Marcus Tindall
-
+44 (0) 118 378 8989
-
Professor
Associate Professor of Mathematical Biology
- Lead
- Lead
- Funding from BBSRC, ESPRC, collaborative institutions and industry
- Developing well informed mathematical models of biological and biomedical processes including lipoprotein metabolism, bacterial chemotaxis and tumour growth
- Use of ordinary differential and partial differential equations to elucidate the importance of system mechanisms
- Using computational and analytical (asymptotic) techniques
Member of the
Impact, Enterprise and Outreach
- NC3R committee member.
- Number of collaborative projects with industry.
- STEM Ambassador.
- Hold regular outreach days on mathematical modelling for A-level students.
Teaching
- I teach and lead a range of modules in both Biological Sciences and Mathematics & Statistics:
| Biological Sciences | |
| Systems Biology (B13BP7) | |
| Mathematics & Statistics | |
| 1st year | Calculus (MA1MM1) |
| 2nd year | Mathematical Modelling (MA2COM) |
| 3rd & 4th year and MSc students | Mathematical Biology (MA3MB, MAMB11) |
Visit Marcus's Website
Publications
-
Vavouraki, N.
ORCID: 0000-0003-2581-4935
,
Tomkins, J.
ORCID: 0000-0003-3010-6634
,
Kara, E.
ORCID: 0000-0001-5428-6743
,
Houlden, H.
,
Hardy, J.
,
Tindall, M.
,
Lewis, P.
ORCID: 0000-0003-4537-0489
,
Manzoni, C.
(2021)
Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias.
iScience
, 24
(5).
ISSN:
2589-0042
|
doi:
https://dx.doi.org/10.1016/j.isci.2021.102484
- Derrick, D. , Wolton, K. , Currie, R. , Tindall, M. (2021) A mathematical model of the role of aggregation in sonic hedgehog signalling. PLoS computational biology , 17 (2). ISSN: 1553-7358 | doi: https://dx.doi.org/10.1371/journal.pcbi.1008562
- Mazet, F. , Tindall, M. , Gibbins, J. , Fry, M. (2020) A model of the PI cycle reveals the regulating roles of lipid-binding proteins and pitfalls of using mosaic biological data. Scientific Reports , 10 (1). pp 0. ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-020-70215-7
- Stainer, A. , Sasikumar, P. , Bye, A. , Unsworth, A. , Holbrook, L. , Tindall, M. , Lovegrove, J. , Gibbins, J. (2019) The metabolites of the dietary flavonoid quercetin possess potent antithrombotic activity, and interact with aspirin to enhance antiplatelet effects. TH Open , 3 (3). pp. e244-e258. ISSN: 2512-9465 | doi: https://dx.doi.org/10.1055/s-0039-1694028
- Stainer, A. , Sasikumar, P. , Bye, A. , Unsworth, A. , Holbrook, L. , Tindall, M. , Lovegrove, J. , Gibbins, J. (2019) Quercetin and its methylated metabolites possess anti-thrombotic properties that interact with aspirin to enhance its anti-platelet effects. TH Open , 3 (3). pp. e244-e258. ISSN: 2512-9465 | doi: https://dx.doi.org/10.1055/s-0039-1694028
- Ward, J. , Franks, S. , Tindall, M. , King, J. , Curtis, A. , Evans, G. (2019) Mathematical modelling of contact dermatitis from nickel and chromium. Journal of Mathematical Biology , 79 (2). pp. 595-630. ISSN: 0303-6812 | doi: https://dx.doi.org/10.1007/s00285-019-01371-2
