Staff Profile:Professor Kim Watson

Position / Job Title:
Professor in Structural Biochemistry
Areas of Interest:
  • Unravelling sequence-structure-function relationships of proteins
  • Drug discovery using computer-aided and structure-based approaches
  • Protein engineering for industry
  • Understanding molecular mechanisms of disease
  • Bile acid metabolism, lipid profiling and health
  • Gut-liver-brain axis and health
Research groups / Centres:

Member of the Molecular & Cellular Medicine Group


Pre 2005

Watson KA, Johnson LNJ, Leoffen P, Gillham D, Eggleston D, Collins P, Moynihan JM, DTI government report (2004) "Structural Genomics in Japan and China" following invitation to coordinate and lead a fully funded DTI mission. The report describes the findings from a DTI funded mission to China and Japan to explore emerging HTP technologies and provide opportunities for UK collaboration/technology transfer.

Brown, K., Carpenter E., Watson, KA, Coggins, JR, Hawkins, AR, Koch, MH, Svergun, DI. (2003) "Twists and turns: a tale of two shikimate-pathway enzymes." Biochem. Soc. Trans., 31, 543-547.

Nathalie Marchand-Geneste, Kimberly A. Watson, Bjorn K. Alsberg, and Ross D. King, (2002) "New Approach to Pharmacophore Mapping and QSAR Analysis Using Inductive Logic Programming. Application to Thermolysin Inhibitors and Glycogen Phosphorylase b Inhibitors".J. Med. Chem., 45, 399-409.

Katerina Tsitsanou, Nikos G. Oikonomakos, Spiros E. Zographos, V. Skamnaki, Mary Gregoriou, Kimberly A. Watson, Louise N. Johnson, George W.J. Fleet, Protein Science, 1999, 8, 741-749. "Effect of commonly used cryoprotectants on glycogen phosphorylase activity and structure"

Kimberly A. Watson, Claire McCleverty, Silvano Geremia, Silvain Cottaz, Hughes Driguez, Louise N. Johnson, The EMBO Journal, 1999, 18, 4619. "Phosphorylase recognition and phosphorylysis of its oligosaccharide substrate: Answers to a long outstanding question"

Mark O'Reilly, Kimberly A. Watson, Louise N. Johnson, Biochemistry, 1999, 38, 5337-5345. "The crystal structure of the E.coli maltodextrin phosphorylase-acarbose complex"

Marc O'Reilly, Kimberly A. Watson, Reinhard Schinzel, Dieter Palm and Louise N. Johnson, Nature Structural Biology, 1997, 4, 405-412. "Oligosaccharide substrate binding in Escherichia coli maltodextrin phosphorylase"

Manuel Pastor, Gabriele Cruciani and Kimberly A. Watson, J. Med. Chem., 1997, 40, 4089-4102. "A Strategy for the Incorporation of Water Molecules Present in a Ligand-Binding Site into a 3D-QSAR Analysis"

Kimberly A. Watson, Reinhard Schinzel, Deiter Palm and Louise N. Johnson, The EMBO Journal, 1997, 16, 1-14. "The crystal structure of Escherichia coli maltodextrin phosphorylase provides an explanation for the activity without control in this basic archetype of a phosphorylase"

Impact, Enterprise and Outreach:

  • Consultant to Industry for computational and structural biology for drug discovery and engineering enzymes for biotechnology
  • Development of lead compounds and pharmacophores for drug discovery
  • Development and delivery of biopharma skills training for Industry
  • Experience of working with a number of Government organisations
  • Numerous outreach activities to promote student awareness of STEM research
  • Highlighted in 'Women in Research', a photographic exhibition to celebrate women in research at the University of Reading

Esteem Factors:

  • Fellow of the Royal Society of Chemistry
  • Fellow of the Royal Society of Biology and Chartered Biologist
  • Fellow Member, Lister Institute of Preventive Medicine
  • Fellow of the Higher Education Academy
  • Visiting Scientist, MRC Harwell International Centre for Mouse Genetics
  • Visiting Scientist, Diamond Light Source


  • Part 1: Foundation Biology
  • Part 2: Protein Structure and Function
  • Part 3: Structural Proteomics and Synthetic Biology

International Collaborators:

  • Prof. Gabriele Cruciani, University of Perugia, Italy
  • Dr. Edda Battaglia, Gastroenterology, Cardinal Massaia Hospital, Asti, Italy

National Collaborators:

  • Prof. Glenn Gibson, Food Biosciences, University of Reading
  • Dr. Eva Kevei, Biological Sciences, University of Reading
  • Prof. Heather Mortiboys, Sheffield Institute of Translational Neuroscience
  • Prof. Oliver Bandmann, Consultant Neurologist, Sheffield Institute of Translational Neuroscience
  • Dr. Roger Cox, MRC Harwell International Centre for Mouse Genetics
Kim Watson

Contact Details

+44 (0)118 378 6640
+44 (0)118 378 8160
HLS Room 2.02

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