Staff Profile:Dr Kim Watson

Name:

Dr Kim Watson

Job Title:

Associate Professor

Responsibilities:

Associate Professor in Structural Biology

Areas of Interest:

• Funding from BBSRC, Lister Institute of Preventive Medicine, Diamond Light Source, MRC Harwell International Centre for Mouse Genetics, HEA, Industry
• Unravelling structure-function relationships of proteins and protein-ligand complexes
• Drug discovery using computer-aided and structure-based approaches
• Understanding molecular mechanisms of Type 2 diabetes and obesity
• Vaccine development via inflammatory disease response proteins in Chlamydia
• Protein cloning and expression for bioanalytical analysis
• Protein biochemistry and X-ray crystallography of membrane proteins, immune response proteins and, metabolic proteins for diet and health

Member of the Molecular & Cellular Medicine Group

Research groups / Centres:

Impact, Enterprise and Outreach:

• Consultant to Industry for computational and structural biology for drug discovery
• Development of lead compounds and pharmacophores for drug discovery
• Service crystallography
• Development and delivery of biopharma skills training for Industry
• Experience of working with a number of Government organisations
• As member of UK-SETNET led a number of outreach activities to promote student awareness of STEM research
• Highlighted in 'Women in Research', a photographic exhibition to celebrate women in research at the University of Reading

Esteem Factors:

• Fellow of the Royal Society of Chemistry
• Fellow of the Society of Biology
• Fellow Member, Lister Institute of Preventive Medicine
• Chartered Biologist
• Visiting Scientist, MRC Harwell International Centre for Mouse Genetics
• Visiting Scientist, Membrane Protein Laboratory, Imperial College London/Diamond Light Source
• Long-term Visiting Researcher at OPPF, Research Complex at Harwell
• Editorial Board, Journal of Crystallography journal
• 2010-12 Peer Review Panel Member (Panel 2), Diamond Light Source
• 2009-12 Committee member, UK Biological Structures Group, British Crystallographic Association
• 2010-11 Peer Review Panel Member, Athena SWAN
• 2005-10 Business Fellow, London Technology Network (LTN)

Teaching:

• Part 2: Protein Structure and Function

International Collaborators:

• Dr. Ernesto Oviedo-Orta, Norvartis Vaccines and Diagnostics, Siena, Italy
• Prof. Marc le Maire, Université Paris-Sud, Saclay, France

National Collaborators:

• Dr. Roger Cox, MRC Harwell International Centre for Mouse Genetics
• Dr. Isabel de Moraes, Membrane Protein Laboratory, Imperial College/Diamond Light Source
• Dr. Thomas Sørensen, Diamond Light Source
• Dr. Ray Owens and Dr. Louise Bird, OPPF Research Complex at Harwell
• Dr. David Cole, University of Cardiff
• Prof. Hagan Bayley, University of Oxford

Publications:

Y

Jump to: 2017 | 2016 | 2015 | 2014 | 2013 | 2011 | 2010 | 2008 | 2007 | 2005 | 2003

Number of items: 23.

2017

• Moir, L., Bochukova, E. G., Dumbell, R., Banks, G., Bains, R. S., Nolan, P. M., Scudamore, C., Simon, M., Watson, K. A., Keogh, J., Henning, E., Hendricks, A., O'Rahilly, S., Barroso, I., UK10K, C., Sullivan, A. E., Bersten, D. C., Whitelaw, M. L., Kirsch, S., Bentley, E., Farooqi, I. S. and Cox, R. D. (2017) Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety. Molecular Metabolism, 6 (11). pp. 1419-1428. ISSN 2212-8778 doi: https://doi.org/10.1016/j.molmet.2017.08.006

2016

• Ravishankar, D., Watson, K. A., Greco, F. and Osborn, H. M. I. (2016) Novel synthesised flavone derivatives provide significant insight into the structural features required for enhanced anti-proliferative activity. RSC Advances, 6 (69). pp. 64544-64556. ISSN 2046-2069 doi: https://doi.org/10.1039/C6RA11041J

2015

• Wright, B., Watson, K. A., McGuffin, L. J., Lovegrove, J. and Gibbins, J. M. (2015) GRID and docking analyses reveal a molecular basis for flavonoid inhibition of src-family kinase activity. Journal of Nutritional Biochemistry, 26 (11). pp. 1156-1165. ISSN 0955-2863 doi: https://doi.org/10.1016/j.jnutbio.2015.05.004
• Swioklo, S., Watson, K. A., Williamson, E. M., Farrimond, J. A., Putnam, S. E. and Bicknell, K. A. (2015) Defining key structural determinants for the pro-osteogenic activity of flavonoids. Journal of Natural Products, 78 (11). pp. 2598-2608. ISSN 1520-6025 doi: https://doi.org/10.1021/acs.jnatprod.5b00075
• Ravishankar, D., Watson, K. A., Boateng, S. Y., Green, R. J., Greco, F. and Osborn, H. M.I. (2015) Exploring quercetin and luteolin derivatives as antiangiogenic agents. European Journal of Medicinal Chemistry, 97. pp. 259-274. ISSN 0223-5234 doi: https://doi.org/10.1016/j.ejmech.2015.04.056

