Chronic pain affects roughly a third to one-half of UK's population. The UK has a large burden of chronic pain with a prevalence of 43%. Opioid prescription have increased in last few years leading to an opioid epidemic. Pharmacists are one of the most trusted healthcare professionals in the UK's healthcare system and are viewed as reliable source of information for addressing healthcare needs such as opioid therapy optimization for chronic non-cancer pain. This theme will explore pharmacists' role in managing chronic non-cancer pain and opioid medication therapy, from the perspective of pharmacists, patients, and other stakeholders. The studies can be designed both as qualitative and quantitative. In addition, a mix methods approach can be selected. The aim is to provide recommendations to the concerned departments, societies, and the NHS, with a focus on improving service delivery for the patients.