Staff Profile:Dr Patrick Lewis

Name:
Dr Patrick Lewis
Job Title:
Associate Professor
Responsibilities:

Academic editor, PLoS One. STEM ambassador.

Sits on the scientific advisory board of Ataxia UK

Areas of Interest:
My research is focused on understanding the molecular pathways that lead to inherited Parkinson's disease linked to mutations in Leucine rich repeat kinase 2 (LRRK2). Mutations in this gene are the single most common genetic cause of Parkinson's disease, affecting 5-10,000 people in the UK alone. LRRK2 itself is a multidomain enzyme, possessing both kinase and GTPase activities, and much of my work over the past 8 years has been directed at dissecting how mutations impact on these activities, and how they regulate one another. To do this, my group uses a combination of cellular and biochemical approaches, including cellular models for LRRK2 function and in vitro enzymatic assays. We have a particular interest in investigating proteins closely related to LRRK2 as a means to achieving a greater understanding of how LRRK2 itself functions. Our research has highlighted a putative role for LRRK2 in the regulation of autophagy.
Research groups / Centres:
Publications:
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This list was generated on Sat Aug 19 21:35:37 2017 BST.

www.lewislaboratory.com

www.degeneratingneurons.wordpress.com

Funded by: Parkinson's UK, the Michael J. Fox Foundation, the Wellcome trust, the Medical Research Council.

patrick_lewis

Contact Details

Email:
p.a.lewis@reading.ac.uk
Telephone:
+44 (0) 118 378 4561

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