Professor Ying Zheng
Contact
- Email:
- ying.zheng@reading.ac.uk
- Telephone:
- +44 (0) 118 378 7635
- Building
Systems Engineering, Room 183
Responsibilities
Areas of Interest
Professor Ying Zheng received her BEng and PhD from the University of Sheffield, UK. She has been working in the interface of systems engineering and neuroscience for over 10 years. The main direction of her research is to develop mathematical models to understand neural and haemodynamic signals obtained from neuroimaging techniques such as microelectrodes, EEG, laser-Doppler flowmetry, optical imaging spectroscopy and fMRI. The mathematical models are based on physiological measurements (neural and haemodynamic), with the model parameters reflecting aspects of the underlying physiological processes. These mathematical models also generate testable hypotheses to guide the design of further physiological experiments and the refinement of these models.
Professor Zheng is currently working on the development of:
- Spatio-temporal models of local field potential recordings based on the balanced nature of neural excitation and inhibition, with potential applications to the interpretation of EEG recordings;
- Dynamic models of neurovascular coupling, incorporating the underlying mechanisms of vessel dilation and constriction. This will enhance our understanding of the fMRI BOLD signals.
- Dynamic models of blood vessels based on its visco-elastic properties. This is important not only to the interpretation of the fMRI BOLD signal, but also to our understanding of the functions of heart and circulatory system.
Research groups / Centres
Publications
Y
Number of items: 29.
2020
- Kang, S., Hayashi, Y., Bruyns-Haylett, M., Delivopoulos, E. and Zheng, Y. (2020) Model-predicted balance between neural excitation and inhibition was maintained despite of age-related decline in sensory evoked local field potential in rat barrel cortex. Frontiers in Systems Neuroscience, 14 (24). ISSN 1662-5137 doi: https://doi.org/10.3389/fnsys.2020.00024
2019
- Kang, S., Hayashi, Y., Bruyns-Haylett, M., Baker, D. K., Boura, M., Wang, H., Karatzas, K.-A., Serra, I., Bithell, A., Williams, C., Field, D. and Zheng, Y. (2019) Supplemental vitamin B-12 enhances the neural response to sensory stimulation in the barrel cortex of healthy rats but does not affect spontaneous neural activity. Journal of Nutrition, 149 (5). pp. 730-737. ISSN 1541-6100 doi: https://doi.org/10.1093/jn/nxz011
2017
- Bruyns-Haylett, M., Luo, J., Bruyns-Haylett, A. J., Harris, S., Boorman, L., Milne, E., Vautrelle, N., Hayashi, Y., Whalley, B. J., Jones, M., Berwick, J., Riera, J. and Zheng, Y. (2017) The neurogenesis of P1 and N1: a concurrent EEG/LFP study. NeuroImage, 146. pp. 575-588. ISSN 1053-8119 doi: https://doi.org/10.1016/j.neuroimage.2016.09.034
- Kang, S., Bruyns-Haylett, M., Hayashi, Y. and Zheng, Y. (2017) Concurrent recording of co-localised electroencephalography and local field potential in rodent. Journal of Visualized Experiments. 129. ISSN 1940-087X doi: https://doi.org/10.3791/56447
2016
- Song, Y., Torres, R. A., Garcia, S., Frometa, Y., Bae, J., Deshmukh, A., Lin, W.-C., Zheng, Y. and Riera, J. J. (2016) Dysfunction of neurovascular/metabolic coupling in chronic focal epilepsy. IEEE Transactions on Biomedical Engineering, 63 (1). pp. 97-110. ISSN 0018-9294 doi: https://doi.org/10.1109/TBME.2015.2461496
2015
- Boorman, L., Harris, S., Bruyns-Haylett, M., Kennerley, A., Zheng, Y., Martin, C., Jones, M., Redgrave, P. and Berwick, J. (2015) Long-latency reductions in gamma power predict hemodynamic changes that underlie the negative BOLD signal. The Journal of Neuroscience, 35 (11). pp. 4641-4656. ISSN 1529-2401 doi: https://doi.org/10.1523/JNEUROSCI.2339-14.2015
