Staff Profile:Dr Alister McNeish
- Dr Alister McNeish
- Job Title:
- Lecturer in Pharmacology
Pharmacy department outreach coordinator
Deputy exams coordinator
Module convenor for Therapeutics 2 (PM3TH2)
- Areas of Interest:
Cardiovascular disease is the leading cause of mortality in the UK and in our aging population the incidence of cardiovascular disease is increasing. Therefore there is a pressing need for new and better treatments for these diseases. My main focus is on vascular pharmacology. In particular how the endothelial cells, which line inside of blood vessels, communicate and modulate the degree of constriction of the smooth muscle cells that form the wall of blood vessels. Understanding these processes help us develop new strategies for regulating blood flow and blood pressure; perhaps leading to new treatments for cardiovascular diseases. My work falls roughly in to four inter-related themes:
a) Regulation of calcium-activated potassium channels (KCa) found in the endothelium. These channels play a critical role in endothelium derived hyperpolarization (EDH) mediated responses and regulation of blood pressure/flow. This theme also encompasses how such regulation affects EDH responses.
b) Characterisation and elucidation of the mechanisms that underlie the EDH response, particularly in the cerebral vasculature with a particular focus on the role of fatty acid derived metabolites (including fish oils) and reactive oxygen species on these responses.
c) Study of crosstalk/interaction between two of the major endothelium dependant vasodilator pathways, nitric oxide and EDH, and how endothelial dysfunction may lead to changes in these interactions.
d) The role of the endothelium in regulating spontaneous vasoconstrictor tone (myogenic tone) in smooth muscle cells. This has implications on vasomotion (a coordinated oscillatory relaxation and constriction of blood vessels) and vasospasm (uncontrolled vasoconstriction associated with strokes and heart attacks).
My research forms part of the University of Readings Institute of Cardiovascular and Metabolic Research (ICMR; http://www.reading.ac.uk/icmr/) and has recently been funded by The Royal Society and the British Heart Foundation. The latter award is a 3 year project grant to investigate the regulation of EDH/KCa by thromboxane receptors and Rho kinase and is being conducted by my postdoctoral researcher Dr Claudia Bauer.
As well as research I have an active role in university and academic life. I am currently module convenor for PM3TH2 on the MPharm degree programme and am deputy exams officer and the outreach coordinator for the Reading School of Pharmacy. I am a member of the British Pharmacological Society, The Physiological Society and Microcirculation Society. I serve on the editorial boards of the British Journal of Pharmacology and Frontiers in Vascular Physiology
- Research groups / Centres:
YNumber of items: 9.
- Gauthier, K. M., Campbell, W. B. and McNeish, A. J. (2014) Regulation of KCa2.3 andendothelium-dependent hyperpolarization (EDH) in the rat middle cerebral artery: the role of lipoxygenase metabolites and isoprostanes. PeerJ, 2. e414. ISSN 2167-8359 doi: 10.7717/peerj.414
- McNeish, A., Roux, B. T., Aylett, S.-B. , Van Den Brink, A. M. and Cottrell, G. S. (2012) Endosomal proteolysis regulates calcitonin gene-related peptide responses in mesenteric arteries. British Journal of Pharmacology, 167 (8). pp. 1679-1690. ISSN 1476-5381 doi: 10.1111/j.1476-5381.2012.02129.x
- McNeish, A. J., Altayo-Jimenez, F., Cottrell, G. S. and Garland, C. J. (2012) Statins and selective inhibition of Rho kinase protect small conductance calcium-activated potassium channel function (KCa2.3) in cerebral arteries. PLoS ONE, 7 (10). e46735. ISSN 1932-6203 doi: 10.1371/journal.pone.0046735
