Staff Profile:Dr Katja Strohfeldt

Name:

Dr Katja Strohfeldt-Venables

Job Title:

Lecturer in Pharmaceutical Chemistry and Admissions Tutor Chemistry 2.21

Responsibilities:

Resident Tutor Stenton Hall, UoR.

Admissions Tutor, School of Pharmacy.

Early Career University Teaching Fellow (2011 - ).

Areas of Interest:

Metal-based Anti-cancer Drugs

This aspect of my research is based on the synthesis, analysis and biological testing of metal-based anti-cancer drugs. The search for effective anti-cancer drugs is still a very important task in modern research, especially in chemistry, as a result of the wide variety of tumor types and problems of toxicity associated with conventional cancer therapies. Metals of interest for incorporation within organometallic anti-cancer agents are germanium and titanium. The advantage of organogermanium compounds is that they combine cytotoxic activity with a stimulation of the immune system with almost no detectable sign of toxicity. Research in the area of titanium-based complexes as potential anti-cancer drugs showed impressive results over the last 5 years and we believe there is still scope for further improvements. The idea of this research area is to devise and evaluate new organic and organometallic synthetic routes to allow access to biologically interesting anti-cancer agents.

Traditional Chinese Medicine (TCM) Quality Assessment

Traditional Chinese Medicine refers to a range of medical concepts developed in China and based of tradition more than 2000 years ago. It includes herbal medicine, acupuncture, massage and exercise.

Unfortunately, there are some herbal TCM products on the UK market that may be of questionable quality, which may impose a risk to the public. These products may be adulterated with toxic or illegal ingredients or simply produced to a low standard. It may be very difficult to distinguish between those products posing a health risk to the public and herbal TCM products made to an acceptable quality standard.

Currently we are working in collaboration with the MHRA in order to develop analytical standards to identify TCM herbs of acceptable quality. Within the same project we are developing Monographs for the British Pharmacopeia to ensure quality standards being introduced in the commercial market.

Problem-based learning (PBL)

Problem-based learning (PBL) is a student-centered teaching approach, which uses real-life case studies to teach students complex and multifaceted concepts. The targets of PBL include helping students to develop problem-solving skills, self-directed learning, working in teams and continuous professional development.

We are working on developing teaching concepts for a variety of teaching scenarios reaching from Therapeutics lectures and workshops to practical classes in Medicinal Chemistry.

If you are interested in one of the projects or aspects of them, please do not hesitate to contact me.

 

Research groups / Centres:

Publications:

Y

Jump to: 2011 | 2010 | 2009 | 2008 | 2007 | 2006

Number of items: 23.

2011

• Sarsam, S. W., Nutt, D. R., Strohfeldt, K. and Watson, K. A. (2011) Titanocene anticancer complexes and their binding mode of action to human serum albumin: a computational study. Metallomics, 3 (2). pp. 152-161. ISSN 1756-5901 doi: 10.1039/c0mt00041h

2010

• Bauer, J., Stiller, J., Marques-Lopez, E., Strohfeldt, K. A., Christmann, M. and Strohmann , C. (2010) Silyl-Modified Analogues of 2-Tritylpyrrolidine: Synthesis and Applications in Asymmetric Organocatalysis. Chemistry - A European Journal, 16 (42). pp. 12553-12558. ISSN 0947-6539 doi: 10.1002/chem.201002166
• Strohfeldt, K. and Grant, D. T. (2010) A model for self-directed problem-based learning for renal therapeutics. American Journal of Pharmaceutical Education , 74 (9). Article 173.