2014

• Osman, A., Symeou, S., Trisse, V., Watson, K. A., Tzortzis, G. and Charalampopoulos, D. (2014) Synthesis of prebiotic galactooligosaccharides from lactose using bifidobacterial β-galactosidase (BbgIV) immobilised on DEAE-Cellulose, Q-Sepharose and amino-ethyl agarose. Biochemical Engineering Journal, 82. pp. 188-199. ISSN 1369-703X doi: https://doi.org/10.1016/j.bej.2013.11.020

2013

• Antaloae, A. V., Montigny, C., le Maire, M., Watson, K. A. and Sorensen, T. L.-M. (2013) Optimisation of recombinant production of active human cardiac SERCA2a ATPase. PLoS ONE, 8 (8). e71842. ISSN 1932-6203 doi: https://doi.org/10.1371/journal.pone.0071842
• Atanu, F. O., Oviedo-Orta, E. and Watson, K. A. (2013) A novel transport mechanism for MOMP in Chlamydophila pneumoniae and its putative role in immune-therapy. PLoS ONE, 8 (4). e61139. ISSN 1932-6203 doi: https://doi.org/10.1371/journal.pone.0061139

2011

• Sarsam, S. W., Nutt, D. R., Strohfeldt, K. and Watson, K. A. (2011) Titanocene anticancer complexes and their binding mode of action to human serum albumin: a computational study. Metallomics, 3 (2). pp. 152-161. ISSN 1756-5901 doi: https://doi.org/10.1039/c0mt00041h

2010

• Vaiyapuri, S., Wagstaff, S. C., Watson, K. A., Harrison, R. A., Gibbins, J. M. and Hutchinson, E. G. (2010) Purification and functional characterisation of rhiminopeptidase A, a novel aminopeptidase from the venom of Bitis gabonica rhinoceros. PLoS Neglected Tropical Diseases, 4 (8). e796. ISSN 1935-2735 doi: https://doi.org/10.1371/journal.pntd.0000796
• Rajasekaran, M. B., Mitchell, S. A., Gibson, T. M., Hussain, R., Siligardi, G., Andrews, S. C. and Watson, K. A. (2010) Isolation and characterisation of EfeM, a periplasmic component of the putative EfeUOBM iron transporter of Pseudomonas syringae pv. syringae. Biochemical and Biophysical Research Communications, 398 (3). pp. 366-371. ISSN 0006-291X doi: https://doi.org/10.1016/j.bbrc.2010.06.072
• Zhou, H. G., Standfuss, J., Watson, K. A. and Krasel, C. (2010) Structure of full-length arrestin2 in a dimeric crystal form. In: 51st Annual Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und-Toxikologie, 23-25 Mar 2010, Mainz, Germany.
• Rajasekaran, M. B., Nilapwar, S., Andrews, S. C. and Watson, K. A. (2010) EfeO-cupredoxins: major new members of the cupredoxin superfamily with roles in bacterial iron transport. BioMetals, 23 (1). pp. 1-17. ISSN 0966-0844 doi: https://doi.org/10.1007/s10534-009-9262-z

2008

• Pugazhendhi, D., Watson, K. A., Mills, S., Botting, N., Pope, G. S. and Darbre, P. D. (2008) Effect of sulphation on the oestrogen agonist activity of the phytoestrogens genistein and daidzein in MCF-7 human breast cancer cells. Journal of Endocrinology, 197 (3). pp. 503-515. ISSN 0022-0795 doi: https://doi.org/10.1677/joe-07-0384
• Baba-Dikwa, A., Thompson, D., Spencer, N. J., Andrews, S. C. and Watson, K. A. (2008) Overproduction, purification and preliminary X-ray diffraction analysis of YncE, an iron-regulated Sec-dependent periplasmic protein from Escherichia coli. Acta Crystallographica Section F-Structural Biology and Crystallization Communications, 64. pp. 966-969. ISSN 1744-3091 doi: https://doi.org/10.1107/s1744309108029515
• Bamford, V. A., Armour, M., Mitchell, S. A., Cartron, M., Andrews, S. C. and Watson, K. A. (2008) Preliminary X-ray diffraction analysis of YqjH from Escherichia coli: a putative cytoplasmic ferri-siderophore reductase. Acta Crystallographica Section F-Structural Biology and Crystallization Communications, 64 (9). pp. 792-796. ISSN 1744-3091 doi: https://doi.org/10.1107/S174430910802352X

