordings;
- Dynamic models of neurovascular coupling, incorporating the underlying mechanisms of vessel dilation and constriction. This will enhance our understanding of the fMRI BOLD signals.
- Dynamic models of blood vessels based on its visco-elastic properties. This is important not only to the interpretation of the fMRI BOLD signal, but also to our understanding of the functions of heart and circulatory system.
Background
Professor Ying Zheng received her BEng and PhD from the University of Sheffield, UK.Websites/blogs
Publications
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Field, D.
ORCID: 0000-0003-4041-8404
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Cracknell, R.
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Eastwood, J.
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Scarfe, P.
ORCID: 0000-0002-3587-6198
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Williams, C.
ORCID: 0000-0003-4452-671X
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Zheng, Y.
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Tavassoli, T.
(2022)
High‐dose vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression.
Human Psychopharmacology: Clinical and Experimental
, 37
(6).
pp
0.
ISSN:
1099-1077
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doi:
https://dx.doi.org/10.1002/hup.2852
- Kang, S. , Hayashi, Y. , Bruyns-Haylett, M. , Delivopoulos, E. , Zheng, Y. (2020) Model-predicted balance between neural excitation and inhibition was maintained despite of age-related decline in sensory evoked local field potential in rat barrel cortex. Frontiers in Systems Neuroscience , 14 (24). ISSN: 1662-5137 | doi: https://dx.doi.org/10.3389/fnsys.2020.00024
- Kang, S. , Hayashi, Y. , Bruyns-Haylett, M. , Baker, D. , Boura, M. , Wang, H. , Karatzas, K. , Serra, I. , Bithell, A. , Williams, C. , Field, D. , Zheng, Y. (2019) Supplemental vitamin B-12 enhances the neural response to sensory stimulation in the barrel cortex of healthy rats but does not affect spontaneous neural activity. Journal of Nutrition , 149 (5). pp. 730-737. ISSN: 1541-6100 | doi: https://dx.doi.org/10.1093/jn/nxz011
- Kang, S. , Bruyns-Haylett, M. , Hayashi, Y. , Zheng, Y. (2017) Concurrent recording of co-localised electroencephalography and local field potential in rodent. Journal of Visualized Experiments ISSN: 1940-087X | doi: https://dx.doi.org/10.3791/56447
- Bruyns-Haylett, M. , Luo, J. , Bruyns-Haylett, A. , Harris, S. , Boorman, L. , Milne, E. , Vautrelle, N. , Hayashi, Y. , Whalley, B. , Jones, M. , Berwick, J. , Riera, J. , Zheng, Y. (2017) The neurogenesis of P1 and N1: a concurrent EEG/LFP study. NeuroImage , 146 pp. 575-588. ISSN: 1053-8119 | doi: https://dx.doi.org/10.1016/j.neuroimage.2016.09.034
- Song, Y. , Torres, R. , Garcia, S. , Frometa, Y. , Bae, J. , Deshmukh, A. , Lin, W. , Zheng, Y. , Riera, J. (2016) Dysfunction of neurovascular/metabolic coupling in chronic focal epilepsy. IEEE Transactions on Biomedical Engineering , 63 (1). pp. 97-110. ISSN: 0018-9294 | doi: https://dx.doi.org/10.1109/TBME.2015.2461496
- Boorman, L. , Harris, S. , Bruyns-Haylett, M. , Kennerley, A. , Zheng, Y. , Martin, C. , Jones, M. , Redgrave, P. , Berwick, J. (2015) Long-latency reductions in gamma power predict hemodynamic changes that underlie the negative BOLD signal. The Journal of Neuroscience , 35 (11). pp. 4641-4656. ISSN: 1529-2401 | doi: https://dx.doi.org/10.1523/JNEUROSCI.2339-14.2015