- Cucurull-Sanchez, L. , Chappell, M. , Chelliah, V. , Amy Cheung, S. , Derks, G. , Penney, M. , Phipps, A. , Malik-Sheriff, R. , Timmis, J. , Tindall, M. , van der Graaf, P. , Vicini, P. , Yates, J. (2019) Best practices to maximize the use and reuse of quantitative and systems pharmacology models: recommendations from the United Kingdom quantitative and systems pharmacology network. CPT: Pharmacometrics & Systems Pharmacology , 8 (5). pp. 259-272. ISSN: 2163-8306 | doi: https://dx.doi.org/10.1002/psp4.12381
- Maldonado, E. , Fisher, C. , Mazzatti, D. , Barber, A. , Tindall, M. , Plant, N. , Kierzek, A. , Moore, J. (2018) Multi-scale, whole-system models of liver metabolic adaptation to fat and sugar in non-alcoholic fatty liver disease. NPJ Systems Biology and Applications , 4 ISSN: 2056-7189 | doi: https://dx.doi.org/10.1038/s41540-018-0070-3
- Tindall, M. (2018) System insights into hemostasis: open questions and the role of mathematical modelling: comment on “Modeling thrombosis in silico: Frontiers, challenges, unresolved problems and milestones” by A.V. Belyaev et al.. Physics of Life Reviews , 26-27 pp. 106-107. ISSN: 1571-0645 | doi: https://dx.doi.org/10.1016/j.plrev.2018.06.011
- Pool, F. , Sweby, P. , Tindall, M. (2018) An integrated mathematical model of cellular cholesterol biosynthesis and lipoprotein metabolism. Processes , 6 (8). ISSN: 2227-9717 | doi: https://dx.doi.org/10.3390/pr6080134
- Snowden, T. , van der Graaf, P. , Tindall, M. (2018) Model reduction in mathematical pharmacology: integration, reduction and linking of PBPK and systems biology models. Journal of Pharmacokinetics and Pharmacodynamics , 45 (4). pp. 537-555. ISSN: 1573-8744 | doi: https://dx.doi.org/10.1007/s10928-018-9584-y
- Edgington, M. and Tindall, M. (2018) Mathematical analysis of the Escherichia coli chemotaxis signalling pathway. Bulletin of Mathematical Biology , 80 (4). pp. 758-787. ISSN: 1522-9602 | doi: https://dx.doi.org/10.1007/s11538-018-0400-z
- Pool, F. , Currie, R. , Sweby, P. , Salazar, J. , Tindall, M. (2018) A mathematical model of the mevalonate cholesterol biosynthesis pathway. Journal of Theoretical Biology , 443 pp. 157-176. ISSN: 0022-5193 | doi: https://dx.doi.org/10.1016/j.jtbi.2017.12.023
- Dede, E. , Tindall, M. , Cherrie, J. , Hankin, S. , Collins, C. (2018) Physiologically-based pharmacokinetic and toxicokinetic models for estimating human exposure to five toxic elements through oral ingestion. Environmental toxicology and pharmacology , 57 pp. 104-114. ISSN: 1872-7077 | doi: https://dx.doi.org/10.1016/j.etap.2017.12.003
- Snowden, T. , van der Graaf, P. , Tindall, M. (2017) Methods of model reduction for large-scale biological systems: a survey of current methods and trends. Bulletin of Mathematical Biology , 79 (7). pp. 1449-1486. ISSN: 1522-9602 | doi: https://dx.doi.org/10.1007/s11538-017-0277-2
- Snowden, T. , van der Graaf, P. , Tindall, M. (2017) A combined model reduction algorithm for controlled biochemical systems. BMC Systems Biology , 11 (1). ISSN: 1752-0509 | doi: https://dx.doi.org/10.1186/s12918-017-0397-1
- Mazet, F. , Dunster, J. , Jones, C. , Vaiyapuri, S. , Tindall, M. , Fry, M. , Gibbins, J. (2015) A high-density immunoblotting methodology for quantification of total protein levels and phosphorylation modifications. Scientific Reports , 5 ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/srep16995
