Staff Profile:Professor Rebecca Green

Name:

Professor Becky Green

Job Title:

Head of Department

Responsibilities:

Head of Department

Areas of Interest:

Rebecca's scientific interests lie in the study of protein behaviour, and in linking their structural features to functional properties. Most recently, her research has focused on the lipid (cell membrane) binding behaviour of antimicrobial and anticancer peptides and proteins.

Within the area of food security, Rebecca's recent research has focused on seed defence proteins and peptides, particularly the functional properties of puroindolines and purothionins. These proteins also have potential, with antifungal and antimicrobial activity, pharmaceutically. From the point of view of lipid biophysics, her research has focused on defining the role of different lipid constituents within biological membranes and how these provide potential binding sites for polymers, peptides and proteins.

Rebecca also has broader research interests in the areas of biomaterials and biophysical chemistry, and works on a number of related projects, including protein-polyphenol interactions, formulation solutions for poorly-water soluble drugs and polymer binding to lipid surfaces in advanced drug delivery. Her research regularly utilises STFC and other central facilities; neutron (ISIS, ILL) and X-ray (Diamond) reflectivity and scattering methods.

Research groups / Centres:

Publications:

Y

Jump to: 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003

Number of items: 41.

2018

• Florek, O. B., Clifton, L. A., Wilde, M., Arnold, T., Green, B. and Frazier, R. (2018) Lipid composition in fungal membrane models: effect of lipid fluidity. Acta Crystallographica Section D: Biological Crystallography, 74 (12). pp. 1233-1244. ISSN 1399-0047 doi: https://doi.org/10.1107/S2059798318009440

2017

• Sanders, M. R., Clifton, L. A., Frazier, R. A. and Green, R. J. (2017) Tryptophan to arginine substitution in puroindoline b alters binding to model eukaryotic membranes. Langmuir, 33 (19). pp. 4847-4853. ISSN 0743-7463 doi: https://doi.org/10.1021/acs.langmuir.6b03030
• Ropiak, H. M., Lachmann, P., Ramsay, A., Green, R. J. and Mueller-Harvey, I. (2017) Identification of structural features of condensed tannins that affect protein aggregation. PLoS ONE, 12 (1). e0170768. ISSN 1932-6203 doi: https://doi.org/10.1371/journal.pone.0170768
• Wilde, M., Green, R. J., Sanders, M. R. and Greco, F. (2017) Biophysical studies in polymer therapeutics: the interactions of anionic and cationic PAMAM dendrimers with lipid monolayers. Journal of Drug Targeting, 25 (9-10). pp. 910-918. ISSN 1029-2330 doi: https://doi.org/10.1080/1061186X.2017.1365877

2016

• Sanders, M. R., Clifton, L. A., Frazier, R. A. and Green, R. J. (2016) The role of lipid composition on the interaction between a tryptophan-rich protein and model bacterial membranes. Langmuir, 38 (8). pp. 2050-2057. ISSN 0743-7463 doi: https://doi.org/10.1021/acs.langmuir.5b04628

2015

• Karonen, M., Oraviita, M., Mueller-Harvey, I., Salminen, J.-P. and Green, R. J. (2015) Binding of an oligomeric ellagitannin series to bovine serum albumin (BSA): analysis by isothermal titration calorimetry (ITC). Journal of Agricultural and Food Chemistry, 63 (49). pp. 10647-10654. ISSN 0021-8561 doi: https://doi.org/10.1021/acs.jafc.5b04843
• Albarkah, Y. R., Green, R. J. and Khutoryanskiy, V. V. (2015) Probing the mucoadhesive interactions between porcine gastric mucin and some water-soluble polymers. Macromolecular Bioscience, 15 (11). pp. 1546-1553. ISSN 1616-5187 doi: https://doi.org/10.1002/mabi.201500158
• Ravishankar, D., Watson, K. A., Boateng, S. Y., Green, R. J., Greco, F. and Osborn, H. M.I. (2015) Exploring quercetin and luteolin derivatives as antiangiogenic agents. European Journal of Medicinal Chemistry, 97. pp. 259-274. ISSN 0223-5234 doi: https://doi.org/10.1016/j.ejmech.2015.04.056