2014
- Harris, S., Ma, H., Zhao, M., Boorman, L., Zheng, Y., Kennerley, A., Bruyns-Haylett, M., Overton, P. G., Berwick, J. and Schwartz, T. H. (2014) Coupling between gamma-band power and cerebral blood volume during recurrent acute neocortical seizures. NeuroImage, 97. pp. 62-70. ISSN 1053-8119 doi: https://doi.org/10.1016/j.neuroimage.2014.04.014
- Vidal-Rosas, E. E., Billings, S. A., Zheng, Y., Mayhew, J. E., Johnston, D., Kennerley, A. J. and Coca, D. (2014) Reduced-order modeling of light transport in tissue for real-time monitoring of brain hemodynamics using diffuse optical tomography. Journal of Biomedical Optics, 19 (2). 026008. ISSN 1560-2281 doi: https://doi.org/10.1117/1.JBO.19.2.026008
2013
- Benn, Y., Wilkinson, I. D., Zheng, Y., Kadosh, K. C., Romanowski, C. A.J., Siegal, M. and Varley, R. (2013) Differentiating core and co-opted mechanisms in calculation: The neuroimaging of calculation in aphasia. Brain and Cognition, 82 (3). pp. 254-264. ISSN 0278-2626 doi: https://doi.org/10.1016/j.bandc.2013.04.012
- Bruyns-Haylett, M., Harris, S., Boorman, L., Zheng, Y., Berwick, J. and Jones, M. (2013) The resting-state neurovascular coupling relationship: rapid changes in spontaneous neural activity in the somatosensory cortex are associated with haemodynamic fluctuations that resemble stimulus-evoked haemodynamics. European Journal of Neuroscience, 38 (6). pp. 2902-2906. ISSN 1460-9568 doi: https://doi.org/10.1111/ejn.12295
- Martin, C., Zheng, Y., Sibson, N. R., Mayhew, J. E.W. and Berwick, J. (2013) Complex spatiotemporal haemodynamic response following sensory stimulation in the awake rat. NeuroImage, 66. pp. 1-8. ISSN 1053-8119 doi: https://doi.org/10.1016/j.neuroimage.2012.10.006
2012
- Zheng, Y., Luo, J. J., Harris, S., Kennerley, A., Berwick, J., Billings, S. A. and Mayhew, J. (2012) Balanced excitation and inhibition: Model based analysis of local field potentials. NeuroImage, 63 (1). pp. 81-94. ISSN 1053-8119 doi: https://doi.org/10.1016/j.neuroimage.2012.06.040
- Kennerley, A. J., Mayhew, J. E., Boorman, L., Zheng, Y. and Berwick, J. (2012) Is optical imaging spectroscopy a viable measurement technique for the investigation of the negative BOLD phenomenon? A concurrent optical imaging spectroscopy and fMRI study at high field (7T). NeuroImage, 61 (1). pp. 10-20. ISSN 1053-8119 doi: https://doi.org/10.1016/j.neuroimage.2012.03.015
- Benn, Y., Zheng, Y., Wilkinson, I. D., Siegal, M. and Varley, R. (2012) Language in calculation: A core mechanism? Neuropsychologia, 50 (1). pp. 1-10. ISSN 0028-3932 doi: https://doi.org/10.1016/j.neuropsychologia.2011.09.045
2011
- Kennerley, A. J., Harris, S., Bruyns-Haylett, M., Boorman, L., Zheng, Y., Jones, M. and Berwick, J. (2011) Early and late stimulus-evoked cortical hemodynamic responses provide insight into the neurogenic nature of neurovascular coupling. Journal of Cerebral Blood Flow & Metabolism, 32 (3). pp. 468-480. ISSN 1559-7016 doi: https://doi.org/10.1038/jcbfm.2011.163
2010
- Zheng, Y., Pan, Y., Harris, S., Billings, S., Coca, D., Berwick, J., Jones, M., Kennerley, A., Johnston, D., Martin, C., Devonshire, I. M. and Mayhew, J. (2010) A dynamic model of neurovascular coupling: Implications for blood vessel dilation and constriction. NeuroImage, 52 (3). pp. 1135-1147. ISSN 1053-8119 doi: https://doi.org/10.1016/j.neuroimage.2010.01.102
- Harris, S., Jones, M., Zheng, Y. and Berwick, J. (2010) Does neural input or processing play a greater role in the magnitude of neuroimaging signals? Frontiers in Neuroenergetics, 2. pp. 1-7. ISSN 1662-6427 doi: https://doi.org/10.3389/fnene.2010.00015
