Staff Profile:Marleen Wilde

Ms Marleen Wilde
Job Title:
Teaching Associate in Pharmaceutics

Mainly lab-based teaching support on MPharm Programme (PM1B, PM2A2, PM2B and PM4A)

Pt-PhD student (Pharmaceutics)

Pharmacy Postgraduate Representative (Graduate School)

Senior Common Room Committee Member and Junior Wine Steward

Areas of Interest:

Although there are more and more new drug molecules developed to fight antimicrobial resistance or life-threatening diseases such as cancer, many of them have not made it yet into clinical trials or the market because their interaction with biological membranes is poorly understood. In my PhD project I use a class of polymeric molecules for drug delivery with a defined structures called dendrimers to study their interactions with a number of lipid membrane models of varying complexity. I am using a various biophysical methods, such as scattering (neutrons, X-rays, DLS), spectroscopic (UV-Vis, FTIR, Fluorescence), and thermal (DSC, nano-DSC) techniques and surface pressure measurements to probe the influence of surface charge, solution salinity, pH, temperature or methanol content on the interaction of the dendrimer molecules with the lipid membranes but also on the behaviour of the molecules on their own in solution. During the biophysical testing we also had access to the INTER and SURF beamline at the ISIS neutron source and the BioSAXS B21 beamline at Diamond Light Source (Harwell, UK). In collaboration with the Maths Department there is another PhD student working on simulations and theoretical modelling on this project to match my experimental results. More complex studies involve cytotoxicity testing on a variety of cancer cell lines and antimicrobial activity screening on bacteria and fungi.

Research groups / Centres:

Pharmaceutics, CAF

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This list was generated on Thu Apr 25 21:30:06 2019 UTC.
M.Sc. Medical Biotechnology
B.Sc. Medical Biotechnology
Professional Qualification and Accreditation as Medical-technical Assistant for Functional Diagnostics

Associate Fellow of the Higher Education Academy (AFHEA)

Student member of UKICRS, Biochemical Society, CSI, and Macro Group

Marleen Wilde Staff Profile Photo

Contact Details

+44 (0) 118 378 6375
Chemistry LG43

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