CH3O1-Advanced Organic Chemistry - Synthesis of Complex Targets

Module Provider: Chemistry
Number of credits: 10 [5 ECTS credits]
Level:6
Terms in which taught: Autumn term module
Pre-requisites: CH2OR1 Further Organic Chemistry
Non-modular pre-requisites:
Co-requisites:
Modules excluded:
Module version for: 2017/8

Module Convenor: Dr Geoffrey Brown

Email: g.d.brown@reading.ac.uk

Summary module description:
To extend the synthetic methods introduced in previous years to the preparation, characterisation and manipulation of macromolecules and materials of biological and synthetic origin.

Aims:
To extend the synthetic methods introduced in previous years to the preparation, characterisation and manipulation of macromolecules and materials of biological and synthetic origin.

Assessable learning outcomes:
Students who have successfully completed this module will be able to:
• Describe the various classes of chiral molecules that are available from natural sources.
• Outline the use of these chiral precursors in the synthesis of more complex natural products.
• Choose appropriate methods for the synthesis of specific polymers.
• Outline the relationship between structure and physical characteristics of macromolecular materials.

Additional outcomes:

Lectures will provide an overview of the synthesis and utility of natural and non-natural monomer units and their assembly into complex polymers. Students will gain experience of the chemistry used in the construction of such complex materials via workshops.


Outline content:

G D Brown (10 lectures) Introduction to the Chemistry of the Chiral Pool Structures, typical reactions, protection and use of carbohydrates in synthesis. A survey of basic amino acid synthesis; N- and C-terminal protection and activation; peptide coupling in solution and in the solid phase. F J Davis and W C Hayes (10 lectures) Polymer Chemistry Radical, cationic and anionic polymerisation processes and the structural classes of the polymers that may be formed. Molecular weight determination, polymer characterisation.


Brief description of teaching and learning methods:

Two one hour lectures per week with two workshops on related material .


Contact hours:
  Autumn Spring Summer
Lectures 20
Seminars 2
Guided independent study 78
       
Total hours by term 100.00
       
Total hours for module 100.00

Summative Assessment Methods:
Method Percentage
Written exam 80
Set exercise 20

Other information on summative assessment:

Students will attend 2 workshops on the material covered in this module. Attendance is compulsory. A workshop comprises both written work and oral contribution. A maximum of 20 marks is available for the written work and 5 marks for the oral contribution for each workshop set. Submission dates: Workshops to operate as detailed on Blackboard


Formative assessment methods:

Penalties for late submission:
The Module Convenor will apply the following penalties for work submitted late, in accordance with the University policy.

  • where the piece of work is submitted up to one calendar week after the original deadline (or any formally agreed extension to the deadline): 10% of the total marks available for the piece of work will be deducted from the mark for each working day (or part thereof) following the deadline up to a total of five working days;
  • where the piece of work is submitted more than five working days after the original deadline (or any formally agreed extension to the deadline): a mark of zero will be recorded.

  • The University policy statement on penalties for late submission can be found at: http://www.reading.ac.uk/web/FILES/qualitysupport/penaltiesforlatesubmission.pdf
    You are strongly advised to ensure that coursework is submitted by the relevant deadline. You should note that it is advisable to submit work in an unfinished state rather than to fail to submit any work.

    Length of examination:
    1.5 hours

    Requirements for a pass:
    A mark of 40% overall.

    Reassessment arrangements:
    Reassessment will be held in August and will be by examination only worth 100%.

    Final year students are not eligible to resit this module unless they have failed their degree programme overall.

    Additional Costs (specified where applicable):

    Last updated: 8 May 2017

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