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HI-FIVE – University of Reading

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  • HI-FIVE study


Recruitment is closed for this study

This study aims to investigate the effects of fish oil supplements on cardiovascular health. The role of diet is significant in the prevention and treatment of cardiovascular diseases and we will be testing the number and profile of extra-cellular vesicles (EVs) in the blood and the way the EVs in the blood behave.

 EVs are tiny particles released from many types of cells and from platelets, particularly when they are stimulated, activated or damaged. High numbers of EVs in the blood have been associated with a higher risk of CVD, but it is not clear exactly what EVs do in the body. Fish oil, containing omega-3 (or n-3) polyunsaturated fatty acids (n-3 PUFA), is suggested to have a favourable effect on several risk factors associated with CVDs.

Can you help us to test the effects of fish oil on cardiovascular health?

We are aiming to recruit male and female participants between the ages of 40 and 70 years, non-smokers, who are generally healthy, but may be considered to have moderate risk for heart disease.

  • Willing to take fish oil supplements
  • Willing to attend 5x 30 min visits at the Hugh Sinclair Unit of Human Nutrition (University of Reading)


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