2009

• Vessieres, A., Plamont, M.-A., Cabestaing, C., Claffey, J., Dieckmann, S., Hogan, M., Mueller-Bunz, H., Strohfeldt, K. A. and Tacke, M. (2009) Proliferative and anti-proliferative effects of titanium- and iron-based metallocene anti-cancer drugs. Journal of Organometallic Chemistry , 694 (6). pp. 874-879. ISSN 0022-328X doi: DOI:10.1016/j.jorganchem.2008.11.071

2008

• Dowling, C.M. , Claffrey, J., Cuffe, S., Fichtner, I., Pampillon, C., Sweeney, N.J., Strohfeldt, K., Watson, R., William, G. and Tacke, M. (2008) Antitumor activity of Titanocene Y in xenografted PC3 tumors in mice. Letters in Drug Design & Discovery, 5 (2). pp. 141-144. ISSN 1570-1808 doi: 10.2174/157018008783928463
• Strohfeldt, K. A. and Tacke, M. (2008) Bioorganometallic fulvene-derived titanocene anti-cancer drugs. Chemical Society Reviews, 37 (6). pp. 1174-1187. ISSN 0306-0012 doi: DOI:10.1039/b707310k
• Pampillon, C., Claffey, J., Strohfeldt, K. and Tacke, M. (2008) Synthesis and cytotoxicity studies of new dimethylamino-functionalised and aryl-substituted titanocene anti-cancer agents. European Journal of Medicinal Chemistry, 43 (1). pp. 122-128. ISSN 0223-5234 doi: 10.1016/j.ejmech.2007.02.011

2007

• Oberschmidt, O., Hanauske, A.R., Pampillón, C., Strohfeldt, K., Sweeney, N.J. and Tacke, M. (2007) Antiproliferative activity of Titanocene Y against tumor colony-forming units. Anticancer Drugs, 18 (3). pp. 317-322. ISSN 0959-4973 doi: 10.1097/CAD.0b013e3280115f86
• Beckhove, P., Oberschmidt, O., Hanauske, A.R., Pampillon, C., Schirrmacher, V., Sweeney, N.J., Strohfeldt, K. and Tacke, M. (2007) Antitumor activity of Titanocene Y against freshly explanted human breast tumor cells and in xenografted MCF-7 tumors in mice. Anti-cancer Drugs, 18 (3). pp. 311-316. ISSN 0959-4973 doi: 10.1097/CAD.0b013e328010a6f7
• Strohfeldt, K., Müller-Bunz, H., Pampillon, C. and Tacke, M. (2007) Proliferative and antiproliferative effects in substituted titanocene anticancer drugs. Transition Metal Chemistry, 32 (7). pp. 971-980. ISSN 0340-4285 doi: 10.1007/s11243-007-0265-8
• Bannon, J.H., Fichtner, I., O'Neill, A., Pampillon, C., Sweeney, N.J., Strohfeldt, K., Watson, R.W., Tacke, M. and McGee, M.M. (2007) Substituted titanocenes induce caspase-dependent apoptosis in human epidermoid carcinoma cells in vitro and exhibit antitumour activity in vivo. British Journal of Cancer, 97 (9). pp. 1234-1241. ISSN 0007-0920 doi: 10.1038/sj.bjc.6604021
• Pampillón, C., Sweeney, N.J., Strohfeldt, K. and Tacke, M. (2007) Synthesis and cytotoxicity studies of new dimethylamino-functionalised and hetero aryl-substituted titanocene anti-cancer drugs. Journal of Organometallic Chemistry, 692 (11). pp. 2153-2159. ISSN 022-328x doi: 10.1016/j.jorganchem.2007.01.045
• Pampillón, C., Claffey, J., Hogan, M., Strohfeldt, K. and Tacke, M. (2007) Synthesis and cytotoxicity studies of new dimethylamino-functionalised and indolyl-substituted titanocene anti-cancer drugs. Transition Metal Chemistry, 32 (4). pp. 434-441. ISSN 0340-4285 doi: 10.1007/s11243-006-0183-1
• Müller-Bunz, H., Dix, I., Lou, Y., Pampillón, C., Strohfeldt, K., Sweeney, N.J. and Tacke, M. (2007) A series of novel 6-aryl fulvenes: impact of substitution on the phenyl ring, characterised by X-Ray crystallography. Zeitschrift Fur Kristallographie, 222 (7). pp. 376-382. ISSN 0044-2968
• Sweeney, N.J., Claffey, J., Müller-Bunz, H., Pampillon, C., Strohfeldt, K. and Tacke, M. (2007) The synthesis and cytotoxic evaluation of a series of benzodioxole substituted titanocenes. Applied Organometallic Chemistry, 21 (2). pp. 57-65. ISSN 0268-2605 doi: 10.1002/aoc.1177

