Staff Profile:Dr Mark Dallas

Name:
Dr Mark Dallas
Job Title:
Lecturer in Cellular and Molecular Neuroscience
Responsibilities:

Editorial board The Journal of Pharmaceutics & Pharmacology

Expert Advisory panel Biochemistry Journal

Neuroscience Theme Lead (The Physiological Society)

ARUK Oxford Network Committee member

STEM ambassador

Alzheimer's Society PhD Review Panel

Editorial Board Member Physiology News

Areas of Interest:

Neurodegenerative diseases include a number of disorders that have different symptoms and effects, all of which act through the mechanism of compromising the brain's capacity to control itself or the body by damaging cells known as neurons that facilitate normal brain function. Various cellular proteins are involved in regulating normal physiological function including ion channels and neurotransmitter transporters. These complex proteins are expressed in various cell types within the central nervous system and are influenced by a host of endogenous and exogenous signalling molecules. Active research into these proteins is important as they underlie a host of pathological conditions, including neurodegenerative diseases. My research primarily uses electrophysiological techniques coupled with molecular biology experiments to further our understanding of ion channel and transporter physiology within the central nervous system.

One family of transporter proteins that I am currently interested in is the glutamate transporters expressed in both neurones and astrocytes. It is widely reported that the astrocytes specific transporters become dysfunctional in neurological disorders, so by understanding more about how they are regulated, I aim to unravel new therapeutic targets for a host of neurodegenerative diseases. Current research focuses on the astrocyte transporters and how their activity is regulated by oxidative and nitrosative stress, both implicated in Alzheimer's disease pathogenesis. As part of my research into Alzheimer's disease I am a member of the Oxford Alzheimer's Research UK network

I am also interested in the so called gasotransmitters and their actions as key signalling molecules in both the cardiovascular and nervous systems. These molecules (nitric oxide, carbon monoxide and hydrogen sulfide) are generated throughout the body and can either be toxic or protective to cells. A growing body of evidence suggests that these gasotransmitters regulate cellular signalling cascades by targeting specific ion channels and that this can dictate toxicity vs protection. My focus here is to understand how these gasotransmitters influence a range of cellular functions and be potentially used as cardioprotective or neuroprotective agents.

Research in the lab is generously funded by The Royal Society, The Physiological Society, The Alzheimer's Association and Alzheimer's Research UK.

Collaborations

Professor Whalley (University of Reading)
Dr Bithell (University of Reading)
Dr Kerrigan (University of Exeter)
Professor Randall (University of Exeter)
Professor Peers (University of Leeds)
Dr Nicholls (University of Oxford)
Dr Ribe (University of Oxford)

Watch this video to find out about dementia research at the University.

Research groups / Centres:
Publications:
Y
Jump to: 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2005
Number of items: 39.

2017

2016

2015

2014

2013

2012

2011

2010

2009

2008

2007

2005

This list was generated on Tue Jun 27 14:56:50 2017 BST.
Mark_Dallas

Contact Details

Email:
m.dallas@reading.ac.uk
Telephone:
+44 (0) 118 378 5203

Page navigation

Opportunities

A range of projects are available within this laboratory in which opportunities for PhD projects exist, focusing on the regulation of astrocyte function utilising primary cell culture and brain slice model systems. These studies focus on ion channels and neurotransmitter transporters that may be potential substrates for the gasotransmitters. A PhD in this clinically important area of neuroscience research will provide specialist training in neurobiology, electrophysiology and a broad training in cell biology approaches. While specific projects will be advertised, expressions of interest from government or self-funded candidates are always welcome.

 

Search Form

A-Z lists