Vascular function and reactivity

  • Dr Anne Marie Minihane
  • Dr Julie Lovegrove
  • Dr Jeremy Spencer
  • Prof Christine Williams
  • Dr Trevor George
  • Dr Abby Thompson
  • Dr Mary Chong
  • Dr Ana Rodriguez
  • Dr Kim Jackson
  • Michele Robinson
  • Roz Moore (PhD student)
  • Katie Newens (PhD student)
  • Wachire Jirarattanarangsri (PhD student)

The 'health'and reactivity of the blood vessels are recognised as being important determinants of the development and progression of atherosclerosis and highly predictive of future cardiovascular disease onset. Within the group, using a range of state-of-the art non-invasive techniques we are investigating the acute and chronic impact of dietary component on vascular function and reactivity in humans. The techniques employed include flow mediated dilation (FMD), Laser Doppler Iontophoresis (LDI), Pulse Wave Velocity (PWV) and digital volume pulse (DVP). The impact of fat composition, and a range of flavonoids are currently under investigation. Molecular mechanisms responsible for the observed changes are investigated using molecular biology and cell culture techniques, with nitric oxide (NO) production and conservation being a particular focus.

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