2014

• Dobreva, M., Green, R.J., Mueller-Harvey, I., Salminen, J.-P., Howlin, B.J. and Frazier, R. (2014) Size and molecular flexibility affect the binding of ellagitannins to bovine serum albumin. Journal of Agricultural and Food Chemistry, 62 (37). pp. 9186-9194. ISSN 0021-8561 doi: https://doi.org/10.1021/jf502174r
• Dabkowska, A. P., Barlow, D. J., Clifton, L. A., Hughes, A. V., Webster, J. R. P., Green, R. J., Quinn, P. J. and Lawrence, M. J. (2014) Calcium-mediated binding of DNA to 1,2-distearoyl-sn-glycero-3-phosphocholine-containing mixed lipid monolayers. Soft Matter, 10 (11). pp. 1685-1695. ISSN 1744-683X doi: https://doi.org/10.1039/c3sm52747f

2013

• Sanders, M. R., Clifton, L. A., Neylon, C., Frazier, R. A. and Green, R. J. (2013) Selected wheat seed defense proteins exhibit competitive binding to model microbial lipid interfaces. Journal of Agricultural and Food Chemistry, 61 (28). pp. 6890-6900. ISSN 1520-5118 doi: https://doi.org/10.1021/jf401336a

2012

• Clifton, L. A., Sanders, M., Kinane, C., Arnold, T., Edler, K. J., Neylon, C., Green, R. J. and Frazier, R. A. (2012) The role of protein hydrophobicity in thionin–phospholipid interactions: a comparison of α1 and α2-purothionin adsorbed anionic phospholipid monolayers. Physical Chemistry Chemical Physics, 14 (39). pp. 13569-13579. ISSN 1463-9076 doi: https://doi.org/10.1039/C2CP42029E

2011

• Clifton, L. A., Sanders, M. R., Hughes, A. V., Neylon, C., Frazier, R. A. and Green, R. J. (2011) Lipid binding interactions of antimicrobial plant seed defence proteins: puroindoline-a and β-purothionin. Physical Chemistry Chemical Physics, 13 (38). pp. 17153-17162. ISSN 1463-9076 doi: https://doi.org/10.1039/c1cp21799b
• Clifton, L. A., Sanders, M. R., Castelletto, V., Rogers, S. E., Heenan, R. K., Neylon, C., Frazier, R. and Green, R. J. (2011) Puroindoline-a, a lipid binding protein from common wheat, spontaneously forms prolate protein micelles in solution. Physical Chemistry Chemical Physics, 13 (19). pp. 8881-8888. ISSN 1463-9076 doi: https://doi.org/10.1039/c0cp02247k
• Rizi, K., Green, B., Donaldson, M. and Williams, A. (2011) Production of pH-responsive microparticles by spray drying: investigation of experimental parameter effects on morphological and release properties. Journal of Pharmaceutical Sciences, 100 (2). pp. 566-579. ISSN 1520-6017 doi: https://doi.org/10.1002/jps.22291
• Dobreva, M. A., Frazier, R. A., Mueller-Harvey, I., Clifton, L.A., Gea, A. and Green, R. J. (2011) Binding of pentagalloyl glucose to two globular proteins occurs via multiple surface sites. Biomacromolecules, 12 (3). pp. 710-715. ISSN 1525-7797 doi: https://doi.org/10.1021/bm101341s
• Rizi, K., Green, R. J., Khutoryanskaya, O., Donaldson, M. and Williams, A. C. (2011) Mechanisms of burst release from pH-responsive polymeric microparticles. Journal of Pharmacy and Pharmacology, 63 (9). pp. 1141-1155. ISSN 0022-3573 doi: https://doi.org/10.1111/j.2042-7158.2011.01322.x
• Rizi, K., Green, R. J., Donaldson, M. X. and Williams, A. C. (2011) Using pH abnormalities in diseased skin to trigger and target topical therapy. Pharmaceutical Research, 28 (10). pp. 2589-2598. ISSN 0724-8741 doi: https://doi.org/10.1007/s11095-011-0488-4

