Biomedical, molecular and analytical chemistry
Much of the emphasis within the Biomedical, Molecular and Analytical Chemistry (BMAC) section revolves around the development of new methodologies for the synthesis of medicines and biologically active natural products as well as the application and development of (bio)analytical methods to identify and characterise important (bio)molecules, from health biomarkers and medical target compounds to environmental pollutants and forensic markers.
A large subgroup in BMAC is interested in the synthesis of molecules/materials with function such as metal catalysts, peptides and functionalised ligands. In addition to classical approaches our section also uses enabling technologies such as continuous flow, photochemistry and electrochemistry to achieve these transformations.
We also feature experts in a range of analytical techniques ably supported by those who use their expertise to answer important questions in the development of novel materials and technologies that support future health and the protection of our environment. Modern 'omics' technologies and biological mass spectrometry are currently being utilised to identify diseases in hospitals or to monitor the health of farm animals with a 'One Health' as well as 'P4' (Predictive, Preventive, Personalized and Participatory) medical approach in mind. Nuclear Magnetic Resonance (NMR) is used to probe the biosynthesis pathways of medicinal natural products in plants (artemisinin from artemisia annua), and to investigate the fundamental processes involved in the origin of life.
We also house a world-class spectroelectrochemical analysis laboratory allowing the integration of electrochemistry with molecular spectroscopy (UV/VIS/near-IR/mid-IR/far-FIR/Raman/VCD) at variable temperatures. This allows the observation of short-lived species and several collaborative projects are looking into molecular electronics, photo-redox-catalytic processes in artificial photosynthesis (green fuels) and organometallic electrochemistry.
Research Group Members
- Professor M.J. Almond (affiliate member)
- Dr G.D. Brown
- Professor R. Cramer (Head of Section)
- Dr P. Cranwell (affiliate member)
- Professor F. Hartl
- Professor L.M. Harwood
- Dr J.E. McKendrick
- Dr A.T. Russell
- Dr C. Smith