2007

• Lamanna, C., Catalano, A., Carocci, A., Di Mola, A., Franchini, C., Tortorella, V., Vanderheyden, P. M., Sinicropi, M. S., Watson, K. A. and Sciabola, S. (2007) AT(1) receptor ligands: virtual-screening-based design with TOPP descriptors, synthesis, and biological evaluation of pyrrolidine derivatives. ChemMedChem, 2 (9). pp. 1298-310. ISSN 1860-7179 doi: https://doi.org/10.1002/cmdc.200700082
• Cartron, M. L., Mitchell, S., Woodhall, M. R., Andrews, S. C. and Watson, K. A. (2007) Preliminary X-ray diffraction analysis of YcdB from Escherichia coli: a novel haem-containing and Tat-secreted periplasmic protein with a potential role in iron transport. Acta Crystallographica Section F-Structural Biology and Crystallization Communications, 63. pp. 37-41. ISSN 1744-3091 doi: https://doi.org/10.1107/s174430910604509x
• Armour, M., Cartron, M. L., Mitchell, S. A., Bamford, V. A., Watson, K. A. and Andrews, S. C. (2007) YqjH: a novel cytopolasmic siderophore reductase found in eschericia coli. American Journal of Hematology, 82 (6). p. 582. ISSN 0361-8609

2005

• Archontis, G., Watson, K. A., Xie, Q., Andreou, G., Chrysina, E. D., Zographos, S. E., Oikonomakos, N. G. and Karplus, M. (2005) Glycogen phosphorylase inhibitors: a free energy perturbation analysis of glucopyranose spirohydantoin analogues. Proteins, 61 (4). pp. 984-98. ISSN 0887-3585
• Watson, K. A. (2005) How China and Japan are solving the protein puzzle. Global Watch, 44. pp. 4-7.
• Watson, K. A., Chrysina, E. D., Tsitsanou, K. E., Zographos, S. E., Archontis, G., Fleet, G. W. and Oikonomakos, N. G. (2005) Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase. Proteins: Structure, Function and Bioinformatics, 61 (4). pp. 966-83. ISSN 0887-3585 doi: https://doi.org/10.1002/prot.20653

2003

• Browning, K., Carpenter, E., Watson, K., Coggins, J., Hawkins, A., Koch, M. and Svergun, D. (2003) Twists and turns: a tale of two shikimate-pathway enzymes. Biochemical Society Transactions, 31 (3). pp. 543-547. ISSN 1470-8752

This list was generated on Fri Apr 20 06:01:30 2018 UTC.

Pre 2005

Watson KA, Johnson LNJ, Leoffen P, Gillham D, Eggleston D, Collins P, Moynihan JM, DTI government report (2004) "Structural Genomics in Japan and China" following invitation to coordinate and lead a fully funded DTI mission. The report describes the findings from a DTI funded mission to China and Japan to explore emerging HTP technologies and provide opportunities for UK collaboration/technology transfer.

Brown, K., Carpenter E., Watson, KA, Coggins, JR, Hawkins, AR, Koch, MH, Svergun, DI. (2003) "Twists and turns: a tale of two shikimate-pathway enzymes." Biochem. Soc. Trans., 31, 543-547.

Nathalie Marchand-Geneste, Kimberly A. Watson, Bjorn K. Alsberg, and Ross D. King, (2002) "New Approach to Pharmacophore Mapping and QSAR Analysis Using Inductive Logic Programming. Application to Thermolysin Inhibitors and Glycogen Phosphorylase b Inhibitors".J. Med. Chem., 45, 399-409.

Katerina Tsitsanou, Nikos G. Oikonomakos, Spiros E. Zographos, V. Skamnaki, Mary Gregoriou, Kimberly A. Watson, Louise N. Johnson, George W.J. Fleet, Protein Science, 1999, 8, 741-749. "Effect of commonly used cryoprotectants on glycogen phosphorylase activity and structure"

Kimberly A. Watson, Claire McCleverty, Silvano Geremia, Silvain Cottaz, Hughes Driguez, Louise N. Johnson, The EMBO Journal, 1999, 18, 4619. "Phosphorylase recognition and phosphorylysis of its oligosaccharide substrate: Answers to a long outstanding question"

Mark O'Reilly, Kimberly A. Watson, Louise N. Johnson, Biochemistry, 1999, 38, 5337-5345. "The crystal structure of the E.coli maltodextrin phosphorylase-acarbose complex"

Marc O'Reilly, Kimberly A. Watson, Reinhard Schinzel, Dieter Palm and Louise N. Johnson, Nature Structural Biology, 1997, 4, 405-412. "Oligosaccharide substrate binding in Escherichia coli maltodextrin phosphorylase"

Manuel Pastor, Gabriele Cruciani and Kimberly A. Watson, J. Med. Chem., 1997, 40, 4089-4102. "A Strategy for the Incorporation of Water Molecules Present in a Ligand-Binding Site into a 3D-QSAR Analysis"

Kimberly A. Watson, Reinhard Schinzel, Deiter Palm and Louise N. Johnson, The EMBO Journal, 1997, 16, 1-14. "The crystal structure of Escherichia coli maltodextrin phosphorylase provides an explanation for the activity without control in this basic archetype of a phosphorylase"