University of Reading cookie policy

We use cookies on reading.ac.uk to improve your experience, monitor site performance and tailor content to you

Read our cookie policy to find out how to manage your cookie settings

Kate Williams

Unknown
  • 100
  • Professor of Public Engagement with History

Academic background

I have completed my undergraduate training in Molecular Biology, masters in Bioanalytical methods and PhD in Food and Nutritional Sciences. Now I am involved in post-doctoral research project looking at improving prebiotic supplements for gut microbiome in collaboration with Clasado Biosciences (UK).

Research areas

Enzyme biotechnology, structural biology, gut microbiome, nutrition.

Expertise

Cloning, recombinant enzyme technology, microbiology, recombinant yeast technology, complex carbohydrate analysis, macromolecular crystallography.

Awards and distinctions

Biotechnology YES 2019 - participation (our team were close to getting to finals). Pint of Science 2019 event - delivered a presentation to large audience about the benefits of prebiotics. Continuing this outreach activity every year.

Connections

Some examples might include

Papers

Peer-reviewed publications:

  • Cole, A. R., Ofer, S., Ryzhenkova, K., Baltulionis, G., Hornyak, P., Savva, R. (2013). "Architecturally diverse proteins converge on an analogous mechanism to inactivate Uracil-DNA glycosylase." Nucleic acids research 41(18): 8760-8775.

    Impact factor: 10.16; Web of Science: 7 citations; last cited 2016

Structures published in the Protein Data Bank (PDB):

  • 4L5N Crystallographic Structure of HHV-1 Uracil-DNA Glycosylase complexed with the Bacillus phage PZA inhibitor protein p56, Cole, A.R., Sapir, O., Ryzhenkova, K., Baltulionis, G., Hornyak, P., Savva, R., 2013

    Total downloads (since 2013): 26,176

    Date of last download: 2018-02-01

Unreleased structures published in the PDB (pending publication):

  • 5NQJ Aspergillus oryzae Leucine Aminopeptidase A proenzyme Watson, K.A., Baltulionis, G.
  • 5NQL Aspergillus oryzae Leucine Aminopeptidase A mature enzyme Watson, K.A., Baltulionis, G.
  • 5NRJ Flavourzyme Leucine Aminopeptidase A mature enzyme Watson, K.A., Baltulionis, G.

Manuscripts in preparation to peer-reviewed scientific journals:

  • Crystal structures of Aspergillus oryzae LapA precursor and mature enzyme: role of propeptide in inhibition and as intramolecular chaperone

    G. Baltulionis1,2, M. Blight3, A. Robin3, D. Charalampopoulos2, K.A. Watson1*

    School of Biological Sciences1 and Department of Food and Nutritional Sciences2, Whiteknights Campus, University of Reading, Reading, UK, RG6 6AS; Biocatalysts Limited3, Cefn Coed Parc Nantgarw, Wales, UK, CF15 7QQ.

    Submitted to: Journal of Molecular Biology (Impact factor: 5.2)

  • Flavourzyme - isolation and structural studies of native Aspergillus oryzae leucine aminopeptidase A reveals a thermal unfolding pathway

    G. Baltulionis1,2, M. Blight3, A. Robin3, D. Charalampopoulos2, K.A. Watson1*

    School of Biological Sciences1 and Department of Food and Nutritional Sciences2, Whiteknights Campus, University of Reading, Reading, UK, RG6 6AS; Biocatalysts Limited3, Cefn Coed Parc Nantgarw, Wales, UK, CF15 7QQ.

    Intended submission to: Journal of Agricultural and Food Chemistry (Impact f: 3.15)