Dr Simon Clarke
Responsibilities
Associate Professor in Cellular Microbiology
- School Erasmus coordinator
Areas of Interest
- Funding from British Heart Foundation, The Royal Society, The Felix Scholarship
- Pathogenicity and virulence in Gram positive bacteria
- Staphylococcal infections of the cardiovascular system
- Survival and colonisation of Staphylococcus aureus in the gut
Member of
- Microbiology Research Group
- Institute for Cardiovascular & Metabolic Research
Impact, Enterprise and Outreach
- Interviews with BBC Radio Berkshire
- Developed schools outreach material for the Society for General Microbiology
Esteem Factors
- Expert advisor for a Wellcome Trust Health Innovation Challenge Fund committee meeting and member of interview panel
Teaching
- Part 1: Introductory Microbiology, Pathology: Introduction to Human Disease, Practical Biochemistry
- Part 2: Function of the Bacterial Cell, Immunology
- Part 3: Bacterial Pathogens, Mechanisms of Microbial Function, Use and Abuse of the Microbial World, Microbiology Field Trip
Research groups / Centres
Publications
Y
Number of items: 14.
2017
- Sannasiddappa, T. H., Lund, P. A. and Clarke, S. R. (2017) In vitro antibacterial activity of unconjugated and conjugated bile salts on Staphylococcus aureus. Frontiers in Microbiology, 8. 1581. ISSN 1664-302X doi: https://doi.org/10.3389/fmicb.2017.01581
- Lopes Pires, M. E., Clarke, S. R., Marcondes, S. and Gibbins, J. M. (2017) Lipopolysaccharide potentiates platelet responses via toll-like receptor 4-stimulated Akt-Erk-PLA2 signalling. PLoS ONE, 12 (11). e0186981. ISSN 1932-6203 doi: https://doi.org/10.1371/journal.pone.0186981
2015
- Sannasiddappa, T., Hood, G., Hanson, K., Costabile, A., Gibson, G. and Clarke, S. (2015) Staphylococcus aureus MnhF mediates cholate efflux and facilitates survival under human colonic conditions. Infection and Immunity, 83 (6). pp. 2350-2357. ISSN 0019-9567 doi: https://doi.org/10.1128/IAI.00238-15
2014
- Murray, E., Crowley, R., Truman, A., Clarke, S., Cottam, J., Jadhav, G., Steele, V., O'Shea, P., Lindholm, C., Cockayne, A., Chhabra, R., Chan, W. C. and Williams, P. (2014) Targeting Staphylococcus aureus quorum sensing with non-peptidic small molecule inhibitors. Journal of Medicinal Chemistry, 57 (6). pp. 2813-2819. ISSN 0022-2623 doi: https://doi.org/10.1021/jm500215s
2013
- Waller, A. K., Sage, T., Kumar, C., Carr, T., Gibbins, J. M. and Clarke, S. R. (2013) Staphylococcus aureus lipoteichoic acid inhibits platelet activation and thrombus formation via the Paf receptor. Journal of Infectious Diseases, 208 (12). pp. 2046-2057. ISSN 1537-6613 doi: https://doi.org/10.1093/infdis/jit398
2011
- Sannasiddappa, T.H., Costabile, A., Gibson, G. and Clarke, S. (2011) The influence of Staphylococcus aureus on gut microbial ecology in an in vitro continuous culture human colonic model system. PLoS ONE, 6 (8). E23227. ISSN 1932-6203
- Jackson, R. W., Johnson, L. J., Clarke, S. R. and Arnold, D. L. (2011) Bacterial pathogen evolution: breaking news. Trends in Genetics, 27 (1). pp. 32-40. ISSN 0168-9525 doi: https://doi.org/10.1016/j.tig.2010.10.001
2010
- Clarke, S. R. (2010) Phenol-soluble modulins of Staphylococcus aureus lure neutrophils into battle. Cell Host and Microbe, 7 (6). pp. 423-424. ISSN 1931-3128 doi: https://doi.org/10.1016/j.chom.2010.05.015
2009
- Clarke, S. R., Andre, G., Walsh, E. J., Dufrene, Y. F., Foster, T. J. and Foster, S. J. (2009) Iron-regulated surface determinant protein a mediates adhesion of staphylococcus aureus to human corneocyte envelope proteins. Infection and Immunity, 77 (6). pp. 2408-2416. ISSN 0019-9567 doi: https://doi.org/10.1128/iai.01304-08
2008
- Jensen, R. O., Winzer, K., Clarke, S. R., Chan, W. C. and Williams, P. (2008) Differential recognition of Staphylococcus aureus quorum-sensing signals depends on both extracellular loops 1 and 2 of the transmembrane sensor AgrC. Journal of Molecular Biology, 381 (2). pp. 300-309. ISSN 0022-2836 doi: https://doi.org/10.1016/j.jmb.2008.06.018
- Clarke, S. R. and Foster, S. J. (2008) IsdA protects Staphylococcus aureus against the bactericidal protease activity of apolactoferrin. Infection and Immunity, 76 (4). pp. 1518-1526. ISSN 0019-9567 doi: https://doi.org/10.1128/IAI.01530-07
2007
- Wright, A. C., Cole, J. M., Newport, R. J., Fisher, C. E., Clarke, S. J., Sinclair, R. N., Fischer, H. E. and Cuello, G. J. (2007) The Neutron Diffraction Anomalous Dispersion Technique and its Application to Sm2O3.4P2O5. Nuclear Instruments & Methods in Physics Research. Section A., 571 (3). pp. 622-635. ISSN 0168-9002 doi: https://doi.org/10.1016/j.nima.2006.11.045
- Tiyawisutsri, R., Holden, M. T., Tumapa, S., Rengpipat, S., Clarke, S. R., Foster, S. J., Nierman, W. C., Day, N. P. and Peacock, S. J. (2007) Burkholderia Hep_Hag autotransporter (BuHA) proteins elicit a strong antibody response during experimental glanders but not human melioidosis. BMC Microbiology, 7 (19). p. 19. ISSN 1471-2180 doi: https://doi.org/10.1186/1471-2180-7-19
- Clarke, S.R. , Mohamed, R. , Bian, L. , Routh, A.F. , Kokai-Kun, J.F. , Mond, J.J. , Tarkowski, A. and Foster, S.J. (2007) The staphylococcus aureus surface protein IsdA mediates resistance to the innate defenses of human skin. Cell Host and Microbe, 1 (3). pp. 192-212. ISSN 1931-3128 doi: https://doi.org/10.1016/j.chom.2007.04.005
Other publications
Clarke SR, Foster SJ. (2006) Surface adhesins of Staphylococcus aureus. Advances in Microbial Physiology. 51:187-224.
Clarke SR, Brummell KJ, Horsburgh MJ, McDowell PW, Mohamad SA, Stapleton MR, Acevedo J, Read RC, Day NP, Peacock SJ, Mond JJ, Kokai-Kun JF, Foster SJ. (2006) Identification of in vivo-expressed antigens of Staphylococcus aureus and their use in vaccinations for protection against nasal carriage. Journal of Infectious Diseases. 193:1098-1108.
Pourmand MR, Clarke SR, Schuman RF, Mond JJ, Foster SJ. (2006) Identification of antigenic components of Staphylococcus epidermidis expressed during human infection. Infection and Immunity. 74:4644-4654.