- McNeish, A., Altayo-Jimenez, F. and Garland, C. J. (2010) Evidence both L-type and non-L-type voltage-dependent calcium channels contribute to cerebral artery vasospasm following loss of NO in the rat. Vascular Pharmacology, 53 (3-4). pp. 151-159. ISSN 1537-1891 doi: 10.1016/j.vph.2010.06.002
- Yuill, K. H., McNeish, A., Kansui, Y., Garland, C. J. and Dora , K. A. (2010) Nitric oxide suppresses cerebral vasomotion by sGC-independent effects on ryanodine receptors and voltage-gated calcium channels. Journal of Vascular Research, 47 (2). pp. 93-107. ISSN 1018-1172 doi: 10.1159/000235964
- Dora, K. A., Gallagher, N. T., McNeish, A. and Garland, C. J. (2008) Modulation of endothelial cell KCa3.1 Channels during endothelium-derived hyperpolarizing factor signaling in mesenteric resistance arteries. Circulation Research, 102 (10). pp. 1427-1255. ISSN 0009-7330 doi: 10.1161/CIRCRESAHA.108.172379
- McNeish, A. and Garland , C. J. (2007) Thromboxane A2 inhibition of SKCa after NO synthase block in rat middle cerebral artery. British Journal of Pharmacology, 151 (4). pp. 441-449. ISSN 1476-5381 doi: 10.1038/sj.bjp.0707240
- McNeish, A., Sandow, S.L., Neylon, C.B., Chen, M.X., Dora, K. A. and Garland, C.J. (2006) Evidence for involvement of both IKCa and SKCa channels in hyperpolarizing responses of the rat middle cerebral artery. Stroke, 37 (5). pp. 1277-1282. ISSN 0039-2499 doi: 10.1161/01.STR.0000217307.71231.43
- McNeish, A. J., Dora, K. A. and Garland, C. J. (2005) Possible role for K+ in endothelium-derived hyperpolarizing factor–linked dilatation in rat middle cerebral artery. Stroke, 36 (7). pp. 1526-1532. ISSN 0039-2499 doi: 10.1161/01.STR.0000169929.66497.73
- McNeish AJ, Altayo FJ, Garland CJ. Evidence both L-type and non-L-type
voltage-dependent calcium channels contribute to cerebral artery vasospasm
following loss of NO in the rat. Vascul Pharmacol. 2010 Sep-Oct;53(3-4):151-9.
Epub 2010 Jun 22. PubMed PMID: 20601125.
- Yuill KH, McNeish AJ, Kansui Y, Garland CJ, Dora KA. Nitric oxide suppresses
cerebral vasomotion by sGC-independent effects on ryanodine receptors and
voltage-gated calcium channels. J Vasc Res. 2010;47(2):93-107. Epub 2009 Sep 4.
PubMed PMID: 19729956.
- Dora KA, Gallagher NT, McNeish A, Garland CJ. (2008) Modulation of Endothelial Cell KCa3.1 Channels during Endothelium-Derived Hyperpolarizing Factor Signalling in Mesenteric Resistance Arteries. Circ. Res., 102, 1247-1255. Pubmed PMID: PMC2629615
- McNeish AJ, Garland CJ. Thromboxane A2 inhibition of SKCa after NO synthase
block in rat middle cerebral artery. Br J Pharmacol. 2007 Jun;151(4):441-9. Epub
2007 Apr 10. PubMed PMID: 17420777; PubMed Central PMCID: PMC2013971.
- McNeish AJ, Sandow SL, Neylon CB, Chen MX, Dora KA, Garland CJ. Evidence for
involvement of both IKCa and SKCa channels in hyperpolarizing responses of the
rat middle cerebral artery. Stroke. 2006 May;37(5):1277-82. Epub 2006 Mar 23.
PubMed PMID: 16556879.
- McNeish AJ, Dora KA, Garland CJ. Possible role for K+ in endothelium-derived
hyperpolarizing factor-linked dilatation in rat middle cerebral artery. Stroke.
2005 Jul;36(7):1526-32. Epub 2005 Jun 2. PubMed PMID: 15933259.
Member of the ICMR http://www.reading.ac.uk/icmr/
Member of the molecular neuroscience research group
Member of the British Pharmacological Society, the Physiological Society, and the British Microcirculation Society
Member of editorial board of of the British Journal of Pharmacology http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291476-5381 and Frontiers in Vascular Physiology http://community.frontiersin.org/people/AlisterMcNeish/34788