- Bruyns-Haylett, M., Zheng, Y., Berwick, J. and Jones, M. (2010) Temporal coupling between stimulus-evoked neural activity and hemodynamic responses from individual cortical columns. Physics in Medicine and Biology, 55 (8). pp. 2203-2219. ISSN 1361-6560 doi: https://doi.org/10.1088/0031-9155/55/8/006
- Boorman, L., Kennerley, A. J., Johnston, D., Jones, M., Zheng, Y., Redgrave, P. and Berwick, J. (2010) Negative blood oxygen level dependence in the rat: a model for investigating the role of suppression in neurovascular coupling. Journal of Neuroscience, 30 (12). pp. 4285-4294. ISSN 0270-6474 doi: https://doi.org/10.1523/JNEUROSCI.6063-09.2010
2009
- Zheng, Y. and Mayhew, J. (2009) A time-invariant visco-elastic windkessel model relating blood flow and blood volume. NeuroImage, 47 (4). pp. 1371-1380. ISSN 1053-8119 doi: https://doi.org/10.1016/j.neuroimage.2009.04.022
- Wei, H.-L., Zheng, Y., Pan, Y., Coca, D., Li, L.-M., Mayhew, J.E.W. and Billings, S.A. (2009) Model estimation of cerebral hemodynamics between blood flow and volume changes: A data-based modeling approach. IEEE Transactions on Biomedical Engineering, 56 (6). pp. 1606-1616. ISSN 0018-9294 doi: https://doi.org/10.1109/TBME.2009.2012722
- Lefebvre, V., Zheng, Y., Martin, C., Devonshire, I. M., Harris, S. and Mayhew, J. E. (2009) A dynamic causal model of the coupling between pulse stimulation and neural activity. Neural Computation, 21 (10). pp. 2846-2868. ISSN 0899-7667 doi: https://doi.org/10.1162/neco.2009.07-08-820
2008
- Martindale, J., Kennerley, A. J., Johnston, D., Zheng, Y. and Mayhew, J. E. (2008) Theory and generalization of Monte Carlo models of the BOLD signal source. Magnetic Resonance in Medicine, 59 (3). pp. 607-618. ISSN 1522-2594 doi: https://doi.org/10.1002/mrm.21512
2005
- Zheng, Y., Johnston, D., Berwick, J., Chen, D., Billings, S. and Mayhew, J. (2005) A three-compartment model of the hemodynamic response and oxygen delivery to brain. NeuroImage, 28 (4). pp. 925-939. ISSN 1053-8119 doi: https://doi.org/10.1016/j.neuroimage.2005.06.042
- Martindale, J., Berwick, J., Martin, C., Kong, Y., Zheng, Y. and Mayhew, J. (2005) Long duration stimuli and nonlinearities in the neural–haemodynamic coupling. Journal of Cerebral Blood Flow and Metabolism, 25 (5). pp. 651-661. ISSN 1559-7016 doi: https://doi.org/10.1038/sj.jcbfm.9600060
2004
- Kong, Y., Zheng, Y., Johnston, D., Martindale, J., Jones, M., Billings, S. and Mayhew, J. (2004) A model of the dynamic relationship between blood flow and volume changes during brain activation. Journal of Cerebral Blood Flow and Metabolism, 24 (12). pp. 1382-1392. ISSN 1559-7016 doi: https://doi.org/10.1097/01.WCB.0000141500.74439.53
2003
- Papadakis, N. G., Zheng, Y. and Wilkinson, I. D. (2003) Analysis of diffusion tensor magnetic resonance imaging data using principal component analysis. Physics in Medicine and Biology, 48 (24). N343-N350. ISSN 1361-6560 doi: https://doi.org/10.1088/0031-9155/48/24/N01
- Martindale, J., Mayhew, J., Berwick, J., Jones, M., Martin, C., Johnston, D., Redgrave, P. and Zheng, Y. (2003) The hemodynamic impulse response to a single neural event. Journal of Cerebral Blood Flow and Metabolism, 23. pp. 546-555. ISSN 1559-7016 doi: https://doi.org/10.1097/01.WCB.0000058871.46954.2B
2002
- Zheng, Y., Martindale, J., Johnston, D., Jones, M., Berwick, J. and Mayhew, J. (2002) A model of the hemodynamic response and oxygen delivery to brain. NeuroImage, 16 (3A). pp. 617-637. ISSN 1053-8119 doi: https://doi.org/10.1006/nimg.2002.1078
Other Publications
OTHER INFORMATION
Study for a PhD with Professor Ying Zheng
EEG/LPF Workshop