Staff Profile:Dr Kim Watson

Position / Job Title:
Associate Professor in Structural Biology
Areas of Interest:
  • Unravelling structure-function relationships of proteins and protein-ligand complexes
  • Drug discovery using computer-aided and structure-based approaches
  • Understanding molecular mechanisms of Type 2 diabetes and obesity
  • Vaccine development via inflammatory disease response proteins in Chlamydia
  • Protein cloning and expression for bioanalytical analysis
  • Protein biochemistry and X-ray crystallography of membrane proteins, immune response proteins and, metabolic proteins for diet and health
Research groups / Centres:

Member of the Molecular & Cellular Medicine Group


Pre 2005

Watson KA, Johnson LNJ, Leoffen P, Gillham D, Eggleston D, Collins P, Moynihan JM, DTI government report (2004) "Structural Genomics in Japan and China" following invitation to coordinate and lead a fully funded DTI mission. The report describes the findings from a DTI funded mission to China and Japan to explore emerging HTP technologies and provide opportunities for UK collaboration/technology transfer.

Brown, K., Carpenter E., Watson, KA, Coggins, JR, Hawkins, AR, Koch, MH, Svergun, DI. (2003) "Twists and turns: a tale of two shikimate-pathway enzymes." Biochem. Soc. Trans., 31, 543-547.

Nathalie Marchand-Geneste, Kimberly A. Watson, Bjorn K. Alsberg, and Ross D. King, (2002) "New Approach to Pharmacophore Mapping and QSAR Analysis Using Inductive Logic Programming. Application to Thermolysin Inhibitors and Glycogen Phosphorylase b Inhibitors".J. Med. Chem., 45, 399-409.

Katerina Tsitsanou, Nikos G. Oikonomakos, Spiros E. Zographos, V. Skamnaki, Mary Gregoriou, Kimberly A. Watson, Louise N. Johnson, George W.J. Fleet, Protein Science, 1999, 8, 741-749. "Effect of commonly used cryoprotectants on glycogen phosphorylase activity and structure"

Kimberly A. Watson, Claire McCleverty, Silvano Geremia, Silvain Cottaz, Hughes Driguez, Louise N. Johnson, The EMBO Journal, 1999, 18, 4619. "Phosphorylase recognition and phosphorylysis of its oligosaccharide substrate: Answers to a long outstanding question"

Mark O'Reilly, Kimberly A. Watson, Louise N. Johnson, Biochemistry, 1999, 38, 5337-5345. "The crystal structure of the E.coli maltodextrin phosphorylase-acarbose complex"

Marc O'Reilly, Kimberly A. Watson, Reinhard Schinzel, Dieter Palm and Louise N. Johnson, Nature Structural Biology, 1997, 4, 405-412. "Oligosaccharide substrate binding in Escherichia coli maltodextrin phosphorylase"

Manuel Pastor, Gabriele Cruciani and Kimberly A. Watson, J. Med. Chem., 1997, 40, 4089-4102. "A Strategy for the Incorporation of Water Molecules Present in a Ligand-Binding Site into a 3D-QSAR Analysis"

Kimberly A. Watson, Reinhard Schinzel, Deiter Palm and Louise N. Johnson, The EMBO Journal, 1997, 16, 1-14. "The crystal structure of Escherichia coli maltodextrin phosphorylase provides an explanation for the activity without control in this basic archetype of a phosphorylase"

Impact, Enterprise and Outreach:

  • Consultant to Industry for computational and structural biology for drug discovery
  • Development of lead compounds and pharmacophores for drug discovery
  • Service crystallography
  • Development and delivery of biopharma skills training for Industry
  • Experience of working with a number of Government organisations
  • As member of UK-SETNET led a number of outreach activities to promote student awareness of STEM research
  • Highlighted in 'Women in Research', a photographic exhibition to celebrate women in research at the University of Reading

Esteem Factors:

  • Fellow of the Royal Society of Chemistry
  • Fellow of the Society of Biology
  • Fellow Member, Lister Institute of Preventive Medicine
  • Chartered Biologist
  • Visiting Scientist, MRC Harwell International Centre for Mouse Genetics
  • Visiting Scientist, Membrane Protein Laboratory, Imperial College London/Diamond Light Source
  • Long-term Visiting Researcher at OPPF, Research Complex at Harwell
  • Editorial Board, Journal of Crystallography journal
  • 2010-12 Peer Review Panel Member (Panel 2), Diamond Light Source
  • 2009-12 Committee member, UK Biological Structures Group, British Crystallographic Association
  • 2010-11 Peer Review Panel Member, Athena SWAN
  • 2005-10 Business Fellow, London Technology Network (LTN)


  • Part 2: Protein Structure and Function

International Collaborators:

  • Dr. Ernesto Oviedo-Orta, Norvartis Vaccines and Diagnostics, Siena, Italy
  • Prof. Marc le Maire, Université Paris-Sud, Saclay, France

National Collaborators:

  • Dr. Roger Cox, MRC Harwell International Centre for Mouse Genetics
  • Dr. Isabel de Moraes, Membrane Protein Laboratory, Imperial College/Diamond Light Source
  • Dr. Thomas Sørensen, Diamond Light Source
  • Dr. Ray Owens and Dr. Louise Bird, OPPF Research Complex at Harwell
  • Dr. David Cole, University of Cardiff
  • Prof. Hagan Bayley, University of Oxford

Contact Details

+44 (0)118 378 6640
+44 (0)118 378 8160
126 Harborne

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