Dr Michael Fry
Responsibilities
Associate Professor in Biomedical Sciences
Areas of Interest
- Funding from British Heart Foundation
- Development of a mathematical model of platelet signalling and function - the Virtual Platelet - for in silico experimentation, drug discovery and diagnosis.
- Analysis of the non-genomic functions of histone deacetylases in cellular signalling using proteomic approaches - platelets as a model system.
- Analysis of phosphoinositide 3-kinases in cancer
- Evolution of cellular signalling systems
Member of
- Molecular & Cellular Medicine Group
- Institute for Cardiovascular & Metabolic Research
Impact, Enterprise and Outreach
- Joint Inventor on several patents linked to phosphoinositide 3-kinase research
- Host annual training day for British Biology Olympiad Finalists, Hosted BBO UK finals in 2013
- Local Ambassador for the Biochemical Society
Teaching
- Part 1: The living Cell, The Living Cell 2, Laboratory and Study Skills for Biomedicine
- Part 2: Science Communication, Life and Death of a Cell, Molecular Biology of the Gene, Protein Structure and Function.
- Part 3: Cell Communication and Disease, Cancer
Local Collaborators
- Prof. Jon Gibbins, School of Biological Sciences
- Dr Chris Jones, School of Biological Sciences
- Dr Marcus Tindall, Department of Mathematics and Statistics
- Dr Fazil Baksh, Department of Mathematics and Statistics
- Dr Philippa Darbre, School of Biological Sciences
International Collaborators
- Dr Bernard Payrastre, Inserm U1048, I2MC and Université Paul Sabatier, Toulouse, France
National Collaborators
- Prof. Marco Falasca, Queen Mary University, London
- Dr Tania Maffuccci, Queen Mary University, London
Research groups / Centres
Publications
Y
Number of items: 12.
2020
- Mazet, F., Tindall, M. J., Gibbins, J. M. and Fry, M. J. (2020) A model of the PI cycle reveals the regulating roles of lipid-binding proteins and pitfalls of using mosaic biological data. Scientific Reports, 10 (1). 13244. ISSN 2045-2322 doi: https://doi.org/10.1038/s41598-020-70215-7
2018
- Mazet, F. and Fry, M. J. (2018) Precise quantification of platelet proteins and their phosphorylation states. In: Gibbins, J. M. and Mahaut-Smith, M. (eds.) Platelets and Megakaryocytes: Volume 4, Advanced Protocols and Perspectives. Humana Press, New York, pp. 113-125. ISBN 9781493985845 doi: https://doi.org/10.1007/978-1-4939-8585-2_7
2015
- Mazet, F., Dunster, J. L., Jones, C. I., Vaiyapuri, S., Tindall, M. J., Fry, M. J. and Gibbins, J. M. (2015) A high-density immunoblotting methodology for quantification of total protein levels and phosphorylation modifications. Scientific Reports, 5. 16995. ISSN 2045-2322 doi: https://doi.org/10.1038/srep16995
- Bye, A. P., Unsworth, A. J., Vaiyapuri, S., Stainer, A. R., Fry, M. J. and Gibbins, J. M. (2015) Ibrutinib inhibits platelet integrin αIIbβ3 outside-in signaling and thrombus stability but not adhesion to collagen. Arteriosclerosis Thrombosis and Vascular Biology, 35 (11). pp. 2326-2335. ISSN 1524-4636 doi: https://doi.org/10.1161/ATVBAHA.115.306130
- Dunster, J. L., Mazet, F., Fry, M. J., Gibbins, J. M. and Tindall, M. J. (2015) Regulation of early steps of GPVI signal transduction by phosphatases: a systems biology approach. PLoS Computational Biology, 11 (11). e1004589. ISSN 1553-734X doi: https://doi.org/10.1371/journal.pcbi.1004589
2011
- Ray, S., Fry, M. J. and Darbre, P. D. (2011) Enhanced sensitivity to rapamycin following long-term oestrogen deprivation in MCF-7, T-47-D and ZR-75-1 human breast cancer cells. Journal of Endocrinology, 208. pp. 21-29. ISSN 0022-0795 doi: https://doi.org/10.1677/JOE-10-0137
2009
- Fry, M. J. (2009) Phosphoinositide (PI) 3-kinase assays. Methods in Molecular Biology, 462. pp. 345-362. ISSN 1064-3745 doi: https://doi.org/10.1007/978-1-60327-115-8
2006
- Traer, C. J., Foster, F. M., Abraham, S. M. and Fry, M. J. (2006) Are class II phosphoinositide 3-kinases potential targets for anticancer therapies? Bull Cancer, 93 (5). E53-8. ISSN 1769-6917
- Pendaries, C., Tronchere, H., Arbibe, L., Mounier, J., Gozani, O., Cantley, L., Fry, M. J., Gaits-Iacovoni, F., Sansonetti, P. J. and Payrastre, B. (2006) PtdIns(5)P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection. Embo Journal, 25 (5). pp. 1024-1034. ISSN 0261-4189 doi: https://doi.org/10.1038/sj.emboj.7601001
2005
- Maffucci, T., Cooke, F. T., Foster, F. M., Traer, C. J., Fry, M. J. and Falasca, M. (2005) Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration. Journal of Cell Biology, 169 (5). pp. 789-799. ISSN 0021-9525 doi: https://doi.org/10.1083/jcb.200408005
2003
- Barry, F. A., Graham, G. J., Fry, M. J. and Gibbins, J. M. (2003) Regulation of glycogen synthase kinase 3 in human platelets: a possible role in platelet function? FEBS Letters, 553 (1-2). pp. 173-178. ISSN 0014-5793 doi: https://doi.org/10.1016/s0014-5793(03)01015-9
- Foster, F. M., Traer, C. J., Abraham, S. M. and Fry, M. J. (2003) The phosphoinositide (PI) 3-kinase family. Journal of Cell Science, 116 (15). pp. 3037-3040. ISSN 0021-9533 doi: https://doi.org/10.1242/jcs.00609
Pre 2003
Fry MJ. Phosphoinositide 3-kinase signalling in breast cancer: how big a role might it play? (2001) Breast Cancer Res. 3: 304-12.