- Harris, S. , Ma, H. , Zhao, M. , Boorman, L. , Zheng, Y. , Kennerley, A. , Bruyns-Haylett, M. , Overton, P. , Berwick, J. , Schwartz, T. (2014) Coupling between gamma-band power and cerebral blood volume during recurrent acute neocortical seizures. NeuroImage , 97 pp. 62-70. ISSN: 1053-8119 | doi: https://dx.doi.org/10.1016/j.neuroimage.2014.04.014
- Vidal-Rosas, E. , Billings, S. , Zheng, Y. , Mayhew, J. , Johnston, D. , Kennerley, A. , Coca, D. (2014) Reduced-order modeling of light transport in tissue for real-time monitoring of brain hemodynamics using diffuse optical tomography. Journal of Biomedical Optics , 19 (2). ISSN: 1560-2281 | doi: https://dx.doi.org/10.1117/1.JBO.19.2.026008
- Bruyns-Haylett, M. , Harris, S. , Boorman, L. , Zheng, Y. , Berwick, J. , Jones, M. (2013) The resting-state neurovascular coupling relationship: rapid changes in spontaneous neural activity in the somatosensory cortex are associated with haemodynamic fluctuations that resemble stimulus-evoked haemodynamics. European Journal of Neuroscience , 38 (6). pp. 2902-2906. ISSN: 1460-9568 | doi: https://dx.doi.org/10.1111/ejn.12295
- Benn, Y. , Wilkinson, I. , Zheng, Y. , Kadosh, K. , Romanowski, C. , Siegal, M. , Varley, R. (2013) Differentiating core and co-opted mechanisms in calculation: The neuroimaging of calculation in aphasia. Brain and Cognition , 82 (3). pp. 254-264. ISSN: 0278-2626 | doi: https://dx.doi.org/10.1016/j.bandc.2013.04.012
- Martin, C. , Zheng, Y. , Sibson, N. , Mayhew, J. , Berwick, J. (2013) Complex spatiotemporal haemodynamic response following sensory stimulation in the awake rat. NeuroImage , 66 pp. 1-8. ISSN: 1053-8119 | doi: https://dx.doi.org/10.1016/j.neuroimage.2012.10.006
- Benn, Y. , Zheng, Y. , Wilkinson, I. , Siegal, M. , Varley, R. (2012) Language in calculation: A core mechanism?. Neuropsychologia , 50 (1). pp. 1-10. ISSN: 0028-3932 | doi: https://dx.doi.org/10.1016/j.neuropsychologia.2011.09.045
- Kennerley, A. , Mayhew, J. , Boorman, L. , Zheng, Y. , Berwick, J. (2012) Is optical imaging spectroscopy a viable measurement technique for the investigation of the negative BOLD phenomenon? A concurrent optical imaging spectroscopy and fMRI study at high field (7T). NeuroImage , 61 (1). pp. 10-20. ISSN: 1053-8119 | doi: https://dx.doi.org/10.1016/j.neuroimage.2012.03.015
- Zheng, Y. , Luo, J. , Harris, S. , Kennerley, A. , Berwick, J. , Billings, S. , Mayhew, J. (2012) Balanced excitation and inhibition: Model based analysis of local field potentials. NeuroImage , 63 (1). pp. 81-94. ISSN: 1053-8119 | doi: https://dx.doi.org/10.1016/j.neuroimage.2012.06.040
- Kennerley, A. , Harris, S. , Bruyns-Haylett, M. , Boorman, L. , Zheng, Y. , Jones, M. , Berwick, J. (2011) Early and late stimulus-evoked cortical hemodynamic responses provide insight into the neurogenic nature of neurovascular coupling. Journal of Cerebral Blood Flow & Metabolism , 32 (3). pp. 468-480. ISSN: 1559-7016 | doi: https://dx.doi.org/10.1038/jcbfm.2011.163
- Harris, S. , Jones, M. , Zheng, Y. , Berwick, J. (2010) Does neural input or processing play a greater role in the magnitude of neuroimaging signals?. Frontiers in Neuroenergetics , 2 pp. 1-7. ISSN: 1662-6427 | doi: https://dx.doi.org/10.3389/fnene.2010.00015
- Zheng, Y. , Pan, Y. , Harris, S. , Billings, S. , Coca, D. , Berwick, J. , Jones, M. , Kennerley, A. , Johnston, D. , Martin, C. , Devonshire, I. , Mayhew, J. (2010) A dynamic model of neurovascular coupling: Implications for blood vessel dilation and constriction. NeuroImage , 52 (3). pp. 1135-1147. ISSN: 1053-8119 | doi: https://dx.doi.org/10.1016/j.neuroimage.2010.01.102