- Dunster, J. , Mazet, F. , Fry, M. , Gibbins, J. , Tindall, M. (2015) Regulation of early steps of GPVI signal transduction by phosphatases: a systems biology approach. PLoS Computational Biology , 11 (11). ISSN: 1553-734X | doi: https://dx.doi.org/10.1371/journal.pcbi.1004589
- Edgington, M. and Tindall, M. (2015) Understanding the link between single cell and population scale responses of Escherichia coli in differing ligand gradients. Computational and Structural Biotechnology Journal , 13 pp. 528-538. ISSN: 2001-0370 | doi: https://dx.doi.org/10.1016/j.csbj.2015.09.003
- Edgington, M. and Tindall, M. (2014) Fold-change detection in a whole-pathway model of Escherichia coli chemotaxis. Bulletin of Mathematical Biology , 76 (6). pp. 1376-1395. ISSN: 0092-8240 | doi: https://dx.doi.org/10.1007/s11538-014-9965-3
- Tindall, M. and Clerk, A. (2014) Modelling negative feedback networks for activating transcription factor 3 predicts a dominant role for miRNAs in immediate early gene regulation. PLoS Computational Biology , 10 (5). ISSN: 1553-734X | doi: https://dx.doi.org/10.1371/journal.pcbi.1003597
- Bhattacharya, B. , Sweby, P. , Minihane, A. , Jackson, K. , Tindall, M. (2014) A mathematical model of the sterol regulatory element binding protein 2 cholesterol biosynthesis pathway. Journal of Theoretical Biology , 349 pp. 150-162. ISSN: 0022-5193 | doi: https://dx.doi.org/10.1016/j.jtbi.2014.01.013
- Lee, T. , Baines, M. , Langdon, S. , Tindall, M. (2013) A moving mesh approach for modelling avascular tumour growth. Applied Numerical Mathematics , 72 pp. 99-114. ISSN: 1689274 | doi: https://dx.doi.org/10.1016/j.apnum.2013.06.001
- Wright, B. , Tindall, M. , Lovegrove, J. , Gibbins, J. (2013) Investigating flavonoids as molecular templates for the design of small-molecule inhibitors of cell signaling. Journal of Food Science , 78 (12). pp. N1921-N1928. ISSN: 1750-3841 | doi: https://dx.doi.org/10.1111/1750-3841.12293
- Kojadinovic, M. , Armitage, J. , Tindall, M. , Wadhams, G. (2013) Response kinetics in the complex chemotaxis signalling pathway of Rhodobacter sphaeroides. Journal of the Royal Society Interface , 10 (81). ISSN: 1742-5662 | doi: https://dx.doi.org/10.1098/rsif.2012.1001
- Tindall, M. (2012) Mathematics as a tool in the Life Sciences.
- Tindall, M. , Gaffney, E. , Maini, P. , Armitage, J. (2012) Theoretical insights into bacterial chemotaxis. Wiley interdisciplinary reviews. Systems biology and medicine , 4 (3). pp. 247-259. ISSN: 1939-005X | doi: https://dx.doi.org/10.1002/wsbm.1168
- Giraldo, A. , Barrett, O. , Tindall, M. , Fuller, S. , Amirak, E. , Bhattacharya, B. , Sugden, P. , Clerk, A. (2012) Feedback regulation by Atf3 in the endothelin-1-responsive transcriptome of cardiomyocytes: Egr1 is a principal Atf3 target. Biochemical Journal , 444 (2). pp. 343-355. ISSN: 0264-6021 | doi: https://dx.doi.org/10.1042/BJ20120125
- Murray, P. , Edwards, C. , Tindall, M. , Maini, P. (2012) Classifying general nonlinear force laws in cell-based models via the continuum limit. Physical Review E , 85 (2). ISSN: 1550-2376 | doi: https://dx.doi.org/10.1103/PhysRevE.85.021921
- Tindall, M. , Dyson, L. , Smallbone, K. , Maini, P. (2012) Modelling acidosis and the cell cycle in multicellular tumour spheroids. Journal of Theoretical Biology , 298 pp. 107-115. ISSN: 0022-5193 | doi: https://dx.doi.org/10.1016/j.jtbi.2011.11.009
