Staff Profile:Dr Francesco Tamagnini

Name:

Dr Francesco Tamagnini

Job Title:

Lecturer in Pharmacology

Responsibilities:

Areas of Interest:

I am a neurophysiologist. My research is focused on the characterization of functional correlates of dementia. My lab work is complemented by my teaching experience and public outreach commitment.

• Characterization of epileptic-like single cell membrane excitability alterations and synaptic plasticity impairments in the temporal lobe of mouse models of dementia.
• Characterization of electrophysiological maturity of stem-cell derived neurons grown onto 2D (e.g. diamond) and 3D (e.g. designed hydrogels) substrates.
• Development and validation of computer-based models of neuronal function.
• Development of non-invasive, EEG-based diagnostic and prognostic tools for Alzheimer's disease.

My outreach commitment is aimed at two main objectives:

1. Raise awareness on Alzheimer's and dementia, while describing the fascinating machinery of the brain and its role in high cognitive functions.
2. Promote an informed debate on animal research with a focus on its ethical, legislative and practical aspects. 

Research groups / Centres:

School of Pharmacy, Pharmacology Group

Publications:

Y

Jump to: 2020 | 2019 | 2018 | 2017 | 2015 | 2014

Number of items: 15.

2020

• Bercea, C.-I., Cottrell, G. S. ORCID: https://orcid.org/0000-0001-9098-7627, Tamagnini, F. ORCID: https://orcid.org/0000-0002-8741-5094 and McNeish, A. J. (2020) Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and hypertension: a review of vasodilatory mechanisms of DHA and EPA. British Journal of Pharmacology. ISSN 0007-1188 doi: https://doi.org/10.1111/bph.15336 (In Press)
• Tamagnini, F. ORCID: https://orcid.org/0000-0002-8741-5094 (2020) Nucleated, outside-out, somatic, macropatch recordings in native neurons. In: Mark, D. and Damian, B. (eds.) Patch Clamp Electrophysiology Methods and Protocols. Humana, New York, NY, pp. 229-242. ISBN 9781071608173 doi: https://doi.org/10.1007/978-1-0716-0818-0_11
• Tait, L., Tamagnini, F., Stothart, G., Barvas, E., Monaldini, C., Frusciante, R., Volpini, M., Guttmann, S., Coulthard, E., Brown, J., Kazanina, N. and Goodfellow, M. (2020) EEG microstate complexity for aiding early diagnosis of Alzheimer’s disease. Scientific Reports. ISSN 2045-2322 (In Press)
• Bianchi, R., Eilers, W., Pellati, F., Corsi, L., Foster, H., Foster, K. and Tamagnini, F. (2020) Hippocampal synaptic and membrane function in the DBA/2J-mdx mouse model of Duchenne muscular dystrophy. Molecular and Cellular Neuroscience, 104. 103482. ISSN 1044-7431 doi: https://doi.org/10.1016/j.mcn.2020.103482

2019

• Stephen, T.-L., Tamagnini, F., Piegsa, J., Sung, K., Harvey, J., Oliver-Evans, A., Murray, T. K., Ahmed, Z., Hutton, M. L., Randall, A., O' Neill, M. J. and Jackson, J. S. (2019) Imbalance in the response of pre- and post-synaptic components to amyloidopathy. Scientific Reports, 9. 14837. ISSN 2045-2322 doi: https://doi.org/10.1038/s41598-019-50781-1

2018

• Palombo, F., Tamagnini, F., Jeynes, C., Mattana, S., Swift, I., Nallala, J., Hancock, J., Brown, J. T., Randall, A. D. and Stone, N. (2018) Detection of Aβ plaque-associated astrogliosis in Alzheimer’s disease brain by spectroscopic imaging and immunohistochemistry. Analyst, 143 (4). pp. 850-857. ISSN 0003-2654 doi: https://doi.org/10.1039/c7an01747b
• Palombo, F., Masia, F., Mattana, S., Tamagnini, F., Borri, P., Langbein, W. and Fioretto, D. (2018) Hyperspectral analysis applied to micro-Brillouin maps of amyloid-beta plaques in Alzheimer’s disease brains. Analysis, 143 (24). pp. 6095-6102. ISSN 1467-8284 doi: https://doi.org/10.1039/C8AN01291A
• Tamagnini, F., Cotton, M., Goodall, O., Harrison, G., Jeynes, C., Palombo, F., Tomkow, J., Tomkow, T. and Wedgwood, K. (2018) ‘Of Mice and Dementia’: A filmed conversation on the use of animals in dementia research. Dementia, 17 (8). pp. 1055-1063. ISSN 1741-2684 doi: https://doi.org/10.1177/1471301218789560

2017

• Tamagnini, F., Walsh, D., Brown, J. T., Bondulich, M. K., Hanger, D. P. and Randall, A. D. (2017) Hippocampal neurophysiology is modified by a disease-associated C-terminal fragment of tau protein. Neurobiology of Aging, 60. pp. 44-56. ISSN 0197-4580 doi: https://doi.org/10.1016/j.neurobiolaging.2017.07.005
• Mattana, S., Caponi, S., Tamagnini, F., Fioretto, D. and Palombo, F. (2017) Viscoelasticity of amyloid plaques in transgenic mouse brain studied by Brillouin microspectroscopy and correlative Raman analysis. Journal of Innovative Optical Health Sciences, 10 (6). 1742001. ISSN 1793-7205 doi: https://doi.org/10.1142/S1793545817420019

2015

• Tamagnini, F., Novelia, J., Kerrigan, T. L., Brown, J. T., Tsaneva-Atanasova, K. and Randall, A. D. (2015) Altered intrinsic excitability of hippocampal CA1 pyramidal neurons in aged PDAPP mice. Frontiers in Cellular Neuroscience, 9. ISSN 1662-5102 doi: https://doi.org/10.3389/fncel.2015.00372
• Nistor, P. A., May, P. W., Tamagnini, F., Randall, A. D. and Caldwell, M. A. (2015) Long-term culture of pluripotent stem-cell-derived human neurons on diamond – a substrate for neurodegeneration research and therapy. Biomaterial, 61. pp. 139-149. ISSN 0142-9612 doi: https://doi.org/10.1016/j.biomaterials.2015.04.050
• Tamagnini, F., Scullion, S., Brown, J. T. and Randall, A. D. (2015) Intrinsic excitability changes induced by acute treatment of hippocampal CA1 pyramidal neurons with exogenous amyloid β peptide. Hippocampus, 25 (7). pp. 786-797. ISSN 1050-9631 doi: https://doi.org/10.1002/hipo.22403
• Mehrban, N., Zhu, B., Tamagnini, F., Young, F. I., Wasmuth, A., Hudson, K. L., Thomson, A. R., Birchall, M. A., Randall, A. D., Song, B. and Woolfson, D. N. (2015) Functionalized α-helical peptide hydrogels for neural tissue engineering. ACS Biomaterials Science & Engineering, 1 (6). pp. 431-439. ISSN 2373-9878 doi: https://doi.org/10.1021/acsbiomaterials.5b00051

2014

• Tamagnini, F., Scullion, S., Brown, J. T. and Randall, A. D. (2014) Low concentrations of the solvent dimethyl sulphoxide alter intrinsic excitability properties of cortical and hippocampal pyramidal cells. PLoS ONE, 9 (3). e92557. ISSN 1932-6203 doi: https://doi.org/10.1371/journal.pone.0092557

This list was generated on Sun Jan 17 12:09:08 2021 UTC.