Staff Profile:Professor Martin J Woodward

Name:
Professor Martin Woodward
Job Title:
Professor of Human Gut Microbiome Studies
Responsibilities:
Research
Areas of Interest:

The focus of current research is upon the modulation of the gut flora particularly in food producing animals to reduce the carriage of food borne pathogens such as Salmonella, E. coli O157 and Campylobacter. The approaches used have been integrated analyses of the use of current interventions such as antibiotic usage with dietary modification through the use of pre- and pro-biotics to alter the gut flora and its metabolism. Using the in vitro gut model systems developed here at Reading, these analyses will make use of contemporary metagenomic and metabonomic approaches to assess and refine potential interventions. A key tool will be the development of genome scale metabolic models of the pathogens and selected commensal flora in early attempts to understand metabolic interactions between them with a view to altering metabolic activity as a method of pathogen control. Vaccines against Salmonella Typhimurium and Enteritis and E. coli have been developed and commercialised.

The EU policy established in 2006 requiring the food animal producing sector of agriculture to refrain from use of antibiotics in animal feed, prophylactic as opposed to therapeutic use, has resulted in the re-emergence of many endemic animal diseases. Understanding the impact of this change is crucial for the sustainability of production and much research effort has focused upon the transmissibility of antimicrobial resistance within and between commensal and pathogen populations, the role of efflux pumps in low level resistance and persistence of pathogens in the gut and the impact of disinfection on the control of pathogens. With regard to re-emergent endemic diseases, research has focused on the veterinary aspects of animal microbiology. Specifically, working towards the intervention of a number of animal gastrointestinal diseases such as colibacillosis, necrotic enteritis and avian spirochaetosis in poultry as well as necrotising and systemic diseases of cattle, namely the polymicrobial foot rots digital dermatitis and leptospirosis. New diagnostics have been developed and interventions including vaccines and probiotics studied.

Research groups / Centres:
Publications:
Y
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EXTERNAL ACTIVITIES: E

Editorial Board member for Veterinary Microbiology, Microbiology, FEMS and Reviewer for numerous other journals including ASM (J Bact, Appl Env Microbiol), PloS One, J Med Microbiol etc

Qualifications:
PhD
BSc

Contact Details

Email:
m.j.woodward@reading.ac.uk
Telephone:
+44 (0) 118 378 8727
Building:
Food Nutritional Science 3-28

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