Staff Profile:Dr Angela Bithell

Name:

Dr Angela Bithell

Job Title:

Lecturer in Stem Cell Biology and Regenerative Medicine

Responsibilities:

Research Division Lead for Pharmacy

Pharmacy Diversity and Inclusion Lead (including Athena SWAN)

SCFP Diversity and Inclusion Committee member (including Athena SWAN)

SCFP Career's Champion (as part of SCFP Athena SWAN)

Main Teaching: MPharm Programme (including PM2A2, PM3A, PM3B, PM4A)

Areas of Interest:

My research interests are in the molecular and cellular mechanisms that underlie normal developmental of the central nervous system (CNS) and CNS-related disorders. A current specific focus in my group is the development and use of 2D and 3D stem cell-derived neuronal-glial in vitro models to investigate the underlying mechanisms of neurodegenerative diseases (including Alzheimer's disease) and as drug discovery and screening platforms. Other work includes combining model systems and 'omics technologies to determine the gene regulatory networks and role of the epigenome in stem cells (pluripotent and neural), neurons and glia in health and disease.

Professional Membership/External Committee Membership:

• Fellow of the Higher Education Academy (FHEA)
• Reading Local Group Representative for the British Neuroscience Association (BNA)
• Alzheimer's UK (ARUK) Oxford Network Committee member

Research groups / Centres:

Publications:

Y

Jump to: 2019 | 2018 | 2016 | 2015 | 2013 | 2012 | 2011 | 2010 | 2008 | 2005 | 2003

Number of items: 20.

2019

• Wade, J. J., Breslin, K., Wong-Lin, K., Harkin, J., Flanagan, B., Van Zalinge, H., Hall, S., Dallas, M., Bithell, A., Verkhratsky, A. and McDaid, L. (2019) Calcium microdomain formation at the perisynaptic cradle due to NCX reversal: a computational study. Frontiers in Cellular Neuroscience, 13. 185. ISSN 1662-5102 doi: https://doi.org/10.3389/fncel.2019.00185
• Kang, S., Hayashi, Y., Bruyns-Haylett, M., Baker, D. K., Boura, M., Wang, H., Karatzas, K.-A., Serra, I., Bithell, A., Williams, C., Field, D. and Zheng, Y. (2019) Supplemental vitamin B-12 enhances the neural response to sensory stimulation in the barrel cortex of healthy rats but does not affect spontaneous neural activity. Journal of Nutrition, 149 (5). pp. 730-737. ISSN 1541-6100 doi: https://doi.org/10.1093/jn/nxz011

2018

• Centeno, E. G. Z., Cimarosti, H. and Bithell, A. (2018) 2D versus 3D human induced pluripotent stem cell-derived cultures for neurodegenerative disease modelling. Molecular Neurodegeneration, 13 (1). 27. ISSN 1750-1326 doi: https://doi.org/10.1186/s13024-018-0258-4

2016

• Michelucci, A., Bithell, A., Burney, M. J., Johnston, C. E., Wong, K.-Y., Teng, S.-W., Desai, J., Gumbleton, N., Anderson, G., Stanton, L. W., Williams, B. P. and Buckley, N. J. (2016) The neurogenic potential of astrocytes is regulated by inflammatory signals. Molecular Neurobiology, 53 (6). pp. 3724-3739. ISSN 1559-1182 doi: https://doi.org/10.1007/s12035-015-9296-x
• Bhinge, A., Namboori, S. C., Bithell, A., Soldati, C., Buckley, N. J. and Stanton, L. W. (2016) MiR-375 is essential for human spinal motor neuron development and may be involved in motor neuron degeneration. Stem Cells, 34 (1). pp. 124-134. ISSN 1066-5099 doi: https://doi.org/10.1002/stem.2233

2015

• Smith, I., Haag, M., Ugbode, C., Tams, D., Rattray, M., Przyborski, S., Bithell, A. and Whalley, B. J. (2015) Neuronal-glial populations form functional networks in a biocompatible 3D scaffold. Neuroscience Letters, 609. pp. 198-202. ISSN 0304-3940 doi: https://doi.org/10.1016/j.neulet.2015.10.044
• Soldati, C., Caramanica, P., Burney, M. J., Toselli, C., Bithell, A., Augusti-Tocco, G., Stanton, L. W., Biagioni, S., Buckley, N. J. and Cacci, E. (2015) RE1 silencing transcription factor/neuron-restrictive silencing factor regulates expansion of adult mouse subventricular zone-derived neural stem/progenitor cells in vitro. Journal of Neuroscience Research, 93 (8). pp. 1203-1214. ISSN 1097-4547 doi: https://doi.org/10.1002/jnr.23572
• Raposo, A. A. S. F., Vasconcelos, F. F., Drechsel, D., Marie, C., Johnston, C., Dolle, D., Bithell, A., Gillotin, S., van den Berg, D. L. C., Ettwiller, L., Flicek, P., Crawford, G. E., Parras, C. M., Berninger, B., Buckley, N. J., Guillemot, F. and Castro, D. S. (2015) Ascl1 coordinately regulates gene expression and the chromatin landscape during neurogenesis. Cell reports, 10 (9). pp. 1544-1556. ISSN 2211-1247 doi: https://doi.org/10.1016/j.celrep.2015.02.025