- Boorman, L. , Kennerley, A. , Johnston, D. , Jones, M. , Zheng, Y. , Redgrave, P. , Berwick, J. (2010) Negative blood oxygen level dependence in the rat: a model for investigating the role of suppression in neurovascular coupling. Journal of Neuroscience , 30 (12). pp. 4285-4294. ISSN: 0270-6474 | doi: https://dx.doi.org/10.1523/JNEUROSCI.6063-09.2010
- Bruyns-Haylett, M. , Zheng, Y. , Berwick, J. , Jones, M. (2010) Temporal coupling between stimulus-evoked neural activity and hemodynamic responses from individual cortical columns. Physics in Medicine and Biology , 55 (8). pp. 2203-2219. ISSN: 1361-6560 | doi: https://dx.doi.org/10.1088/0031-9155/55/8/006
- Wei, H. , Zheng, Y. , Pan, Y. , Coca, D. , Li, L. , Mayhew, J. , Billings, S. (2009) Model estimation of cerebral hemodynamics between blood flow and volume changes: A data-based modeling approach. IEEE Transactions on Biomedical Engineering , 56 (6). pp. 1606-1616. ISSN: 0018-9294 | doi: https://dx.doi.org/10.1109/TBME.2009.2012722
- Zheng, Y. and Mayhew, J. (2009) A time-invariant visco-elastic windkessel model relating blood flow and blood volume. NeuroImage , 47 (4). pp. 1371-1380. ISSN: 1053-8119 | doi: https://dx.doi.org/10.1016/j.neuroimage.2009.04.022
- Lefebvre, V. , Zheng, Y. , Martin, C. , Devonshire, I. , Harris, S. , Mayhew, J. (2009) A dynamic causal model of the coupling between pulse stimulation and neural activity. Neural Computation , 21 (10). pp. 2846-2868. ISSN: 0899-7667 | doi: https://dx.doi.org/10.1162/neco.2009.07-08-820
- Martindale, J. , Kennerley, A. , Johnston, D. , Zheng, Y. , Mayhew, J. (2008) Theory and generalization of Monte Carlo models of the BOLD signal source. Magnetic Resonance in Medicine , 59 (3). pp. 607-618. ISSN: 1522-2594 | doi: https://dx.doi.org/10.1002/mrm.21512
- Martindale, J. , Berwick, J. , Martin, C. , Kong, Y. , Zheng, Y. , Mayhew, J. (2005) Long duration stimuli and nonlinearities in the neural–haemodynamic coupling. Journal of Cerebral Blood Flow and Metabolism , 25 (5). pp. 651-661. ISSN: 1559-7016 | doi: https://dx.doi.org/10.1038/sj.jcbfm.9600060
- Zheng, Y. , Johnston, D. , Berwick, J. , Chen, D. , Billings, S. , Mayhew, J. (2005) A three-compartment model of the hemodynamic response and oxygen delivery to brain. NeuroImage , 28 (4). pp. 925-939. ISSN: 1053-8119 | doi: https://dx.doi.org/10.1016/j.neuroimage.2005.06.042
- Kong, Y. , Zheng, Y. , Johnston, D. , Martindale, J. , Jones, M. , Billings, S. , Mayhew, J. (2004) A model of the dynamic relationship between blood flow and volume changes during brain activation. Journal of Cerebral Blood Flow and Metabolism , 24 (12). pp. 1382-1392. ISSN: 1559-7016 | doi: https://dx.doi.org/10.1097/01.WCB.0000141500.74439.53
- Papadakis, N. , Zheng, Y. , Wilkinson, I. (2003) Analysis of diffusion tensor magnetic resonance imaging data using principal component analysis. Physics in Medicine and Biology , 48 (24). pp. N343-N350. ISSN: 1361-6560 | doi: https://dx.doi.org/10.1088/0031-9155/48/24/N01
- Martindale, J. , Mayhew, J. , Berwick, J. , Jones, M. , Martin, C. , Johnston, D. , Redgrave, P. , Zheng, Y. (2003) The hemodynamic impulse response to a single neural event. Journal of Cerebral Blood Flow and Metabolism , 23 pp. 546-555. ISSN: 1559-7016 | doi: https://dx.doi.org/10.1097/01.WCB.0000058871.46954.2B
- Zheng, Y. , Martindale, J. , Johnston, D. , Jones, M. , Berwick, J. , Mayhew, J. (2002) A model of the hemodynamic response and oxygen delivery to brain. NeuroImage , 16 (3A). pp. 617-637. ISSN: 1053-8119 | doi: https://dx.doi.org/10.1006/nimg.2002.1078