2010

• Frazier, R. A., Deaville, E. R., Green, R. J., Stringano, E., Willoughby, I., Plant, J. and Mueller-Harvey, I. (2010) Interactions of tea tannins and condensed tannins with proteins. Journal of Pharmaceutical and Biomedical Analysis , 51 (2). pp. 490-495. ISSN 0731-7085 doi: https://doi.org/10.1016/j.jpba.2009.05.035
• Lambourne, J., Tosi, P., Marsh, J., Bhandari, D., Green, R. , Frazier, R. and Shewry, P. R. (2010) Characterisation of an s-type low molecular weight glutenin subunit of wheat and its proline and glutamine-rich repetitive domain. Journal of Cereal Science, 51 (1). pp. 96-104. ISSN 0733-5210 doi: https://doi.org/10.1016/j.jcs.2009.10.003

2009

• Pasut, G., Greco, F., Mero, A., Mendichi, R., Fante, C., Green, R. J. and Veronese, F. (2009) Polymer-drug conjugates for combination anticancer therapy: investigating the mechanism of action. Journal of Medicinal Chemistry, 52 (20). pp. 6499-6502. ISSN 0022-2623 doi: https://doi.org/10.1021/jm900804m
• Deepika, G., Green, R. J., Frazier, R. A. and Charalampopoulos, D. (2009) Effect of growth time on the surface and adhesion properties of Lactobacillus rhamnosus GG. Journal of Applied Microbiology, 107 (4). pp. 1230-1240. ISSN 1364-5072 doi: https://doi.org/10.1111/j.1365-2672.2009.04306.x

2008

• Clifton, L. A., Green, R. J., Hughes, A. V. and Frazier, R. A. (2008) Interfacial structure of wild-type and mutant forms of puroindoline-b bound to DPPG monolayers. Journal of Physical Chemistry B, 112 (49). pp. 15907-15913. ISSN 1520-6106 doi: https://doi.org/10.1021/jp806016h
• Mulheran, P. .A., Pellenc, D., Bennett, R. A., Green, R. J. and Sperrin, M. (2008) Mechanisms and dynamics of protein clustering on a solid surface. Physical Review Letters, 100 (6). 068102. ISSN 0031-9007 doi: https://doi.org/10.1103/PhysRevLett.100.068102
• Pellenc, D., Bennett, R. A., Green, R. G., Sperrin, M. and Mulheran, P. A. (2008) New insights on growth mechanisms of protein clusters at surfaces: an AFM and simulation study. Langmuir, 24 (17). pp. 9648-9655. ISSN 0743-7463 doi: https://doi.org/10.1021/la801246k
• Castelletto, V., Hamley, I. W., Clifton, L. A. and Green, R. J. (2008) Osmotic pressure and aggregate shape in BSA/poly (ethylene glycol)-lipid/Dextran solutions. Biophysical Chemistry, 134 (1-2). pp. 34-38. ISSN 0301-4622 doi: https://doi.org/10.1016/j.bpc.2008.01.004

2007

• Clifton, L. A., Green, R. J. and Frazier, R. A. (2007) Puroindoline-b mutations control the lipid binding interactions in mixed puroindoline-a: puroindoline-b systems. Biochemistry, 46 (48). pp. 13929-13937. ISSN 0006-2960 doi: https://doi.org/10.1021/bi701680w
• Deaville, E., Green, B., Mueller-Harvey, I., Willoughby, I. and Frazier, R. (2007) Hydrolyzable tannin structures influence relative globular and random coil protein binding strengths. Journal of Agricultural and Food Chemistry, 55 (11). pp. 4554-4561. ISSN 0021-8561 doi: https://doi.org/10.1021/jf063770o
• Clifton, L. A., Lad, M. D., Green, R. J. and Frazier, R. A. (2007) Single amino acid substitutions in puroindoline-b mutants influence lipid binding properties. Biochemistry, 46 (8). pp. 2260-2266. ISSN 0006-2960 doi: https://doi.org/10.1021/bi062190h
• Lad, M.D., Birembaut, F., Clifton, L.A., Frazier, R.A., Webster, J.R.P. and Green, R.J. (2007) Antimicrobial peptide-lipid binding interactions and binding selectivity. Biophysical Journal, 92 (10). pp. 3575-3586. ISSN 0006-3495 doi: https://doi.org/10.1529/biophysj.106.097774
• Clifton, L.A., Green, R.J. and Frazier, R.A. (2007) Lipid selectivity of puroindolines and its relationship to endosperm hardness. In: Lookhart, G.L. and Ng, P.K.W. (eds.) Gluten proteins 2006. AACC International, St Paul, pp. 68-72. ISBN 9781891127571