2013

• Denk, F., Huang, W., Sidders, B., Bithell, A., Crow, M., Grist, J., Sharma, S., Ziemek, D., Rice, A. S.C., Buckley, N. J. and McMahon, S. B. (2013) HDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain. Pain, 154 (9). pp. 1668-1679. ISSN 0304-3959 doi: https://doi.org/10.1016/j.pain.2013.05.021
• Burney, M. J., Johnston, C., Wong, K.-Y., Teng, S.-W., Beglopoulos, V., Stanton, L. W., Williams, B. P., Bithell, A. and Buckley, N. J. (2013) An epigenetic signature of developmental potential in neural stem cells and early neurons. Stem Cells, 31 (9). pp. 1868-1880. ISSN 1066-5099 doi: https://doi.org/10.1002/stem.1431
• Soldati, C., Bithell, A., Johnston, C., Wong, K.-Y., Stanton, L. W. and Buckley, N. J. (2013) Dysregulation of REST-regulated coding and non-coding RNAs in a cellular model of Huntington's disease. Journal of Neurochemistry, 124 (3). pp. 418-30. ISSN 0022-3042 doi: https://doi.org/10.1111/jnc.12090

2012

• Soldati, C., Bithell, A., Johnston, C., Wong, K.-Y., Teng, S.-W., Beglopoulos, V., Stanton, L. W. and Buckley, N. J. (2012) Repressor element 1 silencing transcription factor couples loss of pluripotency with neural induction and neural differentiation. Stem Cells, 30 (3). pp. 425-434. ISSN 1066-5099 doi: https://doi.org/10.1002/stem.1004

2011

• Castro, D. S., Martynoga, B., Parras, C., Ramesh, V., Pacary, E., Johnston, C., Drechsel, D., Lebel-Potter, M., Garcia, L. G., Hunt, C., Dolle, D., Bithell, A., Ettwiller, L., Buckley, N. and Guillemot, F. (2011) A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets. Genes & Development, 25 (9). pp. 930-945. ISSN 1549-5477 doi: https://doi.org/10.1101/gad.627811
• Bithell, A. (2011) REST: transcriptional and epigenetic regulator. Epigenomics, 3 (1). pp. 47-58. ISSN 1750-192X doi: https://doi.org/10.2217/EPI.10.76
• Soldati, C., Bithell, A., Conforti, P., Cattaneo, E. and Buckley, N. J. (2011) Rescue of gene expression by modified REST decoy oligonucleotides in a cellular model of Huntington's disease. Journal of Neurochemistry, 116 (3). pp. 415-425. ISSN 0022-3042 doi: https://doi.org/10.1111/j.1471-4159.2010.07122.x

2010

• Buckley, N. J., Johnson, R., Zuccato, C., Bithell, A. and Cattaneo, E. (2010) The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease. Neurobiology of Disease, 39 (1). pp. 28-39. ISSN 1095-953x doi: https://doi.org/10.1016/j.nbd.2010.02.003
• Bithell, A., Hsu, T., Kandanearatchi, A., Landau, S., Everall, I. P., Tsuang, M. T., Chana, G. and Williams, B. P. (2010) Expression of the Rap1 guanine nucleotide exchange factor, MR-GEF, is altered in individuals with bipolar disorder. PLoS ONE, 5 (4). e10392. ISSN 1932-6203 doi: https://doi.org/10.1371/journal.pone.0010392

2008

• Bithell, A., Finch, S. E., Hornby, M. F. and Williams, B. P. (2008) Fibroblast growth factor 2 maintains the neurogenic capacity of embryonic neural progenitor cells in vitro but changes their neuronal subtype specification. Stem Cells, 26 (6). pp. 1565-1674. ISSN 1066-5099 doi: https://doi.org/10.1634/stemcells.2007-0832

2005

• Bithell, A. and Williams, B. P. (2005) Neural stem cells and cell replacement therapy: making the right cells. Clinical Science, 108 (1). pp. 13-22. ISSN 0143-5221

2003

• Bithell, A., Alberta, J., Hornby, F., Stiles, C. D. and Williams, B. P. (2003) Expression of the guanine nucleotide exchange factor, mr-gef, is regulated during the differentiation of specific subsets of telencephalic neurons. Brain Research, 146 (1-2). pp. 107-18. ISSN 0006-8993 doi: https://doi.org/10.1016/j.devbrainres.2003.09.017

This list was generated on Mon Jul 22 14:41:28 2019 UTC.