2006

• Fichtner, I., Pampillon, C., Sweeney, N.J., Strohfeldt, K. and Tacke, M. (2006) Anti-tumor activity of Titanocene Y in xenografted Caki-1 tumors in mice. Anti-Cancer Drugs, 17 (3). pp. 333-336. ISSN 0959-4973
• Valadares, M.C., Ramos, A.L., Rehmann, F.J.K., Sweeney, N.J., Strohfeldt, K., Tacke, M. and Queiroz, M.L.S. (2006) Antitumour activity of [1,2-di(cyclopentadienyl)-1,2-di(p-N,N-dimethylaminophenyl)-ethanediyl] titanium dichloride in xenografted Ehrlich's ascites tumour. European Journal of Pharmacology, 534 (1-3). pp. 264-270. ISSN 0014-2999 doi: 10.1016/j.ejphar.2006.01.056
• Strohmann, C., Dilsky, S. and Strohfeldt, K. (2006) Crystal structures of [PhLi center dot(-)-sparteine](2), [PhOLi center dot(-)-sparteine](2), and the mixed aggregate [PhLi center dot PhOLi center dot 2(-)-sparteine]. Organometallics, 25 (1). pp. 41-44. ISSN 0276-7333 doi: 10.1021/om050794w
• Pampillon, C., Mendoza, O., Sweeney, N.J., Strohfeldt, K. and Tacke, M. (2006) Diarylmethyl substituted titanocenes: promising anti-cancer drugs. Polyhedron, 25 (10). pp. 2101-2108. ISSN 0277-5387 doi: 10.1016/j.poly.2006.01.007
• Pampillon, C., Sweeney, N.J., Strohfeldt, K. and Tacke, M. (2006) Diheteroarylmethyl substituted titanocenes: a novel class of possible anti-cancer drugs. Inorganica Chimica Acta, 359 (12). pp. 3969-3975. ISSN 0020-1693 doi: 10.1016/j.ica.2006.05.021
• Strohfeldt, K., Muller-Bunz, H., Pampillon, C., Sweeney, N.J. and Tacke, M. (2006) Glycol methyl ether and glycol amine substituted titanocenes as antitumor agents. European Journal of Inorganic Chemistry (22). pp. 4621-4628. ISSN 1434-1948 doi: 10.1002/ejic.200600586
• Sweeney, N., Gallagher, W.M., Muller-Bunz, H., Pampillon, C., Strohfeldt, K. and Tacke, M. (2006) Heteroaryl substituted titanocenes as potential anti-cancer drugs. Journal of Inorganic Biochemistry, 100 (9). pp. 1479-1486. ISSN 0162-0134 doi: 10.1016/j.jinorgbio.2006.04.006
• O'Connor, K., Gill, C., Tacke, M., Rebmann, F.J.K., Strohfeldt, K., Sweeney, N., Fitzpatrick, J.M. and Watson, R.W.G. (2006) Novel titanocene anti-cancer drugs and their effect on apoptosis and the apoptotic pathway in prostate cancer cells. Apoptosis, 11 (7). pp. 1205-1214. ISSN 1360-8185 doi: 10.1007/s10495-006-6796-1

This list was generated on Sun May 27 12:21:56 2012 BST.

 

Qualifications:

BSc/PGCE (Wuerzburg); Phd (Wuerzburg); PGCAP (Reading);
Professional Membership:
Member of the Royal Society of Chemistry (MRSC)
Fellow of the Higher Education Academy (FHEA)