2006

• Frazier, R., Papadopoulou, A. and Green, R. (2006) Isothermal titration calorimetry study of epicatechin binding to serum albumin. Journal of Pharmaceutical and Biomedical Analysis , 41 (5). pp. 1602-1605. ISSN 0731-7085 doi: https://doi.org/10.1016/j.jpba.2006.02.004
• Lad, M.D., Birembaut, F., Matthew, J.M., Frazier, R. and Green, R. J. (2006) The adsorbed conformation of globular proteins at the air/water interface. Physical Chemistry Chemical Physics, 8 (18). pp. 2179-2186. ISSN 1463-9076 doi: https://doi.org/10.1039/b515934b

2005

• Papadopoulou, A., Green, R. J. and Frazier, R. A. (2005) Interaction of flavonoids with bovine serum albumin: a fluorescence quenching study. Journal of Agricultural and Food Chemistry , 53 (1). pp. 158-163. ISSN 0021-8561 doi: https://doi.org/10.1021/jf048693g
• Cooper, A., Kennedy, M.W., Fleming, R.I., Wokosin, D.L., Su, T.J., Green, R.J., Lu, J.R. , Wilson, E.H. and Videler, H. (2005) Adsorption of frog foam nest proteins at the air-water interface. Biophysical Journal, 88 (3). pp. 2114-2125. ISSN 0006-3495 doi: https://doi.org/10.1529/biophysj.104.046268
• Lad, M.D., Birembaut, F., Frazier, R.A. and Green, R.J. (2005) Protein-lipid interactions at the air/water interface. Physical Chemistry Chemical Physics, 7 (19). pp. 3478-3485. ISSN 1463-9076 doi: https://doi.org/10.1039/b506558p

2004

• Jeganathan, P., Green, R. E., Norris, K., Vogiatzakis, I. N., Bartsch, A., Wotton, S. R., Bowden, C. G. R., Griffiths, G. H., Pain, D. and Rahmani, A. R. (2004) Modelling habitat selection and distribution of the critically endangered Jerdon's courser Rhinoptilus bitorquatus in scrub jungle: an application of a new tracking method. Journal of Applied Ecology, 41 (2). pp. 224-237. ISSN 0021-8901 doi: https://doi.org/10.1111/j.0021-8901.2004.00897.x

2003

• Frazier, R. A., Papadopoulou, A., Mueller-Harvey, I., Kissoon, D. and Green, R. J. (2003) Probing protein−tannin interactions by isothermal titration microcalorimetry. Journal of Agricultural and Food Chemistry, 51 (18). pp. 5189-5195. ISSN 0021-8561 doi: https://doi.org/10.1021/jf021179v
• Lad, M. D., Ledger, V. M., Briggs, B., Green, R. J. and Frazier, R. A. (2003) Analysis of the SDS−Lysozyme binding isotherm. Langmuir, 19 (12). pp. 5098-5103. ISSN 0743-7463 doi: https://doi.org/10.1021/la0269560
• Lad, M.D., Ledger, V.M., Briggs, B., Green, R.J. and Frazier, R.A. (2003) Analysis of the SDS-lysozyme binding isotherm. Langmuir, 19 (12). pp. 5098-5103. ISSN 0743-7463 doi: https://doi.org/10.1021/la0269560
• Frazier, R.A., Papadopoulou, A., Mueller-Harvey, I., Kissoon, D. and Green, R.J. (2003) Probing protein-tannin interactions by isothermal titration microcalorimetry. Journal of Agricultural and Food Chemistry, 51 (18). pp. 5189-5195. ISSN 0021-8561 doi: https://doi.org/10.1021/jf021179v

This list was generated on Wed Aug 21 12:39:03 2019 UTC.