- Artzrouni, M. , Begg, C. , Chabiniok, R. , Clairambault, J. , Foss, A. , Hargrove, J. , Lee, E. , Siggers, J. , Tindall, M. (2011) The first international workshop on the role and impact of mathematics in medicine: a collective account. American Journal of Translational Research , 3 (5). pp. 492-497. ISSN: 1943-8141
- Murray, P. , Walter, A. , Fletcher, A. , Edwards, C. , Tindall, M. , Maini , P. (2011) Comparing a discrete and continuum model of the intestinal crypt. Physical Biology , 8 (2). ISSN: 1478-3975 | doi: https://dx.doi.org/10.1088/1478-3975/8/2/026011
- Tindall, M. , Porter, S. , Maini, P. , Armitage, J. (2010) Modeling chemotaxis reveals the role of reversed phosphotransfer and a bi-functional kinase-phosphatase. PLoS Computational Biology , 6 (8). ISSN: 1553-734X | doi: https://dx.doi.org/10.1371/journal.pcbi.1000896
- Tindall, M. , Wattis, . , O'Malley, . , Pickersgill, . , Jackson, K. (2009) A continuum receptor model of hepatic lipoprotein metabolism. Journal of Theoretical Biology , 257 (3). pp. 371-384. ISSN: 0022-5193 | doi: https://dx.doi.org/10.1016/j.jtbi.2008.11.016
- Tindall, . , Porter, . , Wadhams, . , Maini, . , Armitage, . (2009) Spatiotemporal modelling of CheY complexes in Escherichia coli chemotaxis. Progress in Biophysics & Molecular Biology , 100 (1-3). pp. 40-46. ISSN: 0079-6107 | doi: https://dx.doi.org/10.1016/j.pbiomolbio.2009.06.005
- Murray, . , Edwards, . , Tindall, . , Maini, . (2009) From a discrete to a continuum model of cell dynamics in one dimension. Physical Review E , 80 (3). pp. 10. ISSN: 1539-3755 | doi: https://dx.doi.org/10.1103/PhysRevE.80.031912
- Tindall, . , Please, . , Peddie, . (2008) Modelling the formation of necrotic regions in avascular tumours. Mathematical Biosciences , 211 (1). pp. 34-55. ISSN: 0025-5564 | doi: https://dx.doi.org/10.1016/j.mbs.2007.09.002
- Tindall, . , Maini, . , Porter, . , Armitage, . (2008) Overview of mathematical approaches used to model bacterial chemotaxis II: bacterial populations. Bulletin of Mathmatical Biology , 70 (6). pp. 1570-607. ISSN: 1522-9602 | doi: https://dx.doi.org/10.1007/s11538-008-9322-5
- Tindall, . , Porter, . , Maini, . , Gaglia, . , Armitage, . (2008) Overview of mathematical approaches used to model bacterial chemotaxis I: the single cell. Bullitin of Mathmatical Biology , 70 (6). pp. 1525-69. ISSN: 1522-9602 | doi: https://dx.doi.org/10.1007/s11538-008-9321-6
- Tindall, . , Maini, . , Armitage, . , Singleton, . , Mason, . (2008) Intracellular signalling during bacterial chemotaxis. SEB Experimental Biology Series , 61 (8). pp. 161-74. ISSN: 0081-1386
- Tindall, . , Peletier, . , Severens, . , Veldman, . , de Mol, . (2008) Understanding post-operative temperature drop in cardiac surgery: a mathematical model. Mathematical Medicine and Biology , 25 (4). pp. 323-35. ISSN: 1477-8602 | doi: https://dx.doi.org/10.1093/imammb/dqn022
- Franks, . , Ward, . , Tindall, . , King, . , Curtis, . , Evans, . (2008) A mathematical model of the in vitro keratinocyte response to chromium and nickel exposure. Toxicol In Vitro , 22 (4). pp. 1088-93. ISSN: 0887-2333 | doi: https://dx.doi.org/10.1016/j.tiv.2008.01.018