CH4O4-Oligosaccharides and Natural Products

Module Provider: Chemistry
Number of credits: 10 [5 ECTS credits]
Level:7
Terms in which taught: Spring term module
Pre-requisites:
Non-modular pre-requisites:
Co-requisites:
Modules excluded:
Current from: 2019/0

Module Convenor: Dr Geoffrey Brown

Email: g.d.brown@reading.ac.uk

Type of module:

Summary module description:
This module aims to provide the student with an overview of advanced organic chemistry.

Aims:
To enable the student to gain an understanding of the breadth of modern chemistry and demonstrate that organic chemistry is a multi-disciplinary science. Additionally, students will take part in a group-based problem solving exercise that will help them to understand how a medicinal chemist applies synthetic organic chemistry to the development of a drug.

Assessable learning outcomes:
Students who have successfully completed this module will be able to:
• Understand the biological role played by complex carbohydrates and describe current synthetic methodology for the construction of such molecules.
• Outline the different classes of secondary metabolites and describe their biosynthesis.
• Carry out an analysis of the synthesis of a potential drug and design routes to prepare analogue structures.
• Demonstrate an ability to plan a synthesis to deliver a range of compounds for a drug discovery programme.

Additional outcomes:

Outline content:

Synthesis in Medicinal Chemistry (10 workshops) – In this part of the course the class will be split into teams and each team assigned a synthetic, medicinal chemistry task. The team will be charged with completing the task set through appropriate division of labour. The problem will rely heavily on synthetic chemistry and the students’ ability to research the literature, taking advantage of databases such as Reaxys and SciFinder. The exercise will be assessed via an oral and written component. Feedback and guidance is available during the timetabled workshops.



Oligosaccharides (6 hours). Different strategies for the synthesis of oligosacharrides of biological significance will be discussed, including enzymatic and solid phase syntheses.



Natural Products and their Biosynthesis (8 hours). Most classes of secondary metabolites will be covered, including terpenoids and steroids (derived from both the mevalonate and DXP pathways), alkaloids (derived from amino acids) and acetogenins. In addition to their biosynthesis, the medicinal and/or toxicological importance of natural products will be stressed, as well as their ecological significance.


Brief description of teaching and learning methods:
10 x 1 hour workshop seminars. 14 x 1 hour lectures with 2 associated tutorials.
Summer hours are scheduled for revision.

Contact hours:
  Autumn Spring Summer
Lectures 14
Tutorials 2
Supervised time in studio/workshop 10
Guided independent study: 54 20
       
Total hours by term 0 80 20
       
Total hours for module 100

Summative Assessment Methods:
Method Percentage
Written exam 50
Written assignment including essay 30
Oral assessment and presentation 20

Summative assessment- Examinations:

1.5 hour. 


Summative assessment- Coursework and in-class tests:

Synthesis exercise: 50%. Students will attend seminars to assist with a team chemical synthesis problem. Each student will be assessed by an individual written piece of work (30%) and by giving a team oral presentation on their work (20%) and in each case we will examine how the team worked together to achieve the common goal as well as the individual’s work. Submission dates as detailed on Blackboard.


Formative assessment methods:

Feedback in seminars to assist with a team chemical synthesis problem.

Students will attend tutorials on the lecture material covered in this module. Attendance is compulsory. Tutorials to be submitted as detailed on Blackboard.


Penalties for late submission:
The Module Convener will apply the following penalties for work submitted late:

  • where the piece of work is submitted after the original deadline (or any formally agreed extension to the deadline): 10% of the total marks available for that piece of work will be deducted from the mark for each working day[1] (or part thereof) following the deadline up to a total of five working days;
  • where the piece of work is submitted more than five working days after the original deadline (or any formally agreed extension to the deadline): a mark of zero will be recorded.

  • The University policy statement on penalties for late submission can be found at: http://www.reading.ac.uk/web/FILES/qualitysupport/penaltiesforlatesubmission.pdf
    You are strongly advised to ensure that coursework is submitted by the relevant deadline. You should note that it is advisable to submit work in an unfinished state rather than to fail to submit any work.

    Assessment requirements for a pass:
    An overall mark of 50%.

    Reassessment arrangements:

    Reassessment arrangements are in accordance with University policy. Reassessment of the written examination (50%) is held during the University administered re-examination period in August. Failed coursework (a written report worth 30% and an oral presentation worth 20%) may be re-assessed by an alternative assignment before or during the August re-examination period.

    Final year students are not eligible to resit this module unless they have failed their degree programme overall.


    Additional Costs (specified where applicable):

    Last updated: 8 April 2019

    THE INFORMATION CONTAINED IN THIS MODULE DESCRIPTION DOES NOT FORM ANY PART OF A STUDENT'S CONTRACT.

    Things to do now