Staff Profile:Dr Wing-Man Lau
- Dr Wing Man Lau
- Job Title:
- Lecturer in Pharmacy Practice
- Areas of Interest:
Transdermal and topical drug delivery: Delivery of drugs via the skin is advantageous because it avoids first-pass metabolism and minimises systemic side effects. However, the outer skin barrier prevents effective drug uptake. The focus of this work is on the use of sophisticated drug design and delivery systems (e.g. pro-drugs/co-drugs; biologically/mechanically triggered, site-specific drug release from polymers) to overcome the outer skin barrier.
Drug toxicity testing: Our work focuses on the impact of the drug system at the cellular level using a range of tissue culture and molecular biology techniques including immunocytochemistry, flow cytometry and Western Blot analysis. The ultimate aim is to improve drug formulation, bioavailability, safety and patient acceptability.
Wound healing: In this work, we study the cellular effects of different wound healing treatments (including hyperbaric oxygen therapy) using monolayer cell cultures and to understand the cellular mechanisms underpinning the wound healing process.
Other research interests are:
Clinical practice research: This work involves promoting the effective use of drugs in the primary and secondary care settings, by enhancing the roles of various healthcare professionals in patient education. This is done by identifying the current barriers to effective drug use and raising public awareness on avoiding adverse effects and improving dosing accuracy.
Pharmacy Education: I also have interest in the use of technology in pharmacy education, investigating the benefit of various teaching methods and their impact in enhancing teaching and learning environment.
- Research groups / Centres:
YNumber of items: 8.
- Filippov, S. K., Bogomolova, A. , Kaberov, L. , Velychkivska, N., Starovoytova, L., Cernochova, Z., Rogers, S. E., Lau, W. M., Khutoryanskiy, V. V. and Cook, M. T. (2016) Internal nanoparticle structure of temperature-responsive self-assembled PNIPAM-b-PEG-b-PNIPAM triblock copolymers in aqueous solutions: NMR, SANS and light scattering studies. Langmuir, 32 (21). pp. 5314-5323. ISSN 1520-5827 doi: 10.1021/acs.langmuir.6b00284
- Khateb, K. A., Ozhmukhametova, E. K., Mussin, M. N., Seilkhanov, S. K., Rakhypbekov, T. K., Lau, W. M. and Khutoryanskiy, V. V. (2016) In situ gelling systems based on Pluronic F127/Pluronic F68 formulations for ocular drug delivery. International Journal of Pharmaceutics, 502 (1-2). pp. 70-79. ISSN 0378-5173 doi: 10.1016/j.ijpharm.2016.02.027
- Ng, K. W., Lau, W. M. and Williams, A. C. (2015) Towards pain-free diagnosis of skin diseases through multiplexed microneedles: biomarker extraction and detection using a highly sensitive blotting method. Drug Delivery and Translational Research, 5 (4). pp. 387-396. ISSN 2190-393X doi: 10.1007/s13346-015-0231-5
- Lau, W. M., Heard, C. M. and White, A. W. (2013) Design, synthesis and in vitro degradation of a novel co-drug for the treatment of psoriasis. Pharmaceutics, 5 (2). pp. 232-245. ISSN 1999-4923 doi: 10.3390/pharmaceutics5020232
- Lau, W. M., Ng, K. W., Sakenyte, K. and Charles, M. H. (2012) Distribution of esterase activity in porcine ear skin, and the effects of freezing and heat separation. International Journal of Pharmaceutics, 433 (1-2). pp. 10-15. ISSN 0378-5173 doi: 10.1016/j.ijpharm.2012.04.079
- Lau, W. M., Ng, K. W., White, A. W. and Heard, C. M. (2011) Therapeutic and cytotoxic effects of the novel antipsoriasis codrug, naproxyl-dithranol, on HaCaT cells. Molecular Pharmaceutics, 8 (6). pp. 2398-2407. ISSN 1543-8392 doi: 10.1021/mp200327k
- Lau, W.-M., White, A. W. and Heard, C. M. (2010) Topical delivery of a naproxen-dithranol co-drug: in vitro skin penetration, permeation, and staining. Pharmaceutical Research, 27 (12). pp. 2734-2742. ISSN 0724-8741 doi: 10.1007/s11095-010-0274-8
- Lau, W.-M., White, A.W., Gallagher, S.J., Donaldson, M., McNaughton, G. and Heard, C.M. (2008) Scope and Limitations of The Co-Drug Approach to Topical Drug Delivery. Current Pharmaceutical Design, 14 (8). pp. 794-802. ISSN 1381-6128 doi: DOI:10.2174/138161208784007653
Mockaityte, I, Ng, KW, Lau, WM. (Podium) Controlled topical antioxidant delivery to the skin using the co-drug approach (Podium). APS PharmSci 2013, Edinburgh, UK. Sep 2013
Khateb, KA, Lau, WM, Khutoryanskiy, V. Synthesising and characterising a new temperature responsive triblock copolymer based on PNIPAAm and PEG. 2013 Young Researchers Pharmaceutics and Biopharmaceutics Meeting, Reading, Aug 2013
Khateb, KA, Lau, WM, Khutoryanskiy, V. Pluronic-based in situ gelling systems for ocular drug delivery (Poster). UK & Ireland Controlled Release Society Symposium, Reading, Apr 2013.
Khateb, KA, Lau, WM, Khutoryanskiy, V. Thermo-reversible in situ gelling systems for ocular drug delivery. Polymeric and Self-Assembled Hydrogels 2012 conference, King's College London, UK. Poster Prize. Sep 2012
Lau, W.M. Examining community pharmacists' role in relation to the use of topical corticosteroids. 1st Pharmacy Practice Research Showcase, Reading, UK. Feb 2013. (invited speaker)
Lau, W.M. et al. Improved topical delivery and skin staining effect of dithranol using the co-drug approach (Poster). Perspectives in Percutaneous Penetration 13th International Conference, France. Apr 2012
Sakenyte, K and Lau, W.M. Skin enzymes facilitated pro-drug and co-drug hydrolysis - implications for topical drug delivery. 69th BPSA Annual Conference, Portsmouth, UK. Apr 2011.
PhD opportunities (self-funded):
A number of opportunities are currently available for self-funded PhD students to undertake research in the areas of:
Topical and transdermal drug delivery
Vaccine design and formulation
Infectious diseases diagnosis and treatment
Safety and efficacy of traditional and herbal medicinesIf you are interested in the above areas and would like to discuss the possibility to join our research group as a PhD student, please contact Dr Wing Man Lau for an informal discussion.